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ARVO Annual Meeting Abstract June 2020

Acute Responses of Lens Epithelial Cells to Cataract Surgery

Samuel G Novo; Mahbubul H Shihan; Yan Wang; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3981. doi:

ARVO Annual Meeting Abstract June 2020

αVβ8 integrin- a potential druggable target to prevent posterior capsular opacification (PCO)

Mahbubul H Shihan; Yan Wang; Thomas Arnold; Dean Sheppard; Amha Atakilit; Nicole Rossi; Adam P Faranda; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3986. doi:

ARVO Annual Meeting Abstract June 2020

The function of α5β1-integrin in fibrotic PCO

Imane ASSAKHI; Yan Wang; Melinda K Duncan; Mahbubul H Shihan; Adam P Faranda

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5034. doi:

ARVO Annual Meeting Abstract June 2020

Cholesterol-25 Hydroxylase Mediates PCO Pathogenesis

Joseph Stevenson; Yan Wang; Mahbubul H Shihan; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5036. doi:

ARVO Annual Meeting Abstract June 2020

The molecular basis of aniridic cataract

Adam P Faranda; Samuel G Novo; Mahbubul H Shihan; Yan Wang; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5134. doi:

ARVO Annual Meeting Abstract July 2019

Immediate early genes as drivers of inflammation and posterior capsular opacification following cataract surgery

Samuel Novo; Mahbubul H. Shihan; Yan Wang; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6447. doi:

ARVO Annual Meeting Abstract July 2019

The role of αVβ8-integrin in posterior capsular opacification (PCO)

Melinda K Duncan; Mahbubul H. Shihan; Nicole M. Rossi; Yan Wang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6449. doi:

Lens October 2018

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery

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Jian Jiang; Mahbubul H. Shihan; Yan Wang; Melinda K. Duncan
TAGS: cataract surgery, inflammation, inflammatory response, lens (device), lens epithelial cell, lens, crystalline, genes, surgical procedures, operative, cytokine
Invest. Ophthalmol. Vis. Sci.. 2018; 59(12):4986-4997. doi: https://doi.org/10.1167/iovs.18-25067

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Regulation of BMP and TGFβ signaling in Posterior Capsular Opacification (PCO)

Mahbubul Shihan; Erin Jackson; Yan Wang; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1602. doi:

ARVO Annual Meeting Abstract July 2018

Lens epithelial cells rapidly initiate the innate immune response following cataract surgery

Melinda K Duncan; jian jiang; Mahbubul Shihan; Yan Wang; Samuel Novo

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1607. doi:

Lens August 2017

β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

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Yichen Wang; Anne M. Terrell; Brittany A. Riggio; Deepti Anand; Salil A. Lachke; Melinda K. Duncan
TAGS: integrins, lens (device), lens, crystalline, egr1 gene, stress response, fibrosis
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):3896-3922. doi: https://doi.org/10.1167/iovs.17-21721

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Canonical Wnt activity is dynamic in the developing lens and upregulates dramatically in fibrotic lens cells

Melinda K Duncan; Yichen Wang; Priyha Mahesh; Yan Wang

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3195. doi:

ARVO Annual Meeting Abstract June 2017

Regulation of TGF-β bioavailability in lens

Mahbubul Shihan; Mallika Pathania; Yan Wang; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3786. doi:

ARVO Annual Meeting Abstract June 2017

Dysregulation of canonical Wnt signaling may result in aniridia fibrosis syndrome (AFS)

Yichen Wang; Yan Wang; Christopher D Riemann; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2043. doi:

ARVO Annual Meeting Abstract September 2016

Beta1 integrin is a negative regulator of lens epithelial to fiber cell differentiation in the early lens

Melinda K Duncan; Mallika Pathania; Yan Wang

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

The role of CD24 in age related cataracts

Ramachandran Balasubramanian; Melinda K Duncan; Yichen Wang

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

β1-integrin deletion from lens activates AKT signaling and EGR1 expression in the epithelium leading to fibrosis and apoptosis

Yichen Wang; Anne M Terrell; Deepti Anand; Salil Anil Lachke; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

The Role of β5 and β6-Integrin in Lens EMT and Posterior Capsular Opacification

Mahbubul Shihan; Yan Wang; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2013. doi:

ARVO Annual Meeting Abstract June 2015

Molecular Mechanisms of Aniridia Fibrosis Syndrome (AFS)

Yichen Wang; Yan Wang; Christopher Riemann; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):897. doi:

ARVO Annual Meeting Abstract June 2015

Prox1 and fibroblast growth factor receptors function in a novel regulatory loop to control lens fiber differentiation and gene expression

Dylan Scott Audette; Deepti Anand; Tammy So; Troy Rubenstein; Frank J Lovicu; Salil Anil Lachke; Melinda K Duncan

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4836. doi:

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Acute Responses of Lens Epithelial Cells to Cataract Surgery

αVβ8 integrin- a potential druggable target to prevent posterior capsular opacification (PCO)

The function of α5β1-integrin in fibrotic PCO

Cholesterol-25 Hydroxylase Mediates PCO Pathogenesis

The molecular basis of aniridic cataract

Immediate early genes as drivers of inflammation and posterior capsular opacification following cataract surgery

The role of αVβ8-integrin in posterior capsular opacification (PCO)

Lens Epithelial Cells Initiate an Inflammatory Response Following Cataract Surgery

Regulation of BMP and TGFβ signaling in Posterior Capsular Opacification (PCO)

Lens epithelial cells rapidly initiate the innate immune response following cataract surgery

β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

Canonical Wnt activity is dynamic in the developing lens and upregulates dramatically in fibrotic lens cells

Regulation of TGF-β bioavailability in lens

Dysregulation of canonical Wnt signaling may result in aniridia fibrosis syndrome (AFS)

Beta1 integrin is a negative regulator of lens epithelial to fiber cell differentiation in the early lens

The role of CD24 in age related cataracts

β1-integrin deletion from lens activates AKT signaling and EGR1 expression in the epithelium leading to fibrosis and apoptosis

The Role of β5 and β6-Integrin in Lens EMT and Posterior Capsular Opacification

Molecular Mechanisms of Aniridia Fibrosis Syndrome (AFS)

Prox1 and fibroblast growth factor receptors function in a novel regulatory loop to control lens fiber differentiation and gene expression

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