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Retina June 2025

Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan

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Chien-Chien Cheng; Chien-Yu Lin; Ting-Chieh Ko; Yu-Shu Huang; Chu-Hsuan Huang; Chang-Hao Yang; Tzyy-Chang Ho; Pei-Lung Chen; Ta-Ching Chen
TAGS: alstrom syndrome, genotype, taiwan, obesity, electroretinography, massively-parallel genome sequencing, visual impairment
Trans. Vis. Sci. Tech.. 2025; 14(6):22. https://doi.org/10.1167/tvst.14.6.22

Includes: Supplemental Content

Cornea & External Disease June 2025

Analysis of In Vivo Sclera Impact on the Biomechanics of Myopic Eyes

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Ruisi Xie; Yan Huo; Yutong Li; Zhengyuan Qu; Haohan Zou; Yan Wang
TAGS: biomechanics, cornea, eye, myopia, sclera
Trans. Vis. Sci. Tech.. 2025; 14(6):8. https://doi.org/10.1167/tvst.14.6.8

Includes: Supplemental Content

Glaucoma May 2025

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

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Huiwen Ye; Yanlin Feng; Wu Xiang; Zihao Lin; Yue Li; Wen Hu; Keyu Liu; Shuya Tao; Qinmeng Shu; Jiawei Wang; Fan Xu; Yue Xu; Yantao Wei; Jingjing Huang
TAGS: ferroptosis, mice, glutamate, glutamates, excitotoxicity, low tension glaucoma, lipid peroxidation, retina, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):26. https://doi.org/10.1167/iovs.66.5.26

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging April 2025

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

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Yan-Jie Li; Zeng-Yu Zhang; Tian-Yue Liu; Hai-Yan Liu; Lu-Lu Shi; Rong-Xia Cao; Chao-Ran Lv; Zeng-Hui Zhang
TAGS: angiogram, fluid flow, microcirculation, optical coherence tomography, retina, thyroid carcinoma, papillary, carcinoma, perfusion, inflammation, inspection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):73. https://doi.org/10.1167/iovs.66.4.73

Retina April 2025

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

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Yi-Han Huang; Yu-Shu Huang; Chien-Yu Lin; Ying-Ju Lai; Chang-Hao Yang; Tzzy-Chang Ho; Yi-Ting Hsieh; Po-Ting Yeh; Tso-Ting Lai; Chao-Wen Lin; Chung-May Yang; Pei-Lung Chen; Ta-Ching Chen
TAGS: constriction procedure, disease progression, retinitis pigmentosa, taiwanese, x-linked inheritance, eye, phenotype, exons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):59. https://doi.org/10.1167/iovs.66.4.59

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Temporal Contour Integration Deficits in Children With Amblyopia

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang
TAGS: amblyopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):27. https://doi.org/10.1167/iovs.66.4.27

Cornea April 2025

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

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Yujing Lin; Lingling Yang; Ya Li; Shengqian Dou; Zhenzhen Zhang; Qingjun Zhou
TAGS: antigens, cd25, cornea, diabetes mellitus, mice, nerve degeneration, t-lymphocytes, neuropathy, neuronal outgrowth, neurons
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):15. https://doi.org/10.1167/iovs.66.4.15

Includes: Supplemental Content

Article April 2025

Template-based attentional guidance and generic procedural learning in contextual guided visual search: Evidence from reduced response time variability

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Hongyu Yang; Shasha Zhu; Senlin Liu; Lixia Yuan; Xiaowei Xie; Xuelian Zang
TAGS: cerebral vasospasm, chorionic villi sampling, cyclical vomiting syndrome, learning, reaction time, training, visual search, epoch protocol
Journal of Vision. 2025; 25(4):1. https://doi.org/10.1167/jov.25.4.1

Includes: Supplemental Content

Lens April 2025

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

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Yuti Liu; Jiazhen Yao; Mingxue Ren; Lingxia Ye; An-Peng Pan; Xu Xu
TAGS: cataract, fluorocarbons, prevalence, national health and nutrition examination survey, adult
Trans. Vis. Sci. Tech.. 2025; 14(4):1. https://doi.org/10.1167/tvst.14.4.1

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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Mingsu Shi; Rongmei Zhou; Weiai Shen; Yu Liang; Yihan Zhang; Lingyun Liu; Runyi Shao; Yanxi Fang; Chen Zhao; Lianqun Wu
TAGS: bodily secretions, genes, graves' ophthalmopathy, muscle of orbit, polymerase chain reaction, rna, sequence analysis, rna, sincalide, cell proliferation, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):46. https://doi.org/10.1167/iovs.66.3.46

Includes: Supplemental Content

Retinal Cell Biology March 2025

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

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Xiaodi Zhou; Xiaoxiao Xu; Qiong Wang; Yanting Lai; Linyan Zhang; Yunfeng Lin; Xiaoyan Ding; Limei Sun
TAGS: endothelial cells, hypoxia, notch1 gene, retinal neovascularization, rna, small interfering, signal transduction, proteins, neovascularization, pathologic, ischemia, fluorescence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):39. https://doi.org/10.1167/iovs.66.3.39

Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Lens March 2025

Changes in Lens Thickness and Power Before and After Myopia Onset

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Jiaqing Zhang; Ling Jin; Qianyun Chen; Decai Wang; Xiang Chen; Yuting Li; Yabin Qu; Rong Lin; Mingguang He; Ian G. Morgan; Lixia Luo; Yangfa Zeng; Xiaotong Han
TAGS: lens, crystalline, myopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):36. https://doi.org/10.1167/iovs.66.3.36

Includes: Supplemental Content

Cornea March 2025

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

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Ting Wang; Xiaoqin Chen; Mengdi Li; Hua Bi; Xiaoyan Yang; Muhan Sun; Yue Liu; Lihua Li; Bin Zhang
TAGS: cornea, eye, lens (device), lens, crystalline, myopia, orthokeratology contact lenses, optics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):29. https://doi.org/10.1167/iovs.66.3.29

Includes: Supplemental Content

Cornea March 2025

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

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Zhao-Jing Lu; Jin-Guo Ye; Jing-Ni Li; Jiang-Bo Liang; Ming Zhou; Qiu-Ling Hu; Qi-Kai Zhang; Yu-Heng Lin; Ying-Feng Zheng
TAGS: corneal epithelium, genes, mice, wounds and injuries, chromatin, cornea, wound healing, multiomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):9. https://doi.org/10.1167/iovs.66.3.9

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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Pingbo Ouyang; Jia Qi; Boding Tong; Yunping Li; Jiamin Cao; Lujue Wang; Tongxin Niu; Xin Qi
TAGS: butyrates, fibroblasts, gastrointestinal microbiome, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):5. https://doi.org/10.1167/iovs.66.3.5

Includes: Supplemental Content

Glaucoma February 2025

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

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Haiyan Li; Devon H. Harvey; Jiannong Dai; Steven P. Swingle; Anthony M. Compton; Chenna Kesavulu Sugali; Kamesh Dhamodaran; Jing Yao; Tsai-Yu Lin; Todd Sulchek; Taeyoon Kim; C. Ross Ethier; Weiming Mao
TAGS: actins, adhesions, computer simulation, trabecular meshwork, cell nucleus, green fluorescent proteins, diagnostic imaging, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):65. https://doi.org/10.1167/iovs.66.2.65

Includes: Multimedia, Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Cornea & External Disease February 2025

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

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Debbie Marie Ng; Xiu Wang; Chang Liu; MingYi Yu; Isabelle Xin Yu Lee; Jipson Hon Fai Wong; Regina Kay Ting Wong; Diana Xin Hui Chan; Yu-Chi Liu; Louis Hak Tien Tong
TAGS: ocular pain, pain, rasch model, reliability, surveys
Trans. Vis. Sci. Tech.. 2025; 14(2):20. https://doi.org/10.1167/tvst.14.2.20

Includes: Supplemental Content

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Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan

Analysis of In Vivo Sclera Impact on the Biomechanics of Myopic Eyes

Ferroptosis Contributes to Retinal Ganglion Cell Loss in GLAST Knockout Mouse Model of Normal Tension Glaucoma

Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study

The Exponential Constriction Model of the Ellipsoid Zone in Taiwanese Individuals With RPGR-Related X-Linked Retinitis Pigmentosa

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Temporal Contour Integration Deficits in Children With Amblyopia

CD4 + CD25 − T-Cell–Secreted IFN-γ Promotes Corneal Nerve Degeneration in Diabetic Mice

Template-based attentional guidance and generic procedural learning in contextual guided visual search: Evidence from reduced response time variability

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

Targeted siRNA Delivery Against RUNX1 Via tFNA: Inhibiting Retinal Neovascularization and Restoring Vessels Through Dll4/Notch1 Signaling

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

Changes in Lens Thickness and Power Before and After Myopia Onset

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

Single-Cell Multiomics Analysis of Early Wound Response Programs in the Mouse Corneal Epithelium

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

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