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ARVO Annual Meeting Abstract June 2020

Reversal of aging-induced and glaucoma-induced vision loss by in vivo epigenetic reprogramming

Bruce Ksander; Yuancheng Lu; Anitha Krishnan; Benedikt Brommer; Xiao Tian; Margarita Meer; Daniel Vera; Chen Wang; Qiurui Zeng; Doudou Yu; Steve Horvath; Meredith S Gregory-Ksander; Zhigang He; David Sinclair

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2364. doi:

ARVO Annual Meeting Abstract June 2020

InflaMab: A novel NLRP3 Inflammasome inhibitor provides neuroprotection in a mouse model of glaucoma

Melody Chemaly; Anitha Krishnan; Anthony J Bjourson; Aaron Peace; Meredith S Gregory-Ksander; Victoria McGilligan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2365. doi:

ARVO Annual Meeting Abstract June 2020

Intravitreal administration of AAV2.soluble Fas ligand gene therapy following glaucoma injury restores retinal ganglion cell function and stops disease progression

Meredith S Gregory-Ksander; Maleeka Shrestha; Khoa Nguyen; Ann Marshak-Rothstein; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2366. doi:

ARVO Annual Meeting Abstract July 2019

Pharmacologic inhibition of the NLRP3 inflammasome - a novel neuroprotective therapy for glaucoma

Anitha Krishnan; Malvika Dua; Claire H Mitchell; Wennan Lu; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2256. doi:

ARVO Annual Meeting Abstract July 2019

Fas signaling triggers glial-mediated neuroinflammation in glaucoma

Meredith S Gregory-Ksander; Wennan Lu; Claire H Mitchell; Andrew Kocab; David N Zacks; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2257. doi:

ARVO Annual Meeting Abstract July 2018

A small peptide inhibitor of the Fas receptor prevents axon degeneration and death of retinal ganglion cells in a microbead-induced mouse model of glaucoma.

Meredith S Gregory-Ksander; Andrew J Kocab; David N Zacks; Anitha krishnan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6139. doi:

ARVO Annual Meeting Abstract June 2017

Destructive neuroinflammation triggered by activation of the NLRP3 inflammasome in the glaucomatous optic nerve head

Meredith S Gregory-Ksander; Fei Fei; anitha krishnan; Te-Chen Tzeng; Deepa Subramanian; Douglas Golenbock; Ann Marshak-Rothstein; Bruce Ksander

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2021. doi:

ARVO Annual Meeting Abstract September 2016

Soluble Fas ligand provides long-term protection in a chronic mouse model of glaucoma by inhibiting glial activation, inflammation, and apoptosis

Meredith S Gregory-Ksander; Fei Fei; Ann Marshak-Rothstein; Bruce Ksander; Anitha Krishnan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Toxigenic Staphylococcus aureus -induced mucin secretion by conjunctival goblet cells is dependent upon IL-1β via Ca 2+ and ERK1/2 signaling

Darlene A Dartt; Dayu Li; Robin R Hodges; Marit Lippestad; Michael S Gilmore; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5868. doi:

ARVO Annual Meeting Abstract June 2015

Gene therapy treatment with AAV-soluble Fas ligand protects retinal ganglion cells during development of Glaucoma

Anitha Krishnan; Fei Fei; Alexander Jones; Bruce R Ksander; Ann Marshak Rothstein; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2594. doi:

ARVO Annual Meeting Abstract June 2015

Preventing glaucoma by blocking activation of the NLRP3 inflammasome in the optic nerve head

Fei Fei; Anitha Krishnan; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3485. doi:

ARVO Annual Meeting Abstract June 2015

Vascular normalization: A novel method for inhibiting vascular leakage in age-related macular degeneration

Adarsha Koirala; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4800. doi:

ARVO Annual Meeting Abstract June 2015

Toxigenic Staphylococcus Aureus bacteria activate conjunctival goblet cell NLRP3 inflammasomes using TLR 2, TLR1, and α toxin

Darlene A Dartt; Dayu Li; Robin R Hodges; Michael Gilmore; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4846. doi:

ARVO Annual Meeting Abstract April 2014

Soluble Fas ligand is a neuroprotective molecule critical in restricting glaucomatous damage to retinal ganglion cells

Anitha Krishnan; Alexander Jones; Ann Marshak Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2194. doi:

ARVO Annual Meeting Abstract April 2014

Regulation of vascular leakage by Fas Ligand: Distinguishing the role of soluble from membrane FasL in unique knock-in mice with laser-induced choroidal neovascularization

Adarsha Koirala; Ann Marshak-Rothstein; Bruce R Ksander; Meredith S Gregory-Ksander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):80. doi:

ARVO Annual Meeting Abstract April 2014

IL-1R is essential for neutrophil recruitment, while TLR2 is essential for neutrophil mediated killing of Staphylococcus aureus during endophthalmitis

Meredith S Gregory-Ksander; William J Vincent; Michelle Crane; Sean McGuire

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):856. doi:

ARVO Annual Meeting Abstract March 2012

Open Angle Glaucoma In Soluble Guanylate Cyclase α1-deficient Mice And Its Association With The Gucy1a3/gucy1b3 Locus In Humans

Emmanuel S. Buys; Yu-Chieh Ko; Jae-Hee Kang; Douglas Rhee; Peter Brouckaert; Janey L. Wiggs; Meredith S. Gregory-Ksander; Louis R. Pasquale; Kenneth D. Bloch; Bruce R. Ksander

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5295. doi:

ARVO Annual Meeting Abstract March 2012

Protective Role of Soluble FasL in Photoreceptor Cell Loss

Dimosthenis Mantopoulos; Yusuke Murakami; George Trichonas; Meredith S. Gregory-Ksander; Dean Cestari; Bruce R. Ksander; Demetrios Vavvas

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6361. doi:

ARVO Annual Meeting Abstract March 2012

TLR2 Mediated Upregulation Of Ciliary Body-derived CRAMP Is Critical In Defense Against S. Aureus Induced Endophthalmitis

Meredith S. Gregory-Ksander; Michelle Crane; William J. Vincent

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3649. doi:

ARVO Annual Meeting Abstract April 2011

Expression Of Nalp3 Inflammasome Components In Human And Rat Conjunctival Goblet Cells

Victoria E. McGilligan; Meredith S. Gregory-Ksander; Tara C. Moore; Johnny E. Moore; Robin R. Hodges; Darlene A. Dartt

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4788. doi:

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