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Retinal Cell Biology June 2025

Characterization of Bruch's Membrane Formation in Human Fetal Retina and De Novo Membrane Synthesis by hPSC-Derived Retinal Pigment Epithelium

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Emily P. Lanning; Matthew J. Branch; Philippa Harding; Miriam Margari; Alexander J. Smith; Robin R. Ali; Rachael A. Pearson
TAGS: biological response modifiers, bruch's basal membrane, fetus, proteins, retina, retinal pigment epithelium, tissue membrane, elastin, fibronectins, immunohistochemistry
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):40. https://doi.org/10.1167/iovs.66.6.40

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Advancing stem cell-derived photoreceptor replacement therapy

Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):10.

ARVO Annual Meeting Abstract June 2024

Characterisation of Bruch’s membrane development in human fetal retina and de novo membrane synthesis by hPSC-derived Retinal Pigment Epithelium

Emily Lanning; Philippa Harding; Jessica Kapadia; Miriam Margari; Robin Ali; Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4524.

ARVO Annual Meeting Abstract June 2024

Retinoic acid (RA) catabolising enzyme CYP26A1 but not FGF8 is expressed during human macular formation, and inhibiting RA signalling in hPSC-derived retinal organoids leads to increased photoreceptor markers

Philippa Harding; OCGT Stem Cell Team; Robin Ali; Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6694.

Genetics August 2020

Phenotype Driven Analysis of Whole Genome Sequencing Identifies Deep Intronic Variants that Cause Retinal Dystrophies by Aberrant Exonization

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Matteo Di Scipio; Erika Tavares; Shriya Deshmukh; Isabelle Audo; Kit Green-Sanderson; Yuliya Zubak; Fayçal Zine-Eddine; Alexander Pearson; Anjali Vig; Chen Yu Tang; Antonio Mollica; Jonathan Karas; Anupreet Tumber; Caberry W. Yu; Gail Billingsley; Michael D. Wilson; Christina Zeitz; Elise Héon; Ajoy Vincent
TAGS: genetic pedigree, introns, phenotype, retinal dystrophies, reverse transcriptase polymerase chain reaction, rna splicing, whole genome sequencing
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):36. https://doi.org/10.1167/iovs.61.10.36

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Strategies to restore visual function in end-stage retinal disease by stem cell-derived photoreceptor translantation

Rachael A Pearson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2203.

ARVO Annual Meeting Abstract July 2019

A large epidemiological study of Leber’s hereditary optic neuropathy (LHON)

Alexander Liam Pearson; Lissa Poincenot; Rustum Karanjia

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2264.

ARVO Annual Meeting Abstract July 2019

The yield of "clinical" genetic testing in inherited retinal disease: experience at the Hospital for Sick Children, Toronto, Canada

Vaishnavi Batmanabane; Alexander Liam Pearson; Caberry Yu; Ajoy Vincent; Elise Heon

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3976.

ARVO Annual Meeting Abstract March 2012

Transplantation Of Es Cell-derived Retinal Cells Into The Adult Retina

Anai Gonzalez Cordero; Emma L. West; Claire Hippert; Yanai Duran; Rachael A. Pearson; Jane C. Sowden; Robin R. Ali

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):314.

ARVO Annual Meeting Abstract March 2012

Photoreceptor Transplantation In The Degenerating Retina: Breadth Of Application And Manipulation Of The Microenvironment To Enhance Efficiency

Amanda C. Barber; Claire Hippert; Yanai Duran; Emma L. West; Jorn Lakowski; Jim W. Bainbridge; Jane C. Sowden; Robin R. Ali; Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):323.

ARVO Annual Meeting Abstract March 2012

Time-course And Characterisation Of Transplanted Photoreceptor Precursor Migration And Maturation

Katherine M. Warre Cornish; Jane C. Sowden; Robin R. Ali; Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):324.

ARVO Annual Meeting Abstract March 2012

Modelling Photoreceptor Development Using Embryonic Stem Cell-derived 3D Retinal Cultures

Emma L. West; Anai Gonzalez Cordero; Livia S. Carvalho; Rachael A. Pearson; Jane C. Sowden; Robin R. Ali

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1320.

ARVO Annual Meeting Abstract March 2012

Towards Photoreceptor Replacement Therapy: Identifying The Cell Surface Marker Profile Of Photoreceptor Precursors

Jorn Lakowski; Yating Han; Anai A. Gonzalez-Cordero; Emma West; Robin R. Ali; Rachael A. Pearson; Jane C. Sowden

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2695.

ARVO Annual Meeting Abstract April 2011

FameTM Studies: Intraocular Pressure Related Events

P A. Pearson; FAME Study Group

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):556.

ARVO Annual Meeting Abstract April 2011

Retinal Repair In The Degenerating Retina: Assessing Photoreceptor Transplantation In Models Of Retinal Disease

Amanda C. Barber; Claire Hippert; Jane C. Sowden; Robin R. Ali; Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4019.

ARVO Annual Meeting Abstract April 2011

The Adult Retinal Environment Favours New Rod Cell Integration And Limits Cone Cell Differentiation Following Transplantation Of Crx.gfp Precursor Cells

Jane C. Sowden; Michael Baron; Jorn Lakowski; Ya-Ting Han; James W. Bainbridge; Rachael A. Pearson; Robin R. Ali

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5895.

ARVO Annual Meeting Abstract April 2011

Characterisation Of Gliosis In Different Models Of Retinitis Pigmentosa

Claire Hippert; Amanda C. Barber; Jane C. Sowden; Robin R. Ali; Rachael A. Pearson

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1836.

ARVO Annual Meeting Abstract April 2011

Effective Transplantation Of Photoreceptor Precursor Cells Selected Via Cell Surface Antigen Expression

Jorn Lakowski; Yating Han; Rachael A. Pearson; Robin R. Ali; Jane C. Sowden

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2225.

ARVO Annual Meeting Abstract April 2011

Transcriptome Analysis Of Crx-expressing Photoreceptor Precursor Cells For Photoreceptor Cell Replacement Therapy

Ya-Ting Han; Jorn Lakowski; Mike Baron; Rachael A. Pearson; Robin R. Ali; Jane C. Sowden

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2229.

ARVO Annual Meeting Abstract April 2010

Generation of New Cone and Rod Photoreceptors in Models of Retinal Degeneration by Transplantation of Crx-Positive Precursor Cells

M. Baron; J. Lakowski; J. W. Bainbridge; A. Barber; R. A. Pearson; R. R. Ali; J. C. Sowden

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3147.

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Characterization of Bruch's Membrane Formation in Human Fetal Retina and De Novo Membrane Synthesis by hPSC-Derived Retinal Pigment Epithelium

Advancing stem cell-derived photoreceptor replacement therapy

Characterisation of Bruch’s membrane development in human fetal retina and de novo membrane synthesis by hPSC-derived Retinal Pigment Epithelium

Retinoic acid (RA) catabolising enzyme CYP26A1 but not FGF8 is expressed during human macular formation, and inhibiting RA signalling in hPSC-derived retinal organoids leads to increased photoreceptor markers

Phenotype Driven Analysis of Whole Genome Sequencing Identifies Deep Intronic Variants that Cause Retinal Dystrophies by Aberrant Exonization

Strategies to restore visual function in end-stage retinal disease by stem cell-derived photoreceptor translantation

A large epidemiological study of Leber’s hereditary optic neuropathy (LHON)

The yield of "clinical" genetic testing in inherited retinal disease: experience at the Hospital for Sick Children, Toronto, Canada

Transplantation Of Es Cell-derived Retinal Cells Into The Adult Retina

Photoreceptor Transplantation In The Degenerating Retina: Breadth Of Application And Manipulation Of The Microenvironment To Enhance Efficiency

Time-course And Characterisation Of Transplanted Photoreceptor Precursor Migration And Maturation

Modelling Photoreceptor Development Using Embryonic Stem Cell-derived 3D Retinal Cultures

Towards Photoreceptor Replacement Therapy: Identifying The Cell Surface Marker Profile Of Photoreceptor Precursors

FameTM Studies: Intraocular Pressure Related Events

Retinal Repair In The Degenerating Retina: Assessing Photoreceptor Transplantation In Models Of Retinal Disease

The Adult Retinal Environment Favours New Rod Cell Integration And Limits Cone Cell Differentiation Following Transplantation Of Crx.gfp Precursor Cells

Characterisation Of Gliosis In Different Models Of Retinitis Pigmentosa

Effective Transplantation Of Photoreceptor Precursor Cells Selected Via Cell Surface Antigen Expression

Transcriptome Analysis Of Crx-expressing Photoreceptor Precursor Cells For Photoreceptor Cell Replacement Therapy

Generation of New Cone and Rod Photoreceptors in Models of Retinal Degeneration by Transplantation of Crx-Positive Precursor Cells

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