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Articles December 2019

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

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Francisco J. Valiente-Soriano; Arturo Ortín-Martínez; Johnny Di Pierdomenico; Diego García-Ayuso; Alejandro Gallego-Ortega; Juan A. Miralles de Imperial-Ollero; Manuel Jiménez-López; María Paz Villegas-Pérez; Larry A. Wheeler; Manuel Vidal-Sanz
TAGS: brain-derived neurotrophic factor, brimonidine, ciliary neurotrophic factor, fibroblast growth factor 2, lip, phototoxicity, retina, retinal cone, opsin, mice
Trans. Vis. Sci. Tech.. 2019; 8(6):36. doi: https://doi.org/10.1167/tvst.8.6.36

ARVO Annual Meeting Abstract September 2016

Study of the neuroprotective effects of BDNF, bFGF, CNTF or several doses of PEDF in a focal Light-emission-diode (LED) - induced phototoxicity model in adult albino mice

F Javier Valiente-Soriano; Diego García-Ayuso; Arturo Ortin-Martinez; Manuel Jimenez-Lopez; Yolanda Caja-Matas; Antonio Cánovas-León; Jose Manuel Bernal-Garro; S Patricia Becerra; María Paz Villegas-Pérez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):186. doi:

ARVO Annual Meeting Abstract September 2016

Repeated intravitreal injections cause stronger microglial and macroglial reactions than single injections

María Paz Villegas-Pérez; Johnny Di Pierdomenico; Diego Garcia-Ayuso; Manuel Jimenez-Lopez; Ana María Gómez-Ramírez; Marta Agudo-Barriuso; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2676. doi:

ARVO Annual Meeting Abstract September 2016

Quantitative and topographical microglial cell changes in the ganglion cell layer and inner plexiform layer after optic nerve axotomy

Manuel Vidal-Sanz; Francisco M Nadal-Nicolas; Paloma Sobrado-Calvo; Manuel Jimenez-Lopez; Giuseppe Rovere; Maria C Sanchez-Migallon; Leticia Nieto-Lopez; Fernando Lucas-Ruiz; Manuel Salinas-Navarro; Marta Agudo-Barriuso

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2226. doi:

Retina September 2016

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion

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Wahiba Hadj-Saïd; Nicolas Froger; Ivana Ivkovic; Manuel Jiménez-López; Élisabeth Dubus; Julie Dégardin-Chicaud; Manuel Simonutti; César Quénol; Nathalie Neveux; María Paz Villegas-Pérez; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Jose-Alain Sahel; Serge Picaud; Diego García-Ayuso
TAGS: retina, retinal cone, taurine, retinal degeneration, retinal ganglion cells, mice, opsin
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4692-4703. doi: https://doi.org/10.1167/iovs.16-19535

Retinal Cell Biology July 2016

Different Ipsi- and Contralateral Glial Responses to Anti-VEGF and Triamcinolone Intravitreal Injections in Rats

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Johnny Di Pierdomenico; Diego García-Ayuso; Manuel Jiménez-López; Marta Agudo-Barriuso; Manuel Vidal-Sanz; María Paz Villegas-Pérez
TAGS: antibodies, anti-vascular endothelial growth factor therapy, injections, intravitreal injections, microglia, rats, retina, triamcinolone, eye, glial fibrillary acidic protein
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3533-3544. doi: https://doi.org/10.1167/iovs.16-19618

Retina September 2015

Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer

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Francisco M. Nadal-Nicolás; Paloma Sobrado-Calvo; Manuel Jiménez-López; Manuel Vidal-Sanz; Marta Agudo-Barriuso
TAGS: axotomy, ganglia, optic nerve, retina, retinal ganglion cells, amacrine cells, melanopsin, cell nucleus, neuroglia
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):6095-6112. doi: https://doi.org/10.1167/iovs.15-17195

Retina July 2015

Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats

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Francisco M. Nadal-Nicolás; Maria H. Madeira; Manuel Salinas-Navarro; Manuel Jiménez-López; Caridad Galindo-Romero; Arturo Ortín-Martínez; Ana Raquel Santiago; Manuel Vidal-Sanz; Marta Agudo-Barriuso
TAGS: axotomy, melanopsin, retina, rats, down-regulation, spinal cord injuries, albinism, optic nerve injuries
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4309-4323. doi: https://doi.org/10.1167/iovs.15-16963

ARVO Annual Meeting Abstract June 2015

Retinal distribution of cone and retinal ganglion cell degenerations in taurine-depleted mice

Wahiba Hadj Said; Diego García-Ayuso; Nicolas G Froger; Ivana Ivkovic; Manuel Jiménez-López; Julie Degardin; Manuel SIMONUTTI; Manuel Vidal-Sanz; Jose Alain Sahel; Serge A Picaud

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4646. doi:

ARVO Annual Meeting Abstract June 2015

Focal Light-emitting-diode (LED)-induced cone photoreceptor degeneration in mice can be prevented with Brimonidine or trophic factors.

Manuel Vidal-Sanz; F Javier Valiente-Soriano; Arturo Ortin-Martinez; Diego García-Ayuso; Manuel Jiménez-López; Jose M Bernal-Garro; Luis Alarcón-Martínez; Larry A Wheeler; Maria Paz Villegas-Perez

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5667. doi:

Glaucoma March 2015

BDNF Rescues RGCs But Not Intrinsically Photosensitive RGCs in Ocular Hypertensive Albino Rat Retinas

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Francisco J. Valiente-Soriano; Francisco M. Nadal-Nicolás; Manuel Salinas-Navarro; Manuel Jiménez-López; Jose M. Bernal-Garro; Maria P. Villegas-Pérez; Marta Agudo-Barriuso; Manuel Vidal-Sanz
TAGS: brain-derived neurotrophic factor, ocular hypertension, retina, albinism, melanopsin
Invest. Ophthalmol. Vis. Sci.. 2015; 56(3):1924-1936. doi: https://doi.org/10.1167/iovs.15-16454

ARVO Annual Meeting Abstract April 2014

DIFFERENCES IN CONE TYPE PROPORTIONS AND DISTRIBUTION BETWEEN PIGMENTED AND ALBINO STRAINS OF ADULT MICE

Manuel Vidal-Sanz; Arturo Ortin-Martinez; Francisco Manuel Nadal-Nicolas; Manuel Jimenez-Lopez; Juan J Alburquerque-Bejar; Leticia Nieto-Lopez; Maria Paz Villegas-Perez; Marta Agudo

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4366. doi:

ARVO Annual Meeting Abstract April 2014

Characterization of a new model of focal cone degeneration induced by a Light-emitting-diode (LED).

F Javier Valiente-Soriano; Arturo Ortin-Martinez; Diego García-Ayuso; Manuel Jimenez-Lopez; Luis Alarcon-Martinez; Jose Manuel Bernal-Garro; Francisco Manuel Nadal-Nicolas; Marta Agudo; Maria Paz Villegas-Perez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4368. doi:

ARVO Annual Meeting Abstract April 2014

Cone neuroprotection afforded by Brimonidine and BDNF in a new model of focal Light-Emitting-Diode (LED)-induced phototoxicity

Arturo Ortin-Martinez; F Javier Valiente-Soriano; Diego García-Ayuso; Manuel Jimenez-Lopez; Luis Alarcon-Martinez; Jose Manuel Bernal-Garro; Leticia Nieto-Lopez; Marta Agudo; Maria Paz Villegas-Perez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4369. doi:

Retina August 2013

Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival

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Diego García-Ayuso; Arturo Ortín-Martínez; Manuel Jiménez-López; Caridad Galindo-Romero; Nicolás Cuenca; Isabel Pinilla; Manuel Vidal-Sanz; Marta Agudo-Barriuso; María P. Villegas-Pérez
TAGS: rats, retinal cone, rod photoreceptors, tissue degeneration, retinal degeneration, retina, photoreceptors, mosaicism
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5888-5900. doi: https://doi.org/10.1167/iovs.13-12643

ARVO Annual Meeting Abstract March 2012

Sectorial Loss Of Retinal Ganglion Cells In The RCS Rat

Diego Garcia-Ayuso; Manuel Salinas-Navarro; Marta Agudo-Barriuso; Francisco Manuel Nadal-Nicolás; Manuel Jiménez-López; Caridad Galindo-Romero; Manuel Vidal-Sanz; María Paz Villegas-Pérez

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3487. doi:

ARVO Annual Meeting Abstract March 2012

Quantitative And Qualitative Analyses Of The Nerve Fiber Layer Degeneration After Optic Nerve Axotomy In Adult Mice.

Maria-Cielo Sanchez-Migallon; Manuel Salinas-Navarro; Manuel Jimenez-Lopez; Francisco Nadal-Nicolas; Leticia Nieto-Lopez; F. Javier Valiente-Soriano; Paloma Sobrado-Calvo; Maria-Paz Villegas-Perez; Manuel Vidal-Sanz; Marta Agudo-Barriuso

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3488. doi:

ARVO Annual Meeting Abstract April 2011

Compensatory Functional Retinal Changes After Light Damage In Albino Mice

Luis Alarcon-Martinez; Luis Montalban-Soler; Manuel Jimenez-Lopez; Marcelino Aviles-Trigueros; Francisco Javier Valiente-Soriano; Caridad Galindo-Romero; Francisco Manuel Nadal-Nicolas; María del Cielo Sánchez-Migallón Carreras; Manuel Vidal-Sanz; Maria Paz Villegas-Perez

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):708. doi:

ARVO Annual Meeting Abstract April 2011

Shortly After Ocular Hypertension There Is Loss Of Retinal Ganglion Cells, But Not Of Other Cells Of The Ganglion Cell Layer Of The Retina

Manuel Salinas-Navarro; Francisco Manuel Nadal-Nicolás; Leticia López-Nieto; Manuel Jiménez-López; Arturo Ortín-Martínez; Diego García-Ayuso; Caridad Galindo-Romero; Marta Agudo-Barriuso; María Paz Villegas-Pérez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2459. doi:

ARVO Annual Meeting Abstract April 2011

Patterns Of Light-mediated C-fos Activity In The Medial Visual Cortex Of Mice Lacking Both Rods And Cones

F Javier Valiente-Soriano; Diego García-Ayuso; Arturo Ortín-Martínez; Ma'ayan Semo; Manuel Jiménez-López; Carlos Gias; Maria Paz Villegas-Pérez; Peter Coffey; Manuel Vidal-Sanz; Anthony A. Vugler

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3464. doi:

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Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

Study of the neuroprotective effects of BDNF, bFGF, CNTF or several doses of PEDF in a focal Light-emission-diode (LED) - induced phototoxicity model in adult albino mice

Repeated intravitreal injections cause stronger microglial and macroglial reactions than single injections

Quantitative and topographical microglial cell changes in the ganglion cell layer and inner plexiform layer after optic nerve axotomy

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion

Different Ipsi- and Contralateral Glial Responses to Anti-VEGF and Triamcinolone Intravitreal Injections in Rats

Long-Term Effect of Optic Nerve Axotomy on the Retinal Ganglion Cell Layer

Transient Downregulation of Melanopsin Expression After Retrograde Tracing or Optic Nerve Injury in Adult Rats

Retinal distribution of cone and retinal ganglion cell degenerations in taurine-depleted mice

Focal Light-emitting-diode (LED)-induced cone photoreceptor degeneration in mice can be prevented with Brimonidine or trophic factors.

BDNF Rescues RGCs But Not Intrinsically Photosensitive RGCs in Ocular Hypertensive Albino Rat Retinas

DIFFERENCES IN CONE TYPE PROPORTIONS AND DISTRIBUTION BETWEEN PIGMENTED AND ALBINO STRAINS OF ADULT MICE

Characterization of a new model of focal cone degeneration induced by a Light-emitting-diode (LED).

Cone neuroprotection afforded by Brimonidine and BDNF in a new model of focal Light-Emitting-Diode (LED)-induced phototoxicity

Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival

Sectorial Loss Of Retinal Ganglion Cells In The RCS Rat

Quantitative And Qualitative Analyses Of The Nerve Fiber Layer Degeneration After Optic Nerve Axotomy In Adult Mice.

Compensatory Functional Retinal Changes After Light Damage In Albino Mice

Shortly After Ocular Hypertension There Is Loss Of Retinal Ganglion Cells, But Not Of Other Cells Of The Ganglion Cell Layer Of The Retina

Patterns Of Light-mediated C-fos Activity In The Medial Visual Cortex Of Mice Lacking Both Rods And Cones

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