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Meeting Abstract (14)
Journal Articles (3)

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Investigative Ophthalmology & Visual Science (17)

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ARVO Annual Meeting Abstract (14)
Retinal Cell Biology (2)
Biochemistry and Molecular Biology (1)

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Eye Anatomy and Disorders (3)
Genetics (3)
Biochemistry and Molecular Biology (2)
Retinal Cell Biology (2)
Retina (1)

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choroideremia (2)
mice (2)
electroretinography (1)
embryo (1)
epithelium (1)
eye (1)
face (1)
genes (1)
inner ear (1)
mice, knockout (1)

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Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria, organelles
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. doi: 10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract July 2018

Retinal Gene Therapy for Choroideremia in a Multicenter Dose Escalation Phase I/II Clinical Trial

Robert E MacLaren; Kanmin Xue; Alun R Barnard; Maria In?s Patrício; Thomas L Edwards; Susan Downes; Andrew Lotery; Graeme Black; Andrew Webster; Jasleen K Jolly; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1195. doi:

ARVO Annual Meeting Abstract June 2017

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

Miguel C Seabra; Matthew Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1039. doi:

ARVO Annual Meeting Abstract June 2015

Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles

Oleg E Tolmachov; Tanya Tolmachova; Diogo A. Feleciano; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5890. doi:

ARVO Annual Meeting Abstract June 2015

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Tanya Tolmachova; Diogo A. Feleciano; Clare E. Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2321. doi:

ARVO Annual Meeting Abstract April 2014

Improved visual function in patients with choroideremia undergoing subretinal gene therapy

Robert E MacLaren; Markus Groppe; Alun R Barnard; Tanya Tolmachova; Frans P Cremers; Graeme C Black; Andrew Lotery; Susan M Downes; Andrew Webster; Miguel C Seabra; Choroideremia Gene Therapy Study Group

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):832. doi:

ARVO Annual Meeting Abstract April 2014

Translational bypass therapy using ataluren to treat nonsense-mediated choroideremia

Dhani Tracey-White; Valerie De Luca; Clare Futter; Anthony T Moore; Andrew Webster; Miguel C Seabra; Christian P Hamel; Vasiliki Kalatzis; Mariya Moosajee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3302. doi:

ARVO Annual Meeting Abstract April 2014

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Tanya Tolmachova; Diogo A Feleciano; Silene Wavre-Shapton; Martin J Evans; Clare Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3459. doi:

ARVO Annual Meeting Abstract April 2014

Mechanisms of photoreceptor degeneration in choroideremia

Ingrid Porpino Meschede; Tanya Tolmachova; Miguel C Seabra; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4367. doi:

ARVO Annual Meeting Abstract March 2012

Uncovering the VEGF Secretory Pathway in Retinal Pigment Epithelium: the Rab Proteins’ Role

Ines P. Rodrigues; Cristiana F. Pires; Miguel C. Seabra; Jose S. Ramalho

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3024. doi:

ARVO Annual Meeting Abstract March 2012

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

Clare Futter; Ingrid P. Meschede; Silene T. Wavre; Mafalda Lopes Da Silva; Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3701. doi:

ARVO Annual Meeting Abstract March 2012

Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial

Robert E. MacLaren; Markus Groppe; Alun R. Barnard; Tanya Tolmachova; Matthew J. During; Susan M. Downes; Andrew J. Lotery; Graeme C. Black; Andrew R. Webster; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5577. doi:

ARVO Annual Meeting Abstract March 2012

Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium

Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1132. doi:

ARVO Annual Meeting Abstract March 2012

Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors

Miguel C. Seabra; Oleg Tolmachov; Robert E. MacLaren; Tanya Tolmachova

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1926. doi:

ARVO Annual Meeting Abstract March 2012

Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia

Alun R. Barnard; Tanya Tolmachova; Miguel C. Seabra; Robert E. MacLaren

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1933. doi:

Biochemistry and Molecular Biology October 2010

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

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Tanya Tolmachova; Silene T. Wavre-Shapton; Alun R. Barnard; Robert E. MacLaren; Clare E. Futter; Miguel C. Seabra
TAGS: choroideremia, electroretinography, mice, knockout, photoreceptors, mice, tissue degeneration, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):4913-4920. doi: 10.1167/iovs.09-4892

Retinal Cell Biology June 2009

Single choroideremia Gene in Nonmammalian Vertebrates Explains Early Embryonic Lethality of the Zebrafish Model of Choroideremia

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Mariya Moosajee; Merrin Tulloch; Rudi A. Baron; Cheryl Y. Gregory-Evans; José B. Pereira-Leal; Miguel C. Seabra
TAGS: phenotype, choroideremia, embryo, genes, vertebrates, zebrafish, proteins
Invest. Ophthalmol. Vis. Sci.. 2009; 50(6):3009-3016. doi: 10.1167/iovs.08-2755

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Online ISSN: 1552-5783

Investigative Ophthalmology & Visual Science
Journal of Vision
Translational Vision Science & Technology

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