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ARVO Annual Meeting Abstract June 2020

AAV gene therapy restores ON-bipolar cell function in a canine model of LRIT3 -congenital stationary night blindness

Keiko Miyadera; Karolina Roszak; Ana Ripolles Garcia; Evelyn Santana; Sommer M Iffrig; Meike Visel; Leah Byrne; William A Beltran; John Gerard Flannery; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2298. doi:

ARVO Annual Meeting Abstract June 2020

Single-cell ATAC-seq analysis of mouse, non-human primate and human retina

Zhouhuan Xi; Molly Johnson; Bilge Esin Ozturk; Serhan Turunç; William Stauffer; Leah Byrne

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3178. doi:

ARVO Annual Meeting Abstract June 2020

AAV capsid variants target canine and primate bipolar cells after subretinal and intravitreal delivery

William A Beltran; Natalia Dolgova; Valerie L Dufour; Iwabe Simone; Ryan F. Boyd; Joshua T Bartoe; Gustavo D Aguirre; David L schaffer; John Gerard Flannery; Leah Byrne

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4489. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Gene delivery to the primate retina

Leah Byrne

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4. doi:

ARVO Annual Meeting Abstract July 2019

A modular linked-AAV building block system for gene and protein delivery

Bilge Esin Ozturk; Timothy P Day; Serhan Turunc; Sara Jabalameli; John Gerard Flannery; Jose Alain Sahel; Leah Byrne

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2901. doi:

ARVO Annual Meeting Abstract July 2018

AAV mediated delivery of NT4 specifically to Müller glial cells promotes retinal ganglion cell survival in the DBA/2J mouse model of glaucoma.

Anna M Demetriades; Chendong Pan; Leah Byrne; Jeffrey Harder; Simon W John; John Gerard Flannery

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6135. doi:

ARVO Annual Meeting Abstract September 2016

Müller glial cell-specific GDNF expression promotes retinal ganglion cell survival in DBA/2J mice

Anna M Demetriades; Chendong Pan; Leah C Byrne; Erum Ahmed; Jeffrey Harder; Simon W John; John Gerard Flannery

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Directed evolution identifies novel AAV capsid variants for targeting the canine outer retina following intravitreal delivery

Leah C Byrne; Meike Visel; Valerie Dufour; Felipe Pompeo Marinho; Gustavo D Aguirre; William A Beltran; David Schaffer; John Gerard Flannery

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):776. doi:

ARVO Annual Meeting Abstract September 2016

Retinal Cells Generate and Secrete Cytokines and Bioreactive Lipids that Promote Choriocapillaris Homeostasis

Peter D Westenskow; Salome Murinello; Daniel Feitelberg; Edith Aguilar; Leah C Byrne; John Gerard Flannery; Gary Siuzdak; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract June 2015

Neuroprotective effect of AAV-mediated cell-specific expression of GDNF in Müller glial cells versus retinal ganglion cells in a murine model of glaucoma

Chendong Pan; Noreen Shaikh; Steven Gu; Leah Byrne; Meike Visel; Thomas Walter Chalberg; David Schaffer; John Gerard Flannery; Anna M Demetriades

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2421. doi:

ARVO Annual Meeting Abstract June 2015

CRALBP is required for the function of the mammalian retina visual cycle and normal M-cone vision

Yunlu Xue; Susan Shen; Jonathan Jui; Alan C Rupp; Leah Byrne; Samer Hattar; John Gerard Flannery; Joseph C Corbo; Vladimir J Kefalov

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1703. doi:

OSA Fall Vision Meeting Abstract December 2014

In vivo imaging of ChR2-RCaMP expression in retinal neurons of a transgenic blind mouse model

Soon Cheong; Wanyue Song; Leah Byrne; Revathi Balasubramanian; William Merigan

Journal of Vision. 2014; 14(15):35. doi: https://doi.org/10.1167/14.15.35

ARVO Annual Meeting Abstract April 2014

Angiogenin is a potent modulator of neovascularization and inflammation that is upregulated in various human retinal diseases

Carli M Wittgrove; Liliana P Paris; Yoshihiko Usui; Yoshihiro Wakabayashi; Edith Aguilar; Daniel Feitelberg; Peter D Westenskow; Leah C Byrne; John Gerard Flannery; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2242. doi:

ARVO Annual Meeting Abstract April 2014

Cone Photoreceptors Can Generate the Potent Neurotrophic and Pro-angiogenic Fatty Acid Amide Erucamide

Peter D Westenskow; Toshihide Kurihara; Yoshihiko Usui; Stephen Bravo; Junhua Wang; Leah C Byrne; Yoshihiro Wakabayashi; John Gerard Flannery; Gary Suizdak; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5753. doi:

ARVO Annual Meeting Abstract June 2013

AAV-mediated Combination Therapy of Neurotrophic and Anti-Apoptotic Factors in a Mouse Model of Inherited Retinal Degeneration

Cecile Fortuny; Leah Byrne; Deniz Dalkara; Trevor Lee; Bilge Esin Ozturk

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2746. doi:

ARVO Annual Meeting Abstract June 2013

Mouse Cone Dark Adaptation Relies on Two Visual Cycles and Is Substantially Retarded in Mice Lacking RDH8 and ABCA4

Alexander Kolesnikov; Peter Tang; Akiko Maeda; Leah Byrne; John Flannery; Krzysztof Palczewski; Vladimir Kefalov

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1699. doi:

ARVO Annual Meeting Abstract March 2012

Circadian Rhythm in a Photo-Insensitive Mouse Model with Retinal Expression of Exogenous Light-Gated Ion Channels

Trevor S. Lee; Deniz Dalkara; Leah Byrne; Stephan G. Jarjisian; Meike Visel; Lance J. Kriegsfeld; John G. Flannery

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1898. doi:

ARVO Annual Meeting Abstract March 2012

Creation of a Macular Telangiectasia Rodent Model

Fakhra I. Khalid; Leah C. Byrne; Trevor Lee; John G. Flannery

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1640. doi:

ARVO Annual Meeting Abstract March 2012

AAV-Mediated Delivery of RdCVF and RdCVFL in a Mouse Model of Retinal Degeneration

Leah C. Byrne; Deniz Dalkara; Emmanuelle Clerin; Steven K. Fisher; Jose A. Sahel, Jr.; Thierry D. Leveillard; John G. Flannery

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1907. doi:

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