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Retina March 2025

Neuronal Degeneration and Glial Activation in the Absence of Vascular Changes in Human Retinas of Patients With Diabetes

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Henar Albertos-Arranz; Natalia Martínez-Gil; Xavier Sánchez-Sáez; Julio Cesar Molina-Martín; Pedro Lax; Nicolas Cuenca
TAGS: diabetes mellitus, retina, retinal diseases, neuronal degeneration, horizontal cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):53. https://doi.org/10.1167/iovs.66.3.53

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

RNA-seq reveals differential expression genes related to visual cycle in Prph2 knock-in mice

Enola Missonnier; Ceren Sahin; Lorena Vidal-Gil; Carla Sanchez-Castillo; Isabel Ortuño-Lizarán; Xavier Sánchez-Sáez; Pedro Lax; Nicolas Cuenca; Natalia Martinez-Gil

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4738.

ARVO Annual Meeting Abstract June 2024

The regulation of immune system is involved in PRPH2 knock-in mouse retinal degeneration.

Lorena Vidal-Gil; Enola Missonnier; Natalia Martinez-Gil; Laura Fernández-Sánchez; Oksana Kutsyr; Marina Pastor-Mas; María José Ruiz-Pastor; Henar Albertos-Arranz; Victoria Maneu; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4737.

Genetics October 2023

A Slc38a8 Mouse Model of FHONDA Syndrome Faithfully Recapitulates the Visual Deficits of Albinism Without Pigmentation Defects

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Ana Guardia; Almudena Fernández; Davide Seruggia; Virginie Chotard; Carla Sánchez-Castillo; Oksana Kutsyr; Xavier Sánchez-Sáez; Esther Zurita; Marta Cantero; Alexandra Rebsam; Nicolás Cuenca; Lluís Montoliu
TAGS: albinism, mice, pigmentation, syndrome, homozygote
Invest. Ophthalmol. Vis. Sci.. 2023; 64(13):32. https://doi.org/10.1167/iovs.64.13.32

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Synaptic connectivity impairment and neuronal degeneration in the macula of diabetic patients along with the vascular abnormalities

Henar Albertos-Arranz; Oksana Kutsyr Kolesnyk; Lorena Vidal-Gil; Isabel Ortuño-Lizarán; Xavier Sánchez-Sáez; María José Ruiz-Pastor; Natalia Martínez-Gil; Carla Sánchez-Castillo; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):569.

ARVO Annual Meeting Abstract June 2023

PRPH2 -associated alterations in retinal function and morphology involve inflammatory responses in a CRISPR-generated mouse model

Oksana Kutsyr Kolesnyk; María José Ruiz-Pastor; Xavier Sánchez-Sáez; Carla Sánchez-Castillo; Henar Albertos-Arranz; Natalia Martínez-Gil; Isabel Ortuño-Lizarán; Lorena Vidal-Gil; Laura Fernández-Sánchez; Agustina Noailles; Victoria Maneu; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1548.

ARVO Annual Meeting Abstract June 2022

Retinas of human donors with COVID-19 disease show morphological alterations and signs of inflammation including glial activation

Henar Albertos-Arranz; Natalia Martínez-Gil; Xavier Sánchez-Sáez; Agustina Noailles; María José Ruiz-Pastor; Carla Sánchez-Castillo; Clara Monferrer-Adsuara; Lidia Remolí-Sargues; Pedro Lax; Ramón Calvo-Andrés; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):975 – F0372.

ARVO Annual Meeting Abstract June 2022

Starbust amacrine cells impairment in a rat model of chronic ocular hypertension.

Maria D Pinazo-Duran; Agustina Noailles; Aloma Mayordomo-febrer; Silvia Maria Sanz-Gonzalez; Pedro Lax; Maria del Mar Lopez-Murcia; oksana kutsir; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):935 – A0404.

ARVO Annual Meeting Abstract June 2022

Topical ocular GLP-1 (FNP120) administration preserves retinal function and morphology in a retinitis pigmentosa mouse model

Oksana Kutsyr; Laura Fernández-Sánchez; Victoria Maneu; Pedro Lax; Carmen Lagunas; Andrés G. Fernández; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1774 – F0323.

ARVO Annual Meeting Abstract June 2022

Changes in retinal and choroidal capillary plexus evaluated by OCTA in type 1 diabetic patients without diabetic retinopathy

Isabel Pinilla Lozano; Maria Sopeña; Maria Dolores Diaz-Barreda; Ana Boned-Murillo; Isabel Bartolome; Guisela Fernandez-Espinosa; Nicolas Cuenca; Elvira Orduna-Hospital

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2892 – F0045.

ARVO Annual Meeting Abstract June 2022

The loss of visual motion perception in Parkinson's disease could be explained by the degeneration of starburst amacrine cells and the impairment of their synaptic contacts with dopaminergic cells

Xavier Sánchez-Sáez; Isabel Ortuño-Lizarán; Carla Sánchez-Castillo; Oksana Kutsyr; Henar Albertos-Arranz; Victoria Maneu; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4135 – F0372.

ARVO Annual Meeting Abstract June 2022

The transporter of the omega-3 fatty acid DHA (MFSD2a) is expressed in the human neural retina.

María José Ruiz-Pastor; Xavier Sánchez-Sáez; Agustina Noailles; Natalia Martínez-Gil; Victoria Maneu; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4124 – F0361.

Glaucoma May 2022

Sodium Hyaluronate-Induced Ocular Hypertension in Rats Damages the Direction-Selective Circuit and Inner/Outer Retinal Plexiform Layers

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Agustina Noailles; Oksana Kutsyr; Aloma Mayordomo-Febrer; Pedro Lax; María López-Murcia; Silvia M. Sanz-González; María Dolores Pinazo-Durán; Nicolás Cuenca
TAGS: ocular hypertension, sodium, rats, eye, intraocular pressure, injections, retina
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):2. https://doi.org/10.1167/iovs.63.5.2

ARVO Annual Meeting Abstract June 2021

Phenotypic differences in the PRPH2 mutation in members of the same family assessed with OCT and OCTA

Henar Albertos-Arranz; Xavier Sánchez-Sáez; Natalia Martínez-Gil; María José Ruiz-Pastor; Isabel Pinilla; Rosa M. Coco-Martín; Jesús Delgado; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2443.

ARVO Annual Meeting Abstract June 2021

Lipidomics analysis shows a prominent decrease of DHA in rd10 mouse retina.

María José Ruiz-Pastor; Oksana Kutsyr; Natalia Martínez-Gil; Henar Albertos-Arranz; Victoria Maneu; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2970.

ARVO Annual Meeting Abstract June 2021

High-fat consumption accelerates retinal degeneration and alters the gut microbiome in retinitis pigmentosa mice

Oksana Kutsyr; Agustina Noailles; Natalia Martínez-Gil; Laura Fernández-Sánchez; Lucía Maestre-Carballa; Manuel Martínez-García; Victoria Maneu; Nicolas Cuenca; Pedro Lax

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3072.

ARVO Annual Meeting Abstract June 2021

CRISPR generated mouse model of central areolar choroidal dystrophy with a Prph2 mutation reproduces human dystrophy features.

Xavier Sánchez-Sáez; Henar Albertos-Arranz; María José Ruiz-Pastor; Oksana Kutsyr; Natalia Martínez-Gil; Carmen Aguilera; Lucía Méndez; Patricia Hernández-Carabias; Victoria Maneu; Pedro Lax; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3071.

Retinal Cell Biology August 2020

Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration

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Oksana Kutsyr; Xavier Sánchez-Sáez; Natalia Martínez-Gil; Emilio de Juan; Pedro Lax; Victoria Maneu; Nicolás Cuenca
TAGS: inflammation, light intensity, mice, mice, inbred c57bl, nerve degeneration, oxidative stress, photoreceptors, retina, tissue degeneration, rpe65 protein
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):1. https://doi.org/10.1167/iovs.61.10.1

Retinal Cell Biology July 2019

Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

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Sarah L. Roche; Oksana Kutsyr; Nicolás Cuenca; Thomas G. Cotter
TAGS: mice, norgestrel, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3221-3235. https://doi.org/10.1167/iovs.19-27246

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

The peripheral retina as a stem cell niche: evidence of human adult neurogenesis

Isabel Ortuño Lizarán; Daniel A Peterson; Nicolas Cuenca

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3335.

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Neuronal Degeneration and Glial Activation in the Absence of Vascular Changes in Human Retinas of Patients With Diabetes

RNA-seq reveals differential expression genes related to visual cycle in Prph2 knock-in mice

The regulation of immune system is involved in PRPH2 knock-in mouse retinal degeneration.

A Slc38a8 Mouse Model of FHONDA Syndrome Faithfully Recapitulates the Visual Deficits of Albinism Without Pigmentation Defects

Synaptic connectivity impairment and neuronal degeneration in the macula of diabetic patients along with the vascular abnormalities

PRPH2 -associated alterations in retinal function and morphology involve inflammatory responses in a CRISPR-generated mouse model

Retinas of human donors with COVID-19 disease show morphological alterations and signs of inflammation including glial activation

Starbust amacrine cells impairment in a rat model of chronic ocular hypertension.

Topical ocular GLP-1 (FNP120) administration preserves retinal function and morphology in a retinitis pigmentosa mouse model

Changes in retinal and choroidal capillary plexus evaluated by OCTA in type 1 diabetic patients without diabetic retinopathy

The loss of visual motion perception in Parkinson's disease could be explained by the degeneration of starburst amacrine cells and the impairment of their synaptic contacts with dopaminergic cells

The transporter of the omega-3 fatty acid DHA (MFSD2a) is expressed in the human neural retina.

Sodium Hyaluronate-Induced Ocular Hypertension in Rats Damages the Direction-Selective Circuit and Inner/Outer Retinal Plexiform Layers

Phenotypic differences in the PRPH2 mutation in members of the same family assessed with OCT and OCTA

Lipidomics analysis shows a prominent decrease of DHA in rd10 mouse retina.

High-fat consumption accelerates retinal degeneration and alters the gut microbiome in retinitis pigmentosa mice

CRISPR generated mouse model of central areolar choroidal dystrophy with a Prph2 mutation reproduces human dystrophy features.

Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration

Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease

The peripheral retina as a stem cell niche: evidence of human adult neurogenesis

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