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Cornea June 2025

FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

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Zhiwei Zha; Juan Li; Shuang Xie; Xunjie Shang; Zixin Xu; Haiyuan Chang; Kaisheng Wang; Yang Liu; Wei Chen
TAGS: dry eye syndromes, endoplasmic reticulum stress, fgf10 protein, human, mice, cornea, corneal epithelium, up-regulation (physiology), eye, body tissue, stress
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):72. https://doi.org/10.1167/iovs.66.6.72

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit June 2025

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

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Huy Nguyen; Russell B. Fletcher; Tom Lopez; Elizabeth Whisler; Kelsey R. Logas; Navrose Dhaliwal; Timothy Suen; Mengrui Zhang; Archana Dilip; Tom Z. Yuan; Hayoung Go; Jay Ye; Parthasarathy Sampathkumar; Nick Suen; Hui Chen; Wen-Chen Yeh; Yang Li; Yorick Post
TAGS: lacrimal gland, ligation, acinar cells, mice, body tissue, wounds and injuries, organoids
Trans. Vis. Sci. Tech.. 2025; 14(6):19. https://doi.org/10.1167/tvst.14.6.19

Includes: Supplemental Content

Cornea June 2025

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

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Ning Wang; Yizhou Li; Xiaolei Wang; Lingling Yang; Jing Zhang; Jun Cheng; Xiaoyue Jiang; Xia Qi; Chao Wei; Qingjun Zhou; Ya Li; Suxia Li

Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):28. https://doi.org/10.1167/iovs.66.6.28

Includes: Supplemental Content

Retina June 2025

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

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Wenbo Zhang; Xuecong Zhou; Jiacheng Liu; Tian Tian; Yu Guo; Chen Ling; Jingjing Xu; Qijie Wei; Yang Liu; Yuan Wu
TAGS: arterial disease, brain, cadasil, infarction, leukoencephalopathies, retinal vessels, subcortical
Trans. Vis. Sci. Tech.. 2025; 14(6):17. https://doi.org/10.1167/tvst.14.6.17

Cornea June 2025

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

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Yizhou Li; Feijia Xie; Lingling Yang; Xiaolei Wang; Yangyang Zhang; Hongqi Ge; Min Wang; Rui Cao; Qingjun Zhou; Ya Li
TAGS: cornea, epithelium, mice, stem cells, taurine, wound healing, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):25. https://doi.org/10.1167/iovs.66.6.25

Includes: Supplemental Content

Glaucoma June 2025

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

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Jianqi Chen; Xiaohua Zhuo; Yangjiani Li; Yingting Zhu; Zhidong Li; Xinyue Shen; Yehong Zhuo; Hongmei Tan; Lei Lei
TAGS: body tissue, genes, open-angle glaucoma
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):7. https://doi.org/10.1167/iovs.66.6.7

Includes: Supplemental Content

Cornea April 2025

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

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Min Wang; Rong Chen; Yao Wang; Ya Li; Qingjun Zhou; Rui Cao; Yizhou Li; Hongqi Ge; Xiaolei Wang; Lingling Yang
TAGS: cornea, keratins, limbal stem cells, proteins, stress, epithelium, mice, corneal epithelium, rna, messenger, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):55. https://doi.org/10.1167/iovs.66.4.55

Includes: Supplemental Content

Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Cornea April 2025

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

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Yuzhou Wang; Zhiqiang Xu; Linzhi Wei; Yang Lu; Yizhou Shi; Shiyu Wen; Xiujuan Lv; Kaiyan Huang; Fan Lu; Jia Qu; Liang Hu
TAGS: hmgb1 protein, mice, toll-like receptor 4, inflammation, dry eye syndromes, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):28. https://doi.org/10.1167/iovs.66.4.28

Includes: Supplemental Content

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Glaucoma March 2025

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

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Kunal Kanwar; Rithambara Ramachandran; Joshua D. Stein; Chris A. Andrews; Azraa S. Chaudhury; Maryam Ige; Xueqing Zhou; Shikha Marwah; Yang Li; Charlesnika T. Evans; Abel N. Kho; Paul J. Bryar; Dustin D. French; on behalf of the Sight Outcomes Research Collaborative (SOURCE) Consortium
TAGS: open-angle glaucoma, optic nerve, disease progression
Trans. Vis. Sci. Tech.. 2025; 14(3):15. https://doi.org/10.1167/tvst.14.3.15

Includes: Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Cornea February 2025

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

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Fang Han; Leyi Wang; Jiayin Wu; Lin Shen; Yangyang Li; Hui Guo; Jianqiao Li
TAGS: keratitis, leucine-rich repeat serine/threonine-protein kinase 2, lrrk2 gene, signal pathway, signal transduction pathways, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):13. https://doi.org/10.1167/iovs.66.2.13

Includes: Supplemental Content

Cornea December 2024

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

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Zhiwei Zha; Decheng Xiao; Zihao Liu; Fangli Peng; Xunjie Shang; Zhenzhen Sun; Yang Liu; Wei Chen
TAGS: cyclophosphamide, doxorubicin, prednisone, and vincristine, dry eye syndromes, nlr family, pyrin domain-containing 3 protein, signal pathway, signal transduction pathways, stress, mice, endoplasmic reticulum, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):34. https://doi.org/10.1167/iovs.65.14.34

Includes: Supplemental Content

Cornea September 2024

RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus

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Yunhai Dai; Shilan Mao; Xinyi Zang; Hongqi Ge; Jing Feng; Yalin Wang; Xia Qi; Lingling Yang; Qingjun Zhou; Xiaolei Wang
TAGS: cornea, diabetes mellitus, type 2, human herpesvirus 1, infections, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):36. https://doi.org/10.1167/iovs.65.11.36

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

The Effects of Physical Effort on Time Perception

Li Yang; Rachel Francis; Hyung-Bum Park; Weiwei Zhang

Journal of Vision. 2024; 24(10):717. https://doi.org/10.1167/jov.24.10.717

Vision Sciences Society Annual Meeting Abstract September 2024

A comparison of tasks for constructing the category space of natural scenes

Pei-Ling Yang; Diane M. Beck

Journal of Vision. 2024; 24(10):401. https://doi.org/10.1167/jov.24.10.401

Retina July 2024

Characterization of Ocular Morphology in Col4a3 −/− Mice as a Murine Model for Alport Syndrome

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Yuwei Wang; Ruilin Zhu; Liang Zhao; Fang Wang; Yanqin Zhang; Shiguang Liu; Jie Ding; Liu Yang
TAGS: mice, hereditary nephritis, collagen type iv, language morphology, morphology, lens capsule, crystalline
Trans. Vis. Sci. Tech.. 2024; 13(7):16. https://doi.org/10.1167/tvst.13.7.16

Includes: Supplemental Content

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FGF10 Protects the Corneal Epithelium From Dry Eye-Induced Oxidative and ER Stress Via Upregulation of SLC7A11

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice

Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

SLC6A6-Mediated Taurine Uptake Sustains Corneal Epithelial Stem/Progenitor Cell Function to Counteract Age-Related Dysfunction

Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG

Expression Distribution of Keratins in Normal and Pathological Corneas and the Regulatory Role of Krt17 on Limbal Stem Cells

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

KGF-2 Alleviates Dry Eye Disease by Regulating the HMGB1/TLR4 Pathway

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

The Association of Social Determinants of Health on Monitoring for Disease Progression Among Patients With Primary Open-Angle Glaucoma

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease

RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus

The Effects of Physical Effort on Time Perception

A comparison of tasks for constructing the category space of natural scenes

Characterization of Ocular Morphology in Col4a3 −/− Mice as a Murine Model for Alport Syndrome

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