Search | IOVS | ARVO Journals

Showing 1 – 20 of 59

SORT: Best Match Most Recent Oldest

VIEW: Basic | Expanded

ARVO Annual Meeting Abstract June 2024

Host cell protein impurities are not a relevant driver of gene therapy-associated immune response

Immanuel Philipp Seitz; Eduardo Bocanegra; Felix Reichel; Stylianos Michalakis; Martin Biel; Karl Ulrich Bartz-Schmidt; Tobias Peters; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5345.

ARVO Annual Meeting Abstract June 2023

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A -associated Retinitis pigmentosa

Felix Friedrich Lambert Reichel; Stylianos Michalakis; Dominik M Fischer; laura kuehlewein; Tobias Peters; Susanne Kohl; Karl-Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Martin Biel; Katarina Stingl; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):782.

ARVO Annual Meeting Abstract June 2023

Evidence of potential early-stage ocular tertiary lymphoid tissue formation following high dose retinal AAV8 gene therapy

Kirsten Bucher; Daniela Süsskind; Martin Biel; Stylianos Michalakis; Karl-Ulrich Bartz-Schmidt; Tobias Peters; M Dominik Fischer; Simon J Clark

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3911.

ARVO Annual Meeting Abstract June 2021

Gene Therapy Successfully Restores Retinal Function and Delays Degeneration in a Mouse Model of CNGB1-linked Retinitis Pigmentosa

Lena Zobel; Johanna E Wagner; Catherine R O'Riordan; Amy M Frederick; Martin Biel; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3069.

ARVO Annual Meeting Abstract June 2020

Gene augmentation therapy in a large animal model of PDE6A -Retinitis Pigmentosa results in functional and structural rescue for at least 2.5 years.

Laurence Mireille Occelli; Stylianos Michalakis; Martin Biel; consortium RD-Cure; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1913.

ARVO Annual Meeting Abstract July 2019

The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency

Michael Robert Butler; Hongwei Ma; Fan Yang; Jacob Rapp; Yun-Zheng Le; Katsuhiko Mikoshiba; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4864.

ARVO Annual Meeting Abstract July 2019

A fluorescence-based assay for improvement of dual hybrid AAV vectors in the retina

Elvir Becirovic; Lisa Maria Riedmayr; Martin Biel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2902.

ARVO Annual Meeting Abstract July 2019

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

G. Alex Ochakovski; Ahmad Zhour; Laura Kuehlewein; Susanne Kohl; Andrea Rindtorff; Karl Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Stylianos Michalakis; Martin Biel; Bernd Wissinger; Tobias Peters; Barbara Wilhelm; M. Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2921.

ARVO Annual Meeting Abstract July 2019

The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency

Hongwei Ma; Fan Yang; Michael Robert Butler; Jacob Rapp; Yun-Zheng Le; Katsuhiko Mikoshiba; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4207.

ARVO Annual Meeting Abstract July 2019

Digenic triallelic inheritance in cone photoreceptor cyclic nucleotide gated channel associated retinopathies

Susanne Kohl; Markus Burkard; Timm Kraetzig; Naoyuki Tanimoto; Britta Baumann; Martin Biel; Robert Lukowski; Mathias W Seeliger; Stylianos Michalakis; Bernd Wissinger; Peter Ruth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):419.

ARVO Annual Meeting Abstract July 2018

New insights into the mechanisms of retinal degeneration due to Phosphodiesterase 6 (PDE6) deficiency

Regine Lotte Muehlfriedel; Vithiyanjali Sothilingam; Marina Garcia Garrido; Naoyuki Tanimoto; Susanne Beck; Stylianos Michalakis; Martin Biel; Francois Paquet-Durand; Mathias W Seeliger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):998.

ARVO Annual Meeting Abstract July 2018

Differential Disease Profiles of Two Retinitis Pigmentosa Point Mutations in Rhodopsin Correlate with the Mutant Effects on mRNA Splicing

Lisa Maria Riedmayr; Sybille Boehm; Martin Biel; Elvir Becirovic

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4496.

ARVO Annual Meeting Abstract July 2018

cGMP/PKG Signaling Regulation of Endoplasmic Reticulum Calcium Channels in Cyclic Nucleotide-gated Channel-deficient Cones

Fan Yang; Hongwei Ma; Michael Butler; Wolfgang Baehr; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4966.

ARVO Annual Meeting Abstract July 2018

CRISPR/Cas9 and antisense oligonucleotides for therapy of a deep intronic CLRN1 splice mutation

Elvir Becirovic; Lisa Maria Riedmayr; Martin Biel

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5334.

ARVO Annual Meeting Abstract July 2018

Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells

Victoria Splith; Sybille Boehm; Johanna Wagner; Martin Biel; Elvir Becirovic; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5663.

ARVO Annual Meeting Abstract July 2018

Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa.

Johanna Wagner; Christian Schön; Catherine O'Riordan; Abraham Scaria; Seng Cheng; Martin Biel; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5664.

ARVO Annual Meeting Abstract July 2018

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

M Dominik Fischer; Stylianos Michalakis; Barbara Wilhelm; Nadine Kahle; Tobias Peters; Karl Ulrich Bartz-Schmidt; Susanne Kohl; Mathias W Seeliger; Nicole Weisschuh; Ditta Zobor; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2982.

Retina April 2018

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

PDF

Felix F. Reichel; Tobias Peters; Barbara Wilhelm; Martin Biel; Marius Ueffing; Bernd Wissinger; Karl U. Bartz-Schmidt; Reinhild Klein; Stylianos Michalakis; M. Dominik Fischer; for the RD-CURE Consortium

Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1910-1915. https://doi.org/10.1167/iovs.17-22494

Includes: Supplemental Content

Retina November 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

PDF

Immanuel P. Seitz; Stylianos Michalakis; Barbara Wilhelm; Felix F. Reichel; G. Alex Ochakovski; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger; Karl U. Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: cohort studies, disease vectors, dna, gene transfer techniques, genome, injections, primates, spatial vectors, body tissue, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5792-5801. https://doi.org/10.1167/iovs.17-22473

Includes: Supplemental Content

Retina August 2017

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

PDF

G. Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; Bernd Wissinger; Martin Biel; K. Ulrich Bartz-Schmidt; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: gene therapy, injections, primates, safety, serotonin uptake inhibitors, retina, eye, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4155-4160. https://doi.org/10.1167/iovs.17-22402

Includes: Supplemental Content

1 2 3

Next 20 Results »

NARROW

Content Type

Journal

Article Type

Topics

Tags

Specify Date Range

Host cell protein impurities are not a relevant driver of gene therapy-associated immune response

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A -associated Retinitis pigmentosa

Evidence of potential early-stage ocular tertiary lymphoid tissue formation following high dose retinal AAV8 gene therapy

Gene Therapy Successfully Restores Retinal Function and Delays Degeneration in a Mouse Model of CNGB1-linked Retinitis Pigmentosa

Gene augmentation therapy in a large animal model of PDE6A -Retinitis Pigmentosa results in functional and structural rescue for at least 2.5 years.

The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency

A fluorescence-based assay for improvement of dual hybrid AAV vectors in the retina

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency

Digenic triallelic inheritance in cone photoreceptor cyclic nucleotide gated channel associated retinopathies

New insights into the mechanisms of retinal degeneration due to Phosphodiesterase 6 (PDE6) deficiency

Differential Disease Profiles of Two Retinitis Pigmentosa Point Mutations in Rhodopsin Correlate with the Mutant Effects on mRNA Splicing

cGMP/PKG Signaling Regulation of Endoplasmic Reticulum Calcium Channels in Cyclic Nucleotide-gated Channel-deficient Cones

CRISPR/Cas9 and antisense oligonucleotides for therapy of a deep intronic CLRN1 splice mutation

Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells

Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa.

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

To View More...

You must be signed into an individual account to use this feature.