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ARVO Annual Meeting Abstract June 2022

The serine biosynthetic enzyme, PHGDH, is essential for retinal health

Marin Gantner; Regis Fallon; Yoichiro Ideguchi; Caleb Bates; Michal Handzlik; Martina Wallace; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):870. doi:

ARVO Annual Meeting Abstract June 2022

Reducing serine and glycine leads to impaired RPE phagocytosis

Caleb Bates; Regis Fallon; Yoichiro Ideguchi; Andrew Greer; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2489 – F0196. doi:

ARVO Annual Meeting Abstract June 2022

Patient iPSC-RPE implicate mitochondrial defects in Macular Telangiectasia

Sarah Giles; Brendan Ansell; Sarah Harkins-Perry; Martina Wallace; Marin Gantner; Regis Fallon; Alec Johnson; Barbara Hart; Melanie Bahlo; Rando Allikmets; Christian Metallo; Paul S Bernstein; Martin Friedlander; Kevin Thomas Eade

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2449 – F0393. doi:

ARVO Annual Meeting Abstract July 2019

Reduced serine synthesis in patient-derived retinal pigmented epithelium leads to localized lipid dysfunction in MacTel

Kevin Eade; sarah giles; Sarah Harkins-Perry; Regis Fallon; Marin Gantner; michelle baldini; Martina Wallace; Rando Allikmets; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3852. doi:

ARVO Annual Meeting Abstract July 2019

Reduced systemic serine levels lead to retinal defects in a mouse model of MacTel

Marin Gantner; Martina Wallace; Regis Fallon; Michal Handzlik; Kevin Eade; Ilham Polis; Alex Ideguchi; Maki Kitano; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4954. doi:

ARVO Annual Meeting Abstract July 2019

MacTel patients carry rare phosphoglycerate dehydrogenase (PHGDH) variants with reduced enzymatic activity

Regis Fallon; Rebecca Berlow; Jana Zernant; Takayuki Nagasaki; Marin Gantner; Sarah Harkins-Perry; Kevin Eade; Rando Allikmets; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5994. doi:

ARVO Annual Meeting Abstract July 2018

Modeling the cell specific origins of MacTel using a large patient iPSC-RPE library

Kevin Eade; Marin Gantner; sarah Victor; Regis Fallon; sarah harkins-perry; Alec Johnson; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4584. doi:

ARVO Annual Meeting Abstract July 2018

Rare variants in the phosphoglycerate dehydrogenase (PHGDH) gene in MacTel patients lead to decreased enzymatic activity

Regis Fallon; Jana Zernant; Takayuki Nagasaki; Marin Gantner; sarah harkins-perry; Kevin Eade; Rando Allikmets; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5409. doi:

ARVO Annual Meeting Abstract June 2017

Mitochondrial activity in the retina relies on glycolysis independent of substrate availability

Marin Gantner; kevin eade; Edith Aguilar; Mitchell Prins; Alec Johnson; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3013. doi:

ARVO Annual Meeting Abstract June 2017

Role of PPAR-alpha in Retinal Mitochondrial Function

Rui Cheng; Elizabeth P Moran; Kelu Zhou; Marin Gantner; Jian-Xing (Jay) Ma

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3020. doi:

ARVO Annual Meeting Abstract June 2017

CNTF treatment prevents development of pathological tuft formation in VLDLR -/- mice

Edith Aguilar; Felicitas Bucher; Mauricio Rosenfeld; Susumu Sakimoto; Salome Murinello; Marin Gantner; kevin eade; Sophia Diaz-Aguilar; Maki Kitano; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):189. doi:

ARVO Annual Meeting Abstract September 2016

Reducing retinal oxidative metabolism to arrest progression of ischemic retinopathies

Liliana P Paris; Marin L Gantner; Peter D Westenskow; Tim U Krohne; Edith Aguilar; Yoshihiko Usui; Jennifer K Trombley; Daniel Feitelberg; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):103. doi:

ARVO Annual Meeting Abstract September 2016

Implications for iPS-based disease modeling: significant variability is observed in RPE cells differentiated from identical sources

Marin L Gantner; Jennifer Hazen; Valentina Lo Sardo; Kevin Eade; Mitchell Prins; Peter D Westenskow; Ashley Barnett; Alec Johnson; Kristin Baldwin; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6061. doi:

ARVO Annual Meeting Abstract June 2015

Hypoxic stress alters the metabolic capacity and output of RPE cells leading to photoreceptor degeneration

Marin Gantner; Toshihide Kurihara; Yoshihiko Usui; Peter D Westenskow; Edith Aguilar; Ashley Barnett; Mitchell Prins; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):39. doi:

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