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ARVO Annual Meeting Abstract June 2020

Vascular endothelial growth factor (VEGF) induces retinal edema and neuroretinal dysfunction in diabetic rats.

Allen C Clermont; Nivetha Murugesan; Lloyd P Aiello

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1385. doi:

ARVO Annual Meeting Abstract June 2020

Novel oral plasma kallikrein inhibitor KV998076 is protective against intravitreal VEGF and TNFα induced retinal edema and neuroretinal dysfunction

Nivetha Murugesan; Allen C Clermont; Stephen Pethen; Lily Li; Edward Duckworth; Sally L Hampton; Edward Feener

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4863. doi:

ARVO Annual Meeting Abstract July 2019

Novel oral plasma kallikrein (PKa) inhibitors KV998052 and KV998054 ameliorate VEGF-induced retinal thickening in a murine model of retinal edema

Nivetha Murugesan; Allen C Clermont; Stephen J Pethen; Lily Li; Edward J Duckworth; Sally L Hampton; Edward Feener

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2596. doi:

ARVO Annual Meeting Abstract July 2019

Complement C3 mediates vascular endothelial growth factor (VEGF) induced retinal edema but not visual dysfunction in mice.

Allen C Clermont; Alex Feener; Nivetha Murugesan; Lloyd P Aiello; Edward Feener

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2791. doi:

ARVO Annual Meeting Abstract July 2018

Vascular endothelial growth factor (VEGF) mediates electroretinogram (ERG) dysfunction in mice through plasma kallikrein and nitric oxide

Allen C Clermont; Fabricio Simao; Nivetha Murugesan; Paul Huang; Lloyd P Aiello; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3463. doi:

ARVO Annual Meeting Abstract July 2018

A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema

Nivetha Murugesan; Allen C Clermont; Louise J Rushbrooke; Peter A Robson; Robrecht Thoonen; Stephen J Pethen; Sally L Hampton; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3464. doi:

ARVO Annual Meeting Abstract June 2017

Effects of Vascular endothelial growth factor (VEGF) on electroretinogram (ERG) amplitude in rats are mediated by bradykinin.

Allen C Clermont; Nivetha Murugesan; Tuna Ustunkaya; Brianna Mastromarino; Lloyd P Aiello; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5347. doi:

ARVO Annual Meeting Abstract September 2016

Title: Complement component 3 (C3) is increased in vitreous in diabetic macular edema and is required for bradykinin (BK)-induced retinal edema.

Nivetha Murugesan; Allen C Clermont; Takeshi Kita; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Increased FXII activity in vitreous of patients with Diabetic Macular Edema (DME) and in animal models of VEGF- and bradykinin-induced retinal edema

Tuna Ustunkaya; Nivetha Murugesan; Allen C Clermont; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4183. doi:

ARVO Annual Meeting Abstract September 2016

Vascular endothelial growth factor (VEGF) and bradykinin induce increased electroretinogram amplitude and decreased visual acuity.

Allen C Clermont; Nivetha Murugesan; Cheng-mao Lin; Sarah R Sheskey; David A Antonetti; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

Retina May 2016

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor–Induced Retinal Dysfunction and Thickening

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Allen Clermont; Nivetha Murugesan; Qunfang Zhou; Takeshi Kita; Peter A. Robson; Louise J. Rushbrooke; D. Michael Evans; Lloyd Paul Aiello; Edward P. Feener
TAGS: edema, plasma kallikrein, vascular endothelial growth factor a, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2390-2399. doi: https://doi.org/10.1167/iovs.15-18272

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Proteomic characterization of retinal edema in rats

Nivetha Murugesan; Allen C Clermont; LeiLei Sun; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4693. doi:

ARVO Annual Meeting Abstract June 2015

Vascular endothelial growth factor (VEGF)- and the kallikrein kinin system (KKS)- induced neuronal dysfunction in a rodent model of retinal edema.

Allen C Clermont; Nivetha Murugesan; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5487. doi:

ARVO Annual Meeting Abstract April 2014

Role of Akt in VEGF-, bradykinin-, and diabetes-induced retinal dysfunction and edema

Ward Fickweiler; Allen C Clermont; Nivetha Murugesan; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2256. doi:

ARVO Annual Meeting Abstract April 2014

Plasma kallikrein (PKal) deficiency ameliorates the effects of vascular endothelial growth factor (VEGF) on retinal hyperpermeability and edema.

Allen C Clermont; Qunfang Zhou; Nivetha Murugesan; Ward Fickweiler; Edward P Feener

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):594. doi:

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