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Cornea April 2025

Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

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Haiqi Xiao; Li Hu; Xiongshi Lin; Linchang Liu; Xing Dong; Liting Yang; Ying Liu; Zhichong Wang; Ying Tian; Shuangyong Wang
TAGS: pax6 transcription factor, soluble fms-like tyrosine kinase 1
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):52. https://doi.org/10.1167/iovs.66.4.52

Includes: Supplemental Content

Biochemistry and Molecular Biology April 2025

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier

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Siyuan Liu; Ning Du; Keke Ge; Jiayue Hu; Wenfang Zhang
TAGS: 1-phosphatidylinositol 3-kinase, endothelial cells, high altitude, hypoxia, cadherins, akt signaling pathway, mice, fluorescent antibody technique, evans blue stain, blood-retinal barrier
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):51. https://doi.org/10.1167/iovs.66.4.51

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

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Wei-Qi Song; Wen-Fang Zhong; Zhi-Hao Li; Dan Liu; Jiao-Jiao Ren; Dong Shen; Jian Gao; Pei-Liang Chen; Jin Yang; Xiao-Meng Wang; Fang-Fei You; Chuan Li; Huan Chen; Jia-Hao Xie; Chen Mao
TAGS: glaucoma, genetic predisposition to disease
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):47. https://doi.org/10.1167/iovs.66.4.47

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2025

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

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Xuechun Wang; Kuan Li; Lingzhi Guo; Xinlong Liu; Yatu Guo; Wei Zhang
TAGS: mice, microglia, visual cortex, interneurons, neurons, small nuclear rna, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):45. https://doi.org/10.1167/iovs.66.4.45

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

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Senmao Li; Jingbin Xie; Jiayan Xiang; Ruyu Yan; Jiangman Liu; Qiwei Fan; Liyuan Lu; Jiaxin Wu; Jun Liu; Yunxia Xue; Ting Fu; Zhijie Li
TAGS: cornea, lacrimal gland, nerve injuries, neurons, rhythm, circadian rhythms, nerve supply, mice, wounds and injuries, sensory nerves
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):40. https://doi.org/10.1167/iovs.66.4.40

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2025

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

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Xiaonan Zhuang; Fengjuan Gao; Yi Xuan; Zhongcui Sun; Xiaofeng Ye; Xin Huang; Rui Jiang; Jihong Wu; Min Wang; Qing Chang; Gezhi Xu; Wei Liu
TAGS: angiogram, atypical, eye, genetics, retinal capillary hemangioma, von hippel-lindau syndrome, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):34. https://doi.org/10.1167/iovs.66.4.34

Includes: Supplemental Content

Visual Neuroscience April 2025

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes

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Qiuyan Wu; Ruihan Hu; Qihong Liu; Fang Li; Yuanyuan Wang; Zuohuizi Yi; Jiajia Yuan; Yilei Shao; Meixiao Shen; Hongmei Zheng; Changzheng Chen
TAGS: eye, retinal blind spot, glaucoma, myopia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):5. https://doi.org/10.1167/iovs.66.4.5

Includes: Supplemental Content

Visual Psychophysics and Physiological Optics April 2025

Temporal Contour Integration Deficits in Children With Amblyopia

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Yan-Ru Chen; Shu-Qi Jiang; Xiang-Yun Liu; Jun-Yun Zhang
TAGS: amblyopia, child
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):27. https://doi.org/10.1167/iovs.66.4.27

Biochemistry and Molecular Biology April 2025

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

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Shuting Lu; Qian Liu; Fan Ye; Ziran Zhang; Lianjun Shi; Xiumiao Li; Wan Mu; Qin Jiang; Biao Yan
TAGS: cholesterol metabolism, lymphangiogenesis, lymphatic vessels, rna, cornea, sutures, circular rna, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):26. https://doi.org/10.1167/iovs.66.4.26

Includes: Supplemental Content

Cornea & External Disease April 2025

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

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Shuaiyi Li; Yiping Liu; Bao Yang; Sulei Lv; Xiulan Zou; Liqun Tang; Licheng Zhou; Zhenyu Jiang; Zejia Liu
TAGS: catabolism, cornea, corneal edema, monte carlo method, transparency, fibril
Trans. Vis. Sci. Tech.. 2025; 14(4):15. https://doi.org/10.1167/tvst.14.4.15

Glaucoma April 2025

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

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Jinpeng Yang; Yangjiani Li; Qi Zhang; Simei Zeng; Haishun Huang; Caiqing Wu; Zhe Liu; Jiahui Tang; Siting Wu; Yuze Chen; Yehong Zhuo; Yangfan Yang; Yiqing Li
TAGS: glaucoma, language morphology, morphology, myopia, optic disk, optic nerve, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):18. https://doi.org/10.1167/iovs.66.4.18

Includes: Supplemental Content

Retina April 2025

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis

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Shanshan Zhu; Lusi Zhang; Ping Tong; Jiawei Chen; Cong Wang; Zewei Wang; Jingyuan Liu; Peiyun Duan; Qian Jiang; Yubing Zhou; Guangshuang Tan; Xian Zhang; Bing Jiang
TAGS: dna, niacinamide, pyroptosis, retinal degeneration, retina, light exposure, mice, neuroinflammatory diseases, photoreceptors, microglia
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):14. https://doi.org/10.1167/iovs.66.4.14

Includes: Supplemental Content

Uveitis April 2025

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

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Hui Liu; Suo Guo; Yaning Liu; Guannan Su; Peizeng Yang
TAGS: chinese (other dialects), signs and symptoms, uveitis, anterior, chinese people, cytomegalovirus, intraocular pressure
Trans. Vis. Sci. Tech.. 2025; 14(4):2. https://doi.org/10.1167/tvst.14.4.2

Includes: Supplemental Content

Article April 2025

Template-based attentional guidance and generic procedural learning in contextual guided visual search: Evidence from reduced response time variability

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Hongyu Yang; Shasha Zhu; Senlin Liu; Lixia Yuan; Xiaowei Xie; Xuelian Zang
TAGS: cerebral vasospasm, chorionic villi sampling, cyclical vomiting syndrome, learning, reaction time, training, visual search, epoch protocol
Journal of Vision. 2025; 25(4):1. https://doi.org/10.1167/jov.25.4.1

Includes: Supplemental Content

Lens April 2025

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

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Yuti Liu; Jiazhen Yao; Mingxue Ren; Lingxia Ye; An-Peng Pan; Xu Xu
TAGS: cataract, fluorocarbons, prevalence, national health and nutrition examination survey, adult
Trans. Vis. Sci. Tech.. 2025; 14(4):1. https://doi.org/10.1167/tvst.14.4.1

Includes: Supplemental Content

Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Cornea & External Disease March 2025

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

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Sunny Kwok; Xueliang Pan; Manqi Pan; Zihao Chen; Madison Ammon; Andrew Hendershot; Jun Liu
TAGS: cornea, keratoconus, ultrasound elastography, ultrasonography, eye
Trans. Vis. Sci. Tech.. 2025; 14(3):22. https://doi.org/10.1167/tvst.14.3.22

Biochemistry and Molecular Biology March 2025

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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Mingsu Shi; Rongmei Zhou; Weiai Shen; Yu Liang; Yihan Zhang; Lingyun Liu; Runyi Shao; Yanxi Fang; Chen Zhao; Lianqun Wu
TAGS: bodily secretions, genes, graves' ophthalmopathy, muscle of orbit, polymerase chain reaction, rna, sequence analysis, rna, sincalide, cell proliferation, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):46. https://doi.org/10.1167/iovs.66.3.46

Includes: Supplemental Content

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Pax6 Directly Regulates the Raver2/sFlt-1 Expression in Corneal Epithelial Cells to Maintain the Cornea's Avascular Privilege

NMN Supplementation Inhibits Endothelial Cell ROS-Mediated Src/Pi3k/Akt Signaling Pathway to Protect High-Altitude Blood-Retinal Barrier

Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk

The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice

Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Novel OCT Angiography Features, von Hippel–Lindau Disease Association, and Genetic Characterization of Juxtapapillary Retinal Capillary Hemangiomas

Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes

Temporal Contour Integration Deficits in Children With Amblyopia

Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling

An Improved Monte Carlo Method for Quantitative Analysis of Transparency Degradation Caused by Corneal Edema

Optic Nerve Morphology Influences Structure-Function Relationship in Early Glaucoma With and Without High Myopia

Nicotinamide Riboside Mitigates Retinal Degeneration by Suppressing Damaged DNA-Stimulated Microglial Activation and STING-Mediated Pyroptosis

Identification of Subtypes of Herpetic Anterior Uveitis and Characterization of Their Clinical Features and Visual Outcome in a Chinese Population

Template-based attentional guidance and generic procedural learning in contextual guided visual search: Evidence from reduced response time variability

Association of Per- and Polyfluoroalkyl Substance Exposure With Cataract Prevalence Among U.S. Adults: A NHANES Analysis (2005–2008)

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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