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ARVO Annual Meeting Abstract June 2015

In Vivo Gene Expression Profiling of the RPE/Choroid Following Intravitreal Steroid Injections Shows Alteration of Circadian Rhythm and Neurotransmitter Signaling

Elad Moisseiev; Zeljka Smit-McBride; Sara Modjtahedi; David Telander; Leonard M Hjelmeland; Lawrence S Morse

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):226.

ARVO Annual Meeting Abstract April 2014

Circulating microRNAs in ocular fluids as a putative novel diagnostic biomarkers for diabetic retinopathy

Zeljka Smit-McBride; Allan A Hunter; Amar P Patel; Leonard M Hjelmeland; Lawrence S Morse

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1277.

ARVO Annual Meeting Abstract April 2014

Differential Age-related Expression of MicroRNA-34a in Mouse Retina and RPE

Krisztina I Forward; Zeljka Smit-McBride; Anthony Nguyen; Matthew Bordbari; Leonard M Hjelmeland

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4517.

ARVO Annual Meeting Abstract April 2014

In Situ Localization of Complement Factor H Gene Expression in the Mouse Eye

Sharon L Oltjen; Leonard M Hjelmeland; Roxana A Radu

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6327.

ARVO Annual Meeting Abstract March 2012

Analysis And Comparison Of Human Circulatory MicroRNA Profiles Of Aqueous And Vitreous Humour From Normal Eyes vs. Those With Diabetic Retinopathy or AMD

Zeljka Smit-McBride; Saadia Rashid; Alfred K. Yu; Susanna S. Park; Leonard M. Hjelmeland; David G. Telander; Lawrence S. Morse

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2438.

ARVO Annual Meeting Abstract March 2012

Age-related Variation of Cytosine Methylation in the Sod2 Promoter in the RPE/choroid and Retina Within and Among Individual BALB/c Mouse Eyes

Leonard M. Hjelmeland; Alfred K. Yu; Zeljka Smit-McBride

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5136.

ARVO Annual Meeting Abstract March 2012

Immunolocalization and Age-related Gene Expression Changes of Complement Factor H in the Posterior Pole of the Mouse Eye

Sharon L. Oltjen; Zeljka Smit-McBride; Leonard M. Hjelmeland

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6558.

Physiology and Pharmacology November 2011

In Vivo Gene Expression Profiling of Retina Postintravitreal Injections of Dexamethasone and Triamcinolone at Clinically Relevant Time Points for Patient Care

PDF

Zeljka Smit-McBride; Sara P. Modjtahedi; Christopher T. Cessna; David G. Telander; Leonard M. Hjelmeland; Lawrence S. Morse
TAGS: genes, retina, signal transduction, dexamethasone, steroids, injections, triamcinolone, patient care, gene expression profiling, semaphorins
Invest. Ophthalmol. Vis. Sci.. 2011; 52(12):8965-8978. https://doi.org/10.1167/iovs.10-7084

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2011

Intracellular Localization Of CFH In The Mouse RPE

Sharon L. Oltjen; Leonard M. Hjelmeland

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):893.

ARVO Annual Meeting Abstract April 2011

MicroRNA Expression In The Aging Mouse RPE/choroid

Zeljka Smit-McBride; Sharon L. Oltjen; Leonard M. Hjelmeland

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):16.

ARVO Annual Meeting Abstract April 2011

To Identify Early And Late Changes In Immunoregulatory Gene Expression Pathways In Retinal Pigment Epithelium (RPE) Induced By Intravitreal Injections Of Triamcinolone Acetonide (TAA) And Dexamethasone (Dex) In The C57BL/6J Mice

Sara P. Modjtahedi; Zeljka Smit-McBride; Albert K. Yu; David G. Telander; Leonard M. Hjelmeland; Lawrence S. Morse

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):27.

Review March 2011

Dark Matters in AMD Genetics: Epigenetics and Stochasticity

PDF

Leonard M. Hjelmeland
TAGS: epigenetics, genes, genetics, methylation, alleles
Invest. Ophthalmol. Vis. Sci.. 2011; 52(3):1622-1631. https://doi.org/10.1167/iovs.10-6765

Retina January 2007

A Strong Genetic Determinant of Hyperoxia-Related Retinal Degeneration on Mouse Chromosome 6

PDF

Zeljka Smit-McBride; Sharon L. Oltjen; Matthew M. LaVail; Leonard M. Hjelmeland
TAGS: chromosomes, human, pair 6, genetics, hyperoxia, mice, mice, inbred c57bl, retinal degeneration, single nucleotide polymorphism, genes
Invest. Ophthalmol. Vis. Sci.. 2007; 48(1):405-411. https://doi.org/10.1167/iovs.06-0854

Includes: Supplemental Content

Retina July 2004

Ultrastructural Aging of the RPE–Bruch’s Membrane–Choriocapillaris Complex in the d -Galactose–Treated Mouse

PDF

Hisashi Ida; Kazuki Ishibashi; Karen Reiser; Leonard M. Hjelmeland; James T. Handa
TAGS: aging, bruch's basal membrane, galactose, mice
Invest. Ophthalmol. Vis. Sci.. 2004; 45(7):2348-2354. https://doi.org/10.1167/iovs.03-1337

Retinal Cell Biology May 2004

Topographic and Age-Dependent Expression of Heme Oxygenase-1 and Catalase in the Human Retinal Pigment Epithelium

PDF

Noritake Miyamura; Tsukihiko Ogawa; Sharon Boylan; Lawrence S. Morse; James T. Handa; Leonard M. Hjelmeland
TAGS: catalase, heme, in situ hybridization, oxygenases, retinal pigment epithelium, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2004; 45(5):1562-1565. https://doi.org/10.1167/iovs.02-0761

Retinal Cell Biology April 2003

Polarized Expression of Monocarboxylate Transporters in Human Retinal Pigment Epithelium and ARPE-19 Cells

PDF

Nancy J. Philp; Dian Wang; Heeyong Yoon; Leonard M. Hjelmeland
TAGS: antibodies, membrane transport proteins, proteins, retinal pigment epithelium, tissue membrane, western blotting, basolateral membrane, fluorescent antibody technique, lactates, protein isoforms
Invest. Ophthalmol. Vis. Sci.. 2003; 44(4):1716-1721. https://doi.org/10.1167/iovs.02-0287

Retinal Cell Biology October 2001

Downregulation of Differentiation Specific Gene Expression by Oxidative Stress in ARPE-19 Cells

PDF

Mitra Alizadeh; Mitsumasa Wada; Claire M. Gelfman; James T. Handa; Leonard M. Hjelmeland
TAGS: down-regulation, fgfr2 gene, gene expression, oxidative stress, rna, messenger, fibroblast growth factor receptors, cell survival
Invest. Ophthalmol. Vis. Sci.. 2001; 42(11):2706-2713.

Retinal Cell Biology September 2001

Induction of an Aging mRNA Retinal Pigment Epithelial Cell Phenotype by Matrix-Containing Advanced Glycation End Products In Vitro

PDF

Shigeru Honda; Behnom Farboud; Leonard M. Hjelmeland; James T. Handa
TAGS: age, aging, genes, glycosylation end products, advanced, phenotype, retinal pigment cell, rna, messenger, rna, apoptosis, annexin a5
Invest. Ophthalmol. Vis. Sci.. 2001; 42(10):2419-2425.

Retinal Cell Biology August 2001

Oxidative Stress–Induced Single-Strand Breaks in Chromosomal Telomeres of Human Retinal Pigment Epithelial Cells In Vitro

PDF

Shigeru Honda; Leonard M. Hjelmeland; James T. Handa
TAGS: aspergillus nuclease s1, chromosomes, dna, hyperoxia, oxidative stress, retinal pigment cell, telomere, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2001; 42(9):2139-2144.

Retinal Cell Biology June 2001

Age and Topographic Variation of Insulin-like Growth Factor–Binding Protein 2 in the Human RPE

PDF

Noritake Miyamura; Kazuaki Mishima; Shigeru Honda; Amy E. Aotaki-Keen; Lawrence S. Morse; James T. Handa; Leonard M. Hjelmeland
TAGS: igfbp2 protein, human, in situ hybridization
Invest. Ophthalmol. Vis. Sci.. 2001; 42(7):1626-1630.

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In Vivo Gene Expression Profiling of the RPE/Choroid Following Intravitreal Steroid Injections Shows Alteration of Circadian Rhythm and Neurotransmitter Signaling

Circulating microRNAs in ocular fluids as a putative novel diagnostic biomarkers for diabetic retinopathy

Differential Age-related Expression of MicroRNA-34a in Mouse Retina and RPE

In Situ Localization of Complement Factor H Gene Expression in the Mouse Eye

Analysis And Comparison Of Human Circulatory MicroRNA Profiles Of Aqueous And Vitreous Humour From Normal Eyes vs. Those With Diabetic Retinopathy or AMD

Age-related Variation of Cytosine Methylation in the Sod2 Promoter in the RPE/choroid and Retina Within and Among Individual BALB/c Mouse Eyes

Immunolocalization and Age-related Gene Expression Changes of Complement Factor H in the Posterior Pole of the Mouse Eye

In Vivo Gene Expression Profiling of Retina Postintravitreal Injections of Dexamethasone and Triamcinolone at Clinically Relevant Time Points for Patient Care

Intracellular Localization Of CFH In The Mouse RPE

MicroRNA Expression In The Aging Mouse RPE/choroid

To Identify Early And Late Changes In Immunoregulatory Gene Expression Pathways In Retinal Pigment Epithelium (RPE) Induced By Intravitreal Injections Of Triamcinolone Acetonide (TAA) And Dexamethasone (Dex) In The C57BL/6J Mice

Dark Matters in AMD Genetics: Epigenetics and Stochasticity

A Strong Genetic Determinant of Hyperoxia-Related Retinal Degeneration on Mouse Chromosome 6

Ultrastructural Aging of the RPE–Bruch’s Membrane–Choriocapillaris Complex in the d -Galactose–Treated Mouse

Topographic and Age-Dependent Expression of Heme Oxygenase-1 and Catalase in the Human Retinal Pigment Epithelium

Polarized Expression of Monocarboxylate Transporters in Human Retinal Pigment Epithelium and ARPE-19 Cells

Downregulation of Differentiation Specific Gene Expression by Oxidative Stress in ARPE-19 Cells

Induction of an Aging mRNA Retinal Pigment Epithelial Cell Phenotype by Matrix-Containing Advanced Glycation End Products In Vitro

Oxidative Stress–Induced Single-Strand Breaks in Chromosomal Telomeres of Human Retinal Pigment Epithelial Cells In Vitro

Age and Topographic Variation of Insulin-like Growth Factor–Binding Protein 2 in the Human RPE

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