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Retina November 2024

Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa

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Akishi Onishi; Yuji Tsunekawa; Michiko Mandai; Aiko Ishimaru; Yoko Ohigashi; Junki Sho; Kazushi Yasuda; Keiichiro Suzuki; Juan Carlos Izpisua Belmonte; Fumio Matsuzaki; Masayo Takahashi
TAGS: genes, genome editing, mice, retinitis pigmentosa, rhodopsin, rod photoreceptors, donors, plasmids, electroporation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):38. https://doi.org/10.1167/iovs.65.13.38

Includes: Supplemental Content

Retinal Cell Biology October 2024

Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation

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Ryutaro Akiba; Hung-Ya Tu; Tomoyo Hashiguchi; Yoshiko Takahashi; Kiminori Toyooka; Yoshihiko Tsukamoto; Takayuki Baba; Masayo Takahashi; Michiko Mandai
TAGS: synapses, tissue transplants, transplantation, photoreceptors, shape, retinal bipolar cells
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):8. https://doi.org/10.1167/iovs.65.12.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage

Michiko Mandai; Keisuke Kajita; Mitsuhiro Nishida; Yasuo Kurimoto; Satoshi Yokota; Sunao Sugita; Atsuta Ozaki; Yoko Miura; Masayo Takahashi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):409.

ARVO Annual Meeting Abstract June 2024

Genomic characterization of human pluripotent stem cell-derived RAX-positive sub-populations that direct retinal layer structuring and non-retinal tissue

Yasuaki Iwama; Tomohiro Masuda; Mika Yoshimura; Michiru Matsumura; Kanako Kawai; Kohji Nishida; Masayo Takahashi; Itoshi Nikaido; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4529.

ARVO Annual Meeting Abstract June 2024

Evaluation of genome edited Islet-1 -/- retinal organoid sheets after transplantation in non-human primate models of retinal macular degeneration

Atsuta Ozaki; Keisuke Kajita; Mitsuhiro Nishida; Shin-ichiro Ito; Satoshi Yokota; Tomohiro Masuda; Mineo Kondo; Yasuo Kurimoto; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5378.

ARVO Annual Meeting Abstract June 2023

Induced pluripotent stem cell derived retinal organoid sheets for regenerative therapy in patients with end-stage retinitis pigmentosa

Michiko Mandai; Yasuhiko Hirami; Sunao Sugita; Akiko Maeda; tadao Maeda; Midori Yamamoto; Hirofumi Uyama; Satoshi Yokota; Masashi Fujihara; Masataka Igeta; Takashi Daimon; Kanako Fujita; Tomoko Ito; Masayo Takahashi; Yasuo Kurimoto

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4628.

ARVO Annual Meeting Abstract June 2023

Stable production of hESC/iPSC-derived retinal progenitor spheroid for cell-based therapies using label-free ghost cytometry sorting

Yasuaki Iwama; Tomohiro Masuda; Hiroko Nomaru; Yoko Kawamura; Yuri Murata; Kohji Nishida; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3691.

ARVO Annual Meeting Abstract June 2022

Rewiring of the adult midget pathway in a primate model of acute photoreceptor loss.

Ryutaro Akiba; Shane Boniec; Hirofumi Uyama; Hung-Ya Tu; Sharm Knecht; Takayuki Baba; Masayo Takahashi; Michiko Mandai; Rachel Wong

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3132.

Retinal Cell Biology October 2021

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

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You-Ren Wu; Tomoyo Hashiguchi; Junki Sho; Shih-Hwa Chiou; Masayo Takahashi; Michiko Mandai
TAGS: embryonic stem cells, mice, n-methylaspartate, retina, retinal ganglion cells, tissue transplants, transplantation, stem cells, synapses, neurites
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):26. https://doi.org/10.1167/iovs.62.13.26

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Low immunogenicity and immunosuppressive property of human ES/iPS cells derived neural retina

Suguru Yamasaki; Sunao Sugita; Matsuri Horiuchi; atsushi kuwahara; Akiyoshi Kishino; Toru Kimura; Masayo Takahashi; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3927.

ARVO Annual Meeting Abstract July 2019

Effect of ambient light and BDNF on photoreceptor synaptogenesis after mouse ESC/iPSC-derived retinal organoid transplantation

Ryutaro Akiba; Take Matsuyama; Hung-Ya Tu; Tomoyo Hashiguchi; Sho Junki; Shuichi Yamamoto; Yasuhiko Tabata; Masayo Takahashi; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3928.

ARVO Annual Meeting Abstract July 2019

Functional examination of genetically engineered human ESC-retinas transplanted in an immunodeficient rat model with retinal degeneration

Hung-Ya Tu; Suguru Yamasaki; atsushi kuwahara; Akiyoshi Kishino; Toru Kimura; Masayo Takahashi; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3929.

ARVO Annual Meeting Abstract July 2019

Survival and maturation of iPSC derived retina after transplantation in MHC matched and mismatched nonhuman primate.

Hirofumi Uyama; Suguru Yamasaki; Yasuo Kurimoto; Masayo Takahashi; Sunao Sugita; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3930.

ARVO Annual Meeting Abstract July 2019

HLA 6 loci matched allogeneic iPS cells derived retinal pigment epithelial cells (iPSC-RPE) transplantation

Masayo Takahashi; Sunao Sugita; Michiko Mandai; Yasuhiro HIrami; Seiji Takagi; Midori Yamamoto; Naoshi Koide; Hirokazu Sakaguchi; Kazuichi Maruyama; Kohji Nishida; Shinya Yamanaka; Yasuo Kurimoto

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3933.

ARVO Annual Meeting Abstract July 2019

Annotation of choroidal neovascularization components in age-related macular degeneration using polarization-sensitive optical coherence tomography with optical coherence tomography angiography

Noriko Miyamoto; Kota Totani; Michiko Mandai; Mitsuhiro Matsuzaki; Satoshi Sugiyama; Masahiro Yamanari; Seiji Takagi; Yasuhiko Hirami; Susumu Oshima; Masayo Takahashi; Yasuo Kurimoto

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3455.

ARVO Annual Meeting Abstract July 2018

Genetical modification to reduce bipolar cells in hESC derived retinas aiming for enhanced host-graft contact after transplantation

Suguru Yamasaki; Tomoyo Hashiguchi; Takehito Watanabe; Keizo Matsushita; Atsushi Kuwahara; Akiyoshi Kishino; Toru Kimura; Masayo Takahashi; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):541.

ARVO Annual Meeting Abstract July 2018

Objective quantification of photoreceptor ribbon synapses in iPS cell-derived retina after transplantation to retinal degeneration model mice

Ryutaro Akiba; Takesi Matsuyama Hoyos; Michiko Mandai; Shuichi Yamamoto; Masayo Takahashi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):553.

ARVO Annual Meeting Abstract July 2018

Genetically engineered iPSC-retina for improved retinal reconstruction after transplantation

Hung-Ya Tu; Takesi Matsuyama; Jianan Sun; Tomoyo Hashiguchi; Junki Sho; Genshiro A. Sunagawa; Momo Fujii; Akishi Onishi; Masayo Takahashi; Michiko Mandai

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1987.

ARVO Annual Meeting Abstract July 2018

Polarization-sensitive swept-source OCT imaging of retinal pigment epithelium and subretinal fibrous tissues

Masahiro Yamanari; Mitsuhiro Matsuzaki; Seiji Takagi; Satoshi Sugiyama; Noriko Miyamoto; Yasuhiko Hirami; Naoshi Koide; Franck Jaillon; Daisuke Suzuki; Kota Totani; Kenji Horikoshi; SUSUMU OSHIMA; Michiko Mandai; Masayo Takahashi; Yasuo Kurimoto

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):291.

ARVO Annual Meeting Abstract July 2018

Observation of the transplanted autologous induced pluripotent stem cell-derived retinal pigment epithelial cell sheet using polarization-sensitive optical coherence tomography

Mitsuhiro Matsuzaki; Seiji Takagi; Michiko Mandai; Satoshi Sugiyama; Masahiro Yamanari; Kota Totani; Noriko Miyamoto; Yasuhiko Hirami; SUSUMU OSHIMA; Masayo Takahashi; Yasuo Kurimoto

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5002.

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Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa

Host-Graft Synapses Form Functional Microstructures and Shape the Host Light Responses After Stem Cell-Derived Retinal Sheet Transplantation

Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage

Genomic characterization of human pluripotent stem cell-derived RAX-positive sub-populations that direct retinal layer structuring and non-retinal tissue

Evaluation of genome edited Islet-1 -/- retinal organoid sheets after transplantation in non-human primate models of retinal macular degeneration

Induced pluripotent stem cell derived retinal organoid sheets for regenerative therapy in patients with end-stage retinitis pigmentosa

Stable production of hESC/iPSC-derived retinal progenitor spheroid for cell-based therapies using label-free ghost cytometry sorting

Rewiring of the adult midget pathway in a primate model of acute photoreceptor loss.

Transplanted Mouse Embryonic Stem Cell–Derived Retinal Ganglion Cells Integrate and Form Synapses in a Retinal Ganglion Cell-Depleted Mouse Model

Low immunogenicity and immunosuppressive property of human ES/iPS cells derived neural retina

Effect of ambient light and BDNF on photoreceptor synaptogenesis after mouse ESC/iPSC-derived retinal organoid transplantation

Functional examination of genetically engineered human ESC-retinas transplanted in an immunodeficient rat model with retinal degeneration

Survival and maturation of iPSC derived retina after transplantation in MHC matched and mismatched nonhuman primate.

HLA 6 loci matched allogeneic iPS cells derived retinal pigment epithelial cells (iPSC-RPE) transplantation

Annotation of choroidal neovascularization components in age-related macular degeneration using polarization-sensitive optical coherence tomography with optical coherence tomography angiography

Genetical modification to reduce bipolar cells in hESC derived retinas aiming for enhanced host-graft contact after transplantation

Objective quantification of photoreceptor ribbon synapses in iPS cell-derived retina after transplantation to retinal degeneration model mice

Genetically engineered iPSC-retina for improved retinal reconstruction after transplantation

Polarization-sensitive swept-source OCT imaging of retinal pigment epithelium and subretinal fibrous tissues

Observation of the transplanted autologous induced pluripotent stem cell-derived retinal pigment epithelial cell sheet using polarization-sensitive optical coherence tomography

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