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ARVO Annual Meeting Abstract June 2022

Dry eye disease and high myopia in teenagers; a reciprocal relationship

Osama Ibrahim Hirayama; Masahiko Ayaki; Erisa Yotsukura; Hidemasa Torii; Kazuno Negishi

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1442 – F0400. doi:

ARVO Annual Meeting Abstract July 2019

Corneal Higher-order Aberrations in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Osama Ibrahim; Takefumi Yamaguchi; Aya Takahashi; Hayate Nakagawa; Yukari Yagi-Yaguchi; Daisuke Tomida; Seika Den; Yoshiyuki Satake; Jun Shimazaki

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4235. doi:

Articles June 2019

Automatic Segmentation of Corneal Microlayers on Optical Coherence Tomography Images

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Amr Elsawy; Mohamed Abdel-Mottaleb; Ibrahim-Osama Sayed; Dan Wen; Vatookarn Roongpoovapatr; Taher Eleiwa; Ahmed M. Sayed; Mariam Raheem; Gustavo Gameiro; Mohamed Abou Shousha
TAGS: cornea, datasets, optical coherence tomography, pixel, artifacts
Trans. Vis. Sci. Tech.. 2019; 8(3):39. doi: https://doi.org/10.1167/tvst.8.3.39

Special Issue November 2018

Application of In Vivo Confocal Microscopy in Dry Eye Disease

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Yukihiro Matsumoto; Osama M. A. Ibrahim
TAGS: cornea, dry eye syndromes, microscopy, confocal, inflammatory cells, neurons, meibomian gland
Invest. Ophthalmol. Vis. Sci.. 2018; 59(14):DES41-DES47. doi: https://doi.org/10.1167/iovs.17-23602

ARVO Annual Meeting Abstract September 2016

The effect of topical rebamipide on environmental stress induced dry eye in the wild type mice

Takashi Kojima; Osama MA Ibrahim; Takaaki Inaba; Shigeru Nakamura; Murat Dogru; Kazuo Tsubota

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2868. doi:

ARVO Annual Meeting Abstract September 2016

Corneal biomechanical changes after Small Incision Lenticule Extraction (SMILE) and Femtosecond Laser Assisted In Situ Keratomileusis (Femto LASIK) using a non contact tonometer with visualization and measurement of corneal deformation.

Ibrahim Osama Sayed-Ahmed

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4873. doi:

Cornea December 2015

Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 ( Sod1 )–Knockout Mice

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Takashi Kojima; Murat Dogru; Osama M. A. Ibrahim; Tais Hitomi Wakamatsu; Masataka Ito; Ayako Igarashi; Takaaki Inaba; Takahiko Shimizu; Takuji Shirasawa; Jun Shimazaki; Kazuo Tsubota
TAGS: conjunctiva, mice, oxidative stress, sod1 gene, superoxides, goblet cells, mucins, aging, mice, knockout, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8382-8391. doi: https://doi.org/10.1167/iovs.15-18295

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

The Effects of 2% Rebapimide Ophthalmic Solution on the Corneal Epithelial Barrier Function of the Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

Murat Dogru; Kazue Aoki; Kazunari Higa; Takashi Kojima; Osama Ibrahim; Takefumi Yamaguchi; Seika Den-Shimazaki; Yoshiyuki Satake; Kazuo Tsubota; Jun Shimazaki

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5608. doi:

ARVO Annual Meeting Abstract April 2014

The Bioniko ophthalmic surgery model: an innovative approach for teaching capsulorhexis

Madhura G Joag; James Wong; Juan Carlos Murillo; Ibrahim Osama Sayed-Ahmed; Afshan Nanji; Nabeel M Shalabi; Anat Galor; Carol L Karp

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1295. doi:

ARVO Annual Meeting Abstract April 2014

Blue Nevus of the Ocular Surface

Ibrahim Osama Sayed-Ahmed; James Wong; Juan Carlos Murillo; Madhura G Joag; Nabeel M Shalabi; Afshan Nanji; Anat Galor; Carol L Karp

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1498. doi:

ARVO Annual Meeting Abstract April 2014

Evaluation of high resolution optical coherence tomography among novice users in the diagnosis of ocular surface squamous neoplasia

Afshan Nanji; Anat Galor; William J Feuer; James Wong; Madhura G Joag; Juan Carlos Murillo; Ibrahim Osama; Nabeel M Shalabi; Carol L Karp

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2448. doi:

Cornea November 2013

The Effects of 2% Rebamipide Ophthalmic Solution on the Tear Functions and Ocular Surface of the Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

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Takeshi Ohguchi; Takashi Kojima; Osama M. Ibrahim; Taeko Nagata; Takahiko Shimizu; Takuji Shirasawa; Tetsuya Kawakita; Yoshiyuki Satake; Kazuo Tsubota; Jun Shimazaki; Susumu Ishida
TAGS: mice, knockout, ophthalmic solutions, rebamipide, sod1 gene, superoxide dismutase 1, rna, messenger, cytokine, conjunctiva, mice
Invest. Ophthalmol. Vis. Sci.. 2013; 54(12):7793-7802. doi: https://doi.org/10.1167/iovs.13-13128

Cornea January 2013

Evaluation of Lipid Oxidative Stress Status in Sjögren Syndrome Patients

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Tais H. Wakamatsu; Murat Dogru; Yukihiro Matsumoto; Takashi Kojima; Minako Kaido; Osama M. A. Ibrahim; Enrique A. Sato; Ayako Igarashi; Yoshiyuki Ichihashi; Yoshiyuki Satake; Jun Shimazaki; Kazuo Tsubota
TAGS: conjunctiva, immunohistochemistry, inflammatory cells, lipids, oxidative stress, sjogren's syndrome, brush cytology, dry eye syndromes
Invest. Ophthalmol. Vis. Sci.. 2013; 54(1):201-210. doi: https://doi.org/10.1167/iovs.12-10325

Cornea April 2012

Corneal and Retinal Effects of Ultraviolet-B Exposure in a Soft Contact Lens Mouse Model

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Osama M. A. Ibrahim; Takashi Kojima; Tais Hitomi Wakamatsu; Murat Dogru; Yukihiro Matsumoto; Yoko Ogawa; Junko Ogawa; Kazuno Negishi; Jun Shimazaki; Yasuo Sakamoto; Hiroshi Sasaki; Kazuo Tsubota
TAGS: contact lenses, hydrophilic, cornea, mice, ultraviolet b radiation, immunohistochemistry, lipids, dna, cytokine, capillary leak syndrome, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2012; 53(4):2403-2413. doi: https://doi.org/10.1167/iovs.11-6863

Includes: Supplemental Content

Cornea November 2011

Effect of Controlled Adverse Chamber Environment Exposure on Tear Functions in Silicon Hydrogel and Hydrogel Soft Contact Lens Wearers

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Takashi Kojima; Yukihiro Matsumoto; Osama M. A. Ibrahim; Tais Hitomi Wakamatsu; Miki Uchino; Kazumi Fukagawa; Junko Ogawa; Murat Dogru; Kazuno Negishi; Kazuo Tsubota
TAGS: contact lenses, hydrophilic, evaporation, hydrogel, osmolar concentration, silicon, visual acuity, signs and symptoms, contact lenses, dry eye syndromes, humidity
Invest. Ophthalmol. Vis. Sci.. 2011; 52(12):8811-8817. doi: https://doi.org/10.1167/iovs.10-6841

Includes: Supplemental Content

Cornea August 2011

The Application of In Vivo Confocal Scanning Laser Microscopy in the Diagnosis and Evaluation of Treatment Responses in Mooren's Ulcer

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Shin Hatou; Murat Dogru; Osama M. A. Ibrahim; Tais Wakamatsu; Enrique Adan Sato; Shigeto Shimmura; Kazuno Negishi; Kazuo Tsubota
TAGS: microscopy, confocal scanning laser, mooren's ulcer, ulcer, eye, disease remission
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6680-6689. doi: https://doi.org/10.1167/iovs.10-5906

ARVO Annual Meeting Abstract April 2011

Evidence For Accelerated Apoptosis And Altered Meibomian Glandular Differentiation In The Sod1 Knock-out Mice Novel Model For Age Related Dry Eye Disease

Osama Ibrahim; Murat Dogru; Takashi Kojima; Yukihiro Matsumoto; Tais Wakamatsu; Ayako Igarashi; Takahiko Shimizu; Jun Shimazaki; Kazuo Tsubota

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3771. doi:

Cornea April 2011

The Efficacy, Sensitivity, and Specificity of Strip Meniscometry in Conjunction with Tear Function Tests in the Assessment of Tear Meniscus

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Osama M. A. Ibrahim; Murat Dogru; Samantha K. Ward; Yukihiro Matsumoto; Tais Hitomi Wakamatsu; Katsushi Ishida; Atsushi Tsuyama; Takashi Kojima; Jun Shimazaki; Kazuo Tsubota
TAGS: reflex, sensitivity and specificity, dry eye syndromes, signs and symptoms, questionnaires
Invest. Ophthalmol. Vis. Sci.. 2011; 52(5):2194-2198. doi: https://doi.org/10.1167/iovs.10-5986

Cornea January 2011

In Vivo Evaluation of Ocular Demodicosis Using Laser Scanning Confocal Microscopy

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Takashi Kojima; Reiko Ishida; Enrique Adan Sato; Tetsuya Kawakita; Osama M. A. Ibrahim; Yukihiro Matsumoto; Minako Kaido; Murat Dogru; Kazuo Tsubota
TAGS: demodex infestations, microscopy, confocal scanning laser
Invest. Ophthalmol. Vis. Sci.. 2011; 52(1):565-569. doi: https://doi.org/10.1167/iovs.10-5477

Cornea August 2010

In Vivo Evaluation of Superior Limbic Keratoconjunctivitis Using Laser Scanning Confocal Microscopy and Conjunctival Impression Cytology

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Takashi Kojima; Yukihiro Matsumoto; Osama M. A. Ibrahim; Enrique Adan Sato; Murat Dogru; Kazuo Tsubota
TAGS: conjunctiva, cytology, microscopy, confocal, microscopy, confocal scanning laser, superior limbic keratoconjunctivitis
Invest. Ophthalmol. Vis. Sci.. 2010; 51(8):3986-3992. doi: https://doi.org/10.1167/iovs.09-4932

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Dry eye disease and high myopia in teenagers; a reciprocal relationship

Corneal Higher-order Aberrations in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Automatic Segmentation of Corneal Microlayers on Optical Coherence Tomography Images

Application of In Vivo Confocal Microscopy in Dry Eye Disease

The effect of topical rebamipide on environmental stress induced dry eye in the wild type mice

Corneal biomechanical changes after Small Incision Lenticule Extraction (SMILE) and Femtosecond Laser Assisted In Situ Keratomileusis (Femto LASIK) using a non contact tonometer with visualization and measurement of corneal deformation.

Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 ( Sod1 )–Knockout Mice

The Effects of 2% Rebapimide Ophthalmic Solution on the Corneal Epithelial Barrier Function of the Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

The Bioniko ophthalmic surgery model: an innovative approach for teaching capsulorhexis

Blue Nevus of the Ocular Surface

Evaluation of high resolution optical coherence tomography among novice users in the diagnosis of ocular surface squamous neoplasia

The Effects of 2% Rebamipide Ophthalmic Solution on the Tear Functions and Ocular Surface of the Superoxide Dismutase-1 ( Sod1 ) Knockout Mice

Evaluation of Lipid Oxidative Stress Status in Sjögren Syndrome Patients

Corneal and Retinal Effects of Ultraviolet-B Exposure in a Soft Contact Lens Mouse Model

Effect of Controlled Adverse Chamber Environment Exposure on Tear Functions in Silicon Hydrogel and Hydrogel Soft Contact Lens Wearers

The Application of In Vivo Confocal Scanning Laser Microscopy in the Diagnosis and Evaluation of Treatment Responses in Mooren's Ulcer

Evidence For Accelerated Apoptosis And Altered Meibomian Glandular Differentiation In The Sod1 Knock-out Mice Novel Model For Age Related Dry Eye Disease

The Efficacy, Sensitivity, and Specificity of Strip Meniscometry in Conjunction with Tear Function Tests in the Assessment of Tear Meniscus

In Vivo Evaluation of Ocular Demodicosis Using Laser Scanning Confocal Microscopy

In Vivo Evaluation of Superior Limbic Keratoconjunctivitis Using Laser Scanning Confocal Microscopy and Conjunctival Impression Cytology

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