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Articles December 2020

Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial

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Evelyn P. Semenov; Rebecca Sheplock; Alejandro J. Roman; David B. McGuigan; Malgorzata Swider; Artur V. Cideciyan; Samuel G. Jacobson

Trans. Vis. Sci. Tech.. 2020; 9(13):13. doi: https://doi.org/10.1167/tvst.9.13.13

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Transient pupillary light reflexes driven by foveal cones in CEP290- or in NPHP5- associated LCA-ciliopathies

Arun kumar Krishnan; Jason Charng; Samuel G Jacobson; Alejandro J Roman; Alexandra Garafalo; Alexander Sumaroka; Malgorzata Swider; Evelyn Semenov; Rebecca Sheplock; Elise Heon; Artur V Cideciyan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1833. doi:

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522. doi:

ARVO Annual Meeting Abstract July 2018

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L Boye; Simone Iwabe; Valerie Dufour; Malgorzata Swider; Karolina Roszak; William W Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6006. doi:

Retina June 2017

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

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Jason Charng; Samuel G. Jacobson; Elise Heon; Alejandro J. Roman; David B. McGuigan, III; Rebecca Sheplock; Mychajlo S. Kosyk; Malgorzata Swider; Artur V. Cideciyan
TAGS: blindness, luminance, photoreceptors, pupil, reflex, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3215-3224. doi: https://doi.org/10.1167/iovs.17-21909

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Interocular Symmetry of Rod and Cone Topography in Human ORF15-RPGR -XLRP Disease Despite Large Intraretinal, Intrafamilial and Interfamilial Variation

Artur V Cideciyan; Jason Charng; Samuel G Jacobson; Alexander Sumaroka; Sharon B. Schwartz; Malgorzata Swider; Alejandro J Roman; Rebecca Sheplock; Manisha Anand; Marc C. Peden; Hemant Khanna; Elise Heon; Alan F. Wright; Anand Swaroop

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3232. doi:

ARVO Annual Meeting Abstract June 2017

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

William A Beltran; Artur V Cideciyan; Raghavi Sudharsan; Michael Massengill; Brian Rossmiller; Valerie Liliane Dufour; felipe Pompeo Marinho; Tatyana Appelbaum; Malgorzata Swider; Mychajlo S. Kosyk; Simone Iwabe; William W Hauswirth; Samuel G Jacobson; Alfred S Lewin; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4483. doi:

Retina May 2017

Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP290 Gene

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Samuel G. Jacobson; Artur V. Cideciyan; Alexander Sumaroka; Alejandro J. Roman; Jason Charng; Monica Lu; Windy Choi; Rebecca Sheplock; Malgorzata Swider; Mychajlo S. Kosyk; Sharon B. Schwartz; Edwin M. Stone; Gerald A. Fishman
TAGS: cohort studies, eye, genes, introns, leber's amaurosis, mutation, outcome measures, questionnaires, vision, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2609-2622. doi: https://doi.org/10.1167/iovs.17-21560

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Comparative Measurements of Rod Function in Retinal Degenerations with Two-color Dark-adapted Perimetry

Artur V Cideciyan; Jason Charng; Malgorzata Swider; Rebecca Sheplock; David B McGuigan; Rodrigo Matsui; Alejandro J Roman; Sharon B Schwartz; Samuel G Jacobson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):131. doi:

ARVO Annual Meeting Abstract September 2016

Fragile Maculas in Patients with Retinal Degeneration due to RPGR - ORF15 Mutations: Spatio-temporal Models of Disease Progression

Jason Charng; Malgorzata Swider; Rebecca Sheplock; Alexander Sumaroka; Alejandro J Roman; Marc Christopher Peden; Elise Heon; Sharon B Schwartz; Samuel G Jacobson; Artur V Cideciyan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):156. doi:

Retina September 2015

Molecular Heterogeneity Within the Clinical Diagnosis of Pericentral Retinal Degeneration

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Rodrigo Matsui; Artur V. Cideciyan; Sharon B. Schwartz; Alexander Sumaroka; Alejandro J. Roman; Malgorzata Swider; Wei Chieh Huang; Rebecca Sheplock; Samuel G. Jacobson
TAGS: cohort studies, heterogeneity, pathophysiology, retinal degeneration, rod photoreceptors, scotoma, vision, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):6007-6018. doi: https://doi.org/10.1167/iovs.15-17174

Includes: Supplemental Content

Retina September 2015

Predicting Progression of ABCA4 -Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front

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Artur V. Cideciyan; Malgorzata Swider; Sharon B. Schwartz; Edwin M. Stone; Samuel G. Jacobson
TAGS: laplace transform damping factor for arterial velocity waveform, laser-doppler flowmetry, meridians, nose, retina, retinal degeneration, follow-up, disease progression, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):5946-5955. doi: https://doi.org/10.1167/iovs.15-17698

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Gene therapy for RPGR -XLRP in a canine model results in retained photoreceptors and vision for at least 2.5 years

William A Beltran; Artur V Cideciyan; Simone Iwabe; Alfred S Lewin; Malgorzata Swider; Jose M Guzman; Sanford L Boye; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre; RC

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2588. doi:

Retina May 2015

Autofluorescence Imaging With Near-Infrared Excitation: Normalization by Reflectance to Reduce Signal From Choroidal Fluorophores

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Artur V. Cideciyan; Malgorzata Swider; Samuel G. Jacobson
TAGS: atrophy, autofluorescence, diagnostic imaging, excitation, melanins, eye, retina, lights, manufactured
Invest. Ophthalmol. Vis. Sci.. 2015; 56(5):3393-3406. doi: https://doi.org/10.1167/iovs.15-16726

Includes: Supplemental Content

Retina January 2015

Pseudo-Fovea Formation After Gene Therapy for RPE65 -LCA

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Artur V. Cideciyan; Geoffrey K. Aguirre; Samuel G. Jacobson; Omar H. Butt; Sharon B. Schwartz; Malgorzata Swider; Alejandro J. Roman; Sam Sadigh; William W. Hauswirth
TAGS: eye, fovea centralis, gene therapy, pathologic nystagmus, retina
Invest. Ophthalmol. Vis. Sci.. 2015; 56(1):526-537. doi: https://doi.org/10.1167/iovs.14-15895

Includes: Multimedia, Supplemental Content

Retina August 2014

TULP1 Mutations Causing Early-Onset Retinal Degeneration: Preserved but Insensitive Macular Cones

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Samuel G. Jacobson; Artur V. Cideciyan; Wei Chieh Huang; Alexander Sumaroka; Alejandro J. Roman; Sharon B. Schwartz; Xunda Luo; Rebecca Sheplock; Joanna M. Dauber; Malgorzata Swider; Edwin M. Stone
TAGS: ciliopathies, diagnostic imaging, mutation, retinal cone, retinal degeneration, vision, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5354-5364. doi: https://doi.org/10.1167/iovs.14-14570

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

RPGR gene augmentation delivered at early, mid and late stage disease in a canine model of XLRP rescues photoreceptor structure and function.

William A Beltran; Artur V Cideciyan; Alfred S Lewin; Simone Iwabe; Malgorzata Swider; Jose-Manuel Guzman; Sanford L Boye; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3321. doi:

ARVO Annual Meeting Abstract June 2013

Photoreceptor Abnormalities in Intermediate Age-Related Macular Degeneration

Sam Sadigh; Artur Cideciyan; Alexander Sumaroka; Wei Chieh Huang; Xunda Luo; Malgorzata Swider; Janet Steinberg; Dwight Stambolian; Samuel Jacobson

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):6281. doi:

Retina March 2013

Abnormal Thickening as well as Thinning of the Photoreceptor Layer in Intermediate Age-Related Macular Degeneration

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Sam Sadigh; Artur V. Cideciyan; Alexander Sumaroka; Wei Chieh Huang; Xunda Luo; Malgorzata Swider; Janet D. Steinberg; Dwight Stambolian; Samuel G. Jacobson
TAGS: age-related macular degeneration, drusen, photoreceptors, eye
Invest. Ophthalmol. Vis. Sci.. 2013; 54(3):1603-1612. doi: https://doi.org/10.1167/iovs.12-11286

Retina February 2012

Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4 -Associated Retinopathy Trials

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Artur V. Cideciyan; Malgorzata Swider; Tomas S. Aleman; Willam J. Feuer; Sharon B. Schwartz; Robert C. Russell; Janet D. Steinberg; Edwin M. Stone; Samuel G. Jacobson
TAGS: macular degeneration, macular function, outcome measures, perimetry, retina, retinal diseases, vision, scotoma
Invest. Ophthalmol. Vis. Sci.. 2012; 53(2):841-852. doi: https://doi.org/10.1167/iovs.11-8415

Includes: Supplemental Content

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Reading Performance in Blue Cone Monochromacy: Defining an Outcome Measure for a Clinical Trial

Transient pupillary light reflexes driven by foveal cones in CEP290- or in NPHP5- associated LCA-ciliopathies

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Pupillary Light Reflexes in Severe Photoreceptor Blindness Isolate the Melanopic Component of Intrinsically Photosensitive Retinal Ganglion Cells

Interocular Symmetry of Rod and Cone Topography in Human ORF15-RPGR -XLRP Disease Despite Large Intraretinal, Intrafamilial and Interfamilial Variation

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

Outcome Measures for Clinical Trials of Leber Congenital Amaurosis Caused by the Intronic Mutation in the CEP290 Gene

Comparative Measurements of Rod Function in Retinal Degenerations with Two-color Dark-adapted Perimetry

Fragile Maculas in Patients with Retinal Degeneration due to RPGR - ORF15 Mutations: Spatio-temporal Models of Disease Progression

Molecular Heterogeneity Within the Clinical Diagnosis of Pericentral Retinal Degeneration

Predicting Progression of ABCA4 -Associated Retinal Degenerations Based on Longitudinal Measurements of the Leading Disease Front

Gene therapy for RPGR -XLRP in a canine model results in retained photoreceptors and vision for at least 2.5 years

Autofluorescence Imaging With Near-Infrared Excitation: Normalization by Reflectance to Reduce Signal From Choroidal Fluorophores

Pseudo-Fovea Formation After Gene Therapy for RPE65 -LCA

TULP1 Mutations Causing Early-Onset Retinal Degeneration: Preserved but Insensitive Macular Cones

RPGR gene augmentation delivered at early, mid and late stage disease in a canine model of XLRP rescues photoreceptor structure and function.

Photoreceptor Abnormalities in Intermediate Age-Related Macular Degeneration

Abnormal Thickening as well as Thinning of the Photoreceptor Layer in Intermediate Age-Related Macular Degeneration

Macular Function in Macular Degenerations: Repeatability of Microperimetry as a Potential Outcome Measure for ABCA4 -Associated Retinopathy Trials

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