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Articles December 2019

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

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Francisco J. Valiente-Soriano; Arturo Ortín-Martínez; Johnny Di Pierdomenico; Diego García-Ayuso; Alejandro Gallego-Ortega; Juan A. Miralles de Imperial-Ollero; Manuel Jiménez-López; María Paz Villegas-Pérez; Larry A. Wheeler; Manuel Vidal-Sanz
TAGS: brain-derived neurotrophic factor, brimonidine, ciliary neurotrophic factor, fibroblast growth factor 2, lip, phototoxicity, retina, retinal cone, opsin, mice
Trans. Vis. Sci. Tech.. 2019; 8(6):36. doi: https://doi.org/10.1167/tvst.8.6.36

ARVO Annual Meeting Abstract July 2019

A novel nintedanib ophthalmic nanosuspension (AG-86893) for the treatment of pterygium

Tan Nguyen; Sandy Lai; Thomas Malone; Larry A Wheeler; Madhu Cherukury

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2094. doi:

ARVO Annual Meeting Abstract July 2019

AG-73305, a novel multi-specific Fc-fusion protein for the treatment of diabetic macular edema

Madhu Cherukury; Artemis Wu; Ben Chang; Tan Nguyen; Larry A Wheeler

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3663. doi:

ARVO Annual Meeting Abstract July 2019

AG-67650, a bi-specific fusion protein for the treatment of wet age-related macular degeneration

Larry A Wheeler; Artemis Wu; Ben Chang; Tan Nguyen; Madhu Cherukury

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5391. doi:

ARVO Annual Meeting Abstract July 2018

Intravitreal Brimonidine Drug Delivery System (Brimo DDS Generation 1) Enhances Spatial Sweep Visual Evoked Potential (sVEP) in a Non-human Primate Model of Chronic Glaucoma

James A Burke; Kai-Ming Zhang; Werhner Orilla; Corine Ghosn; Larry A Wheeler

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1246. doi:

ARVO Annual Meeting Abstract June 2015

Focal Light-emitting-diode (LED)-induced cone photoreceptor degeneration in mice can be prevented with Brimonidine or trophic factors.

Manuel Vidal-Sanz; F Javier Valiente-Soriano; Arturo Ortin-Martinez; Diego García-Ayuso; Manuel Jiménez-López; Jose M Bernal-Garro; Luis Alarcón-Martínez; Larry A Wheeler; Maria Paz Villegas-Perez

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5667. doi:

ARVO Annual Meeting Abstract April 2014

Role of CD147 in Experimental Autoimmune Anterior Uveitis (EAAU)

Jianping Gao; Reuben Sana; Larry A Wheeler; Virginia L Calder; Stephen C Pflugfelder; Margarita Calonge; Jerry Y Niederkorn; Michael E Stern

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1876. doi:

ARVO Annual Meeting Abstract April 2014

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

Won-Kyu Ju; Sang Yeop Kim; Myoung Sup Sim; Keun-Young Kim; Robert N Weinreb; Larry A Wheeler

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2431. doi:

ARVO Annual Meeting Abstract April 2014

Stress-Induced Damage to the Ocular Surface Resembling Dry Eye can Occur Independently of Chronic T cell-mediated Disease

Michael E Stern; Katherine S Held; Chris S Schaumburg; Euikyon Oh; Sveti Ugarte; Larry A Wheeler; Margarita Calonge; Jerry Y Niederkorn; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3059. doi:

ARVO Annual Meeting Abstract April 2014

Regulatory T cell mediated suppression of dendritic cells in a mouse model of dry eye

Katherine S Held; Chris S Schaumburg; Jianping Gao; Julio Nieves; Euikyon Oh; Larry A Wheeler; Virginia L Calder; Jerry Y Niederkorn; Stephen C Pflugfelder; Michael E Stern

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3653. doi:

ARVO Annual Meeting Abstract April 2014

Impact of the Host Microbiota on the Development of Murine Desiccating Stress-Induced Dry Eye Disease

Chris S Schaumburg; Katherine S Held; Annie M Ratanapinta; Madhuri Paul; Larry A Wheeler; Margarita Calonge; Jerry Y Niederkorn; Stephen C Pflugfelder; Michael E Stern

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3657. doi:

Cornea July 2013

Mitochondrial Permeability Transition Pore in Inflammatory Apoptosis of Human Conjunctival Epithelial Cells and T Cells: Effect of Cyclosporin A

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Jianping Gao; Reuben Sana; Virginia Calder; Margarita Calonge; Wanju Lee; Larry A. Wheeler; Michael E. Stern
TAGS: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, apoptosis, cyclosporine, mitochondria, t-lymphocytes, conjunctival epithelial cells, conjunctiva, permeability, inflammation
Invest. Ophthalmol. Vis. Sci.. 2013; 54(7):4717-4733. doi: https://doi.org/10.1167/iovs.13-11681

ARVO Annual Meeting Abstract June 2013

Molecular Mechanisms of Inflammatory Apoptosis of Conjunctival Epithelial Cells and T cells: Effect of Cyclosporin A (CsA)

Jianping Gao; Reuben Sana; Virginia Calder; Margarita Calonge; Wanju Lee; Larry Wheeler; Michael Stern

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2122. doi:

ARVO Annual Meeting Abstract June 2013

Plasmacytoid Dendritic Cells are the Primary Source of IFN-α During the Immunopathogenesis of Desiccating Stress-Induced Dry Eye Disease

Michael Stern; Chris Schaumburg; Jianping Gao; Annie Ratanapinta; Virginia Calder; Larry Wheeler; Jerry Niederkorn; Stephen Pflugfelder; Bruce Beutler; Argyrios Theofilopoulos

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4323. doi:

ARVO Annual Meeting Abstract June 2013

Mice with Desiccating Stress-Induced Dry Eye Develop Trigeminal Neuralgia, Despite Decreased Corneal Sensitivity and Nerve Fiber Degeneration

Chris Schaumburg; Katherine Held; Euikyun Oh; Sveti Ugarte; Larry Wheeler; Margarita Calonge; Jerry Niederkorn; Stephen Pflugfelder; Robert Fox; Michael Stern

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2194. doi:

ARVO Annual Meeting Abstract June 2013

Potential Regulatory T Cell Mechanisms Of Immune Suppression In A Mouse Model Of Dry Eye

Katherine Held; Chris Schaumburg; Jianping Gao; Larry Wheeler; Margarita Calonge; Jerry Niederkorn; Stephen Pflugfelder; Michael Stern

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):919. doi:

Retinal Cell Biology November 2012

Protective Effect of Carnosic Acid, a Pro-Electrophilic Compound, in Models of Oxidative Stress and Light-Induced Retinal Degeneration

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Tayebeh Rezaie; Scott R. McKercher; Kunio Kosaka; Masaaki Seki; Larry Wheeler; Veena Viswanath; Teresa Chun; Rabina Joshi; Marcos Valencia; Shunsuke Sasaki; Terumasa Tozawa; Takumi Satoh; Stuart A. Lipton
TAGS: antioxidants, cell lines, electroretinography, oxidative stress, photoreceptors, retina, retinal degeneration, genes, rats, proteins
Invest. Ophthalmol. Vis. Sci.. 2012; 53(12):7847-7854. doi: https://doi.org/10.1167/iovs.12-10793

Includes: Supplemental Content

Cornea April 2012

Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease

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Michael E. Stern; Chris S. Schaumburg; Karyn F. Siemasko; Jianping Gao; Larry A. Wheeler; Devin A. Grupe; Cintia S. De Paiva; Virginia L. Calder; Margarita Calonge; Jerry Y. Niederkorn; Stephen C. Pflugfelder
TAGS: autoantibodies, dry eye syndromes, mice, immunoglobulin g
Invest. Ophthalmol. Vis. Sci.. 2012; 53(4):2062-2075. doi: https://doi.org/10.1167/iovs.11-9299

ARVO Annual Meeting Abstract March 2012

Cyclosporin A (CsA) Induces T Cell Apoptosis and Protects Human Conjunctival Epithelial Cells (IOBA-NHC) from Stress-Induced Apoptosis via Modulation of the Mitochondria Permeability Transition Pore (MPTP)

Jianping Gao; Reuben Sana; Margarita Calonge; Larry A. Wheeler; Michael E. Stern

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3978. doi:

ARVO Annual Meeting Abstract March 2012

Alterations in Corneal Nerve Fiber Density and Pain Markers during the Progression of Desiccating Stress-Induced Dry Eye Disease

Chris S. Schaumburg; Euikyun Oh; Sveti Patel; Jianping Gao; Larry A. Wheeler; Margarita Calonge; Jerry Y. Niederkorn; Stephen C. Pflugfelder; Robert I. Fox; Michael E. Stern

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1796. doi:

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Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

A novel nintedanib ophthalmic nanosuspension (AG-86893) for the treatment of pterygium

AG-73305, a novel multi-specific Fc-fusion protein for the treatment of diabetic macular edema

AG-67650, a bi-specific fusion protein for the treatment of wet age-related macular degeneration

Intravitreal Brimonidine Drug Delivery System (Brimo DDS Generation 1) Enhances Spatial Sweep Visual Evoked Potential (sVEP) in a Non-human Primate Model of Chronic Glaucoma

Focal Light-emitting-diode (LED)-induced cone photoreceptor degeneration in mice can be prevented with Brimonidine or trophic factors.

Role of CD147 in Experimental Autoimmune Anterior Uveitis (EAAU)

Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

Stress-Induced Damage to the Ocular Surface Resembling Dry Eye can Occur Independently of Chronic T cell-mediated Disease

Regulatory T cell mediated suppression of dendritic cells in a mouse model of dry eye

Impact of the Host Microbiota on the Development of Murine Desiccating Stress-Induced Dry Eye Disease

Mitochondrial Permeability Transition Pore in Inflammatory Apoptosis of Human Conjunctival Epithelial Cells and T Cells: Effect of Cyclosporin A

Molecular Mechanisms of Inflammatory Apoptosis of Conjunctival Epithelial Cells and T cells: Effect of Cyclosporin A (CsA)

Plasmacytoid Dendritic Cells are the Primary Source of IFN-α During the Immunopathogenesis of Desiccating Stress-Induced Dry Eye Disease

Mice with Desiccating Stress-Induced Dry Eye Develop Trigeminal Neuralgia, Despite Decreased Corneal Sensitivity and Nerve Fiber Degeneration

Potential Regulatory T Cell Mechanisms Of Immune Suppression In A Mouse Model Of Dry Eye

Protective Effect of Carnosic Acid, a Pro-Electrophilic Compound, in Models of Oxidative Stress and Light-Induced Retinal Degeneration

Autoantibodies Contribute to the Immunopathogenesis of Experimental Dry Eye Disease

Cyclosporin A (CsA) Induces T Cell Apoptosis and Protects Human Conjunctival Epithelial Cells (IOBA-NHC) from Stress-Induced Apoptosis via Modulation of the Mitochondria Permeability Transition Pore (MPTP)

Alterations in Corneal Nerve Fiber Density and Pain Markers during the Progression of Desiccating Stress-Induced Dry Eye Disease

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