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ARVO Annual Meeting Abstract June 2025

Leveraging Structure-Based Network Analysis to Identify Putative Causative Variants of Inherited Retinal Disease

Blake M. Hauser; Yuyang Luo; Aamilah Chowdhury; Anusha Nathan; Ahmad al-Moujahed; Demetrios Vavvas; Jason Comander; Eric A Pierce; Emily Place; Kinga Maria Bujakowska; Gaurav D. Gaiha; Elizabeth J Rossin

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1344.

ARVO Annual Meeting Abstract June 2025

Changes in extracellular matrix homeostasis in LOXL1-deficient and trabecular meshwork cells from a Pseudoexfoliation patient

Maria Fernanda Suarez; Kristin Marie Perkumas; Michael A Hauser; William Daniel Stamer; Katy Liu

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):851.

ARVO Annual Meeting Abstract June 2025

Expanding ancestral diversity reveals novel insights into African primary open-angle glaucoma genetics

Lauren Cruz; Tyler Garrett Kinzy; Osahon Asowata; Ayombami Alimi; Bryan Gorman; Andrea Waksmunski; Karen Mruk; Jacquelaine Bartlett; Yuki Bradford; Chen Jiang; Rebecca Salowe; Christopher Halladay; Cari Nealon; Linda M Zangwill; Radha Ayyagari; Robert Weinreb; Marylyn Ritchie; Shefali Setia Verma; Helene Choquet; Joan O'Brien; Dana Crawford; Michael A Hauser; Sudha K Iyengar; Neal Peachey; Jessica Cooke Bailey

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2714.

ARVO Annual Meeting Abstract June 2024

Structure-based network analysis identifies pathogenic variants in patients with inherited retinal disease

Blake M. Hauser; Yuyang Luo; Anusha Nathan; Demetrios Vavvas; Jason Comander; Eric A Pierce; Emily Place; Kinga Maria Bujakowska; Gaurav D Gaiha; Elizabeth J Rossin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6029.

ARVO Annual Meeting Abstract June 2024

Development of a Comprehensive Predictive Model for Primary Open-Angle Glaucoma in Individuals of African Ancestry

Shefali Setia Verma; Lannawill Caruth; Yuki Bradford; Yan Zhu; Rebecca Salowe; Tyler Kinzy; Chiea Chuen Khor; Michael A Hauser; Jessica Cooke Bailey; Marylyn D Ritchie; Joan M O'Brien

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2762.

ARVO Annual Meeting Abstract June 2024

LOXL1 regulates TGFβ1-induced fibrosis in conventional outflow cells/tissues via AKT

Maria Fernanda Suarez; Heather M Schmitt; Megan Kuhn; Kristyn Hake; Tara Weisz; Edward Flynn; Katy Liu; Michael A Hauser; Dan W Stamer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4321.

ARVO Annual Meeting Abstract June 2023

Systematic approach to analyzing protein structure predicts mutations associated with inherited retinal disease

Blake M. Hauser; Yuyang Luo; Anusha Nathan; James Chodosh; Lucia Sobrin; Eric A Pierce; Bruce Walker; Gaurav Gaiha; Elizabeth Rossin

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3267.

ARVO Annual Meeting Abstract June 2023

The role of homology modeling on improving associations between functional and structural mutation using structural based network analysis

Yuyang Luo; Blake M. Hauser; Elizabeth Rossin

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1870.

ARVO Annual Meeting Abstract June 2023

Polygenic Risk Score for Glaucoma in African Populations

Jennifer Minjia Chang-Wolf; Sjoerd Jan Driessen; Anna J Sanyiwa; Hassan G Hassan; Colin Cook; Susan E I Williams; Stephen K Akafo; Adeyinka O Ashaye; Caroline C W Klaver; Michael A Hauser; Alberta A H J Thiadens; Pieter Bonnemaijer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2783.

ARVO Annual Meeting Abstract June 2023

LOXL1 modulates TGFβ1-induced fibrosis in conventional outflow cells/tissues

Maria Fernanda Suarez; Heather M Schmitt; Megan Kuhn; Kristyn Hake; Tara Weisz; Edward Flynn III; Katy Liu; Michael A Hauser; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1888.

ARVO Annual Meeting Abstract June 2023

Rare protective variants and glaucoma-relevant cell stressors modulate ANGPTL7 expression

Inas F Aboobakar; Edward Ryan Collantes; Michael A Hauser; Daniel W Stamer; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4353.

ARVO Annual Meeting Abstract June 2022

Characterization of Loxl1 -knockout-induced elastosis in mice with different genetic backgrounds

Maria Fernanda Suarez; Heather Schmitt; Kristyn Hake; Megan Kuhn; TeddiJo Watkins; Michael H Elliott; Michael A Hauser; Daniel W Stamer

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):446.

ARVO Annual Meeting Abstract June 2022

The regulatory role of LOXL1-AS1 in gene expression

Kristyn Hake; Heather Schmitt; Maria Fernanda Suarez; Kristin Marie Perkumas; Michael A Hauser; William Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1293 – F0108.

ARVO Annual Meeting Abstract June 2021

Genetic susceptibility to Loxl1 knockout-induced elastosis in a mouse model

Heather Schmitt; TeddiJo Watkins; Kristyn Hake; Megan Kuhn; Guorong Li; Daniel W Stamer; Michael A Hauser

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):468.

ARVO Annual Meeting Abstract June 2021

LOXL1-AS1 regulates extracellular matrix remodeling, mechanotransduction responses, and cellular morphology in human outflow cells.

Kristyn Hake; Heather Schmitt; William Johnson; Maria Gomez-Caraballo; Kristin Perkumas; Michael A Hauser; Daniel W Stamer

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):558.

ARVO Annual Meeting Abstract June 2021

Identification of ESR1 in aqueous humor outflow pathway tissues

Hannah Youngblood; Jingwen Cai; Kristin Perkumas; Hongfang Yu; Michael A Hauser; W. Daniel Stamer; Yutao Liu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1497.

ARVO Annual Meeting Abstract June 2020

Integrative Prioritization of IOP-associated Genes Using High Throughput Genomic Data

Yutao Liu; Emily Parker; Hannah Youngblood; Jingwen Cai; Kristin Marie Perkumas; Janey Wiggs; Louis R Pasquale; Michael A Hauser; Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):990.

ARVO Annual Meeting Abstract June 2020

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

Janey Wiggs; Puya Gharahkhani; Eric Jorgenson; Pirro G Hysi; Anthony Khawaja; Sarah Pendergrass; Xikun Han; David Mackey; Christopher Hammond; Michael A Hauser; Louis R Pasquale; Caroline Klaver; Michiaki Kubo; Tin Aung; Jamie E Craig; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1890.

ARVO Annual Meeting Abstract June 2020

LOXL1-AS1 regulates extracellular matrix remodeling and mechanotransduction in human primary trabecular meshwork and Schlemm’s canal cells

Heather Schmitt; William M. Johnson; Maria Gomez-Caraballo; Kristin Marie Perkumas; Michael A Hauser; Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4629.

ARVO Annual Meeting Abstract July 2019

The PEXpress lncRNA/hnRNPL complex regulates signaling and morphology of human Schlemm’s canal cells

Heather Schmitt; William Johnson; Shelby Strickland; Michael A Hauser; William D Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3185.

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Leveraging Structure-Based Network Analysis to Identify Putative Causative Variants of Inherited Retinal Disease

Changes in extracellular matrix homeostasis in LOXL1-deficient and trabecular meshwork cells from a Pseudoexfoliation patient

Expanding ancestral diversity reveals novel insights into African primary open-angle glaucoma genetics

Structure-based network analysis identifies pathogenic variants in patients with inherited retinal disease

Development of a Comprehensive Predictive Model for Primary Open-Angle Glaucoma in Individuals of African Ancestry

LOXL1 regulates TGFβ1-induced fibrosis in conventional outflow cells/tissues via AKT

Systematic approach to analyzing protein structure predicts mutations associated with inherited retinal disease

The role of homology modeling on improving associations between functional and structural mutation using structural based network analysis

Polygenic Risk Score for Glaucoma in African Populations

LOXL1 modulates TGFβ1-induced fibrosis in conventional outflow cells/tissues

Rare protective variants and glaucoma-relevant cell stressors modulate ANGPTL7 expression

Characterization of Loxl1 -knockout-induced elastosis in mice with different genetic backgrounds

The regulatory role of LOXL1-AS1 in gene expression

Genetic susceptibility to Loxl1 knockout-induced elastosis in a mouse model

LOXL1-AS1 regulates extracellular matrix remodeling, mechanotransduction responses, and cellular morphology in human outflow cells.

Identification of ESR1 in aqueous humor outflow pathway tissues

Integrative Prioritization of IOP-associated Genes Using High Throughput Genomic Data

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

LOXL1-AS1 regulates extracellular matrix remodeling and mechanotransduction in human primary trabecular meshwork and Schlemm’s canal cells

The PEXpress lncRNA/hnRNPL complex regulates signaling and morphology of human Schlemm’s canal cells

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