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ARVO Annual Meeting Abstract June 2022

GeneTAC™ small molecules reduce toxic nuclear foci and restore normal splicing in corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy (FECD) harboring repeat expansions in transcription factor 4 ( TCF4 )

Andrew Powers; Tommy A Rinkoski; Katie Cheung; Hannah Schehr; Nicola Osgood; Catherine Livelo; Nancy Levin; Muhammad Safadi; Jim Kerr; Chengzhi Zhang; N. Doane Chilcoat; Abhijit Bhat; Keith H Baratz; Eric D Wieben; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2753 – A0242. doi:

ARVO Annual Meeting Abstract June 2022

Effect of the ATP-sensitive potassium channel opener diazoxide on retinal vessel diameter of C57BL/6J mice

Uttio Roy Chowdhury; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3117. doi:

Glaucoma April 2022

Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (K ATP ) Channel Opening Prodrug

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Cynthia L. Pervan-Steel; Uttio Roy Chowdhury; Hemchand K. Sookdeo; Ralph A. Casale; Peter I. Dosa; Thurein M. Htoo; Michael P. Fautsch; Barbara M. Wirostko
TAGS: intraocular pressure, potassium, prodrugs, body tissue, mice, phosphoric monoester hydrolases
Invest. Ophthalmol. Vis. Sci.. 2022; 63(4):26. doi: https://doi.org/10.1167/iovs.63.4.26

Glaucoma February 2022

Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models

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Uttio Roy Chowdhury; J. Cameron Millar; Bradley H. Holman; Kjersten J. Anderson; Peter I. Dosa; Gavin W. Roddy; Michael P. Fautsch
TAGS: animal model, intraocular pressure, mice, ocular hypertension, diazoxide, katp channels, eye, steroids
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):15. doi: https://doi.org/10.1167/iovs.63.2.15

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. doi: https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

Cancer Risk in Patients with Fuchs Endothelial Corneal Dystrophy

Timothy T. Xu; Keith H Baratz; Michael P Fautsch; David O Hodge; Michael A Mahr

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):808. doi:

ARVO Annual Meeting Abstract June 2021

Ocular Tissue Conversion and Activity Profile of QLS-101, a Novel Topical IOP-Lowering Therapeutic

Cynthia Steel; Hemchand K. Sookdeo; Thurein Htoo; Ralph Casale; Uttio Roy Chowdhury; Michael P Fautsch; Barbara M Wirostko

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2755. doi:

ARVO Annual Meeting Abstract June 2021

Systemic and Ocular Toxicology and Pharmacokinetic Profiles of QLS-101, a Novel Topical IOP-Lowering Therapeutic

Barbara M Wirostko; Hemchand K. Sookdeo; Thurein Htoo; Ralph Casale; Uttio Roy Chowdhury; Michael P Fautsch; Cynthia Steel

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2754. doi:

Cornea January 2021

Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion

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Timothy T. Xu; Yi-Ju Li; Natalie A. Afshari; Ross A. Aleff; Tommy A. Rinkoski; Sanjay V. Patel; Leo J. Maguire; Albert O. Edwards; William L. Brown; Michael P. Fautsch; Eric D. Wieben; Keith H. Baratz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(1):17. doi: https://doi.org/10.1167/iovs.62.1.17

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Expression and Familial Transmission of Fuchs’ Endothelial Corneal Dystrophy (FECD) with and without TCF4 Trinucelotide Repeat (TNR) Expansion

Timothy T. Xu; Yi-Ju Li; Natalie A Afshari; Ross A. Aleff; Tommy A Rinkoski; Sanjay V Patel; Leo J Maguire; Michael P Fautsch; Eric Wieben; Keith H Baratz

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1187. doi:

ARVO Annual Meeting Abstract June 2020

Relationship between cerebrospinal fluid pressure and glaucoma in a cohort of Mayo Clinic Rochester, MN patients from 2010 to 2019

Catherine Grace Knier Srivastava; David Fleischman; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1984. doi:

Cornea August 2019

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy

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Eric D. Wieben; Keith H. Baratz; Ross A. Aleff; Krishna R. Kalari; Xiaojia Tang; Leo J. Maguire; Sanjay V. Patel; Michael P. Fautsch
TAGS: corneal endothelium, endothelium, gene expression, genes, hereditary corneal dystrophy, trinucleotide repeat expansion, rna splicing, dna, rna
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3636-3643. doi: https://doi.org/10.1167/iovs.19-27689

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener

Michael P Fautsch; Rachel Kudgus; Tommy Rinkoski; Cheryl Hann; Cindy Bahler; Bradley Holman; Joel Reid; Peter Dosa; Uttio Roy Chowdhury

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3772. doi:

ARVO Annual Meeting Abstract July 2019

Stanniocalcin-1, a downsteam effector molecule in latanoprost signaling, does not signal through the FP receptor for IOP reduction

Gavin Roddy; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3783. doi:

ARVO Annual Meeting Abstract July 2019

CTG Repeat Expansion in TCF4 without Phenotypic Fuchs Dystrophy: a Genetic Analysis

Keith H Baratz; Michael P Fautsch; Ross A. Aleff; Xiaojia Tang; Krishna R. Kalari; Sanjay V Patel; Leo J. Maguire; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3876. doi:

Cornea February 2019

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

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Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kengo Yoshii; Kei Tashiro; Takahiko Sato; Derek J. Blake; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric D. Wieben; Michael P. Fautsch; Keith H. Baratz; Yuya Komori; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Noriko Koizumi
TAGS: corneal endothelium, endothelium, hereditary corneal dystrophy, rna, messenger, trinucleotide repeat expansion, dna, genome, polymerase chain reaction, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):779-786. doi: https://doi.org/10.1167/iovs.18-25760

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany

Yuya Komori; Naoki Okumura; Ryosuke Hayashi; Masakazu Nakano; Kei Tashiro; Kengo Yoshii; Ross Aleff; Malinda Butz; Edward W. Highsmith; Eric Wieben; Michael P. Fautsch; Keith H Baratz; Theofilos Tourtas; Ursula Schlotzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1353. doi:

ARVO Annual Meeting Abstract July 2018

Experimental models of FECD: Current state and future directions

Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3915. doi:

ARVO Annual Meeting Abstract July 2018

RNA splicing and gene expression in corneal endothelium in Fuchs dystrophy from patients with and without TCF4 trinucleotide repeat expansion.

Keith H Baratz; Ross Aleff; Xiaojia Tang; Krishna R. Kalari; Leo J. Maguire; Sanjay V. Patel; Michael P. Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4434. doi:

Cornea June 2018

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

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Nelson S. Winkler; Margherita Milone; Jennifer M. Martinez-Thompson; Harish Raja; Ross A. Aleff; Sanjay V. Patel; Michael P. Fautsch; Eric D. Wieben; Keith H. Baratz
TAGS: endothelium, hereditary corneal dystrophy, myotonic dystrophy, genes, rna, family
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3053-3057. doi: https://doi.org/10.1167/iovs.17-23160

Includes: Supplemental Content

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GeneTAC™ small molecules reduce toxic nuclear foci and restore normal splicing in corneal endothelial cells derived from patients with Fuchs endothelial corneal dystrophy (FECD) harboring repeat expansions in transcription factor 4 ( TCF4 )

Effect of the ATP-sensitive potassium channel opener diazoxide on retinal vessel diameter of C57BL/6J mice

Ocular Hypotensive Properties and Biochemical Profile of QLS-101, a Novel ATP-Sensitive Potassium (K ATP ) Channel Opening Prodrug

Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Cancer Risk in Patients with Fuchs Endothelial Corneal Dystrophy

Ocular Tissue Conversion and Activity Profile of QLS-101, a Novel Topical IOP-Lowering Therapeutic

Systemic and Ocular Toxicology and Pharmacokinetic Profiles of QLS-101, a Novel Topical IOP-Lowering Therapeutic

Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion

Expression and Familial Transmission of Fuchs’ Endothelial Corneal Dystrophy (FECD) with and without TCF4 Trinucelotide Repeat (TNR) Expansion

Relationship between cerebrospinal fluid pressure and glaucoma in a cohort of Mayo Clinic Rochester, MN patients from 2010 to 2019

Gene Expression and Missplicing in the Corneal Endothelium of Patients With a TCF4 Trinucleotide Repeat Expansion Without Fuchs' Endothelial Corneal Dystrophy

Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener

Stanniocalcin-1, a downsteam effector molecule in latanoprost signaling, does not signal through the FP receptor for IOP reduction

CTG Repeat Expansion in TCF4 without Phenotypic Fuchs Dystrophy: a Genetic Analysis

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany

Experimental models of FECD: Current state and future directions

RNA splicing and gene expression in corneal endothelium in Fuchs dystrophy from patients with and without TCF4 trinucleotide repeat expansion.

Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1

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