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ARVO Annual Meeting Abstract June 2024

Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration

Yuancheng Ryan Lu; Margarete Karg; Lindsey A Chew; Kat Kajderowicz; Daisy Y Shu; Xiaojie Qiu; Nasrin Refaian; Shintaro Shirahama; Zhengping Hu; Tessa Bertozzi; David Sinclair; Magali Saint-Geniez; Patricia A D'Amore; Catherine Bowes Rickman; Bruce Ksander; Jonathan Weissman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5307.

ARVO Annual Meeting Abstract June 2024

HDAC inhibition induces double-stranded RNA accumulation in retinal pigment epithelial cells

Kyle Henry Bond; Xiaoqiu Wu; Magali Saint-Geniez; Yi Bao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):754.

ARVO Annual Meeting Abstract June 2023

Discovery of aryl hydrocarbon receptors (AhR) agonist to prevent toxin-induced retinal pigment epithelium (RPE) cell death via a phonotypic high-throughput screening assay

Hongwei Han; Yi Bao; Joshua Schustak; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3007.

ARVO Annual Meeting Abstract June 2023

TNFα secreted by DNA-sensing in macrophage compromises retinal pigment epithelial barrier function

Yi Bao; Michael Twarog; Joshua Schustak; YongYao Xu; Matthew Coble; Katie Dolan; Robert Esterberg; Qian Huang; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2963.

ARVO Annual Meeting Abstract June 2023

Partial epigenetic reprogramming of RPE cells reverses age and rejuvenates mitochondrial metabolism

Margarete Karg; Daisy Y Shu; Yuancheng Lu; yue He; James C. Cameron; Jonathan S. Weissman; George W Bell; David Sinclair; Magali Saint-Geniez; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2966.

ARVO Annual Meeting Abstract June 2022

Dimethyl fumarate blocks TNFα-driven inflammation and metabolic rewiring in retinal pigment epithelial cells

Daisy Y Shu; Tessa C. Fitch; Scott I. Frank; Erik Russell Butcher; Margarete Karg; Siwei Cai; Rishi Shah; Deviprasad Gollapalli; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):873.

ARVO Annual Meeting Abstract June 2022

Sex and Age-Related Changes in RPE Morphology and Function in Mice

Margarete Karg; Emma Hoffmann; Drenushe Krasniqi; Daisy Y Shu; May Moorefield; Hannah Philipose; Bruce Ksander; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3481.

ARVO Annual Meeting Abstract June 2022

Electric stimulation reduces microglia proinflammatory activity in vitro

Anton Lennikov; Menglu Yang; Karen Chang; Li Pan; Daisy Y Shu; Kin-Sang Cho; Magali Saint-Geniez; Darlene A Dartt; Tor Utheim; Dongfeng Chen

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3177 – F0451.

ARVO Annual Meeting Abstract June 2022

Endomucin deletion delays retinal vascular development and inhibits neovascularization in oxygen-induced retinopathy

Zhengping Hu; Issahy Cano; Magali Saint-Geniez; Yin Shan Eric Ng; Patricia A D'Amore

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3167 – F0441.

ARVO Annual Meeting Abstract June 2021

Identification of PGC-1β as promising therapeutic target of neovascular AMD

Siwei Cai; Daisy Y Shu; Hannah Philipose; Erik Butcher; Ilakya Senthilkumar; Scott Frank; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2250.

ARVO Annual Meeting Abstract June 2021

Specific Role of Endomucin in VEGF-induced VEGF Receptor 2 Internalization and Function

Zhengping Hu; Issahy Cano; Magali Saint-Geniez; Yin Shan Eric Ng; Patricia A D'Amore

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2925.

ARVO Annual Meeting Abstract June 2021

Galectin-3 requires VEGF to activate VEGF receptor 2 in retinal endothelial cells

Issahy Cano; Zhengping Hu; Dina Abusamra; Magali Saint-Geniez; Yin Shan Eric Ng; Pablo Argueso; Patricia A D'Amore

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2702.

ARVO Annual Meeting Abstract June 2021

In vivo epigenetic reprogramming reverses the age-induced morphological decline of retinal pigment epithelial cells

Margarete Karg; Yuancheng Lu; Emma Hoffmann; Hannah Philipose; David Sinclair; Bruce Ksander; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3283.

ARVO Annual Meeting Abstract June 2021

TNFα-RUNX1 Pathway Regulates Retinal Endothelial Cell Survival and Response to Oxidative Stress

Hannah Whitmore; Daisy Y Shu; Magali Saint-Geniez; Leo A Kim

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):530.

ARVO Annual Meeting Abstract June 2020

Metabolic alterations during TGFβ2-induced EMT in retinal pigment epithelial (RPE) cells

Daisy Yao Shu; Erik Butcher; Siwei Cai; Ilakya Senthilkumar; Scott Frank; Kiran Kurmi; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3181.

ARVO Annual Meeting Abstract June 2020

Identification of PGC-1β as novel stress response target in neovascular AMD

Siwei Cai; Daisy Yao Shu; Erik Butcher; Ilakya Senthilkumar; Scott Frank; Magali Saint-Geniez

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3537.

ARVO Annual Meeting Abstract June 2020

Anti-angiogenic effects of a novel small molecular activator of PGC-1α

Magali Saint-Geniez; Ilakya Senthilkumar; Siwei Cai; Daisy Yao Shu; Erik Butcher; Scott Frank

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4341.

ARVO Annual Meeting Abstract July 2019

Endomucin and galectin-3 modulate VEGFR2-mediated endothelial functions

Michelle LeBlanc; Issahy Cano; Zhengping Hu; kahira Saez-Torres; Magali Saint-Geniez; Yin Shan Eric Ng; Pablo Argueso; Patricia A. D'Amore

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3259.

ARVO Annual Meeting Abstract July 2019

Metabolic normalization protects RPE against TGFβ-induced epithelial-to-mesenchymal transition

Magali Saint-Geniez; Sangeeta Satish; Hannah Philipose; Mariana Aparecida Rosales

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4412.

ARVO Annual Meeting Abstract July 2019

Endomucin regulates Vascular Endothelial Growth Factor (VEGF) induced endothelium functions through its extracellular domain

Zhengping Hu; Michelle LeBlanc; kahira Saez-Torres; Magali Saint-Geniez; Yin Shan Eric Ng; Patricia A. D'Amore

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5376.

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Genome-wide Screening Identifies Novel Genetic and Epigenetic Factors for the Rejuvenation and Enhancement of RPE to Alleviate Age-related Macular Degeneration

HDAC inhibition induces double-stranded RNA accumulation in retinal pigment epithelial cells

Discovery of aryl hydrocarbon receptors (AhR) agonist to prevent toxin-induced retinal pigment epithelium (RPE) cell death via a phonotypic high-throughput screening assay

TNFα secreted by DNA-sensing in macrophage compromises retinal pigment epithelial barrier function

Partial epigenetic reprogramming of RPE cells reverses age and rejuvenates mitochondrial metabolism

Dimethyl fumarate blocks TNFα-driven inflammation and metabolic rewiring in retinal pigment epithelial cells

Sex and Age-Related Changes in RPE Morphology and Function in Mice

Electric stimulation reduces microglia proinflammatory activity in vitro

Endomucin deletion delays retinal vascular development and inhibits neovascularization in oxygen-induced retinopathy

Identification of PGC-1β as promising therapeutic target of neovascular AMD

Specific Role of Endomucin in VEGF-induced VEGF Receptor 2 Internalization and Function

Galectin-3 requires VEGF to activate VEGF receptor 2 in retinal endothelial cells

In vivo epigenetic reprogramming reverses the age-induced morphological decline of retinal pigment epithelial cells

TNFα-RUNX1 Pathway Regulates Retinal Endothelial Cell Survival and Response to Oxidative Stress

Metabolic alterations during TGFβ2-induced EMT in retinal pigment epithelial (RPE) cells

Identification of PGC-1β as novel stress response target in neovascular AMD

Anti-angiogenic effects of a novel small molecular activator of PGC-1α

Endomucin and galectin-3 modulate VEGFR2-mediated endothelial functions

Metabolic normalization protects RPE against TGFβ-induced epithelial-to-mesenchymal transition

Endomucin regulates Vascular Endothelial Growth Factor (VEGF) induced endothelium functions through its extracellular domain

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