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Meeting Abstract (10)
Journal Articles (1)

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Investigative Ophthalmology & Visual Science (11)

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ARVO Annual Meeting Abstract (10)
Biochemistry and Molecular Biology (1)

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Biochemistry and Molecular Biology (1)
Eye Anatomy and Disorders (1)
Genetics (1)
Retina (1)

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alleles (1)
animals, transgenic (1)
antisense oligonucleotides (1)
eye (1)
injections (1)
mice (1)
painful bladder syndrome (1)
photoreceptors (1)
rhodopsin (1)
rna (1)

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ARVO Annual Meeting Abstract June 2021

Systemic Antisense Oligonucleotide Inhibition of Complement Factor B for Treatment of Geographic Atrophy: Results of a Placebo-controlled Phase 1 Dose-Escalation Study

David S Boyer; Jayashree Sahni; Sascha Fauser; Richard Geary; Eugene Schneider; Michael McCaleb

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):196.

ARVO Annual Meeting Abstract June 2020

Development of IONIS-FB-L Rx to Treat Geographic Atrophy Associated with AMD

Glenn J Jaffe; Jayashree Sahni; Sascha Fauser; Richard S Geary; Eugene Schneider; Michael McCaleb

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4305.

ARVO Annual Meeting Abstract July 2019

Allele specific knock-down of human P23H rhodopsin mRNA and prevention of retinal degeneration in humanized P23H rhodopsin knock-in mouse, following treatment with an intravitreal GAPmer antisense oligonucleotide (QR-1123)

Patricia Biasutto; Peter S Adamson; Kalyan Dulla; Sue Murray; Brett Monia; Michael McCaleb

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5719.

ARVO Annual Meeting Abstract June 2017

Systemic Pharmacodynamic Efficacy of a Complement Factor B Antisense Oligonucleotide in Preclinical and Phase 1 Clinical Studies

Michael McCaleb; Tamar R Grossman; Peter Adamson; Scott Henry; Richard S Geary; Steve G Hughes; Brett P Monia

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1952.

ARVO Annual Meeting Abstract June 2017

Progressive Loss of Rod Sensitivity in Patients with Autosomal Dominant Retinitis Pigmentosa (adRP) due to RHO Pro23His Mutation

Kirsten G Locke; Sarah Duwel; Artur V Cideciyan; David B. McGuigan; Alessandro Iannaccone; John Heckenlively; Samuel G Jacobson; Michael McCaleb; David G Birch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3259.

ARVO Annual Meeting Abstract September 2016

Reduction in Ocular Complement Factor B Protein in Mice and Monkeys by Systemic Administration of Factor B Antisense Oligonucleotide

Tamar R Grossman; Robert B Johnson; Lijiang Shen; Lisa A Hettrick; Scott P Henry; Brett P Monia; Michael McCaleb

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5000.

Biochemistry and Molecular Biology October 2015

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration

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Susan F. Murray; Ali Jazayeri; Michael T. Matthes; Douglas Yasumura; Haidong Yang; Raechel Peralta; Andy Watt; Sue Freier; Gene Hung; Peter S. Adamson; Shuling Guo; Brett P. Monia; Matthew M. LaVail; Michael L. McCaleb
TAGS: alleles, antisense oligonucleotides, eye, mice, photoreceptors, rhodopsin, tissue degeneration, injections, painful bladder syndrome, rna
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6362-6375. https://doi.org/10.1167/iovs.15-16400

ARVO Annual Meeting Abstract June 2015

Identification of a Human Clinical Candidate ASO Selectively Targeting the P23H Variant of Rhodopsin for the Treatment of P23H Rhodopsin-mediated ADRP

Sue F Murray; Ali Jazayeri; Raechel Peralta; Andy Watt; Timothy Vickers; Shuling Guo; Scott P Henry; Peter S Adamson; Brett p Monia; Michael McCaleb

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5402.

ARVO Annual Meeting Abstract June 2015

Amelioration of Photoreceptor Degeneration in a Mouse Model of P23H ADRP Using an Antisense Oligonucleotide (ASO)

Ali Jazayeri; Sue F Murray; Raechel Peralta; Audrey Low; Bea DeBrosse-Serra; Shuling Guo; Brett p Monia; Michael McCaleb

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5403.

ARVO Annual Meeting Abstract April 2014

Prevention of photoreceptor cell degeneration in P23H rats after allele-specific knockdown of mutant Rhodopsin RNA expression using antisense oligonucleotide (ASO) treatment

Sue F Murray; Ali Jazayeri; Matthew M LaVail; Michael T Matthes; Douglas Yasumura; Haidong Yang; Michael McCaleb; Raechel Peralta; Andy Watt; Brett Monia

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1258.

ARVO Annual Meeting Abstract June 2013

Identification and Characterization of Mouse Antisense Oligonucleotides (ASOs) Directed at Rhodopsin

Ali Jazayeri; Raechel Peralta; Andy Watt; Susan Freier; Gene Hung; Bea DeBrosse-Serra; Shuling Guo; Sue Murray; Michael McCaleb; Brett Monia

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):653.

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Online ISSN: 1552-5783

Investigative Ophthalmology & Visual Science
Journal of Vision
Translational Vision Science & Technology

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