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Meeting Abstract (31)
Journal Articles (13)

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Investigative Ophthalmology & Visual Science (44)

Article Type

ARVO Annual Meeting Abstract (31)
Lens (5)
Retina (3)
Biochemistry and Molecular Biology (2)
Cornea (2)
Retinal Cell Biology (1)

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Eye Anatomy and Disorders (11)
Genetics (7)
Immunology and Microbiology (7)
Biochemistry and Molecular Biology (5)
Lens (5)
Retina (3)
Cornea (2)
External Eye Disease (2)
Low Vision (1)
Retinal Cell Biology (1)
Surgery (1)

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calpain (8)
cercopithecidae (7)
lens, crystalline (5)
proteins (5)
lens (device) (4)
calcium (3)
cataract (3)
hypoxia (3)
acinar cells (2)
bodily secretions (2)

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ARVO Annual Meeting Abstract June 2024

Activation of cytosolic and mitochondrial calpains during RGC death in hypoxic, human, iPS-derived retinal organoids

Masayuki Hirata; Yayoi Kishimoto; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2554.

ARVO Annual Meeting Abstract June 2022

Involvement of calpains and caspases in RGC damage in human iPSCs-derived OV cultured under hypoxia

Kana Orihara; Chiho Fukiage; Mitsuyoshi Azuma; Tadashi Yokoi; Noriyuki Azuma

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):989 – F0386.

Retina November 2020

Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants

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Momoko Kobayashi-Otsugu; Kana Orihara; Emi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):13. https://doi.org/10.1167/iovs.61.13.13

ARVO Annual Meeting Abstract July 2019

NRF2 activator RS9 protects corneal epithelium from cell damage in dry eye models

Yuka Matsuda; Mamiko Machida; Yasuhiro Nakagami; Takeshi Nakajima; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):270.

ARVO Annual Meeting Abstract July 2018

Differentiation of human iPSC-derived optic vesicles into numerous types of retinal cells

Kana Orihara; Chiho Yabuta; Mitsuyoshi Azuma; Noriyuki Azuma

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):572.

ARVO Annual Meeting Abstract July 2018

Accumulation of a calpain specific α-spectrin breakdown product in drusen from AMD patients: Possible calpain activation in RPE and photoreceptors

Momoko Kobayashi; Emi Nakajima; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3059.

Biochemistry and Molecular Biology October 2017

Contribution of Calpain and Caspases to Cell Death in Cultured Monkey RPE Cells

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Emi Nakajima; Katherine B. Hammond; Masayuki Hirata; Thomas R. Shearer; Mitsuyoshi Azuma
TAGS: calpain, caspases, hypoxia, retinal pigment cell, cercopithecidae, caspase-3
Invest. Ophthalmol. Vis. Sci.. 2017; 58(12):5412-5420. https://doi.org/10.1167/iovs.17-22325

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

FK962 may ameliorate hypoxia/reoxygenation-induced neuronal cell death in rat retina by promoting neuronal cell maturation

Kana Orihara; Chiho Yabuta; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2568.

ARVO Annual Meeting Abstract September 2016

fMRI Studies: Calpain Inhibitor SNJ-1945 Ameliorates Dysfunction in Injured Rat RGCs

Takayuki Oka; Chiho Yabuta; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3757.

ARVO Annual Meeting Abstract September 2016

Structure-based in silico approach for selection of kinase inhibitors

Tomoyo Miyabe; Shinnosuke Machida; Kazuya Konoura; Takeshi Nakajima; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5019.

Retina September 2015

Hypoxia Activates Calpains in the Nerve Fiber Layer of Monkey Retinal Explants

PDF

Masayuki Hirata; Thomas R. Shearer; Mitsuyoshi Azuma
TAGS: calpain, cercopithecidae, hypoxia, nerve fibers
Invest. Ophthalmol. Vis. Sci.. 2015; 56(10):6049-6057. https://doi.org/10.1167/iovs.15-17360

ARVO Annual Meeting Abstract June 2015

miRNA-203 regulates proliferation in cultured human corneal epithelial cells

Ayumi Nakagawa; Takeshi Nakajima; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5481.

ARVO Annual Meeting Abstract June 2015

Monkey RPE cell death induced by oligomeric A β

Masayuki Hirata; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3777.

ARVO Annual Meeting Abstract June 2015

Transcriptome analysis of VEGF-induced human retinal microvascular endothelial cells

Mamiko Noda; Takeshi Nakajima; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2309.

ARVO Annual Meeting Abstract June 2015

Intracellular uptake of drugs in cultured human corneal epithelial cells

Ayumi Mori; chiho Yabuta; Akira Ohtori; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):263.

Lens August 2014

Loss of Calpastatin Leads to Activation of Calpain in Human Lens Epithelial Cells

PDF

Takeshi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma
TAGS: calpain, epithelial cells, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5278-5283. https://doi.org/10.1167/iovs.14-14778

ARVO Annual Meeting Abstract April 2014

FK962 enhances neurite elongation in cultured rat retinal ganglion cells

Masaki Kakehi; Chiho Yabuta; Ayumi Yoshimatsu; Yayoi Kishimoto; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1724.

ARVO Annual Meeting Abstract April 2014

Hypoxia activates calpain in the nerve fiber layer of monkey retinal explants

Masayuki Hirata; Emi Nakajima; Thomas R Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1744.

ARVO Annual Meeting Abstract April 2014

Selecting Fuchs Patients for Drug Trials Involving Endothelial Cell Migration

Atsuko Fujii; Winston Chamberlain; Mitsuyoshi Azuma; Thomas R Shearer

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):996.

ARVO Annual Meeting Abstract June 2013

Galectin-3 Enhanced Epithelialization in Explanted Monkey Corneas with Alkali Burn

Atsuko Fujii; Thomas Shearer; Mitsuyoshi Azuma

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3881.

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