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ARVO Annual Meeting Abstract June 2024

Long-term maintenance of adult limbal epithelial stem cells (LSC) using Rock Inhibitor and assessment of its effects on cell identity.

Eldo Galo; Francisco Figueiredo; Simi Ali; Majlinda Lako; Lyle Armstrong

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2006.

ARVO Annual Meeting Abstract June 2024

A comprehensive single cell spatio-temporal transcriptional and chromatin accessibility analyses during human retinal organoid development

Birthe Dorgau; Joseph Collin; Agata Rozanska; Veronika Boczonadi; Marina Moya Molina; Adrienne Unsworth; Rafiqul Hussain; Jonathan Coxhead; Tamilvendhan Dhanaseelan; Lyle Armstrong; Rachel Queen; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3316.

ARVO Annual Meeting Abstract June 2024

Evaluation of a novel antisense oligonucleotide therapy targeting a 5’UTR mutation in the RDH12 gene

Manon Bouckaert; Kyana Van Acker; Maria Georgiou; Filip Van Den Broeck; Edith De Bruycker; Alfredo Dueñas Rey; Emma Delanote; Hanne Lenaerts; Melita Kaltak; Elfride De Baere; Katrien Remaut; Louis Delhaye; Julie De Zaeytijd; Bart Peter Leroy; Majlinda Lako; Frauke Coppieters

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5321.

ARVO Annual Meeting Abstract June 2024

Harnessing the power of patient specific organoids to discover new therapeutic treatments for retinoblastoma.

Agata Rozanska; Eleni Sotiriadou; Ian Hardcastle; Gareth Veal; Manoj Parulekar; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5077.

ARVO Annual Meeting Abstract June 2024

Spatiotemporal single cell analyses reveal a transient population of retinal progenitor cells in the ciliary margin of developing human retina

Majlinda Lako; Birthe Dorgau; Joseph Collin; Agata Rozanska; Darin Zerti; Moira Crosier; Rafiqul Hussain; Jonathan Coxhead; Tamil Dhanaseelan Dhanaseelan; Aara Patel; Jane C Sowden; David FitzPatrick; Rachel Queen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6702.

ARVO Annual Meeting Abstract June 2023

A Phase II, prospective, single centre, single arm interventional trial to evaluate the safety and effectiveness of human ex vivo expanded autologous limbal stem cells transplantation for the treatment of unilateral total limbal stem cell deficiency

Francisco C Figueiredo; Oliver Baylis; Hardeep Mudhar; Majlinda Lako; Gustavo Figueiredo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2358.

ARVO Annual Meeting Abstract June 2023

Impact of alternative splicing of ciliary genes on the development and maturation of human photoreceptors.

Marina Moya Molina; Emily Flood; Birthe Hilgen; Sushma Nagaraja-Grellscheid; Lyle Armstrong; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3169.

ARVO Annual Meeting Abstract June 2023

Exploring the onset of retinal degeneration in Joubert Syndrome using retinal organoids

Kae Whiting; Emma Dyke; Marina Moya Molina; Sylvia Van Beersum; Thomas Theil; Majlinda Lako; Nael Nadif Kasri; Ronald Roepman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5075.

ARVO Annual Meeting Abstract June 2022

Spatial transcriptomics of human pluripotent stem cell derived retinal organoids offers new insight in retinal development

Birthe Dorgau; Joseph Collin; Rachel Queen; Agata Rozanska; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1358 – F0289.

ARVO Annual Meeting Abstract June 2022

Elucidating the Mechanism of PRPF-linked Retinitis Pigmentosa

Rob Atkinson; Chunbo Yang; Katarzyna Szymanska; Maria Georgiou; Chia Beh; Joseph Collin; Marina Moya Molina; Ross Laws; Sina Mozaffari-Jovin; Colin Johnson; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2439 – F0383.

ARVO Annual Meeting Abstract June 2022

Modelling monoallelic Stargardt disease with 3D retinal organoids

Avril M Watson; Birthe Dorgau; Valeria Chichagova; Frans P Cremers; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2432 – F0376.

ARVO Annual Meeting Abstract June 2022

Identification and characterization of a novel retina-specific lncRNA upstream ABCA4 with a potential role in ABCA4 -associated inherited retinal disease

Alfredo Dueñas Rey; Víctor López-Soriano; Zelia Corradi; Claire-Marie Dhaenens; Manon Bouckaert; Jasper Verwilt; Avril M Watson; Majlinda Lako; Eva D’haene; Karla Alejandra Ruiz Ceja; Sandro Banfi; Miriam Bauwens; Frans P Cremers; Steve Lefever; Elfride De Baere; Frauke Coppieters

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2628.

ARVO Annual Meeting Abstract June 2022

pRB-depleted pluripotent stem cell retinal organoids mimic retinoblastoma development

Agata Rozanska; Rodrigo Cerna-Chavez; Rachel Queen; Joseph Collin; Darin Zerti; Birthe Dorgau; Chia Shyan Beh; Tracey Davey; Jonathan Coxhead; Rafiqul Hussain; Jumana Al-Aama; David Steel; Nissim Benvenisty; Lyle Armstrong; Manoj Parulekar; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2619.

ARVO Annual Meeting Abstract June 2022

Conjunctival epithelial cells resist productive SARS-CoV-2 infection

Majlinda Lako; Robert Jackson; Catherine Hatton; Jarmila Spegarova; Maria Georgiou; Joseph Collin; Emily Stephenson; Hardeep-Singh Mudhar; Bart Wagner; Paul Rooney; Muzlifah Haniffa Haniffa; Lyle Armstrong; Francisco C Figueiredo; Rachel Queen; Christopher Duncan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3249 – A0284.

ARVO Annual Meeting Abstract June 2022

Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient induced pluripotent stem cells (iPSCs)-derived retinal pigment epithelium (RPE) cells.

Maria Georgiou; Chunbo Yang; Robert Atkinson; Kuan-Ting Pan; Adriana Buskin; Marina Moya Molina; Joseph Collin; Sebastian E. J. Ludwig; Sushma Nagaraja-Grellscheid; Colin Johnson; Robin Ali; Lyle Armstrong; Viktor Korolchuk; Henning Urlaub; Sina Mozaffari-Jovin; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3818.

ARVO Annual Meeting Abstract June 2022

Developing novel differentiation methods for the generation of 3D retinal organoids from cynomolgus macaque iPSCs

Madeleine Carter; Valeria Chichagova; Birthe Dorgau; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3731 – F0337.

ARVO Annual Meeting Abstract June 2021

A single cell atlas of developing and adult cornea in steady state and disease conditions

Majlinda Lako; Joseph Collin; Rachel Queen; Darin Zerti; Sanja Bojic; Birthe Dorgau; Nicky Moyse; Marina Moya Molina; Chunbo Yang; Sunanda Dey; Lyle Armstrong; Francisco C Figueiredo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):743.

Retina May 2021

Dissecting the Transcriptional and Chromatin Accessibility Heterogeneity of Proliferating Cone Precursors in Human Retinoblastoma Tumors by Single Cell Sequencing—Opening Pathways to New Therapeutic Strategies?

PDF

Joseph Collin; Rachel Queen; Darin Zerti; David H Steel; Claire Bowen; Manoj Parulekar; Majlinda Lako
TAGS: chromatin, neoplasms, retinal cone, retinoblastoma, rna, small cytoplasmic, transcription, genetic, heterogeneity
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):18. https://doi.org/10.1167/iovs.62.6.18

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Unravelling the heterogeneity of progenitor cells in the developing human retina through single cell analyses

Joseph Collin; Darin Zerti; Rachel Queen; Birthe Dorgau; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3768.

ARVO Annual Meeting Abstract June 2020

Enhancing immune function of hiPSC-derived retinal organoids by incorporating microglial cells

Valeria Chichagova; Maria Georgiou; Birthe Dorgau; Madeleine Carter; Git Chung; Evelyne Sernagor; Lyle Armstrong; Majlinda Lako

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3797.

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Long-term maintenance of adult limbal epithelial stem cells (LSC) using Rock Inhibitor and assessment of its effects on cell identity.

A comprehensive single cell spatio-temporal transcriptional and chromatin accessibility analyses during human retinal organoid development

Evaluation of a novel antisense oligonucleotide therapy targeting a 5’UTR mutation in the RDH12 gene

Harnessing the power of patient specific organoids to discover new therapeutic treatments for retinoblastoma.

Spatiotemporal single cell analyses reveal a transient population of retinal progenitor cells in the ciliary margin of developing human retina

A Phase II, prospective, single centre, single arm interventional trial to evaluate the safety and effectiveness of human ex vivo expanded autologous limbal stem cells transplantation for the treatment of unilateral total limbal stem cell deficiency

Impact of alternative splicing of ciliary genes on the development and maturation of human photoreceptors.

Exploring the onset of retinal degeneration in Joubert Syndrome using retinal organoids

Spatial transcriptomics of human pluripotent stem cell derived retinal organoids offers new insight in retinal development

Elucidating the Mechanism of PRPF-linked Retinitis Pigmentosa

Modelling monoallelic Stargardt disease with 3D retinal organoids

Identification and characterization of a novel retina-specific lncRNA upstream ABCA4 with a potential role in ABCA4 -associated inherited retinal disease

pRB-depleted pluripotent stem cell retinal organoids mimic retinoblastoma development

Conjunctival epithelial cells resist productive SARS-CoV-2 infection

Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient induced pluripotent stem cells (iPSCs)-derived retinal pigment epithelium (RPE) cells.

Developing novel differentiation methods for the generation of 3D retinal organoids from cynomolgus macaque iPSCs

A single cell atlas of developing and adult cornea in steady state and disease conditions

Dissecting the Transcriptional and Chromatin Accessibility Heterogeneity of Proliferating Cone Precursors in Human Retinoblastoma Tumors by Single Cell Sequencing—Opening Pathways to New Therapeutic Strategies?

Unravelling the heterogeneity of progenitor cells in the developing human retina through single cell analyses

Enhancing immune function of hiPSC-derived retinal organoids by incorporating microglial cells

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