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Lacrimal Apparatus, Eyelids, Orbit June 2025

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

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Huy Nguyen; Russell B. Fletcher; Tom Lopez; Elizabeth Whisler; Kelsey R. Logas; Navrose Dhaliwal; Timothy Suen; Mengrui Zhang; Archana Dilip; Tom Z. Yuan; Hayoung Go; Jay Ye; Parthasarathy Sampathkumar; Nick Suen; Hui Chen; Wen-Chen Yeh; Yang Li; Yorick Post
TAGS: lacrimal gland, ligation, acinar cells, mice, body tissue, wounds and injuries, organoids
Trans. Vis. Sci. Tech.. 2025; 14(6):19. https://doi.org/10.1167/tvst.14.6.19

Includes: Supplemental Content

Cornea June 2025

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

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Mingli Qu; Xiaofei Bai; Mengyao Zhang; Jingyi Wu; Lei Wan; Xiaoyu Li; Qun Wang; Lin Cong; Benxiang Qi; Qingjun Zhou
TAGS: cornea, dry eye syndromes, mice, norepinephrine, sympathetic nervous system, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):13. https://doi.org/10.1167/iovs.66.6.13

Includes: Supplemental Content

Glaucoma June 2025

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

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Xiaowei Yu; Hanxue Zhao; Yan Gao; Tao Zhou; Lin Deng; Miao Zhang; Hongyu Zhong; Feng Mei; Zhijun Li; Longyan Sun; Tianrui Zhang; Yan Shi; Zhigang Fan
TAGS: angle closure glaucoma, chinese (other dialects), chinese people, cohort studies, genetics, genotype, microphthalmos, phenotype, genes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):9. https://doi.org/10.1167/iovs.66.6.9

Includes: Supplemental Content

Artificial Intelligence March 2025

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

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Bo Zheng; Chen Wang; Maotao Zhang; Shaojun Zhu; Maonian Wu; Tao Wu; Weihua Yang; Lu Chen
TAGS: learning, macular disorders, fundus photography, color, datasets
Trans. Vis. Sci. Tech.. 2025; 14(3):4. https://doi.org/10.1167/tvst.14.3.4

Includes: Supplemental Content

Immunology and Microbiology March 2025

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

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Minjie Zhang; Yichen Liang; Han Wu; Rongrong Zong; Xiaobo Zhang; Hui He; Peter Sol Reinach; Zuguo Liu; Long Shen; Wei Li
TAGS: dry eye syndromes, mice, ocular surfaces, sjogren's syndrome, conjunctiva, mice, transgenic
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):2. https://doi.org/10.1167/iovs.66.3.2

Includes: Supplemental Content

Cornea February 2025

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

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Chao Wang; Yu-Zhi Li; Huan Guo; Shi-Rui Zhou; Xi Peng; Jia-Song Wang; Hua-Tao Xie; Ming-Chang Zhang
TAGS: lacrimal gland, nlr family, pyrin domain-containing 3 protein, sirt1 gene, melatonin, pathophysiology, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):51. https://doi.org/10.1167/iovs.66.2.51

Includes: Supplemental Content

Artificial Intelligence February 2025

Deep Learning Approaches to Predict Geographic Atrophy Progression Using Three-Dimensional OCT Imaging

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Kenta Yoshida; Neha Anegondi; Adam Pely; Miao Zhang; Frederic Debraine; Karthik Ramesh; Verena Steffen; Simon S. Gao; Catherine Cukras; Christina Rabe; Daniela Ferrara; Richard F. Spaide; SriniVas R. Sadda; Frank G. Holz; Qi Yang
TAGS: age-related macular degeneration, nonexudative, datasets, deep learning, diagnostic imaging, growth rate
Trans. Vis. Sci. Tech.. 2025; 14(2):11. https://doi.org/10.1167/tvst.14.2.11

Includes: Supplemental Content

Retina January 2025

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

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Lisong Wang; Gaocheng Zou; Yuanye Yan; Ronghua Shi; Yue Guo; Mei Zhang; Li Lu; Kai Dong
TAGS: idebenone, mice, oxidative phosphorylation defect, photoreceptors, retinal detachment, body tissue, mitochondria, retina, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):17. https://doi.org/10.1167/iovs.66.1.17

Includes: Supplemental Content

Physiology and Pharmacology November 2024

Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia

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Miao Zhang; Ruixue Zhang; Jiawen Hao; Xiaoyue Zhao; Zhongyu Ma; Yuan Peng; Bo Bao; Jizhao Xin; Xuewei Yin; Hongsheng Bi; Dadong Guo
TAGS: myopia, quercetin, sclera, caviidae, proteins, body tissue
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):11. https://doi.org/10.1167/iovs.65.13.11

Artificial Intelligence September 2024

Generating Synthesized Fluorescein Angiography Images From Color Fundus Images by Generative Adversarial Networks for Macular Edema Assessment

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Xiaoling Xie; Danba Jiachu; Chang Liu; Meng Xie; Jinming Guo; Kebo Cai; Xiangbo Li; Wei Mi; Hehua Ye; Li Luo; Jianlong Yang; Mingzhi Zhang; Ce Zheng
TAGS: color, datasets, fluorescein angiography, macular edema, specialism
Trans. Vis. Sci. Tech.. 2024; 13(9):26. https://doi.org/10.1167/tvst.13.9.26

Artificial Intelligence September 2024

A Meta-Learning Approach for Classifying Multimodal Retinal Images of Retinal Vein Occlusion With Limited Data

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Danba Jiachu; Li Luo; Meng Xie; Xiaoling Xie; Jinming Guo; Hehua Ye; Kebo Cai; Lingling Zhou; Gang Song; Feng Jiang; Danqing Huang; Mingzhi Zhang; Ce Zheng
TAGS: datasets, learning, retinal vein occlusion, training
Trans. Vis. Sci. Tech.. 2024; 13(9):22. https://doi.org/10.1167/tvst.13.9.22

Vision Sciences Society Annual Meeting Abstract September 2024

Asymmetry for shading direction in visual search persists in inattentional blindness

ShuiEr Han; Yang Shen; Mengmi Zhang

Journal of Vision. 2024; 24(10):317. https://doi.org/10.1167/jov.24.10.317

Biochemistry and Molecular Biology August 2024

Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8 + T Cells and in Uveal Melanoma

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Chen Hou; Qi Wan; Lirong Xiao; Qing Xiao; Meixia Zhang; Naihong Yan
TAGS: heme oxygenase (decyclizing), intraocular melanoma, neoplasms, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):37. https://doi.org/10.1167/iovs.65.10.37

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging August 2024

Are the Hypo-Reflective Clumps Associated With Age-Related Macular Degeneration in Adaptive Optics Ophthalmoscopy Autofluorescent?

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Ysé Borella; Natalie Danielsen; Evelyn M. Markle; Valerie C. Snyder; Daniel M. W. Lee; Min Zhang; Andrew W. Eller; Jay Chhablani; Michel Paques; Ethan A. Rossi
TAGS: age-related macular degeneration, ophthalmoscopy, optics, diagnostic imaging, melanins, phase contrast, scanning laser ophthalmoscopy
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):28. https://doi.org/10.1167/iovs.65.10.28

Includes: Supplemental Content

Retina August 2024

Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial

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Sheng Gao; Ge Ge; Yun Zhang; Meixia Zhang
TAGS: central serous chorioretinopathy, lasers, spironolactone
Trans. Vis. Sci. Tech.. 2024; 13(8):19. https://doi.org/10.1167/tvst.13.8.19

Includes: Supplemental Content

ARVO Imaging in the Eye Conference Abstract July 2024

The impact of caffeine on fixational eye motion and blink rate measured with a tracking scanning laser ophthalmoscope

Jacqueline Theis; Yessica Nunez; Christy Sheehy; Ethan A. Rossi; Michael R. Kozlowski; Balamurali Vasudevan; Julia E. Seaman; Isabel Elaine Allen; Min Zhang; Nicole M. Putnam

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PB00104.

Refractive Intervention June 2024

Effect of Individualized Ocular Refraction Customization Spectacle Lens Wear on Visual Performance in Myopic Chinese Children

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Ye Wu; Ji Kou; Si Lei; Ling Xiong; Qian Chen; Meixia Zhang; Longqian Liu
TAGS: child, lens (device), lens, crystalline, ocular refraction, vision, chinese (other dialects), chinese people
Trans. Vis. Sci. Tech.. 2024; 13(6):21. https://doi.org/10.1167/tvst.13.6.21

Includes: Supplemental Content

Glaucoma June 2024

Repeatability of a Virtual Reality Headset Perimeter in Glaucoma and Ocular Hypertensive Patients

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Rafaella Nascimento e Silva; Julia A. Kim; Yihao Li; Chen Chen; Anisa F. Chaudhry; Andrew R. Berneshawi; Miao Zhang; Adam Villarreal; Jocelyn Liu; Ann Shue; Dolly S. Chang; Robert T. Chang
TAGS: glaucoma, ocular hypertension, virtual reality, eye
Trans. Vis. Sci. Tech.. 2024; 13(6):14. https://doi.org/10.1167/tvst.13.6.14

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Automated periorbital segmentation for gaze measurement in oculoplastic patients

Yelena Bagdasarova; Alexandra Van Brummen; Jolan Wu; Colin Froines; Julia Owen; Cecilia S Lee; Matthew Zhang; Aaron Y Lee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5483.

ARVO Annual Meeting Abstract June 2024

Artificial Intelligence Quantified Outer Retinal Disruption On Optical Coherence Tomography As Clinical Endpoints For Geographic Atrophy

Adam Pely; Simon S. Gao; Katie M Litts; Zhichao Wu; Theodore Leng; Verena Steffen; Hao Chen; Dolly Shuo-Teh Chang; Mohsen Hejrati; Miao Zhang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2344.

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WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

Genetic Spectrum and Genotype-Phenotype Correlations in a Chinese Cohort With Nanophthalmos With Secondary Angle-Closure Glaucoma

An Intelligent Grading Model for Myopic Maculopathy Based on Long-Tailed Learning

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

Melatonin Alleviates Age-Related Lacrimal Gland Dysfunction Via SIRT-1/NLRP3 Pathway

Deep Learning Approaches to Predict Geographic Atrophy Progression Using Three-Dimensional OCT Imaging

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia

Generating Synthesized Fluorescein Angiography Images From Color Fundus Images by Generative Adversarial Networks for Macular Edema Assessment

A Meta-Learning Approach for Classifying Multimodal Retinal Images of Retinal Vein Occlusion With Limited Data

Asymmetry for shading direction in visual search persists in inattentional blindness

Inhibition of Heme Oxygenase 1 Suppresses Growth, Migration, and Invasion, and Regulates Tumor-Infiltrating CD8 + T Cells and in Uveal Melanoma

Are the Hypo-Reflective Clumps Associated With Age-Related Macular Degeneration in Adaptive Optics Ophthalmoscopy Autofluorescent?

Subthreshold Micropulse Laser Versus Oral Spironolactone in Chronic Central Serous Chorioretinopathy: A Quasi-Randomized Controlled Trial

The impact of caffeine on fixational eye motion and blink rate measured with a tracking scanning laser ophthalmoscope

Effect of Individualized Ocular Refraction Customization Spectacle Lens Wear on Visual Performance in Myopic Chinese Children

Repeatability of a Virtual Reality Headset Perimeter in Glaucoma and Ocular Hypertensive Patients

Automated periorbital segmentation for gaze measurement in oculoplastic patients

Artificial Intelligence Quantified Outer Retinal Disruption On Optical Coherence Tomography As Clinical Endpoints For Geographic Atrophy

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