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Research Opportunities November 2021

Report From the National Eye Institute Workshop on Neuro-Ophthalmic Disease Clinical Trial Endpoints: Optic Neuropathies

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Leonard A. Levin; Mohor Sengupta; Laura J. Balcer; Mark J. Kupersmith; Neil R. Miller
TAGS: eye, optic nerve disorders, surrogate endpoints
Invest. Ophthalmol. Vis. Sci.. 2021; 62(14):30. doi: https://doi.org/10.1167/iovs.62.14.30

Articles August 2021

Unsupervised Machine Learning Identifies Quantifiable Patterns of Visual Field Loss in Idiopathic Intracranial Hypertension

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Hiten Doshi; Elena Solli; Tobias Elze; Louis R. Pasquale; Michael Wall; Mark J. Kupersmith
TAGS: antithymoglobulin, arterial tortuosity syndrome, blindness, body weight, datasets, eye, periodic paralysis, potassium-sensitive cardiodysrhythmic type, pseudotumor cerebri, unsupervised machine learning, visual field defects
Trans. Vis. Sci. Tech.. 2021; 10(9):37. doi: https://doi.org/10.1167/tvst.10.9.37

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Unsupervised Machine Learning Identifies Relevant Patterns of Loss, and Quantifies Response to Treatment in Visual Fields from Eyes with Idiopathic Intracranial Hypertension

Hiten Doshi; Elena Solli; Tobias Elze; Louis R Pasquale; Michael Wall; Mark J Kupersmith

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2394. doi:

ARVO Annual Meeting Abstract June 2021

Archetypal Analysis of Visual Fields in Optic Neuritis Reveals Functional Biomarkers Associated with Outcome and Treatment Response

Elena Solli; Hiten Doshi; Tobias Elze; Louis Pasquale; Michael Wall; Mark J Kupersmith

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2101. doi:

ARVO Annual Meeting Abstract June 2020

Defining the Best Functional and Structural Outcome Measures of Deficits After Optic Neuritis

Mark J Kupersmith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3128. doi:

ARVO Annual Meeting Abstract July 2019

Presentation Features for a Multinational Treatment Trial of Nonarteritic Anterior Ischemic Optic Neuropathy

Mark J Kupersmith; Neil Miller; Leonard A Levin; Sharon Klier

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2261. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology August 2017

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations

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Mark J. Kupersmith; Patrick A. Sibony; Sarita Dave
TAGS: nonarteritic anterior ischemic optic neuropathy, eye, edema, optic disk, papilledema, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4286-4291. doi: https://doi.org/10.1167/iovs.17-22140

ARVO Annual Meeting Abstract June 2017

Evolution of Retinal Deformations Due to Acute NAION: Biomechanical Changes Not Related to Increased Pressure in the Neural Canal Region

Mark J Kupersmith; Patrick A Sibony

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5641. doi:

ARVO Annual Meeting Abstract June 2017

Three-Dimensional Bruch’s Membrane Shape Change Over Time with Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT)

Jui-Kai Wang; Caitlin M Danielson; Randy Kardon; Patrick A Sibony; Mark J Kupersmith; Mona K Garvin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4308. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology May 2017

Peripapillary Retinal Pigment Epithelium Layer Shape Changes From Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial

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Jui-Kai Wang; Randy H. Kardon; Johannes Ledolter; Patrick A. Sibony; Mark J. Kupersmith; Mona K. Garvin; for the OCT Sub-Study Committee and the NORDIC Idiopathic Intracranial Hypertension Study Group
TAGS: acetazolamide, placebos, pseudotumor cerebri, shape, retinal pigment epithelium, optic disk
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2554-2565. doi: https://doi.org/10.1167/iovs.16-21089

ARVO Annual Meeting Abstract September 2016

The Idiopathic Intracranial Hypertension Treatment Trial: Outcomes from Months 6 - 12

Michael Wall; Mark J Kupersmith; Elizabeth-Ann Moss; Peggy Auinger

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

The Effect of Treatment of Idiopathic Intracranial Hypertension on Prevalence of Retinal and Choroidal Folds

Mark J Kupersmith; Patrick A Sibony; Steven E Feldon; Jui-Kai Wang; Mona K Garvin; Randy H Kardon

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Paton’s Folds revisited: wrinkles, folds and creases in papilledema

Patrick A Sibony; Mark J Kupersmith

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4553. doi:

ARVO Annual Meeting Abstract September 2016

Three-Dimensional Bruch’s Membrane Shape Model in Cases of Papilledema

Jui-Kai Wang; Samuel Johnson; Randy H Kardon; Patrick A Sibony; Mark J Kupersmith; Mona K Garvin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2016

Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy

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Mark J. Kupersmith; Mona K. Garvin; Jui-Kai Wang; Mary Durbin; Randy Kardon
TAGS: eye, nonarteritic anterior ischemic optic neuropathy, retinal ganglion cells, retinal nerve fiber layer, edema
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3588-3593. doi: https://doi.org/10.1167/iovs.15-18736

Includes: Supplemental Content

Letters to the Editor February 2016

Author Response: Choroidal Folds in Astronauts

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Patrick A. Sibony; Mark J. Kupersmith; Steven E. Feldon; Randy Kardon
TAGS: astronauts, choroidal fold
Invest. Ophthalmol. Vis. Sci.. 2016; 57(2):593. doi: https://doi.org/10.1167/iovs.15-18927

Multidisciplinary Ophthalmic Imaging September 2015

Retinal and Choroidal Folds in Papilledema

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Patrick A. Sibony; Mark J. Kupersmith; Steven E. Feldon; Jui-Kai Wang; Mona Garvin; OCT Substudy Group for the NORDIC Idiopathic Intracranial Hypertension Treatment Trial
TAGS: choroidal fold, eye, optic disk, papilledema, skin wrinkling
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):5670-5680. doi: https://doi.org/10.1167/iovs.15-17459

ARVO Annual Meeting Abstract June 2015

Change in the Deflection of the Neural Canal Opening Over Time with Acetazolamide Treatment in Idiopathic Intracranial Hypertension

Jui-Kai Wang; Patrick A Sibony; Randy H Kardon; Mark J Kupersmith; Mona K Garvin; IIHTT OCT Sub-Study Committee, NORDIC Idiopathic Intracranial Hypertension Study Group

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2233. doi:

ARVO Annual Meeting Abstract June 2015

Papilledema Outcome Evaluation in the OCT Substudy of the Idiopathic Intracranial Hypertension Treatment Trial

Mark J Kupersmith; OCT Sub-Study Committee for the NORDIC Idiopathic Intracranial Hypertension Study Group

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2235. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology May 2015

Photographic Reading Center of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT): Methods and Baseline Results

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William S. Fischer; Michael Wall; Michael P. McDermott; Mark J. Kupersmith; Steven E. Feldon; for the NORDIC Idiopathic Intracranial Hypertension Study Group
TAGS: eye, papilledema, pseudotumor cerebri, reading (activity), edema, optic disk
Invest. Ophthalmol. Vis. Sci.. 2015; 56(5):3292-3303. doi: https://doi.org/10.1167/iovs.15-16465

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Report From the National Eye Institute Workshop on Neuro-Ophthalmic Disease Clinical Trial Endpoints: Optic Neuropathies

Unsupervised Machine Learning Identifies Quantifiable Patterns of Visual Field Loss in Idiopathic Intracranial Hypertension

Unsupervised Machine Learning Identifies Relevant Patterns of Loss, and Quantifies Response to Treatment in Visual Fields from Eyes with Idiopathic Intracranial Hypertension

Archetypal Analysis of Visual Fields in Optic Neuritis Reveals Functional Biomarkers Associated with Outcome and Treatment Response

Defining the Best Functional and Structural Outcome Measures of Deficits After Optic Neuritis

Presentation Features for a Multinational Treatment Trial of Nonarteritic Anterior Ischemic Optic Neuropathy

Nonarteritic Anterior Ischemic Optic Neuropathy Induced Retinal Folds and Deformations

Evolution of Retinal Deformations Due to Acute NAION: Biomechanical Changes Not Related to Increased Pressure in the Neural Canal Region

Three-Dimensional Bruch’s Membrane Shape Change Over Time with Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT)

Peripapillary Retinal Pigment Epithelium Layer Shape Changes From Acetazolamide Treatment in the Idiopathic Intracranial Hypertension Treatment Trial

The Idiopathic Intracranial Hypertension Treatment Trial: Outcomes from Months 6 - 12

The Effect of Treatment of Idiopathic Intracranial Hypertension on Prevalence of Retinal and Choroidal Folds

Paton’s Folds revisited: wrinkles, folds and creases in papilledema

Three-Dimensional Bruch’s Membrane Shape Model in Cases of Papilledema

Retinal Ganglion Cell Layer Thinning Within One Month of Presentation for Non-Arteritic Anterior Ischemic Optic Neuropathy

Author Response: Choroidal Folds in Astronauts

Retinal and Choroidal Folds in Papilledema

Change in the Deflection of the Neural Canal Opening Over Time with Acetazolamide Treatment in Idiopathic Intracranial Hypertension

Papilledema Outcome Evaluation in the OCT Substudy of the Idiopathic Intracranial Hypertension Treatment Trial

Photographic Reading Center of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT): Methods and Baseline Results

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