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Meeting Abstract (8)
Journal Articles (5)

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Investigative Ophthalmology & Visual Science (13)

Article Type

ARVO Annual Meeting Abstract (8)
Biochemistry and Molecular Biology (4)
Glaucoma (1)

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Biochemistry and Molecular Biology (5)
Eye Anatomy and Disorders (5)
Glaucoma (3)
Visual Neuroscience (2)
Genetics (1)

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metabolites (4)
metabolomics (3)
plasma (3)
glaucoma (2)
open-angle glaucoma (2)
optic atrophy, autosomal dominant (2)
polyamines (2)
aging (1)
amino acids (1)
cohort studies (1)

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Showing 1 – 13 of 13

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Glaucoma June 2019

Nicotinamide Deficiency in Primary Open-Angle Glaucoma

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Judith Kouassi Nzoughet; Juan Manuel Chao de la Barca; Khadidja Guehlouz; Stéphanie Leruez; Laurent Coulbault; Stéphane Allouche; Cinzia Bocca; Jeanne Muller; Patrizia Amati-Bonneau; Philippe Gohier; Dominique Bonneau; Gilles Simard; Dan Milea; Guy Lenaers; Vincent Procaccio; Pascal Reynier
TAGS: cohort studies, glaucoma, niacinamide, open-angle glaucoma, pellagra, plasma
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2509-2514. doi: https://doi.org/10.1167/iovs.19-27099

Biochemistry and Molecular Biology September 2018

A Metabolomics Profiling of Glaucoma Points to Mitochondrial Dysfunction, Senescence, and Polyamines Deficiency

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Stéphanie Leruez; Alexandre Marill; Thomas Bresson; Grégoire de Saint Martin; Adrien Buisset; Jeanne Muller; Lydie Tessier; Cédric Gadras; Christophe Verny; Philippe Gohier; Patrizia Amati-Bonneau; Guy Lenaers; Dominique Bonneau; Gilles Simard; Dan Milea; Vincent Procaccio; Pascal Reynier; Juan Manuel Chao de la Barca
TAGS: aging, glaucoma, metabolites, metabolomics, mitochondria, older adult, open-angle glaucoma, pathophysiology, polyamines
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4355-4361. doi: https://doi.org/10.1167/iovs.18-24938

Includes: Supplemental Content

Biochemistry and Molecular Biology February 2018

A Plasma Metabolomic Signature of the Exfoliation Syndrome Involves Amino Acids, Acylcarnitines, and Polyamines

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Stéphanie Leruez; Thomas Bresson; Juan M. Chao de la Barca; Alexandre Marill; Grégoire de Saint Martin; Adrien Buisset; Jeanne Muller; Lydie Tessier; Cédric Gadras; Christophe Verny; Patrizia Amati-Bonneau; Guy Lenaers; Philippe Gohier; Dominique Bonneau; Gilles Simard; Dan Milea; Vincent Procaccio; Pascal Reynier
TAGS: amino acids, exfoliation syndrome, metabolomics, plasma, polyamines, metabolites
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):1025-1032. doi: https://doi.org/10.1167/iovs.17-23055

Includes: Supplemental Content

Biochemistry and Molecular Biology January 2018

A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 ( OPA1 )-Related Disorders

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Cinzia Bocca; Judith Kouassi Nzoughet; Stéphanie Leruez; Patrizia Amati-Bonneau; Marc Ferré; Mariame-Selma Kane; Charlotte Veyrat-Durebex; Juan Manuel Chao de la Barca; Arnaud Chevrollier; Chadi Homedan; Christophe Verny; Dan Miléa; Vincent Procaccio; Gilles Simard; Dominique Bonneau; Guy Lenaers; Pascal Reynier
TAGS: metabolites, metabolomics, optic atrophy, autosomal dominant, plasma, purine metabolism pathway
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):185-195. doi: https://doi.org/10.1167/iovs.17-23027

Biochemistry and Molecular Biology February 2017

Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1 delTTAG/+ Mice

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Juan Manuel Chao de la Barca; Gilles Simard; Emmanuelle Sarzi; Tanguy Chaumette; Guillaume Rousseau; Stéphanie Chupin; Cédric Gadras; Lydie Tessier; Marc Ferré; Arnaud Chevrollier; Valérie Desquiret-Dumas; Naïg Gueguen; Stéphanie Leruez; Christophe Verny; Dan Miléa; Dominique Bonneau; Patrizia Amati-Bonneau; Vincent Procaccio; Christian Hamel; Guy Lenaers; Pascal Reynier; Delphine Prunier-Mirebeau
TAGS: mice, optic atrophy, autosomal dominant, optic nerve, metabolites
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):812-820. doi: https://doi.org/10.1167/iovs.16-21116

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Multiethnic involvement in autosomal dominant optic atrophy; report of a new gene mutation causing optic atrophy and deafness

Dan Milea; Patrizia Amati-Bonneau; Sharon Tow; Dominique Bonneau; Vincent Procaccio; Pascal Reynier; Jing Liang Loo

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6210. doi:

ARVO Annual Meeting Abstract June 2013

Neurological and neuroradiological alterations in OPA1-linked dominant optic atrophy patients

agathe roubertie; Nicolas Leboucq; Hervé Brunel; Emmanuelle Lebars; Michel Mondain; Patrizia Amati Bonneau; Max Villain; Isabelle Meunier; Guy Lenaers; Christian Hamel

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1205. doi:

ARVO Annual Meeting Abstract April 2011

Mutations In Opa8 Are Associated With Mild Optic Atrophy And Severe Deafness

Cecile Delettre; Laetitia Buret; Guy Rebillard; Marie Pequignot; Marcio Do-cruzeiro; Karen Cornille; Marc Lenoir; Patricia Amati-Bonneau; Christian Hamel; Guy Lenaers

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5879. doi:

ARVO Annual Meeting Abstract April 2010

Early Characterization of a New OPA1 Mouse Model of Dominant Optic Atrophy Reveals the Pathophysiological Mechanism of Retinal Ganglion Cells Degeneration

G. Lenaers; E. Sarzi; A. Benyagoub; C. Prouteau; N. Gueguen; P. Amati-Bonneau; D. Bonneau; C. P. Hamel; P. Reynier; C. Delettre

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3841. doi:

ARVO Annual Meeting Abstract May 2008

Validation of Rare Mitochondrial DNA Point Mutations Pathogenic for Leber’s Hereditary Optic Neuropathy (LHON)

L. Iommarini; A. Achilli; F. Pizza; C. La Morgia; M. L. Valentino; D. Bonneau; P. Amati-Bonneau; A. Torroni; V. Carelli

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):1308. doi:

ARVO Annual Meeting Abstract May 2008

New Genotype-Phenotype Correlations in OPA1 Patients With Inherited Optic Neuropathies

G. Lenaers; V. Carelli; P. Amati-Bonneau; D. Milea; C. P. Hamel

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3114. doi:

ARVO Annual Meeting Abstract May 2008

Opa1 Mutations Induce Mitochondrial Dna Instability and Optic Atrophy Plus Phenotypes

V. Carelli; P. Reynier; M. L. Valentino; R. Carroccia; L. Iommarini; C. La Morgia; R. Garesse; G. Lenaers; D. Bonneau; P. Amati-Bonneau

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):5388. doi:

ARVO Annual Meeting Abstract May 2007

Spontaneous Visual Recovery After Acute Bilateral Optic Neuropathy Related to a New Opa1 Mutation in the Alternatively Spliced Exon 5b.

P. Brabet; K. Cornille; P. Amati-Bonneau; Cé. Delettre; A. Muller; D. Milea; P. Reynier; C. P. Hamel; G. Lenaers

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):1667. doi:

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Online ISSN: 1552-5783

Investigative Ophthalmology & Visual Science
Journal of Vision
Translational Vision Science & Technology

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