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Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

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An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Retina January 2025

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

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Guocheng Xiao; Mei Ge; Guoqing Qiao; Shuyu Liu; Na Li; Feng Liu; Yanye Lu; Qiushi Ren; Liqiang Wang
TAGS: adult, myopia, oxygen
Trans. Vis. Sci. Tech.. 2025; 14(1):18. https://doi.org/10.1167/tvst.14.1.18

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Retina January 2025

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

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Lisong Wang; Gaocheng Zou; Yuanye Yan; Ronghua Shi; Yue Guo; Mei Zhang; Li Lu; Kai Dong
TAGS: idebenone, mice, oxidative phosphorylation defect, photoreceptors, retinal detachment, body tissue, mitochondria, retina, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):17. https://doi.org/10.1167/iovs.66.1.17

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Cornea October 2024

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

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Liqiong Zhu; Chaoqun Chen; Siqi Wu; Huizhen Guo; Lingyu Li; Li Wang; Dongmei Liu; Yu Zhan; Xinyue Du; Jiafeng Liu; Jieying Tan; Ying Huang; Kunlun Mo; Xihong Lan; Hong Ouyang; Jin Yuan; Xiangjun Chen; Jianping Ji
TAGS: cornea, homeostasis, pax6 transcription factor, scirrhous adenocarcinoma, epithelium, chronic exertional compartment syndrome, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):40. https://doi.org/10.1167/iovs.65.12.40

Includes: Supplemental Content

Cornea September 2024

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

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Ming Zhou; Zhuo-Xing Shi; Zhong Liu; Shu-Rui Ke; Chao-Yang Wang; Xiao-Lin Liang; Qiu-Ling Hu; Qi-Kai Zhang; Dong-Liang Wang; Li Sun; Yu-Heng Lin; Qi Dai; Ying-Feng Zheng
TAGS: cornea, corneal epithelium, genes, macaca fascicularis, wound healing, epithelium, transcription, genetic, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):43. https://doi.org/10.1167/iovs.65.11.43

Includes: Supplemental Content

ARVO Imaging in the Eye Conference Abstract July 2024

Fully Automated OCT-based Tissue Screening System

Shaohua Pi; Razieh Ganjee; Lingyun Wang; Riley Arbuckle; Chengcheng Zhao; Jose A. Sahel; Bingjie Wang; Yuanyuan Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PB0018.

ARVO Imaging in the Eye Conference Abstract July 2024

Reveal retinal ultra-structure with self-supervised denoising in vis-OCT

Lingyun Wang; Jose A. Sahel; Shaohua Pi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PP009.

Glaucoma July 2024

Differences in Systemic Pulse Waveform Between Individuals With Glaucoma, Glaucoma Suspects, and Healthy Controls

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Hongli Yang; Grant Cull; Mingrui Yang; Lin Wang; Brad Fortune; Stuart K. Gardiner
TAGS: glaucoma, pulse waveform, waveforms, global longitudinal strain, blood pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):20. https://doi.org/10.1167/iovs.65.8.20

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging June 2024

Characterizing Retinal Sensitivity and Structure in Congenital Stationary Night Blindness: A Combined Microperimetry and OCT Study

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Mengting Yu; Wenlong Hao; Mengyi Wang; Zhenbang Ruan; Zixuan Li; Chuqi Xiang; Lili Wang; Yin Hu; Xiao Yang
TAGS: night blindness, congenital stationary
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):35. https://doi.org/10.1167/iovs.65.6.35

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Prediction of postoperative IOL tilt using preoperative 3D OCT imaging and machine learning

Derick Owusu Ansah; Eduardo Martinez-Enriquez; Yue Zhao; Ugur Celik; Mujdat Cetin; Jen Li Dong; Yuli Lim; Li Wang; Douglas Donald Koch; Scott MacRae; Susana Marcos

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6327.

ARVO Annual Meeting Abstract June 2024

Estimation of the IOL position using the full shape of the crystalline lens and machine learning algorithms.

Eduardo Martinez-Enriquez; Yue Zhao; Derick Owusu Ansah; Ugur Celik; Scott MacRae; Mujdat Cetin; Jen Li Dong; Yuli Lim; Li Wang; Douglas Donald Koch; Susana Marcos

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6326.

ARVO Annual Meeting Abstract June 2024

Safety and Efficacy of AAV-mediated Gene Replacement Therapy in Bietti Crystalline Corneoretinal Dystrophy

Liping Yang; Jinyuan Wang; Jinlu Zhang; Shicheng Yu; Hongyan LI; Shaohong Chen; Fan Zhang; Jing Qiao; Baoyuan Qu; Wang Li; Haibo wang; Yuxia Guan; Haihan Zhang; Xiuli Zhao; Likun Wang; Wen-bin Wei

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3287.

ARVO Annual Meeting Abstract June 2024

Detection of Double Layer Sign in OCT using multi-modal learning

Yuka Kihara; Mengxi Shen; Yingying Shi; Liang Wang; Rita Laiginhas; Xiaoshuang Jiang; Alessandro Berni; Jermy Liu; Farhan Hiya; Jianqing Li; Giovanni Gregori; Philip J Rosenfeld; Aaron Y Lee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2382.

ARVO Annual Meeting Abstract June 2024

GAN-based High-definition 3-D Retinal Vasculature in Humans with Commercial OCT

Lingyun Wang; Bingjie Wang; Jay Chhablani; Jose Alain Sahel; Shaohua Pi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3426.

ARVO Annual Meeting Abstract June 2024

Diagnostic and Prognostic Value of Bacillary Layer Detachment in Vogt-Koyanagi-Harada Disease

James Kastner; David Rabinovitch; Yahav Lugassi Zyc; Liang Wang; Alessandro Berni; Anne E Fung; Michaella Goldstein; Omer Trivizki

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5507.

ARVO Annual Meeting Abstract June 2024

The impact of the total macular hyperpigmentation on the onset of persistent choroidal hypertransmission defects in intermediate AMD

Alessandro Berni; Mengxi Shen; Yuxuan Cheng; Gissel Herrera; Farhan Hiya; Jeremy Liu; Liang Wang; Jianqing Li; Omer Trivizki; Robert O'Brien; Giovanni Gregori; Ruikang K Wang; Philip J Rosenfeld

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1023.

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Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

Fully Automated OCT-based Tissue Screening System

Reveal retinal ultra-structure with self-supervised denoising in vis-OCT

Differences in Systemic Pulse Waveform Between Individuals With Glaucoma, Glaucoma Suspects, and Healthy Controls

Characterizing Retinal Sensitivity and Structure in Congenital Stationary Night Blindness: A Combined Microperimetry and OCT Study

Prediction of postoperative IOL tilt using preoperative 3D OCT imaging and machine learning

Estimation of the IOL position using the full shape of the crystalline lens and machine learning algorithms.

Safety and Efficacy of AAV-mediated Gene Replacement Therapy in Bietti Crystalline Corneoretinal Dystrophy

Detection of Double Layer Sign in OCT using multi-modal learning

GAN-based High-definition 3-D Retinal Vasculature in Humans with Commercial OCT

Diagnostic and Prognostic Value of Bacillary Layer Detachment in Vogt-Koyanagi-Harada Disease

The impact of the total macular hyperpigmentation on the onset of persistent choroidal hypertransmission defects in intermediate AMD

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