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ARVO Annual Meeting Abstract June 2024

Multi-omic spatial effects on high-resolution AI-derived retinal thickness

Roberto Bonelli; Victoria E Jackson; Yue Wu; Julia Owen; Samaneh Farashi; Yuka Kihara; Marin Gantner; Catherine A Egan; Katie Williams; Brendan Robert E Ansell; Adnan Tufail; Aaron Y Lee; Melanie Bahlo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):655.

ARVO Annual Meeting Abstract June 2024

Serine and glycine physiology reversibly modulate retinal and peripheral nerve function

Marin Gantner; Regis Fallon; Caleb Bates; Esther Lim; Yoichiro Ideguchi; Takayuki Nagasaki; Michal Handzlik; Roberto Bonelli; Rando Allikmets; Martina Wallace; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):436.

ARVO Annual Meeting Abstract June 2024

Serine and Glycine Deprivation Causes Disease Relevant Changes in the RPE/choroid Transcriptome

Caleb Bates; Regis Fallon; Roberto Bonelli; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):369.

ARVO Annual Meeting Abstract June 2024

Corneal nerve fiber loss as a marker of neuropathy in patients with Macular telangiectasia type 2

Simone Tzaridis; Katie Nardo; Ioannis N. Petropoulos; Roberto Bonelli; Jennifer Trombley; Lea Scheppke; Barbara Hart; Scott Hau; Abraham Olvera-Barrios; Yanling Ouyang; Catherine A Egan; Ferenc B. Sallo; Paul S Bernstein; Rayaz A. Malik; Marin Gantner; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6045.

ARVO Annual Meeting Abstract June 2024

Retinomics.org: Visualizing multi-omic spatial effects on high-resolution AI-derived retinal thickness

Julia Owen; Victoria E Jackson; Roberto Bonelli; Samaneh Farashi; Yuka Kihara; Marin Gantner; Catherine A Egan; Katie Williams; Brendan Robert E Ansell; Adnan Tufail; Melanie Bahlo; Aaron Y. Lee; Yue Wu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):660.

ARVO Annual Meeting Abstract June 2023

Impaired ceramide metabolism is associated with retinal changes in a model of tamoxifen retinopathy

Simone Tzaridis; Courtney R Green; Elena Diaz Rubio; Caleb Bates; Yoichiro Ideguchi; Regis Fallon; Sarah Giles; Elizabeth Mills; Kevin Eade; Christian M Metallo; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3773.

ARVO Annual Meeting Abstract June 2023

The Glycine Cleavage System in Retinal Metabolism and Disease

Caleb Bates; Esther Lim; Regis Fallon; Takayuki Nagasaki; Rando Allikmets; Martina Wallace; Christian M Metallo; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3510.

ARVO Annual Meeting Abstract June 2023

Low serine and glycine levels drive deficits in glycosphingolipid diversity potentially contributing to functional impairment of RPE

Regis Fallon; Grace McGregor; Courtney Green; Michal Handzlik; Christian M Metallo; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4467.

ARVO Annual Meeting Abstract June 2022

The serine biosynthetic enzyme, PHGDH, is essential for retinal health

Marin Gantner; Regis Fallon; Yoichiro Ideguchi; Caleb Bates; Michal Handzlik; Martina Wallace; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):870.

ARVO Annual Meeting Abstract June 2022

Reducing serine and glycine leads to impaired RPE phagocytosis

Caleb Bates; Regis Fallon; Yoichiro Ideguchi; Andrew Greer; Martin Friedlander; Marin Gantner

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2489 – F0196.

ARVO Annual Meeting Abstract June 2022

Patient iPSC-RPE implicate mitochondrial defects in Macular Telangiectasia

Sarah Giles; Brendan Ansell; Sarah Harkins-Perry; Martina Wallace; Marin Gantner; Regis Fallon; Alec Johnson; Barbara Hart; Melanie Bahlo; Rando Allikmets; Christian Metallo; Paul S Bernstein; Martin Friedlander; Kevin Thomas Eade

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2449 – F0393.

ARVO Annual Meeting Abstract July 2019

Reduced serine synthesis in patient-derived retinal pigmented epithelium leads to localized lipid dysfunction in MacTel

Kevin Eade; sarah giles; Sarah Harkins-Perry; Regis Fallon; Marin Gantner; michelle baldini; Martina Wallace; Rando Allikmets; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3852.

ARVO Annual Meeting Abstract July 2019

Reduced systemic serine levels lead to retinal defects in a mouse model of MacTel

Marin Gantner; Martina Wallace; Regis Fallon; Michal Handzlik; Kevin Eade; Ilham Polis; Alex Ideguchi; Maki Kitano; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4954.

ARVO Annual Meeting Abstract July 2019

MacTel patients carry rare phosphoglycerate dehydrogenase (PHGDH) variants with reduced enzymatic activity

Regis Fallon; Rebecca Berlow; Jana Zernant; Takayuki Nagasaki; Marin Gantner; Sarah Harkins-Perry; Kevin Eade; Rando Allikmets; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5994.

ARVO Annual Meeting Abstract July 2018

Modeling the cell specific origins of MacTel using a large patient iPSC-RPE library

Kevin Eade; Marin Gantner; sarah Victor; Regis Fallon; sarah harkins-perry; Alec Johnson; Christian Metallo; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4584.

ARVO Annual Meeting Abstract July 2018

Rare variants in the phosphoglycerate dehydrogenase (PHGDH) gene in MacTel patients lead to decreased enzymatic activity

Regis Fallon; Jana Zernant; Takayuki Nagasaki; Marin Gantner; sarah harkins-perry; Kevin Eade; Rando Allikmets; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5409.

ARVO Annual Meeting Abstract June 2017

CNTF treatment prevents development of pathological tuft formation in VLDLR -/- mice

Edith Aguilar; Felicitas Bucher; Mauricio Rosenfeld; Susumu Sakimoto; Salome Murinello; Marin Gantner; kevin eade; Sophia Diaz-Aguilar; Maki Kitano; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):189.

ARVO Annual Meeting Abstract June 2017

Mitochondrial activity in the retina relies on glycolysis independent of substrate availability

Marin Gantner; kevin eade; Edith Aguilar; Mitchell Prins; Alec Johnson; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3013.

ARVO Annual Meeting Abstract June 2017

Role of PPAR-alpha in Retinal Mitochondrial Function

Rui Cheng; Elizabeth P Moran; Kelu Zhou; Marin Gantner; Jian-Xing (Jay) Ma

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3020.

ARVO Annual Meeting Abstract September 2016

Reducing retinal oxidative metabolism to arrest progression of ischemic retinopathies

Liliana P Paris; Marin L Gantner; Peter D Westenskow; Tim U Krohne; Edith Aguilar; Yoshihiko Usui; Jennifer K Trombley; Daniel Feitelberg; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):103.

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Multi-omic spatial effects on high-resolution AI-derived retinal thickness

Serine and glycine physiology reversibly modulate retinal and peripheral nerve function

Serine and Glycine Deprivation Causes Disease Relevant Changes in the RPE/choroid Transcriptome

Corneal nerve fiber loss as a marker of neuropathy in patients with Macular telangiectasia type 2

Retinomics.org: Visualizing multi-omic spatial effects on high-resolution AI-derived retinal thickness

Impaired ceramide metabolism is associated with retinal changes in a model of tamoxifen retinopathy

The Glycine Cleavage System in Retinal Metabolism and Disease

Low serine and glycine levels drive deficits in glycosphingolipid diversity potentially contributing to functional impairment of RPE

The serine biosynthetic enzyme, PHGDH, is essential for retinal health

Reducing serine and glycine leads to impaired RPE phagocytosis

Patient iPSC-RPE implicate mitochondrial defects in Macular Telangiectasia

Reduced serine synthesis in patient-derived retinal pigmented epithelium leads to localized lipid dysfunction in MacTel

Reduced systemic serine levels lead to retinal defects in a mouse model of MacTel

MacTel patients carry rare phosphoglycerate dehydrogenase (PHGDH) variants with reduced enzymatic activity

Modeling the cell specific origins of MacTel using a large patient iPSC-RPE library

Rare variants in the phosphoglycerate dehydrogenase (PHGDH) gene in MacTel patients lead to decreased enzymatic activity

CNTF treatment prevents development of pathological tuft formation in VLDLR -/- mice

Mitochondrial activity in the retina relies on glycolysis independent of substrate availability

Role of PPAR-alpha in Retinal Mitochondrial Function

Reducing retinal oxidative metabolism to arrest progression of ischemic retinopathies

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