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ARVO Annual Meeting Abstract July 2018

Subanalysis of data from rAAV.sFLT-1 phase 1 and 2a randomized gene therapy trials for wet age-related macular degeneration.

Elizabeth Rakoczy; Aaron Magno; Chooi-May Lai; Mariapia Degli-Esposti; Ian Constable

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1448.

ARVO Annual Meeting Abstract June 2017

Safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration following a phase 2a randomized clinical trial

Elizabeth P Rakoczy; Chooi-May Lai; Aaron Magno; Martyn French; Steve Butler; Samuel Barone; Steven D Schwartz; Mark Blumenkranz; Mariapia Degli-Esposti; Ian Constable

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4476.

ARVO Annual Meeting Abstract September 2016

Association of serum neutralizing antibodies with safety and efficacy outcomes in a Phase 2a trial of rAAV.sFlt-1 in the treatment of wet AMD

Elizabeth P Rakoczy; Chooi-May Lai; Aaron Magno; Martyn French; Samuel Bradley Barone; Steven D Schwartz; Mark Blumenkranz; Mariapia Degli-Esposti; Ian J Constable

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):526.

ARVO Annual Meeting Abstract June 2015

One-year analysis of sFlt-1 and VEGF proteins and immunological markers in the bodily fluids of subjects participating in the Phase I rAAV.sFlt-1 trial.

Elizabeth P Rakoczy; Chooi-May Lai; Aaron Magno; Matthew Wikstrom; Martyn French; Steven D Schwartz; Mark S Blumenkranz; Thomas Walter Chalberg; Mariapia Degli-Espoti; Ian J Constable

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1281.

ARVO Annual Meeting Abstract April 2010

A Non-Invasive in vivo Assessment of the Akimba Mouse Eye

M. C. Lai; I. S. Ali Rahman; C. Li; N. Vagaja; E. P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3663.

ARVO Annual Meeting Abstract April 2010

Assessment of Endothelin-2 Expression in Hyperglycemic and Retinal Neovascularisation Mouse Models

I. S. Ali Rahman; C.-M. Lai; N. Binz; E. P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):116.

Immunology and Microbiology September 2009

rAAV.sFlt-1 Gene Therapy Achieves Lasting Reversal of Retinal Neovascularization in the Absence of a Strong Immune Response to the Viral Vector

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Chooi-May Lai; Marie J. Estcourt; Matthew Wikstrom; Robyn P. Himbeck; Nigel L. Barnett; Meliha Brankov; Lisa B. G. Tee; Sarah A. Dunlop; Mariapia A. Degli-Esposti; Elizabeth P. Rakoczy
TAGS: eye, gene therapy, immune response, mice, retinal neovascularization, viral vector, vascular endothelial growth factor a, proteins
Invest. Ophthalmol. Vis. Sci.. 2009; 50(9):4279-4287. https://doi.org/10.1167/iovs.08-3253

ARVO Annual Meeting Abstract May 2008

Characterization of the Akimba Mouse: A Diabetic Mouse With Ocular and Renal Changes

M. C. Lai; N. Binz; J. A. Eade; M. de Pinho; R. P. Himbeck; E. P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3996.

ARVO Annual Meeting Abstract May 2008

Preclinical Evaluation of rAAV.sFlt-1 in Monkeys: Toxicity and Biodistribution

E. P. Rakoczy; C.-M. Lai; S. Lee; I. Yeo; R. Himbeck; M. Escourt; L. Chi; C. Ang; M. Degli-Espoti

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):1132.

ARVO Annual Meeting Abstract May 2008

Long-Term Upregulation of Endothelin-2 in a VEGF-Driven Mouse Model (trVEGF029) of Retinal Neovascularisation (RNV)

I. S. Ali Rahman; C.-M. Lai; N. Binz; J. A. Eade; P. E. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3061.

ARVO Annual Meeting Abstract May 2007

Retinal and Choroidal Vascular Changes in VEGF Transgenic Models of Retinal Neovascularisation

M. C. Lai; L. Tee; M. Penrose; J. E. O’Shea,; E. P. Rakoczy; S. A. Dunlop

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3412.

ARVO Annual Meeting Abstract May 2007

Inhibition of Retinal Vascular Leakage in a Transgenic Vegf Mouse Model Following Intravitreal Bevacizumab

T. Isaacs; C.-M. Lai; M. Brankov; P. E. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):3405.

ARVO Annual Meeting Abstract May 2007

Identification of a New Angiogenesis Associated Gene in the Retina

E. P. Rakoczy; J. Eade; N. Binz; J. Mills; K. Simpson; T. Speed; C.-M. Lai; C. Graham

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):4964.

Visual Psychophysics and Physiological Optics October 2006

Early Vascular and Neuronal Changes in a VEGF Transgenic Mouse Model of Retinal Neovascularization

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Pauline E. van Eeden; Lisa B. G. Tee; Sherralee Lukehurst; Chooi-May Lai; Elizabeth P. Rakoczy; Lyn D. Beazley; Sarah A. Dunlop
TAGS: mice, transgenic, retinal neovascularization, vascular endothelial growth factor a, vascular lesions, blood capillaries, retina, rhodopsin
Invest. Ophthalmol. Vis. Sci.. 2006; 47(10):4638-4645. https://doi.org/10.1167/iovs.06-0251

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract May 2006

Longevity and Toxicity of AAV–Mediated sFLT–1 Gene Therapy for Ocular Neovascularization in Mice and Monkeys

E.P. Rakoczy; C.–M. Lai; W.–Y. Shen; M. Brankov; N. Barnett; S.–Y. Lee; I. Yeo; C.–L. Ang; M. Degli–Esposti; S. Dunlop

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):833.

ARVO Annual Meeting Abstract May 2004

CHARACTERIZATION OF NEOVASCULAR RESPONSES IN TRANSGENIC MICE WITH TISSUE–SPECIFIC OVEREXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR

W.–Y. Shen; C.–M. Lai; N. Binz; I.J. Constable; S.A. Dunlop; L.D. Beazley; P.E. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):453.

ARVO Annual Meeting Abstract May 2004

Transgenic mouse models with human diabetic retinopathy–like features

C.–M. Lai; L.A. May; M. Gorbatov; M. Brankov; W.–Y. Shen; N. Binz; I.J. Constable; L. Beazley; S. Dunlop; E.P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):500.

ARVO Annual Meeting Abstract May 2004

Long–term modulation of gene expression in the mouse eye following laser photocoagulation

N. Binz; K. Simpson; W.–Y. Shen; C.–M. Lai; T. Speed; E.P. Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2004; 45(13):2504.

Retina April 2003

Functional and Structural Recovery of the Retina after Gene Therapy in the RPE65 Null Mutation Dog

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Kristina Narfström; Martin L. Katz; Ragnheidur Bragadottir; Mathias Seeliger; Ana Boulanger; T. Michael Redmond; Lynette Caro; Chooi-May Lai; P. Elizabeth Rakoczy
TAGS: dog, domestic, eye, gene therapy, mutation, retina, recovery of function, surgical procedures, operative, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2003; 44(4):1663-1672. https://doi.org/10.1167/iovs.02-0595

ARVO Annual Meeting Abstract December 2002

Is rAAV Mediated Upregulation of VEGF Sufficient to Induce a Neovascular Response in the Eye?

M Brankov; C-M Lai; T Zaknich; P Rakoczy

Invest. Ophthalmol. Vis. Sci.. 2002; 43(13):1265.

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Subanalysis of data from rAAV.sFLT-1 phase 1 and 2a randomized gene therapy trials for wet age-related macular degeneration.

Safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration following a phase 2a randomized clinical trial

Association of serum neutralizing antibodies with safety and efficacy outcomes in a Phase 2a trial of rAAV.sFlt-1 in the treatment of wet AMD

One-year analysis of sFlt-1 and VEGF proteins and immunological markers in the bodily fluids of subjects participating in the Phase I rAAV.sFlt-1 trial.

A Non-Invasive in vivo Assessment of the Akimba Mouse Eye

Assessment of Endothelin-2 Expression in Hyperglycemic and Retinal Neovascularisation Mouse Models

rAAV.sFlt-1 Gene Therapy Achieves Lasting Reversal of Retinal Neovascularization in the Absence of a Strong Immune Response to the Viral Vector

Characterization of the Akimba Mouse: A Diabetic Mouse With Ocular and Renal Changes

Preclinical Evaluation of rAAV.sFlt-1 in Monkeys: Toxicity and Biodistribution

Long-Term Upregulation of Endothelin-2 in a VEGF-Driven Mouse Model (trVEGF029) of Retinal Neovascularisation (RNV)

Retinal and Choroidal Vascular Changes in VEGF Transgenic Models of Retinal Neovascularisation

Inhibition of Retinal Vascular Leakage in a Transgenic Vegf Mouse Model Following Intravitreal Bevacizumab

Identification of a New Angiogenesis Associated Gene in the Retina

Early Vascular and Neuronal Changes in a VEGF Transgenic Mouse Model of Retinal Neovascularization

Longevity and Toxicity of AAV–Mediated sFLT–1 Gene Therapy for Ocular Neovascularization in Mice and Monkeys

CHARACTERIZATION OF NEOVASCULAR RESPONSES IN TRANSGENIC MICE WITH TISSUE–SPECIFIC OVEREXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR

Transgenic mouse models with human diabetic retinopathy–like features

Long–term modulation of gene expression in the mouse eye following laser photocoagulation

Functional and Structural Recovery of the Retina after Gene Therapy in the RPE65 Null Mutation Dog

Is rAAV Mediated Upregulation of VEGF Sufficient to Induce a Neovascular Response in the Eye?

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