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ARVO Annual Meeting Abstract June 2024

Characterization and gene-based treatment of a novel CRISPR-Cas9 generated Mak -deficient rat model of photoreceptor degeneration

Lorena Haefeli; Luke A Wiley; Cathryn Cranston; Heather Daggett; Ian Han; Edwin M Stone; Robert F Mullins; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2216.

ARVO Annual Meeting Abstract June 2024

A dual AAV vector approach for the treatment of ABCA4 -associated retinal disease.

Erin R Burnight; Luke A Wiley; Dalyz Ochoa; Katayoun Varzavand; Seongjin Seo; Ian Han; Robert F Mullins; Edwin M Stone; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1540.

ARVO Annual Meeting Abstract June 2024

The role of nicotinamide N-methyltransferase in choroidal endothelial cells: possible role in macular neovascularization

Emma Mae Navratil; Miles J Flamme-Wiese; Adnan Khan; Xiuying Liu; Luke A Wiley; Edwin M Stone; Budd A. Tucker; Robert F Mullins

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4969.

ARVO Annual Meeting Abstract June 2024

Transplantation of cGMP compliant iPSC-derived retinal progenitor cells

Laura R Bohrer; Luke A Wiley; Allison T Wright; Louisa Affatigato; Robert F Mullins; Edwin M Stone; Ian Han; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1541.

ARVO Annual Meeting Abstract June 2024

miR-181 expression and inhibition: a potential new treatment for dominant rhodopsin associated retinitis pigmentosa.

Renato Jensen; Lorena Haefeli; Luke A Wiley; Colleen Stein; Jessica L Fick; Malia Collins; Robert F Mullins; Ian Han; Edwin M Stone; Ryan Boudreau; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2215.

ARVO Annual Meeting Abstract June 2023

The degree of AAV-induced retinal inflammation varies based on serotype and route of delivery: intravitreal, subretinal or suprachoroidal.

Luke A Wiley; Timothy M Boyce; Dalyz Ochoa; Katie M. Sheehan; Edwin M Stone; Robert Mullins; Budd A. Tucker; Ian Han

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2948.

ARVO Annual Meeting Abstract June 2022

Characterization of a novel Pde6b -deficient rat model of retinal degeneration and treatment with cGMP-grade AAV vectors.

Luke A Wiley; Ian Han; Katie M. Sheehan; Brynnon E. Harman; Megan J. Riker; Edwin M Stone; Robert F Mullins; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1783 – F0332.

ARVO Annual Meeting Abstract June 2022

Development of a CRISPR dCas9-KRAB based strategy for treatment for dominant retinal degenerative blindness

Erin R Burnight; Luke A Wiley; Malavika K. Adur; Dalyz Ochoa; Emily E. Kaalberg; Mallory Lang; Jeremy M. Hoffman; Chunhua Jiao; Stephen R Russell; Ian Han; Elliott H Sohn; Jason W. Ross; Robert F Mullins; Edwin M Stone; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1775 – F0324.

ARVO Annual Meeting Abstract June 2021

Pre-clinical toxicity analysis following subretinal transplantation of an iPSC-derived retinal cell graft in immune suppressed rats.

Laura R Bohrer; Ian Han; Jessica A Cooke; Erin R Burnight; Kristin R. Anfinson; Emily K Kaalberg; Mallory J Ulferts; Jeremy M Hoffmann; Kelsey L Wieland; Luke A Wiley; Kristan S Worthington; Katherine N Gibson-Corley; Robert F Mullins; Edwin M Stone; Budd A. Tucker

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2707.

ARVO Annual Meeting Abstract June 2021

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK -associated retinitis pigmentosa.

Budd A. Tucker; Erin R Burnight; Cathryn M Cranston; Jessica L Fick; Austin J Reutzel; Melette R. Devore; Trudi Westfall; C. Anthony Scott; Autumn Marsden; Katherine N Gibson-Corley; Luke A Wiley; Ian Han; Diane Slusarski; Robert F Mullins; Edwin M Stone

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1485.

ARVO Annual Meeting Abstract June 2021

Evaluating the tropism of chimeric helper-dependent adenoviral vectors for delivery of large genes.

Luke A Wiley; Erin R Burnight; Dalyz Ochoa; Malia M. Collins; Katayoun Varzavand; Edwin M Stone; Robert F Mullins; Budd A. Tucker; Ian Han

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1198.

ARVO Annual Meeting Abstract June 2020

Development of 3D retinal grafts for the treatment of retinal degenerative blindness

Laura R Bohrer; Ian C Han; Jessica A Cooke; Erin R Burnight; Arwin Shrestha; Louisa Affatigato; Luke A Wiley; Kristan Worthington; Katherine N Gibson-corley; Robert F Mullins; Edwin M Stone; Budd Tucker

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2511.

ARVO Annual Meeting Abstract June 2020

Characterization of a Novel Mak- deficient Rat Model of Retinal Degeneration and Phenotype Rescue Using Adeno-Associated Virus-Based Gene Therapy

Ian C Han; Luke A Wiley; Christy L Ralston; Emily E Kaalberg; Mallory J Ulferts; Elizabeth L Kennedy; Robert F Mullins; Edwin M Stone; Budd Tucker

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):679.

ARVO Annual Meeting Abstract July 2019

Generation of rod- vs. cone-dominant patient-derived 3D retinal grafts for the treatment of retinal degenerative blindness

Laura R. Bohrer; Jessica A. Cooke; Arwin Shrestha; Erin R. Burnight; Kristin R. Anfinson; Malia M. Collins; Robert F Mullins; Edwin M Stone; Kristan S. Worthington; Luke A. Wiley; Budd Tucker

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2871.

ARVO Annual Meeting Abstract July 2019

Characterizing the immune response to helper-dependent adenovirus in the rat retina.

Luke A. Wiley; Emily E. Kaalberg; Chunhua Jiao; Robert F Mullins; Edwin M Stone; Budd Tucker; Ian Han

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3408.

ARVO Annual Meeting Abstract June 2017

Using pathway-specific reporter and direct conversion constructs to investigate Juvenile Neuronal Ceroid Lipofuscinosis.

Lorenzo L Lones; Erin R Burnight; Dalyz Ochoa; Joseph C Giacalone; Robert A Madumba; Robert F Mullins; Edwin M Stone; Budd Tucker; Luke A Wiley

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):263.

ARVO Annual Meeting Abstract June 2017

Two-Photon Polymerization of High-Resolution 3D, Biodegradable Photoreceptor Cell Scaffolds

Kristan Sorenson Worthington; Jessica R. Thompson; Brian J. Green; Spencer J. Bunn; Emily E. Kaalberg; Rebecca M. Johnston; Luke A Wiley; Robert F Mullins; Edwin M Stone; C. Allan Guymon; Budd Tucker

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3390.

ARVO Annual Meeting Abstract June 2017

The human RPE-choroid in short term organ culture: evaluation of gene expression changes

Robert F Mullins; S Scott Whitmore; Kathleen R Chirco; Grefachew Workalemahu; Shemin Zeng; Adam P DeLuca; XiuYing Liu; Jessica A Penticoff; Luke A Wiley; Edwin M Stone; Budd Tucker

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):619.

ARVO Annual Meeting Abstract June 2017

Development of corneal endothelial cell-specific reporter constructs and a CRISPR-Cas9 genome editing approach to study Fuchs Dystrophy.

Luke A Wiley; Laura R Bohrer; Erin R Burnight; Elizabeth L Kennedy; Edwin M Stone; Mark A Greiner; Michael D Wagoner; Budd Tucker

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1444.

ARVO Annual Meeting Abstract June 2017

Characterization and Treatment of RPGR-associated Photoreceptor Disease

Joseph C Giacalone; Luke A Wiley; Erin R Burnight; Jeaneen Andorf; Luan M Streb; Louisa M Affatigato; Cathryn Cranston; Dalyz Ochoa; Robert F Mullins; Budd Tucker; Edwin M Stone

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4515.

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Characterization and gene-based treatment of a novel CRISPR-Cas9 generated Mak -deficient rat model of photoreceptor degeneration

A dual AAV vector approach for the treatment of ABCA4 -associated retinal disease.

The role of nicotinamide N-methyltransferase in choroidal endothelial cells: possible role in macular neovascularization

Transplantation of cGMP compliant iPSC-derived retinal progenitor cells

miR-181 expression and inhibition: a potential new treatment for dominant rhodopsin associated retinitis pigmentosa.

The degree of AAV-induced retinal inflammation varies based on serotype and route of delivery: intravitreal, subretinal or suprachoroidal.

Characterization of a novel Pde6b -deficient rat model of retinal degeneration and treatment with cGMP-grade AAV vectors.

Development of a CRISPR dCas9-KRAB based strategy for treatment for dominant retinal degenerative blindness

Pre-clinical toxicity analysis following subretinal transplantation of an iPSC-derived retinal cell graft in immune suppressed rats.

Development and biological characterization of a clinical gene transfer vector for the treatment of MAK -associated retinitis pigmentosa.

Evaluating the tropism of chimeric helper-dependent adenoviral vectors for delivery of large genes.

Development of 3D retinal grafts for the treatment of retinal degenerative blindness

Characterization of a Novel Mak- deficient Rat Model of Retinal Degeneration and Phenotype Rescue Using Adeno-Associated Virus-Based Gene Therapy

Generation of rod- vs. cone-dominant patient-derived 3D retinal grafts for the treatment of retinal degenerative blindness

Characterizing the immune response to helper-dependent adenovirus in the rat retina.

Using pathway-specific reporter and direct conversion constructs to investigate Juvenile Neuronal Ceroid Lipofuscinosis.

Two-Photon Polymerization of High-Resolution 3D, Biodegradable Photoreceptor Cell Scaffolds

The human RPE-choroid in short term organ culture: evaluation of gene expression changes

Development of corneal endothelial cell-specific reporter constructs and a CRISPR-Cas9 genome editing approach to study Fuchs Dystrophy.

Characterization and Treatment of RPGR-associated Photoreceptor Disease

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