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ARVO Annual Meeting Abstract June 2022

Airborne exposure to PM 10 induces corneal oxidative stress and disrupts Nrf2 mediated anti-oxidant defenses.

Mallika Somayajulu; Sharon A McClellan; Ahalya Pitchaikannu; Robert Wright; Bridget Croniger; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3623 – A0188. doi:

ARVO Annual Meeting Abstract June 2022

Topical application of anti-miR-183/96/182 cluster causes transient, reversible corneal nerve reduction and demonstrates therapeutic potential against bacterial keratitis

Naman Gupta; Sharon A McClellan; Denise Bessert; Linda D Hazlett; Shunbin Xu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4274. doi:

Cornea December 2021

Prophylactic Knockdown of the miR-183/96/182 Cluster Ameliorates Pseudomonas aeruginosa –Induced Keratitis

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Sharon McClellan; Ahalya Pitchaikannu; Robert Wright; Denise Bessert; Mason Iulianelli; Linda D. Hazlett; Shunbin Xu
TAGS: cornea, infections, keratitis, mice, pseudomonas aeruginosa, neurons, transfection, antagomirs
Invest. Ophthalmol. Vis. Sci.. 2021; 62(15):14. doi: https://doi.org/10.1167/iovs.62.15.14

ARVO Annual Meeting Abstract June 2021

Matriptase Deletion: A Model of Dry Eye.

Linda D Hazlett; Denise Bessert; Sharon A McClellan; Mallika Somayajulu; Karin List

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):856. doi:

ARVO Annual Meeting Abstract June 2021

C57BL/6 and BALB/c mice: Microbiome composition and colonic cell population analysis.

Mallika Somayajulu; Sharon A McClellan; Denise Bessert; Ahalya Pitchaikannu; Mariana Angoa-Perez; Branislava Zagorac; Donald Kuhn; Susmit Suvas; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1944. doi:

ARVO Annual Meeting Abstract June 2021

Effects of Topical Glycyrrhizin Application on the Normal Ocular Surface

Sharon A McClellan; Mallika Somayajulu; Denise Bessert; Ahalya Pitchaikannu; Bao Chau Nguyen; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):397. doi:

ARVO Annual Meeting Abstract June 2020

Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa .

Linda D Hazlett; Sharon McClellan; Mallika Somayajulu; Ahalya Pitchaikannu; Nicholas Carruthers; Paul Stemmer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):453. doi:

ARVO Annual Meeting Abstract June 2020

Diabetic Cornea: Effects of PM 2.5 and glycyrrhizin treatment.

Mallika Somayajulu; Sharon Ann McClellan; Sandamali Ekanayaka; Ahalya Pitchaikannu; Jena J Steinle; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4081. doi:

ARVO Annual Meeting Abstract June 2020

The miR-183/96/182 Cluster Regulates the Functions of Myeloid-derived Corneal Resident Innate Immune Cells

Shunbin Xu; Ardian Coku; Linda D Hazlett; Sharon Ann McClellan; Ahalya Pitchaikannu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4364. doi:

Immunology and Microbiology April 2020

Airborne Particulates Affect Corneal Homeostasis and Immunity

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Mallika Somayajulu; Sandamali Ekanayaka; Sharon A. McClellan; Denise Bessert; Ahalya Pitchaikannu; Kezhong Zhang; Linda D. Hazlett
TAGS: cornea, homeostasis, immunity, infections, mice, oxidative stress, hmgb1 protein, rna, messenger, reverse transcriptase polymerase chain reaction, molecule
Invest. Ophthalmol. Vis. Sci.. 2020; 61(4):23. doi: https://doi.org/10.1167/iovs.61.4.23

ARVO Annual Meeting Abstract July 2019

Is Glycyrrhizin the Magic Bullet for Multi-drug Resistance?

Linda D Hazlett; Sandamali Amarasingha Ekanayaka; Sharon A McClellan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4644. doi:

ARVO Annual Meeting Abstract July 2019

Particulates Mediate Corneal Oxidative Stress, Upregulate Innate Immunity, and Enhance Keratitis

Sandamali Amarasingha Ekanayaka; Sharon A McClellan; Ahalya Pitchaikannu; Rebecca Francis; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5181. doi:

ARVO Annual Meeting Abstract July 2019

The miR-183/96/182 cluster regulates corneal resident macrophages and early response to Pseudomonas aeruginosa infection

Shunbin Xu; Linda D Hazlett; Sharon A McClellan; chithra muraleedharan; Rebecca Francis; Liyue Zhang; Eric van Buren; Jessica Back

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5185. doi:

Immunology and Microbiology July 2019

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

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Linda D. Hazlett; Sandamali A. Ekanayaka; Sharon A. McClellan; Rebecca Francis
TAGS: ciprofloxacin, glycyrrhizic acid, keratitis, pseudomonas aeruginosa
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):2978-2989. doi: https://doi.org/10.1167/iovs.19-27200

ARVO Annual Meeting Abstract July 2018

The miR-183/96/182 Cluster Modulates Pseudomonas aeruginosa -induced Keratitis Through Regulation of Innate Immune Cells

Shunbin Xu; Linda D Hazlett; Chithra Muraleedharan; Sharon A McClellan; Sandamali Amarasingha Ekanayaka; Ronald P Barrett

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1545. doi:

Immunology and Microbiology October 2016

Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis

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Sandamali A. Ekanayaka; Sharon A. McClellan; Ronald P. Barrett; Shikhil Kharotia; Linda D. Hazlett
TAGS: bone plates, glycyrrhizic acid, hmgb1 protein, infections, keratitis, mice, neutrophils, painful bladder syndrome, pseudomonas aeruginosa, reverse transcriptase polymerase chain reaction
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5799-5809. doi: https://doi.org/10.1167/iovs.16-20103

ARVO Annual Meeting Abstract September 2016

A role for NLRC4 in resistance of BALB/c mice infected with P. aeruginosa .

Sharon McClellan; Kerry Vistisen; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):316. doi:

ARVO Annual Meeting Abstract September 2016

Glycyrrhizin is protective against keratitis induced by P. aeruginosa and reduces both neutrophil infiltrate and plate count.

Sandamali Amarasingha Ekanayaka; Sharon A McClellan; Ronald P Barrett; Shikhil Kharotia; Linda D Hazlett

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Biomarkers for Rapid Detection of Pseudomonas aeruginosa in Eye Infections

Ronald P Barrett; Michelle Brusatori; Sally Yurgelevic; Sharon McClellan; Linda D Hazlett; Gregory Auner

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5862. doi:

Immunology and Microbiology April 2016

Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa -Induced Keratitis

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Chithra K. Muraleedharan; Sharon A. McClellan; Ronald P. Barrett; Cui Li; Daniel Montenegro; Thomas Carion; Elizabeth Berger; Linda D. Hazlett; Shunbin Xu
TAGS: cornea, keratitis, mice, micrornas, pseudomonas aeruginosa, neuropeptides, infections, neurons
Invest. Ophthalmol. Vis. Sci.. 2016; 57(4):1506-1517. doi: https://doi.org/10.1167/iovs.16-19134

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Airborne exposure to PM 10 induces corneal oxidative stress and disrupts Nrf2 mediated anti-oxidant defenses.

Topical application of anti-miR-183/96/182 cluster causes transient, reversible corneal nerve reduction and demonstrates therapeutic potential against bacterial keratitis

Prophylactic Knockdown of the miR-183/96/182 Cluster Ameliorates Pseudomonas aeruginosa –Induced Keratitis

Matriptase Deletion: A Model of Dry Eye.

C57BL/6 and BALB/c mice: Microbiome composition and colonic cell population analysis.

Effects of Topical Glycyrrhizin Application on the Normal Ocular Surface

Effects of Glycyrrhizin on Multi-Drug Resistant Pseudomonas aeruginosa .

Diabetic Cornea: Effects of PM 2.5 and glycyrrhizin treatment.

The miR-183/96/182 Cluster Regulates the Functions of Myeloid-derived Corneal Resident Innate Immune Cells

Airborne Particulates Affect Corneal Homeostasis and Immunity

Is Glycyrrhizin the Magic Bullet for Multi-drug Resistance?

Particulates Mediate Corneal Oxidative Stress, Upregulate Innate Immunity, and Enhance Keratitis

The miR-183/96/182 cluster regulates corneal resident macrophages and early response to Pseudomonas aeruginosa infection

Glycyrrhizin Use for Multi-Drug Resistant Pseudomonas aeruginosa : In Vitro and In Vivo Studies

The miR-183/96/182 Cluster Modulates Pseudomonas aeruginosa -induced Keratitis Through Regulation of Innate Immune Cells

Glycyrrhizin Reduces HMGB1 and Bacterial Load in Pseudomonas aeruginosa Keratitis

A role for NLRC4 in resistance of BALB/c mice infected with P. aeruginosa .

Glycyrrhizin is protective against keratitis induced by P. aeruginosa and reduces both neutrophil infiltrate and plate count.

Biomarkers for Rapid Detection of Pseudomonas aeruginosa in Eye Infections

Inactivation of the miR-183/96/182 Cluster Decreases the Severity of Pseudomonas aeruginosa -Induced Keratitis

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