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Cornea February 2019

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kengo Yoshii; Kei Tashiro; Takahiko Sato; Derek J. Blake; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric D. Wieben; Michael P. Fautsch; Keith H. Baratz; Yuya Komori; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: polymerase chain reaction, hereditary corneal dystrophy, dna, endothelium, corneal endothelium, genome, rna, messenger, trinucleotide repeat expansion, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):779-786. doi: 10.1167/iovs.18-25760

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany

Yuya Komori; Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kei Tashiro; Kengo Yoshii; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric Wieben; Michael P. Fautsch; Keith H Baratz; Theofilos Tourtas; Ursula Schlotzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1353. doi:

ARVO Annual Meeting Abstract July 2018

Experimental models of FECD: Current state and future directions

Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3915. doi:

ARVO Annual Meeting Abstract July 2018

RNA splicing and gene expression in corneal endothelium in Fuchs dystrophy from patients with and without TCF4 trinucleotide repeat expansion.

Keith H Baratz; Ross Aleff; Xiaojia Tang; Krishna R. Kalari; Leo J. Maguire; Sanjay V. Patel; Michael P. Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4434. doi:

Cornea June 2018

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

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Nelson S. Winkler; Margherita Milone; Jennifer M. Martinez-Thompson; Harish Raja; Ross A. Aleff; Sanjay V. Patel; Michael P. Fautsch; Eric D. Wieben; Keith H. Baratz
TAGS: myotonic dystrophy, hereditary corneal dystrophy, endothelium, family, genes, rna
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3053-3057. doi: 10.1167/iovs.17-23160

Includes: Supplemental Content

Cornea April 2018

Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy

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Elisabetta Soragni; Lina Petrosyan; Tommy A. Rinkoski; Eric D. Wieben; Keith H. Baratz; Michael P. Fautsch; Joel M. Gottesfeld
TAGS: polymerase chain reaction, western blotting, endothelial cells, fibroblast, hereditary corneal dystrophy, dna, endothelium, corneal endothelium, genes, peptides, antibodies, cornea, cytotoxicity, polyglutamine, transluminal attenuation gradient
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1888-1896. doi: 10.1167/iovs.17-23265

Includes: Supplemental Content

Glaucoma November 2017

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

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Uttio Roy Chowdhury; Tommy A. Rinkoski; Cindy K. Bahler; J. Cameron Millar; Jacques A. Bertrand; Bradley H. Holman; Joseph M. Sherwood; Darryl R. Overby; Kristen L. Stoltz; Peter I. Dosa; Michael P. Fautsch
TAGS: antihypertensive agents, timolol, pharmacotherapy, combined modality therapy, cromakalim, perfusion, prodrugs, oryctolagus cuniculus, aqueous humor, eye, intraocular pressure, mice
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5731-5742. doi: 10.1167/iovs.17-22538

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Investigating the presence of Fuchs endothelial corneal dystrophy in patients with myotonic dystrophy, type 1

Nelson Winkler; Margherita Milone; Harish Raja; Ross Aleff; Sanjay V Patel; Michael P Fautsch; Eric Wieben; Keith Baratz

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3796. doi:

ARVO Annual Meeting Abstract June 2017

Characterization of gene mis-splicing events in Fuchs endothelial corneal dystrophy primary cell cultures

Tommy A. Rinkoski; Cindy K. Bahler; Xiaojia Tang; Krishna R Kalari; Keith Baratz; Sanjay V Patel; Michael P Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1433. doi:

ARVO Annual Meeting Abstract June 2017

Primary cultures of Fuchs corneal endothelial cells harboring the TCF4 repeat expansion in the transcription factor 4 gene have increased susceptibility to oxidative stress

David M Holmes; Tommy A. Rinkoski; Cindy K. Bahler; Keith Baratz; Sanjay V Patel; Eric Wieben; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1437. doi:

ARVO Annual Meeting Abstract June 2017

Pharmacologic profile and distribution of CKLP1, a novel prodrug of the ATP sensitive potassium channel opener levcromakalim, following various modes of administration

Uttio Roy Chowdhury; Rachel A Kudgus; Tommy A. Rinkoski; Joel M Reid; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4595. doi:

Glaucoma May 2017

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost

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Gavin W. Roddy; Kimberly B. Viker; Nelson S. Winkler; Cindy K. Bahler; Bradley H. Holman; David Sheikh-Hamad; Uttio Roy Chowdhury; W. Daniel Stamer; Michael P. Fautsch
TAGS: antihypertensive agents, intraocular pressure, latanoprost, schlemm's canal, molecule
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2715-2724. doi: 10.1167/iovs.16-21004

Cornea January 2017

Trinucleotide Repeat Expansion in the Transcription Factor 4 ( TCF4 ) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy

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Eric D. Wieben; Ross A. Aleff; Xiaojia Tang; Malinda L. Butz; Krishna R. Kalari; Edward W. Highsmith; Jin Jen; George Vasmatzis; Sanjay V. Patel; Leo J. Maguire; Keith H. Baratz; Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):343-352. doi: 10.1167/iovs.16-20900

Includes: Supplemental Content

Glaucoma October 2016

Analysis of Cerebrospinal Fluid Pressure Estimation Using Formulae Derived From Clinical Data

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David Fleischman; Amanda K. Bicket; Sandra S. Stinnett; John P. Berdahl; Jost B. Jonas; Ning Li Wang; Michael P. Fautsch; R. Rand Allingham
TAGS: cerebrospinal fluid pressure, regression analysis, eye, diagnostic spinal puncture, datasets, beijing
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5625-5630. doi: 10.1167/iovs.16-20119

ARVO Annual Meeting Abstract September 2016

Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1

Gavin W Roddy; Douglas Yasumura; Michael Matthes; Marcel Victor Alavi; Sanford L. Boye; Michael P Fautsch; William W Hauswirth; Matthew LaVail

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2737. doi:

ARVO Annual Meeting Abstract September 2016

Ocular hypotensive properties of water soluble prodrugs of the ATP sensitive potassium channel opener cromakalim

Uttio Roy Chowdhury; Kimberly B Viker; Peter I Dosa; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3018. doi:

ARVO Annual Meeting Abstract September 2016

Characterization of mis-splicing events in primary Fuchs corneal endothelial cell cultures harboring TCF4 repeat expansion

Thomas Rinkoski; Keith H Baratz; Uttio Roy Chowdhury; Ross A Aleff; Michael P Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5288. doi:

Glaucoma March 2016

A Porcine Anterior Segment Perfusion and Transduction Model With Direct Visualization of the Trabecular Meshwork

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Ralitsa T. Loewen; Pritha Roy; Daniel B. Park; Adrianna Jensen; Gordon Scott; Devora Cohen-Karni; Michael P. Fautsch; Joel S. Schuman; Nils A. Loewen
TAGS: perfusion, suidae, trabecular meshwork, eye, direct visualization
Invest. Ophthalmol. Vis. Sci.. 2016; 57(3):1338-1344. doi: 10.1167/iovs.15-18125

Includes: Supplemental Content

Glaucoma March 2016

Anatomical Variation of Human Collector Channel Orifices

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Michael D. Bentley; Cheryl R. Hann; Michael P. Fautsch
TAGS: endothelial cells, tissue dissection, endothelium, perfusion, surgical flaps, body tissue, eye, immersion, schlemm's canal, diameter
Invest. Ophthalmol. Vis. Sci.. 2016; 57(3):1153-1159. doi: 10.1167/iovs.15-17753

ARVO Annual Meeting Abstract June 2015

Analysis of the Elastin Fiber System In Normal and Primary Open Angle Glaucoma Eyes Cheryl R. Hann,Santanu Bhattacharya,Michael P. Fautsch,Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Cheryl R Hann; Santanu Bhattacharya; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3302. doi:

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Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany

Experimental models of FECD: Current state and future directions

RNA splicing and gene expression in corneal endothelium in Fuchs dystrophy from patients with and without TCF4 trinucleotide repeat expansion.

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

Investigating the presence of Fuchs endothelial corneal dystrophy in patients with myotonic dystrophy, type 1

Characterization of gene mis-splicing events in Fuchs endothelial corneal dystrophy primary cell cultures

Primary cultures of Fuchs corneal endothelial cells harboring the TCF4 repeat expansion in the transcription factor 4 gene have increased susceptibility to oxidative stress

Pharmacologic profile and distribution of CKLP1, a novel prodrug of the ATP sensitive potassium channel opener levcromakalim, following various modes of administration

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost

Trinucleotide Repeat Expansion in the Transcription Factor 4 ( TCF4 ) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy

Analysis of Cerebrospinal Fluid Pressure Estimation Using Formulae Derived From Clinical Data

Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1

Ocular hypotensive properties of water soluble prodrugs of the ATP sensitive potassium channel opener cromakalim

Characterization of mis-splicing events in primary Fuchs corneal endothelial cell cultures harboring TCF4 repeat expansion

A Porcine Anterior Segment Perfusion and Transduction Model With Direct Visualization of the Trabecular Meshwork

Anatomical Variation of Human Collector Channel Orifices

Analysis of the Elastin Fiber System In Normal and Primary Open Angle Glaucoma Eyes Cheryl R. Hann,Santanu Bhattacharya,Michael P. Fautsch,Department of Ophthalmology, Mayo Clinic, Rochester, MN.

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