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Multidisciplinary Ophthalmic Imaging June 2025

Choroidal Hyperreflective Foci Represent a Common Finding Across Different Types of Macular Atrophy

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Lorena Ulla; Claudio Foti; Alessandro Arrigo; Maurizio Battaglia Parodi; Maria Vittoria Cicinelli; Paola Marolo; Elisabetta Miserocchi; Mario Peronetti; Francesco Bandello; Enrico Borrelli; Michele Reibaldi
TAGS: atrophoderma maculatum
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):42. https://doi.org/10.1167/iovs.66.6.42

Includes: Supplemental Content

Physiology and Pharmacology June 2025

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

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Jessica R. Crawshaw; Eamonn A. Gaffney; Michael Gertz; Philip K. Maini; Antonello Caruso
TAGS: aqueous humor, ranibizumab, vascular endothelial growth factor a, pharmacodynamics, eye diseases, pharmacokinetics, mathematical model
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):20. https://doi.org/10.1167/iovs.66.6.20

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology June 2025

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

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Neringa Jurkute; Heiko Brennenstuhl; Monika Kustermann; Lindsey Van Haute; Christian D. Mutti; Enrico Bugiardini; Takayuki Handa; Masaru Shimura; Axel Petzold; James Acheson; Anthony G. Robson; William L. Macken; Michael G. Hanna; Robert D. S. Pitceathly; Ashirwad Merve; Urania Kotzaeridou; Stefan Kölker; Michael Freilinger; Marcus Erdler; Reginald E. Bittner; Johannes A. Mayr; Yasushi Okazaki; Kei Murayama; Holger Prokisch; Andrew R. Webster; Michal Minczuk; Gavin Arno; Berthold Pemp; Georg F. Hoffmann; Wolfgang M. Schmidt; Patrick Yu-Wai-Man
TAGS: family, mitochondrial diseases, optic atrophy, phenotype, mitochondria, optic nerve disorders, respiratory chain
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):17. https://doi.org/10.1167/iovs.66.6.17

Includes: Supplemental Content

Cornea & External Disease June 2025

Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination

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Anthony Ain; Sylvain Poinard; Thierry Lepine; Oliver Dorado-Cortez; Sébastien Urbaniak; Jean-Marie Papillon; Philippe Gain; Gilles Thuret
TAGS: diagnostic imaging, lighting, slit lamps, light
Trans. Vis. Sci. Tech.. 2025; 14(6):11. https://doi.org/10.1167/tvst.14.6.11

Cornea & External Disease June 2025

Artificial Intelligence Aided Analysis of Anterior Segment Optical Coherence Tomography Imaging to Monitor the Device-Cornea Joint After Synthetic Cornea Implantation

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Esen Karamursel Akpek; Gavin Li; Anthony J. Aldave; Guillermo Amescua; Kathryn A. Colby; Maria S. Cortina; Jose de la Cruz; Jean-Marie A. Parel; Thomas Schmiedel
TAGS: artificial intelligence, cornea, diagnostic imaging, implantation procedure, optical coherence tomography, body tissue, optics
Trans. Vis. Sci. Tech.. 2025; 14(6):1. https://doi.org/10.1167/tvst.14.6.1

Cornea May 2025

Metabolomic Profiling of Ocular Fluid Identifies Host Response Factors for Risk Stratification in Bacterial Endophthalmitis

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Naren Shetty; Padmamalini Mahendradas; Ramaraj Kannan; Samayitree Das; Priyanka Sathe; Rohit Shetty; Arkasubhra Ghosh; Vrushali Deshpande
TAGS: bacterial endophthalmitis, metabolites, metabolomics, immune response, stratification
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):27. https://doi.org/10.1167/iovs.66.5.27

Includes: Supplemental Content

Retina May 2025

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

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Lisa Lombardi; Matthew A. Petoe; Lauren Moussallem; Maria Kolic; Elizabeth K. Baglin; Samuel Stefopoulos; Xerxes Battiwalla; Janine G. Walker; Nick Barnes; Carla J. Abbott; Penelope J. Allen; for the Bionics Institute and Centre for Eye Research Australia Retinal Prosthesis Consortium
TAGS: brca2 gene, congenital heart disease, coronary arteriosclerosis, coronary heart disease, face, flavin-adenine dinucleotide, prostheses, psen1 gene, second language, second lumbar vertebra
Trans. Vis. Sci. Tech.. 2025; 14(5):11. https://doi.org/10.1167/tvst.14.5.11

Retina May 2025

Comparing the Efficiency of Fluid Infusion Systems for Pars Plana Vitrectomy

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Tommaso Rossi; Giorgio Querzoli; Giov Battista Angelini; Veronica Santoro; Camilla Pellizzaro; David H. Steel; Mariacristina Parravano; Mario R. Romano
TAGS: infusion procedures, infusion sets, vitrectomy, trocar, pars plana
Trans. Vis. Sci. Tech.. 2025; 14(5):10. https://doi.org/10.1167/tvst.14.5.10

Genetics May 2025

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

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Andrew Briere; Peter Vo; Benjamin Yang; David Adams; Takanori Amano; Oana Amarie; Zorana Berberovic; Lynette Bower; Steve D. M. Brown; Samantha Burrill; Soo Young Cho; Sharon Clementson-Mobbs; Abigail D'souza; Mohammad Eskandarian; Ann M. Flenniken; Helmut Fuchs; Valerie Gailus-Durner; Yann Hérault; Martin Hrabe de Angelis; Shundan Jin; Russell Joynson; Yeon Kyung Kang; Haerim Kim; Hiroshi Masuya; Hamid Meziane; Ki-Hoan Nam; Hyuna Noh; Lauryl M. J. Nutter; Marcela Palkova; Jan Prochazka; Miles Joseph Raishbrook; Fabrice Riet; Jason Salazar; Radislav Sedlacek; Mohammed Selloum; Kyoung Yul Seo; Je Kyung Seong; Hae-Sol Shin; Toshihiko Shiroishi; Michelle Stewart; Karen Svenson; Masaru Tamura; Heather Tolentino; Sara Wells; Wolfgang Wurst; Atsushi Yoshiki; Louise Lanoue; K. C. Kent Lloyd; Brian C. Leonard; Michel J. Roux; Colin McKerlie; Ala Moshiri; for The International Mouse Phenotyping Consortium
TAGS: genes, hereditary corneal dystrophy, mice, knockout, phenotype determination, proteins, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):7. https://doi.org/10.1167/iovs.66.5.7

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

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Yu Peng; Yuzhou Zhang; Ka Wai Kam; Gavin Wong; Mary Ho; Simon Sezto; Sunny Au; Xiujuan Zhang; Mandy P. H. Ng; Patrick Ip; Alvin Young; Chi Pui Pang; Clement C. Tham; Li Jia Chen; Jason C. Yam
TAGS: health, macular disorders, uk biobank, follow-up
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):63. https://doi.org/10.1167/iovs.66.4.63

Includes: Supplemental Content

Retina April 2025

PCARE -Associated Retinopathy – Genetics, Clinical Characteristics, and Natural History

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Lorenzo Bianco; Alessio Antropoli; Amine Benadji; Raphaël Atia; Oana Palacci; Christel Condroyer; Aline Antonio; Julien Navarro; Maurizio Battaglia Parodi; José-Alain Sahel; Christina Zeitz; Isabelle Audo
TAGS: genetics, natural history, retinal diseases, visual impairment, follow-up, eye
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):61. https://doi.org/10.1167/iovs.66.4.61

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract April 2025

Invited Session I: Focusing on the Human Fovea: Active vision at the foveolar scale: Insights from fixational oculomotor behavior and retinal anatomy

Martina Poletti
TAGS: fovea centralis, vision
Journal of Vision. 2025; 25(5):3. https://doi.org/10.1167/jov.25.5.3

Optica Fall Vision Meeting Abstract April 2025

Poster Session: Chromatic blur detection differences as a function of refractive error

Maria Vinas-Pena; Paulina Dotor-Goytia; Elena Moreno; Victor Rodriguez-Lopez
TAGS: posters, refractive errors
Journal of Vision. 2025; 25(5):18. https://doi.org/10.1167/jov.25.5.18

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology March 2025

Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays

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Julie A. Jurgens; Paola M. Matos Ruiz; Jessica King; Emma E. Foster; Lindsay Berube; Wai-Man Chan; Brenda J. Barry; Raehoon Jeong; Elisabeth Rothman; Mary C. Whitman; Sarah MacKinnon; Cristina Rivera-Quiles; Brandon M. Pratt; Teresa Easterbrooks; Fiona M. Mensching; Silvio Alessandro Di Gioia; Lynn Pais; Eleina M. England; Teresa de Berardinis; Adriano Magli; Feray Koc; Kazuhide Asakawa; Koichi Kawakami; Anne O'Donnell-Luria; David G. Hunter; Caroline D. Robson; Martha L. Bulyk; Elizabeth C. Engle
TAGS: cranium, genes, motor neurons, protein binding, screening, zebrafish, transcription factor, candidate disease gene, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):62. https://doi.org/10.1167/iovs.66.3.62

Includes: Supplemental Content

Cornea & External Disease March 2025

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

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Sunny Kwok; Xueliang Pan; Manqi Pan; Zihao Chen; Madison Ammon; Andrew Hendershot; Jun Liu
TAGS: cornea, keratoconus, ultrasound elastography, ultrasonography, eye
Trans. Vis. Sci. Tech.. 2025; 14(3):22. https://doi.org/10.1167/tvst.14.3.22

Anatomy and Pathology/Oncology March 2025

Clinical Value of MLPA for Prognostic Assessment of Chromosomal Rearrangements and DNA Methylation in Uveal Melanoma

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Andrea Soltysova; Dana Dvorska; Andrej Ficek; Martina Pecimonova; Marek Samec; Ivana Kasubova; Viera Horvathova Kajabova; Lucia Demkova; Pavel Babal; Jela Valaskova; Zuzana Dankova; Bozena Smolkova; Alena Furdova
TAGS: chromosome rearrangements, dna methylation, methylation, patient prognosis, uveal melanoma, dna, neoplasms
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):51. https://doi.org/10.1167/iovs.66.3.51

Includes: Supplemental Content

Visual Neuroscience March 2025

Modulation of All- Trans Retinoic Acid by Light and Dopamine in the Murine Eye

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Sarah Talwar; Reece Mazade; Melissa Bentley-Ford; Jianshi Yu; Nageswara Pilli; Maureen A. Kane; C. Ross Ethier; Machelle T. Pardue
TAGS: eye, mice, tretinoin, retinoids, lighting, dopamine, light exposure
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):37. https://doi.org/10.1167/iovs.66.3.37

Cornea March 2025

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

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Kara Poole; Krithika S. Iyer; David W. Schmidtke; W. Matthew Petroll; Victor D. Varner
TAGS: cornea, fibroblasts, genes, keratocytes, myofibroblasts, transcription, genetic, stromal cells
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):28. https://doi.org/10.1167/iovs.66.3.28

Includes: Supplemental Content

Letters to the Editor March 2025

The visual system does not operate like a camera

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Michele Rucci; Ehud Ahissar; David C. Burr; Igor Kagan; Martina Poletti; Jonathan D. Victor
TAGS: eye movement, photopsia, saccades, vision, visual system, spatial frequency, retina, eye
Journal of Vision. 2025; 25(3):2. https://doi.org/10.1167/jov.25.3.2

Visual Neuroscience February 2025

Immunohistochemistry and Spatial Density of Müller Cells in the Human Fovea

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Rania A. Masri; Ursula Greferath; Erica L. Fletcher; Paul R. Martin; Ulrike Grünert
TAGS: fovea centralis, immunohistochemistry, retina, antibodies, retinal cone, fluorescent antibody technique
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):46. https://doi.org/10.1167/iovs.66.2.46

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Choroidal Hyperreflective Foci Represent a Common Finding Across Different Types of Macular Atrophy

Modeling the Ocular Pharmacokinetics and Pharmacodynamics of Ranibizumab for Improved Understanding and Data Collection Strategies in Ocular Diseases

Biallelic NSUN3 Variants Cause Diverse Phenotypic Spectrum Disease: From Isolated Optic Atrophy to Severe Early-Onset Mitochondrial Disorder

Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination

Artificial Intelligence Aided Analysis of Anterior Segment Optical Coherence Tomography Imaging to Monitor the Device-Cornea Joint After Synthetic Cornea Implantation

Metabolomic Profiling of Ocular Fluid Identifies Host Response Factors for Risk Stratification in Bacterial Endophthalmitis

Face and Available Chair Detection and Localization With a Second-Generation (44-Channel) Suprachoroidal Retinal Prosthesis

Comparing the Efficiency of Fluid Infusion Systems for Pars Plana Vitrectomy

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies

Associations of Cardiovascular Health and New-Onset Age-Related Macular Diseases From UK Biobank

PCARE -Associated Retinopathy – Genetics, Clinical Characteristics, and Natural History

Invited Session I: Focusing on the Human Fovea: Active vision at the foveolar scale: Insights from fixational oculomotor behavior and retinal anatomy

Poster Session: Chromatic blur detection differences as a function of refractive error

Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

Clinical Value of MLPA for Prognostic Assessment of Chromosomal Rearrangements and DNA Methylation in Uveal Melanoma

Modulation of All- Trans Retinoic Acid by Light and Dopamine in the Murine Eye

Corneal Keratocytes, Fibroblasts, and Myofibroblasts Exhibit Distinct Transcriptional Profiles In Vitro

The visual system does not operate like a camera

Immunohistochemistry and Spatial Density of Müller Cells in the Human Fovea

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