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Cornea February 2020

Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells

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Junji Hamuro; Kohsaku Numa; Tomoko Fujita; Munetoyo Toda; Koji Ueda; Yuichi Tokuda; Atushi Mukai; Masakazu Nakano; Morio Ueno; Shigeru Kinoshita; Chie Sotozono
TAGS: cornea, endothelial cells, lactic acid, metabolites, pyruvic acid, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome, enzymes
Invest. Ophthalmol. Vis. Sci.. 2020; 61(2):10. doi: https://doi.org/10.1167/iovs.61.2.10

Includes: Supplemental Content

Physiology and Pharmacology September 2019

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

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Munetoyo Toda; Hiroshi Yukawa; Jun Yamada; Morio Ueno; Shigeru Kinoshita; Yoshinobu Baba; Junji Hamuro
TAGS: anterior chamber of eye, cornea, endothelial cells, eye, fluorescence, mice, quantum dots, diagnostic imaging, injections
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):4008-4020. doi: https://doi.org/10.1167/iovs.19-27788

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Factors influencing the health and longevity of donor corneal endothelial cells

Munetoyo Toda; Koji Kitazawa; Morio Ueno; Yuko Maruyama; Asako Uehara; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3819. doi:

ARVO Annual Meeting Abstract July 2019

A Non-Invasive Physical Biomarker for Evaluation of Corneal Endothelial Cells

Hiroshi Tanaka; Akihisa Yamamoto; Munetoyo Toda; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita; Morio Ueno; Motomu Tanaka

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2156. doi:

Retina December 2018

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy

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Nobuhiro Terao; Hideki Koizumi; Kentaro Kojima; Tetsuya Yamagishi; Kenji Nagata; Koji Kitazawa; Yuji Yamamoto; Kengo Yoshii; Asako Hiraga; Munetoyo Toda; Shigeru Kinoshita; Chie Sotozono; Junji Hamuro
TAGS: central serous chorioretinopathy, cytokine, hypertension, angiogenesis, choroid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5924-5931. doi: https://doi.org/10.1167/iovs.18-25517

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Mitochondria as platforms for dictating differentiation/maturation of human corneal endothelial cells with distinct energy metabolism and metabolomic signatures

Kohsaku Numa; Morio Ueno; Munetoyo Toda; Atsushi Mukai; Kazuko Asada; Asako Uehara; Chie Sotozono; Shigeru Kinoshita; Jyunji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3450. doi:

Cornea April 2017

Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy

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Munetoyo Toda; Morio Ueno; Asako Hiraga; Kazuko Asada; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: cd44 antigens, cell therapy, cornea, endothelial cells, homing-associated cell adhesion molecule, homogeneity, donors, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2011-2020. doi: https://doi.org/10.1167/iovs.16-20703

Cornea October 2016

MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells

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Morio Ueno; Kazuko Asada; Munetoyo Toda; Asako Hiraga; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: cornea, endothelial cells, micrornas, phenotype, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome, cd44 antigens, homing-associated cell adhesion molecule, patient simulation
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5509-5517. doi: https://doi.org/10.1167/iovs.16-19804

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Regulation of mitochondrial respiration under cell culture stress in human corneal endothelial cells

Shigeru Kinoshita; Morio Ueno; Kazuko Asada; Munetoyo Toda; Kazue Nagata; Chie Sotozono; Nobuyoshi Kosaka; Takahiro Ochiya; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Allogeneic sensitization and tolerance induction post corneal endothelial cell injection into the anterior chamber

Jun Yamada; Morio Ueno; Munetoyo Toda; Katsuhiko Shinomiya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

The role of dysregulated expression of miRs in the pathogenesis of bullous keratopathy and Fuchs’ endothelial corneal dystrophy

Kazuko Asada; Morio Ueno; Munetoyo Toda; Asako Hiraga; Monty Montoya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4927. doi:

ARVO Annual Meeting Abstract September 2016

Metabolic plasticity in the cell-state homeostasis and differentiation of cultured human corneal endothelial cells

Junji Hamuro; Morio Ueno; Kazuko Asada; Munetoyo Toda; Monty Montoya; Chie Sotozono; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5278. doi:

ARVO Annual Meeting Abstract September 2016

The cell homogeneity is indispensable for regenerative medicine by cultivated human corneal endothelial cells

Munetoyo Toda; Morio Ueno; Asako Hiraga; Kazuko Asada; Monty Montoya; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5281. doi:

ARVO Annual Meeting Abstract September 2016

Quantifying the adhesion strength of human corneal endothelial cells in an in vitro model

Hiroshi Tanaka; Akihisa Yamamoto; Munetoyo Toda; Junji Hamuro; Chie Sotozono; Shigeru Kinoshita; Morio Ueno; Motomu Tanaka

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5305. doi:

ARVO Annual Meeting Abstract September 2016

Profiles of cytokines in the aqueous humor and serum of bullous keratopathy patients

Morio Ueno; Munetoyo Toda; Asako Hiraga; Koichi Wakimasu; Noriko Koizumi; Naoki Okumura; Kazuko Asada; Chie Sotozono; Junji Hamuro; Shigeru Kinoshita

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):898. doi:

Cornea September 2016

Cell Homogeneity Indispensable for Regenerative Medicine by Cultured Human Corneal Endothelial Cells

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Junji Hamuro; Munetoyo Toda; Kazuko Asada; Asako Hiraga; Ursula Schlötzer-Schrehardt; Monty Montoya; Chie Sotozono; Morio Ueno; Shigeru Kinoshita
TAGS: cd44 antigens, cornea, donors, endothelial cells, homing-associated cell adhesion molecule, homogeneity, patient simulation, regenerative medicine, small patella syndrome, sodium polystyrene sulfonate
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4749-4761. doi: https://doi.org/10.1167/iovs.16-19770

Cornea September 2016

Allogeneic Sensitization and Tolerance Induction After Corneal Endothelial Cell Transplantation in Mice

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Jun Yamada; Morio Ueno; Munetoyo Toda; Katsuhiko Shinomiya; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: cornea, endothelial cells, injections, mice, transplantation, tolerance induction, sensitization, eye
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4572-4580. doi: https://doi.org/10.1167/iovs.15-19020

Cornea September 2016

The Different Binding Properties of Cultured Human Corneal Endothelial Cell Subpopulations to Descemet's Membrane Components

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Munetoyo Toda; Morio Ueno; Jun Yamada; Asako Hiraga; Hiroshi Tanaka; Ursula Schlötzer-Schrehardt; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
TAGS: collagen, cornea, descemet's membrane, endothelial cells, laminin, patient simulation, small patella syndrome, sodium polystyrene sulfonate, stiff-person syndrome, agrin
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4599-4605. doi: https://doi.org/10.1167/iovs.16-20087

Includes: Supplemental Content

Cornea August 2016

Metabolic Plasticity in Cell State Homeostasis and Differentiation of Cultured Human Corneal Endothelial Cells

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Junji Hamuro; Morio Ueno; Kazuko Asada; Munetoyo Toda; Monty Montoya; Chie Sotozono; Shigeru Kinoshita
TAGS: cd44 antigens, cornea, endothelial cells, glucose, homeostasis, metabolites, patient simulation, small patella syndrome, sodium polystyrene sulfonate, starvation
Invest. Ophthalmol. Vis. Sci.. 2016; 57(10):4452-4463. doi: https://doi.org/10.1167/iovs.16-19807

Cornea August 2016

Cultured Human Corneal Endothelial Cell Aneuploidy Dependence on the Presence of Heterogeneous Subpopulations With Distinct Differentiation Phenotypes

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Junji Hamuro; Morio Ueno; Munetoyo Toda; Chie Sotozono; Monty Montoya; Shigeru Kinoshita
TAGS: aneuploidy, cornea, karyotype determination procedure, phenotype, endothelial cells, heterogeneity, donors, flow cytometry, small patella syndrome, sodium polystyrene sulfonate
Invest. Ophthalmol. Vis. Sci.. 2016; 57(10):4385-4392. doi: https://doi.org/10.1167/iovs.16-19771

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Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells

In Vivo Fluorescence Visualization of Anterior Chamber Injected Human Corneal Endothelial Cells Labeled With Quantum Dots

Factors influencing the health and longevity of donor corneal endothelial cells

A Non-Invasive Physical Biomarker for Evaluation of Corneal Endothelial Cells

Association of Upregulated Angiogenic Cytokines With Choroidal Abnormalities in Chronic Central Serous Chorioretinopathy

Mitochondria as platforms for dictating differentiation/maturation of human corneal endothelial cells with distinct energy metabolism and metabolomic signatures

Production of Homogeneous Cultured Human Corneal Endothelial Cells Indispensable for Innovative Cell Therapy

MicroRNA Profiles Qualify Phenotypic Features of Cultured Human Corneal Endothelial Cells

Regulation of mitochondrial respiration under cell culture stress in human corneal endothelial cells

Allogeneic sensitization and tolerance induction post corneal endothelial cell injection into the anterior chamber

The role of dysregulated expression of miRs in the pathogenesis of bullous keratopathy and Fuchs’ endothelial corneal dystrophy

Metabolic plasticity in the cell-state homeostasis and differentiation of cultured human corneal endothelial cells

The cell homogeneity is indispensable for regenerative medicine by cultivated human corneal endothelial cells

Quantifying the adhesion strength of human corneal endothelial cells in an in vitro model

Profiles of cytokines in the aqueous humor and serum of bullous keratopathy patients

Cell Homogeneity Indispensable for Regenerative Medicine by Cultured Human Corneal Endothelial Cells

Allogeneic Sensitization and Tolerance Induction After Corneal Endothelial Cell Transplantation in Mice

The Different Binding Properties of Cultured Human Corneal Endothelial Cell Subpopulations to Descemet's Membrane Components

Metabolic Plasticity in Cell State Homeostasis and Differentiation of Cultured Human Corneal Endothelial Cells

Cultured Human Corneal Endothelial Cell Aneuploidy Dependence on the Presence of Heterogeneous Subpopulations With Distinct Differentiation Phenotypes

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