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Lens April 2025

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

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Dongzhe Zhang; Junwei Qu; Cuncun Ke; Xiumei Kong; Mengyun Liu; Iqbal Nawaz Khan; Shuxin Huang; Haijiao Tian; Tong Xie; Ke Qiu; Jing Li; Mingli Wang; Hui Li; Fengling Yuan; Weikai Guo; Mingya Cao; Jing Zhang; Keke Zhu; Jin Luo; Fengyan Zhang; Xiukun Cui; Hongmei Mu; Yanzhong Hu
TAGS: body tissue, cataract, epithelium, infections, lens (device), macrophages, risk factors, porphyromonas gingivalis, hypertension, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):68. https://doi.org/10.1167/iovs.66.4.68

Includes: Supplemental Content

Letters to the Editor April 2025

The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy

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Qinling Jiang; Lin Mou
TAGS: amino acids, branched-chain, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2025; 14(4):10. https://doi.org/10.1167/tvst.14.4.10

Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Retina March 2025

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

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Zhifan Chen; Shuoxin Liao; Guangzhong Chen; Changmao Li; Chunling Liu; Junbin Liu; Guangyu Wu; Zheng Lyu; Mengya Liu; Xiyu Wu; Guixian Ma; Qianli Meng
TAGS: carotid stenosis, ischemic stroke
Trans. Vis. Sci. Tech.. 2025; 14(3):14. https://doi.org/10.1167/tvst.14.3.14

Includes: Supplemental Content

Cornea March 2025

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

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Ting Wang; Xiaoqin Chen; Mengdi Li; Hua Bi; Xiaoyan Yang; Muhan Sun; Yue Liu; Lihua Li; Bin Zhang
TAGS: cornea, eye, lens (device), lens, crystalline, myopia, orthokeratology contact lenses, optics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):29. https://doi.org/10.1167/iovs.66.3.29

Includes: Supplemental Content

Retinal Cell Biology March 2025

Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen

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Erika M. Shaw; David M. Anderson; Ramesh Periasamy; Kevin L. Schey; Christine A. Curcio; Daniel M. Lipinski
TAGS: drusen, suidae, age-related macular degeneration, pigment
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):18. https://doi.org/10.1167/iovs.66.3.18

Includes: Supplemental Content

Anatomy and Pathology/Oncology March 2025

Magnetic Resonance Dacryocystography for Precise Diagnosis of Lacrimal and Perilacrimal Lesions

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Xuejun Guo; Min Gao; Yulong Qi; Qiao Shi; Qiqiang Li; Mingmei Li; Hongbing Li
TAGS: dacryocystography, lacrimal canaliculus, lacrimal sac, magnetic resonance imaging, vibration, constriction, pathologic, eye, nasolacrimal duct, surgical pathology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):17. https://doi.org/10.1167/iovs.66.3.17

Retina February 2025

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA

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Hiroyuki Takahashi; Yunchan Hwang; Jungeun Won; Muhammad Usman Jamil; Antonio Yaghy; Michelle C. Liang; Caroline R. Baumal; Andre J. Witkin; Kyoko Ohno-Matsui; Jay S. Duker; James G. Fujimoto; Nadia K. Waheed
TAGS: diabetic retinal microaneurysm, diabetic retinopathy, fluid flow, macrophage activation syndrome, meconium aspiration syndrome, retinal microaneurysm, vascular flow, blood capillaries
Trans. Vis. Sci. Tech.. 2025; 14(2):27. https://doi.org/10.1167/tvst.14.2.27

Public Health February 2025

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

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Dan-Lin Li; Min-Xin Liu; Ya-Jie Zheng; Yu Qin; Rong Ma; Gang Liang; Chen-Wei Pan
TAGS: biomechanics, cornea, young adult
Trans. Vis. Sci. Tech.. 2025; 14(2):19. https://doi.org/10.1167/tvst.14.2.19

Retina February 2025

Association Between Hormone Levels and Retinopathy in Patients With Type 2 Diabetes: A Cross-Sectional Study

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Yu Meng; Xueli Yang; Yuxin Fan; Ming Liu; Fengqi Zhou; Qihua Wang; Yuezhu Lu; Yun Zhu; Hua Yan
TAGS: diabetes mellitus, type 2, gonadal hormones, hormones, retinal diseases, testosterone
Trans. Vis. Sci. Tech.. 2025; 14(2):17. https://doi.org/10.1167/tvst.14.2.17

Includes: Supplemental Content

Cornea February 2025

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

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Hao Chi; Li Ma; Fanxing Zeng; Xiaolei Wang; Peng Peng; Xiaofei Bai; Ting Zhang; Wenhui Yin; Yaoyao Yu; Lingling Yang; Qingjun Zhou; Chao Wei; Weiyun Shi
TAGS: aging, allografting, angiotensin converting enzyme 2, cornea, keratoplasty, navitoclax, rejection (psychology), senolytics, stress, transplant rejection
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):15. https://doi.org/10.1167/iovs.66.2.15

Includes: Supplemental Content

Visual Neuroscience February 2025

Expression of Osteopontin in M2 and M4 Intrinsically Photosensitive Retinal Ganglion Cells in the Mouse Retina

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Leonie Kinder; Moritz Lindner
TAGS: mice, osteopontin, retina, retinal ganglion cells, melanopsin
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):14. https://doi.org/10.1167/iovs.66.2.14

Retina January 2025

A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina

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Xiaoyu He; Yidian Fu; Yangfan Xu; Liang Ma; Peiwei Chai; Hanhan Shi; Yizheng Yao; Shengfang Ge; Renbing Jia; Xuyang Wen; Zhi Yang; Xianqun Fan
TAGS: capsid, gene therapy, genes, intravitreal injections, mice, retina, injections, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):6. https://doi.org/10.1167/iovs.66.1.6

Includes: Supplemental Content

Retina November 2024

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

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David A. Antonetti; Cheng-Mao Lin; Sumathi Shanmugam; Heather Hager; Manjing Cao; Xuwen Liu; Alyssa Dreffs; Adam Habash; Steven F. Abcouwer
TAGS: diabetes mellitus, wounds and injuries, mice, retina, photoreceptors, reperfusion injury, streptozocin
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):46. https://doi.org/10.1167/iovs.65.13.46

Includes: Supplemental Content

Low Vision Rehabilitation November 2024

Aligning Visual Prosthetic Development With Implantee Needs

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Lucas Nadolskis; Lily M. Turkstra; Ebenezer Larnyo; Michael Beyeler
TAGS: implants, research personnel, visual prosthesis
Trans. Vis. Sci. Tech.. 2024; 13(11):28. https://doi.org/10.1167/tvst.13.11.28

Includes: Supplemental Content

Genetics November 2024

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

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Mikko Liukkonen; Hanna Heloterä; Leea Siintamo; Bishwa Ghimire; Pirkko Mattila; Niko Kivinen; Joanna Kostanek; Cezary Watala; Maria Hytti; Juha Hyttinen; Ali Koskela; Janusz Blasiak; Kai Kaarniranta
TAGS: cohort studies, finnish, genes, inflammation, oxidative stress, rna, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):30. https://doi.org/10.1167/iovs.65.13.30

Includes: Supplemental Content

Visual Neuroscience November 2024

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

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Zhonghao Yu; Yue Guan; Tian Xia; Xuanwen Li; Mingyue Liu; Yujia Huo; Zhuowei Wang; Zhirong Liu; Yuting Luo; Wentao Yan; Lanfang Sun; Wencan Wu; Baoguo Shen; Yikui Zhang
TAGS: optic nerve, rna, rna, messenger, white matter
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):25. https://doi.org/10.1167/iovs.65.13.25

Includes: Multimedia, Supplemental Content

Retinal Cell Biology November 2024

Single-Cell Multiomics Profiling Reveals Heterogeneity of Müller Cells in the Oxygen-Induced Retinopathy Model

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Xueming Yao; Ziqi Li; Yi Lei; Qiangyun Liu; Siyue Chen; Haokun Zhang; Xue Dong; Kai He; Ju Guo; Mulin Jun Li; Xiaohong Wang; Hua Yan
TAGS: astrocytes, genes, heterogeneity, mice, multiomics, oxygen, retinal diseases, small nuclear rna, cell communication, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):8. https://doi.org/10.1167/iovs.65.13.8

Includes: Supplemental Content

Cornea October 2024

ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation

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Wei Wang; Hua Li; Yiyong Qian; Min Li; Manli Deng; Dexi Bi; Jun Zou
TAGS: acute erythroblastic leukemia, alkalies, burns, choroidal neovascularization, cornea, corneal neovascularization, demethylation, forkhead box protein m1, neovascularization, pathologic, mice
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):34. https://doi.org/10.1167/iovs.65.12.34

Includes: Supplemental Content

Refractive Intervention October 2024

The Effect of Repeated Low-Level Red-Light Therapy on Myopia Control and Choroid

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Ying Liu; Mengxia Zhu; Xiaoqin Yan; Mu Li; Yan Xiang
TAGS: choroid, follow-up, myopia, red light
Trans. Vis. Sci. Tech.. 2024; 13(10):29. https://doi.org/10.1167/tvst.13.10.29

Includes: Supplemental Content

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Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen

Magnetic Resonance Dacryocystography for Precise Diagnosis of Lacrimal and Perilacrimal Lesions

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

Association Between Hormone Levels and Retinopathy in Patients With Type 2 Diabetes: A Cross-Sectional Study

Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)

Expression of Osteopontin in M2 and M4 Intrinsically Photosensitive Retinal Ganglion Cells in the Mouse Retina

A Penetrable AAV2 Capsid Variant for Efficient Intravitreal Gene Delivery to the Retina

Diabetes Renders Photoreceptors Susceptible to Retinal Ischemia-Reperfusion Injury

Aligning Visual Prosthetic Development With Implantee Needs

Oxidative Stress and Inflammation-Related mRNAs Are Elevated in Serum of a Finnish Wet AMD Cohort

Overcoming Low mRNA Expression in White Matter: A Protocol for RNA Extraction From the Optic Nerve in Large Animals for Transcriptomic Analysis

Single-Cell Multiomics Profiling Reveals Heterogeneity of Müller Cells in the Oxygen-Induced Retinopathy Model

ALKBH5 Regulates Corneal Neovascularization by Mediating FOXM1 M6A Demethylation

The Effect of Repeated Low-Level Red-Light Therapy on Myopia Control and Choroid

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