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Articles December 2020

Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial

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Evelyn P. Semenov; Rebecca Sheplock; Alejandro J. Roman; David B. McGuigan; Malgorzata Swider; Artur V. Cideciyan; Samuel G. Jacobson

Trans. Vis. Sci. Tech.. 2020; 9(13):13. doi: https://doi.org/10.1167/tvst.9.13.13

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Transient pupillary light reflexes driven by foveal cones in CEP290- or in NPHP5- associated LCA-ciliopathies

Arun kumar Krishnan; Jason Charng; Samuel G Jacobson; Alejandro J Roman; Alexandra Garafalo; Alexander Sumaroka; Malgorzata Swider; Evelyn Semenov; Rebecca Sheplock; Elise Heon; Artur V Cideciyan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1833. doi:

ARVO Annual Meeting Abstract July 2018

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L Boye; Simone Iwabe; Valerie Dufour; Malgorzata Swider; Karolina Roszak; William W Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6006. doi:

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522. doi:

Retina June 2017

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

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Jason Charng; Samuel G. Jacobson; Elise Heon; Alejandro J. Roman; David B. McGuigan, III; Rebecca Sheplock; Mychajlo S. Kosyk; Malgorzata Swider; Artur V. Cideciyan
TAGS: blindness, luminance, photoreceptors, pupil, reflex, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3215-3224. doi: https://doi.org/10.1167/iovs.17-21909

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Interocular Symmetry of Rod and Cone Topography in Human ORF15-RPGR -XLRP Disease Despite Large Intraretinal, Intrafamilial and Interfamilial Variation

Artur V Cideciyan; Jason Charng; Samuel G Jacobson; Alexander Sumaroka; Sharon B. Schwartz; Malgorzata Swider; Alejandro J Roman; Rebecca Sheplock; Manisha Anand; Marc C. Peden; Hemant Khanna; Elise Heon; Alan F. Wright; Anand Swaroop

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3232. doi:

ARVO Annual Meeting Abstract June 2017

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

William A Beltran; Artur V Cideciyan; Raghavi Sudharsan; Michael Massengill; Brian Rossmiller; Valerie Liliane Dufour; felipe Pompeo Marinho; Tatyana Appelbaum; Malgorzata Swider; Mychajlo S. Kosyk; Simone Iwabe; William W Hauswirth; Samuel G Jacobson; Alfred S Lewin; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4483. doi:

Retina May 2017

Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP290 Gene

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Samuel G. Jacobson; Artur V. Cideciyan; Alexander Sumaroka; Alejandro J. Roman; Jason Charng; Monica Lu; Windy Choi; Rebecca Sheplock; Malgorzata Swider; Mychajlo S. Kosyk; Sharon B. Schwartz; Edwin M. Stone; Gerald A. Fishman
TAGS: cohort studies, eye, genes, introns, leber's amaurosis, mutation, outcome measures, questionnaires, vision, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2609-2622. doi: https://doi.org/10.1167/iovs.17-21560

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Comparative Measurements of Rod Function in Retinal Degenerations with Two-color Dark-adapted Perimetry

Artur V Cideciyan; Jason Charng; Malgorzata Swider; Rebecca Sheplock; David B McGuigan; Rodrigo Matsui; Alejandro J Roman; Sharon B Schwartz; Samuel G Jacobson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):131. doi:

ARVO Annual Meeting Abstract September 2016

Fragile Maculas in Patients with Retinal Degeneration due to RPGR - ORF15 Mutations: Spatio-temporal Models of Disease Progression

Jason Charng; Malgorzata Swider; Rebecca Sheplock; Alexander Sumaroka; Alejandro J Roman; Marc Christopher Peden; Elise Heon; Sharon B Schwartz; Samuel G Jacobson; Artur V Cideciyan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):156. doi:

Retina September 2015

Molecular Heterogeneity Within the Clinical Diagnosis of Pericentral Retinal Degeneration

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Rodrigo Matsui; Artur V. Cideciyan; Sharon B. Schwartz; Alexander Sumaroka; Alejandro J. Roman; Malgorzata Swider; Wei Chieh Huang; Rebecca Sheplock; Samuel G. Jacobson
TAGS: cohort studies, heterogeneity, pathophysiology, retinal degeneration, rod photoreceptors, scotoma, vision, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):6007-6018. doi: https://doi.org/10.1167/iovs.15-17174

Includes: Supplemental Content

Retina September 2015

Predicting Progression of ABCA4 -Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front

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Artur V. Cideciyan; Malgorzata Swider; Sharon B. Schwartz; Edwin M. Stone; Samuel G. Jacobson
TAGS: laplace transform damping factor for arterial velocity waveform, laser-doppler flowmetry, meridians, nose, retina, retinal degeneration, follow-up, disease progression, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):5946-5955. doi: https://doi.org/10.1167/iovs.15-17698

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Gene therapy for RPGR -XLRP in a canine model results in retained photoreceptors and vision for at least 2.5 years

William A Beltran; Artur V Cideciyan; Simone Iwabe; Alfred S Lewin; Malgorzata Swider; Jose M Guzman; Sanford L Boye; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre; RC

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2588. doi:

Retina May 2015

Autofluorescence Imaging With Near-Infrared Excitation: Normalization by Reflectance to Reduce Signal From Choroidal Fluorophores

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Artur V. Cideciyan; Malgorzata Swider; Samuel G. Jacobson
TAGS: atrophy, autofluorescence, diagnostic imaging, excitation, melanins, eye, retina, lights, manufactured
Invest. Ophthalmol. Vis. Sci.. 2015; 56(5):3393-3406. doi: https://doi.org/10.1167/iovs.15-16726

Includes: Supplemental Content

Retina January 2015

Pseudo-Fovea Formation After Gene Therapy for RPE65 -LCA

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Artur V. Cideciyan; Geoffrey K. Aguirre; Samuel G. Jacobson; Omar H. Butt; Sharon B. Schwartz; Malgorzata Swider; Alejandro J. Roman; Sam Sadigh; William W. Hauswirth
TAGS: eye, fovea centralis, gene therapy, pathologic nystagmus, retina
Invest. Ophthalmol. Vis. Sci.. 2015; 56(1):526-537. doi: https://doi.org/10.1167/iovs.14-15895

Includes: Multimedia, Supplemental Content

Retina August 2014

TULP1 Mutations Causing Early-Onset Retinal Degeneration: Preserved but Insensitive Macular Cones

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Samuel G. Jacobson; Artur V. Cideciyan; Wei Chieh Huang; Alexander Sumaroka; Alejandro J. Roman; Sharon B. Schwartz; Xunda Luo; Rebecca Sheplock; Joanna M. Dauber; Malgorzata Swider; Edwin M. Stone
TAGS: ciliopathies, diagnostic imaging, mutation, retinal cone, retinal degeneration, vision, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5354-5364. doi: https://doi.org/10.1167/iovs.14-14570

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

RPGR gene augmentation delivered at early, mid and late stage disease in a canine model of XLRP rescues photoreceptor structure and function.

William A Beltran; Artur V Cideciyan; Alfred S Lewin; Simone Iwabe; Malgorzata Swider; Jose-Manuel Guzman; Sanford L Boye; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3321. doi:

ARVO Annual Meeting Abstract June 2013

Photoreceptor Abnormalities in Intermediate Age-Related Macular Degeneration

Sam Sadigh; Artur Cideciyan; Alexander Sumaroka; Wei Chieh Huang; Xunda Luo; Malgorzata Swider; Janet Steinberg; Dwight Stambolian; Samuel Jacobson

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):6281. doi:

Retina March 2013

Abnormal Thickening as well as Thinning of the Photoreceptor Layer in Intermediate Age-Related Macular Degeneration

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Sam Sadigh; Artur V. Cideciyan; Alexander Sumaroka; Wei Chieh Huang; Xunda Luo; Malgorzata Swider; Janet D. Steinberg; Dwight Stambolian; Samuel G. Jacobson
TAGS: age-related macular degeneration, drusen, photoreceptors, eye
Invest. Ophthalmol. Vis. Sci.. 2013; 54(3):1603-1612. doi: https://doi.org/10.1167/iovs.12-11286

Retina February 2012

Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4 -Associated Retinopathy Trials

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Artur V. Cideciyan; Malgorzata Swider; Tomas S. Aleman; Willam J. Feuer; Sharon B. Schwartz; Robert C. Russell; Janet D. Steinberg; Edwin M. Stone; Samuel G. Jacobson
TAGS: macular degeneration, macular function, outcome measures, perimetry, retina, retinal diseases, vision, scotoma
Invest. Ophthalmol. Vis. Sci.. 2012; 53(2):841-852. doi: https://doi.org/10.1167/iovs.11-8415

Includes: Supplemental Content

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Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial

Transient pupillary light reflexes driven by foveal cones in CEP290- or in NPHP5- associated LCA-ciliopathies

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

Interocular Symmetry of Rod and Cone Topography in Human ORF15-RPGR -XLRP Disease Despite Large Intraretinal, Intrafamilial and Interfamilial Variation

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP290 Gene

Comparative Measurements of Rod Function in Retinal Degenerations with Two-color Dark-adapted Perimetry

Fragile Maculas in Patients with Retinal Degeneration due to RPGR - ORF15 Mutations: Spatio-temporal Models of Disease Progression

Molecular Heterogeneity Within the Clinical Diagnosis of Pericentral Retinal Degeneration

Predicting Progression of ABCA4 -Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front

Gene therapy for RPGR -XLRP in a canine model results in retained photoreceptors and vision for at least 2.5 years

Autofluorescence Imaging With Near-Infrared Excitation: Normalization by Reflectance to Reduce Signal From Choroidal Fluorophores

Pseudo-Fovea Formation After Gene Therapy for RPE65 -LCA

TULP1 Mutations Causing Early-Onset Retinal Degeneration: Preserved but Insensitive Macular Cones

RPGR gene augmentation delivered at early, mid and late stage disease in a canine model of XLRP rescues photoreceptor structure and function.

Photoreceptor Abnormalities in Intermediate Age-Related Macular Degeneration

Abnormal Thickening as well as Thinning of the Photoreceptor Layer in Intermediate Age-Related Macular Degeneration

Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4 -Associated Retinopathy Trials

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