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ARVO Annual Meeting Abstract June 2020

Expression and Familial Transmission of Fuchs’ Endothelial Corneal Dystrophy (FECD) with and without TCF4 Trinucelotide Repeat (TNR) Expansion

Timothy T. Xu; Yi-Ju Li; Natalie A Afshari; Ross A. Aleff; Tommy A Rinkoski; Sanjay V Patel; Leo J Maguire; Michael P Fautsch; Eric Wieben; Keith H Baratz

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1187. doi:

ARVO Annual Meeting Abstract June 2020

Relationship between cerebrospinal fluid pressure and glaucoma in a cohort of Mayo Clinic Rochester, MN patients from 2010 to 2019

Catherine Grace Knier Srivastava; David Fleischman; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1984. doi:

Cornea August 2019

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy

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Eric D. Wieben; Keith H. Baratz; Ross A. Aleff; Krishna R. Kalari; Xiaojia Tang; Leo J. Maguire; Sanjay V. Patel; Michael P. Fautsch
TAGS: corneal endothelium, endothelium, gene expression, genes, hereditary corneal dystrophy, trinucleotide repeat expansion, rna splicing, dna, rna
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3636-3643. doi: https://doi.org/10.1167/iovs.19-27689

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener

Michael P Fautsch; Rachel Kudgus; Tommy Rinkoski; Cheryl Hann; Cindy Bahler; Bradley Holman; Joel Reid; Peter Dosa; Uttio Roy Chowdhury

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3772. doi:

ARVO Annual Meeting Abstract July 2019

Stanniocalcin-1, a downsteam effector molecule in latanoprost signaling, does not signal through the FP receptor for IOP reduction

Gavin Roddy; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3783. doi:

ARVO Annual Meeting Abstract July 2019

CTG Repeat Expansion in TCF4 without Phenotypic Fuchs Dystrophy: a Genetic Analysis

Keith H Baratz; Michael P Fautsch; Ross A. Aleff; Xiaojia Tang; Krishna R. Kalari; Sanjay V Patel; Leo J. Maguire; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3876. doi:

Cornea February 2019

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kengo Yoshii; Kei Tashiro; Takahiko Sato; Derek J. Blake; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric D. Wieben; Michael P. Fautsch; Keith H. Baratz; Yuya Komori; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: corneal endothelium, endothelium, hereditary corneal dystrophy, rna, messenger, trinucleotide repeat expansion, dna, genome, polymerase chain reaction, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):779-786. doi: https://doi.org/10.1167/iovs.18-25760

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

RNA splicing and gene expression in corneal endothelium in Fuchs dystrophy from patients with and without TCF4 trinucleotide repeat expansion.

Keith H Baratz; Ross Aleff; Xiaojia Tang; Krishna R. Kalari; Leo J. Maguire; Sanjay V. Patel; Michael P. Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4434. doi:

ARVO Annual Meeting Abstract July 2018

Experimental models of FECD: Current state and future directions

Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3915. doi:

ARVO Annual Meeting Abstract July 2018

Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany

Yuya Komori; Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kei Tashiro; Kengo Yoshii; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric Wieben; Michael P. Fautsch; Keith H Baratz; Theofilos Tourtas; Ursula Schlotzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1353. doi:

Cornea June 2018

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

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Nelson S. Winkler; Margherita Milone; Jennifer M. Martinez-Thompson; Harish Raja; Ross A. Aleff; Sanjay V. Patel; Michael P. Fautsch; Eric D. Wieben; Keith H. Baratz
TAGS: endothelium, hereditary corneal dystrophy, myotonic dystrophy, genes, rna, family
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3053-3057. doi: https://doi.org/10.1167/iovs.17-23160

Includes: Supplemental Content

Cornea April 2018

Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy

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Elisabetta Soragni; Lina Petrosyan; Tommy A. Rinkoski; Eric D. Wieben; Keith H. Baratz; Michael P. Fautsch; Joel M. Gottesfeld
TAGS: polymerase chain reaction, western blotting, endothelial cells, fibroblast, hereditary corneal dystrophy, dna, endothelium, corneal endothelium, genes, peptides
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1888-1896. doi: https://doi.org/10.1167/iovs.17-23265

Includes: Supplemental Content

Glaucoma November 2017

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

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Uttio Roy Chowdhury; Tommy A. Rinkoski; Cindy K. Bahler; J. Cameron Millar; Jacques A. Bertrand; Bradley H. Holman; Joseph M. Sherwood; Darryl R. Overby; Kristen L. Stoltz; Peter I. Dosa; Michael P. Fautsch
TAGS: antihypertensive agents, aqueous humor, combined modality therapy, cromakalim, eye, intraocular pressure, mice, oryctolagus cuniculus, prodrugs, perfusion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5731-5742. doi: https://doi.org/10.1167/iovs.17-22538

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Characterization of gene mis-splicing events in Fuchs endothelial corneal dystrophy primary cell cultures

Tommy A. Rinkoski; Cindy K. Bahler; Xiaojia Tang; Krishna R Kalari; Keith Baratz; Sanjay V Patel; Michael P Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1433. doi:

ARVO Annual Meeting Abstract June 2017

Primary cultures of Fuchs corneal endothelial cells harboring the TCF4 repeat expansion in the transcription factor 4 gene have increased susceptibility to oxidative stress

David M Holmes; Tommy A. Rinkoski; Cindy K. Bahler; Keith Baratz; Sanjay V Patel; Eric Wieben; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1437. doi:

ARVO Annual Meeting Abstract June 2017

Pharmacologic profile and distribution of CKLP1, a novel prodrug of the ATP sensitive potassium channel opener levcromakalim, following various modes of administration

Uttio Roy Chowdhury; Rachel A Kudgus; Tommy A. Rinkoski; Joel M Reid; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4595. doi:

ARVO Annual Meeting Abstract June 2017

Investigating the presence of Fuchs endothelial corneal dystrophy in patients with myotonic dystrophy, type 1

Nelson Winkler; Margherita Milone; Harish Raja; Ross Aleff; Sanjay V Patel; Michael P Fautsch; Eric Wieben; Keith Baratz

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3796. doi:

Glaucoma May 2017

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost

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Gavin W. Roddy; Kimberly B. Viker; Nelson S. Winkler; Cindy K. Bahler; Bradley H. Holman; David Sheikh-Hamad; Uttio Roy Chowdhury; W. Daniel Stamer; Michael P. Fautsch
TAGS: intraocular pressure, latanoprost, molecule, antihypertensive agents, schlemm's canal
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2715-2724. doi: https://doi.org/10.1167/iovs.16-21004

Cornea January 2017

Trinucleotide Repeat Expansion in the Transcription Factor 4 ( TCF4 ) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy

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Eric D. Wieben; Ross A. Aleff; Xiaojia Tang; Malinda L. Butz; Krishna R. Kalari; Edward W. Highsmith; Jin Jen; George Vasmatzis; Sanjay V. Patel; Leo J. Maguire; Keith H. Baratz; Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):343-352. doi: https://doi.org/10.1167/iovs.16-20900

Includes: Supplemental Content

Glaucoma October 2016

Analysis of Cerebrospinal Fluid Pressure Estimation Using Formulae Derived From Clinical Data

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David Fleischman; Amanda K. Bicket; Sandra S. Stinnett; John P. Berdahl; Jost B. Jonas; Ning Li Wang; Michael P. Fautsch; R. Rand Allingham
TAGS: beijing, cerebrospinal fluid pressure, datasets, diagnostic spinal puncture, eye, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5625-5630. doi: https://doi.org/10.1167/iovs.16-20119

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Expression and Familial Transmission of Fuchs’ Endothelial Corneal Dystrophy (FECD) with and without TCF4 Trinucelotide Repeat (TNR) Expansion

Relationship between cerebrospinal fluid pressure and glaucoma in a cohort of Mayo Clinic Rochester, MN patients from 2010 to 2019

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy

Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener

Stanniocalcin-1, a downsteam effector molecule in latanoprost signaling, does not signal through the FP receptor for IOP reduction

CTG Repeat Expansion in TCF4 without Phenotypic Fuchs Dystrophy: a Genetic Analysis

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

RNA splicing and gene expression in corneal endothelium in Fuchs dystrophy from patients with and without TCF4 trinucleotide repeat expansion.

Experimental models of FECD: Current state and future directions

Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

Characterization of gene mis-splicing events in Fuchs endothelial corneal dystrophy primary cell cultures

Primary cultures of Fuchs corneal endothelial cells harboring the TCF4 repeat expansion in the transcription factor 4 gene have increased susceptibility to oxidative stress

Pharmacologic profile and distribution of CKLP1, a novel prodrug of the ATP sensitive potassium channel opener levcromakalim, following various modes of administration

Investigating the presence of Fuchs endothelial corneal dystrophy in patients with myotonic dystrophy, type 1

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost

Trinucleotide Repeat Expansion in the Transcription Factor 4 ( TCF4 ) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy

Analysis of Cerebrospinal Fluid Pressure Estimation Using Formulae Derived From Clinical Data

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