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ARVO Annual Meeting Abstract June 2025

Protective effects of chemerin from iPSC-derived Müller cells on retinal ganglion cell

Momoko Kobayashi; Yayoi Kishimoto; Mitsuyoshi Azuma; Chiho Fukiage; Noriyuki Azuma

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4910.

ARVO Annual Meeting Abstract June 2025

Nrf2 activators attenuate menadione-induced oxidative stress in monkey retinal pigment epithelial cells

Samantha M Supnet; Takatoshi Uchida; Emi Nakajima; Ryan D Walkup; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3046.

ARVO Annual Meeting Abstract June 2025

Oxidative stress damage in cultured Rhesus lamina cribrosa cells

Ryan D Walkup; Samantha M Supnet; Emi Nakajima; Takatoshi Uchida; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3039.

ARVO Annual Meeting Abstract June 2025

FK962-induced GDNF activates both the AKT and ERK survival pathways simultaneously, protecting RGCs from damage in hypoxic retinas

Takatoshi Uchida; Kana Orihara; Samantha M Supnet; Emi Nakajima; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3427.

ARVO Annual Meeting Abstract June 2024

Activation of cytosolic and mitochondrial calpains during RGC death in hypoxic, human, iPS-derived retinal organoids

Masayuki Hirata; Yayoi Kishimoto; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2554.

ARVO Annual Meeting Abstract June 2022

Involvement of calpains and caspases in RGC damage in human iPSCs-derived OV cultured under hypoxia

Kana Orihara; Chiho Fukiage; Mitsuyoshi Azuma; Tadashi Yokoi; Noriyuki Azuma

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):989 – F0386.

Retina November 2020

Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants

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Momoko Kobayashi-Otsugu; Kana Orihara; Emi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):13. https://doi.org/10.1167/iovs.61.13.13

Immunology and Microbiology December 2019

VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege

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Tomoyuki Kunishige; Hiroko Taniguchi; Tatsukuni Ohno; Miyuki Azuma; Junko Hori
TAGS: allografting, cornea, immune privilege, monoclonal antibodies, t-lymphocytes, mice, immunoglobulin g, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(15):4958-4965. https://doi.org/10.1167/iovs.19-27322

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

NRF2 activator RS9 protects corneal epithelium from cell damage in dry eye models

Yuka Matsuda; Mamiko Machida; Yasuhiro Nakagami; Takeshi Nakajima; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):270.

ARVO Annual Meeting Abstract July 2018

Differentiation of human iPSC-derived optic vesicles into numerous types of retinal cells

Kana Orihara; Chiho Yabuta; Mitsuyoshi Azuma; Noriyuki Azuma

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):572.

ARVO Annual Meeting Abstract July 2018

Accumulation of a calpain specific α-spectrin breakdown product in drusen from AMD patients: Possible calpain activation in RPE and photoreceptors

Momoko Kobayashi; Emi Nakajima; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3059.

Biochemistry and Molecular Biology October 2017

Contribution of Calpain and Caspases to Cell Death in Cultured Monkey RPE Cells

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Emi Nakajima; Katherine B. Hammond; Masayuki Hirata; Thomas R. Shearer; Mitsuyoshi Azuma
TAGS: calpain, caspases, hypoxia, retinal pigment cell, cercopithecidae, caspase-3
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5412-5420. https://doi.org/10.1167/iovs.17-22325

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts

Hiroko Taniguchi; Hidenori Hase; Hisaya Akiba; Hideo Yagita; Miyuki Azuma; Junko Hori

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5734.

ARVO Annual Meeting Abstract September 2016

Role of V-domain Ig suppressor of T cell activation (VISTA) in Anterior Chamber Associated Immune Deviation

Tomoyuki Kunishige; Hiroko Taniguchi; Tatsukuni Ohno; MIyuki Azuma; Junko Hori

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):319.

ARVO Annual Meeting Abstract September 2016

FK962 may ameliorate hypoxia/reoxygenation-induced neuronal cell death in rat retina by promoting neuronal cell maturation

Kana Orihara; Chiho Yabuta; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2568.

ARVO Annual Meeting Abstract September 2016

Structure-based in silico approach for selection of kinase inhibitors

Tomoyo Miyabe; Shinnosuke Machida; Kazuya Konoura; Takeshi Nakajima; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5019.

ARVO Annual Meeting Abstract September 2016

fMRI Studies: Calpain Inhibitor SNJ-1945 Ameliorates Dysfunction in Injured Rat RGCs

Takayuki Oka; Chiho Yabuta; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3757.

Retina September 2015

Hypoxia Activates Calpains in the Nerve Fiber Layer of Monkey Retinal Explants

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Masayuki Hirata; Thomas R. Shearer; Mitsuyoshi Azuma
TAGS: calpain, cercopithecidae, hypoxia, nerve fibers
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):6049-6057. https://doi.org/10.1167/iovs.15-17360

ARVO Annual Meeting Abstract June 2015

Monkey RPE cell death induced by oligomeric A β

Masayuki Hirata; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3777.

ARVO Annual Meeting Abstract June 2015

Mechanisms of V-domain Ig suppressor of T cell activation (VISTA)-mediated acceptance of corneal allografts

Tomoyuki Kunishige; Hiroko Taniguchi; Tatsukuni Ohno; Miyuki Azuma; Junko Hori

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4872.

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Protective effects of chemerin from iPSC-derived Müller cells on retinal ganglion cell

Nrf2 activators attenuate menadione-induced oxidative stress in monkey retinal pigment epithelial cells

Oxidative stress damage in cultured Rhesus lamina cribrosa cells

FK962-induced GDNF activates both the AKT and ERK survival pathways simultaneously, protecting RGCs from damage in hypoxic retinas

Activation of cytosolic and mitochondrial calpains during RGC death in hypoxic, human, iPS-derived retinal organoids

Involvement of calpains and caspases in RGC damage in human iPSCs-derived OV cultured under hypoxia

Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants

VISTA Is Crucial for Corneal Allograft Survival and Maintenance of Immune Privilege

NRF2 activator RS9 protects corneal epithelium from cell damage in dry eye models

Differentiation of human iPSC-derived optic vesicles into numerous types of retinal cells

Accumulation of a calpain specific α-spectrin breakdown product in drusen from AMD patients: Possible calpain activation in RPE and photoreceptors

Contribution of Calpain and Caspases to Cell Death in Cultured Monkey RPE Cells

Role of B7-H3/TLT-2 pathway in immune privilege of corneal allografts

Role of V-domain Ig suppressor of T cell activation (VISTA) in Anterior Chamber Associated Immune Deviation

FK962 may ameliorate hypoxia/reoxygenation-induced neuronal cell death in rat retina by promoting neuronal cell maturation

Structure-based in silico approach for selection of kinase inhibitors

fMRI Studies: Calpain Inhibitor SNJ-1945 Ameliorates Dysfunction in Injured Rat RGCs

Hypoxia Activates Calpains in the Nerve Fiber Layer of Monkey Retinal Explants

Monkey RPE cell death induced by oligomeric A β

Mechanisms of V-domain Ig suppressor of T cell activation (VISTA)-mediated acceptance of corneal allografts

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