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Articles June 2022

Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography

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Diogo Cabral; Ana C. Fradinho; Telmo Pereira; Meera S. Ramakrishnan; Tommaso Bacci; Dong An; Sandra Tenreiro; Miguel C. Seabra; Chandrakumar Balaratnasingam; K. Bailey Freund
TAGS: blood capillaries, diagnostic imaging, optical coherence tomography, venule, fluid flow, arteriole, superficial veins, parafoveal region, eye
Trans. Vis. Sci. Tech.. 2022; 11(6):2. doi: https://doi.org/10.1167/tvst.11.6.2

Includes: Supplemental Content

Retinal Cell Biology July 2021

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

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Cristina Escrevente; Ana S. Falcão; Michael J. Hall; Mafalda Lopes-da-Silva; Pedro Antas; Miguel M. Mesquita; Inês S. Ferreira; M. Helena Cardoso; Daniela Oliveira; Ana C. Fradinho; Thomas Ciossek; Paul Nicklin; Clare E. Futter; Sandra Tenreiro; Miguel C. Seabra
TAGS: granules, lipofuscin, lysosomes, pathophysiology, retinal pigment epithelium, cathepsin d, flow cytometry, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):39. doi: https://doi.org/10.1167/iovs.62.9.39

Includes: Supplemental Content

Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. doi: https://doi.org/10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract July 2018

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

Robert E MacLaren; Kanmin Xue; Alun R Barnard; Maria In?s Patrício; Thomas L Edwards; Susan Downes; Andrew Lotery; Graeme Black; Andrew Webster; Jasleen K Jolly; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1195. doi:

ARVO Annual Meeting Abstract June 2017

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

Miguel C Seabra; Matthew Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1039. doi:

ARVO Annual Meeting Abstract June 2015

Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles

Oleg E Tolmachov; Tanya Tolmachova; Diogo A. Feleciano; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5890. doi:

ARVO Annual Meeting Abstract June 2015

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Tanya Tolmachova; Diogo A. Feleciano; Clare E. Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2321. doi:

ARVO Annual Meeting Abstract April 2014

Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia

Dhani Tracey-White; Valerie De Luca; Clare Futter; Anthony T Moore; Andrew Webster; Miguel C Seabra; Christian P Hamel; Vasiliki Kalatzis; Mariya Moosajee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3302. doi:

ARVO Annual Meeting Abstract April 2014

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Tanya Tolmachova; Diogo A Feleciano; Silene Wavre-Shapton; Martin J Evans; Clare Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3459. doi:

ARVO Annual Meeting Abstract April 2014

Mechanisms of photoreceptor degeneration in choroideremia

Ingrid Porpino Meschede; Tanya Tolmachova; Miguel C Seabra; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4367. doi:

ARVO Annual Meeting Abstract April 2014

Improved visual function in patients with choroideremia undergoing subretinal gene therapy

Robert E MacLaren; Markus Groppe; Alun R Barnard; Tanya Tolmachova; Frans P Cremers; Graeme C Black; Andrew Lotery; Susan M Downes; Andrew Webster; Miguel C Seabra; Choroideremia Gene Therapy Study Group

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):832. doi:

ARVO Annual Meeting Abstract March 2012

Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium

Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1132. doi:

ARVO Annual Meeting Abstract March 2012

Uncovering the VEGF Secretory Pathway in Retinal Pigment Epithelium: the Rab Proteins’ Role

Ines P. Rodrigues; Cristiana F. Pires; Miguel C. Seabra; Jose S. Ramalho

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3024. doi:

ARVO Annual Meeting Abstract March 2012

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

Clare Futter; Ingrid P. Meschede; Silene T. Wavre; Mafalda Lopes Da Silva; Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3701. doi:

ARVO Annual Meeting Abstract March 2012

Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial

Robert E. MacLaren; Markus Groppe; Alun R. Barnard; Tanya Tolmachova; Matthew J. During; Susan M. Downes; Andrew J. Lotery; Graeme C. Black; Andrew R. Webster; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5577. doi:

ARVO Annual Meeting Abstract March 2012

Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors

Miguel C. Seabra; Oleg Tolmachov; Robert E. MacLaren; Tanya Tolmachova

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1926. doi:

ARVO Annual Meeting Abstract March 2012

Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia

Alun R. Barnard; Tanya Tolmachova; Miguel C. Seabra; Robert E. MacLaren

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1933. doi:

Biochemistry and Molecular Biology October 2010

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

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Tanya Tolmachova; Silene T. Wavre-Shapton; Alun R. Barnard; Robert E. MacLaren; Clare E. Futter; Miguel C. Seabra
TAGS: choroideremia, mice, mice, knockout, photoreceptors, retinal pigment epithelium, tissue degeneration, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):4913-4920. doi: https://doi.org/10.1167/iovs.09-4892

Retinal Cell Biology June 2009

Single choroideremia Gene in Nonmammalian Vertebrates Explains Early Embryonic Lethality of the Zebrafish Model of Choroideremia

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Mariya Moosajee; Merrin Tulloch; Rudi A. Baron; Cheryl Y. Gregory-Evans; José B. Pereira-Leal; Miguel C. Seabra
TAGS: choroideremia, embryo, genes, vertebrates, zebrafish, proteins, phenotype
Invest. Ophthalmol. Vis. Sci.. 2009; 50(6):3009-3016. doi: https://doi.org/10.1167/iovs.08-2755

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Macular Vascular Imaging and Connectivity Analysis Using High-Resolution Optical Coherence Tomography

Formation of Lipofuscin-Like Autofluorescent Granules in the Retinal Pigment Epithelium Requires Lysosome Dysfunction

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Mechanisms of photoreceptor degeneration in choroideremia

Improved visual function in patients with choroideremia undergoing subretinal gene therapy

Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium

Uncovering the VEGF Secretory Pathway in Retinal Pigment Epithelium: the Rab Proteins’ Role

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial

Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors

Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

Single choroideremia Gene in Nonmammalian Vertebrates Explains Early Embryonic Lethality of the Zebrafish Model of Choroideremia

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