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ARVO Annual Meeting Abstract July 2018

Efficient choroidal neovascularization reduction by Sleeping Beauty Transposon-mediated PEDF gene delivery in rat iris and retinal pigment epithelial cells by using a clinical electroporator

Patricia Fernandez; Sergio Recalde; Maria Hernandez; Laura Garcia-Garcia; Jaione Bezunartea; Juan Roberto Rodriguez; Corinne Marie; Daniel Scherman; Zsuzsanna Izsvak; Martina Kropp; Sandra Johnen; Gabriele Thumann; Alfredo García-Layana

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):223. doi:

ARVO Annual Meeting Abstract July 2018

Different gender risk distribution of CRP and A69S frequencies in wet-AMD Spanish patients

Maria Hernandez; Sergio Recalde; Javier Zarranz-Ventura; Blanca Molins; Maite Moreno; Jaione Bezunartea; Alfredo Adán; Patricia Fernandez; Alfredo García-Layana

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1427. doi:

ARVO Annual Meeting Abstract July 2018

Recovering of inflammatory and oxidative stress damage in retinal epithelial and endothelial cells: synergistic action of anti-oxidant and vitamin D

Sergio Recalde; Maria Hernandez; Jaione Bezunartea; Maite Moreno; Idoia Belza; Alfredo García-Layana; Patricia Fernandez

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2479. doi:

Genetics May 2018

Toward the Mutational Landscape of Autosomal Dominant Retinitis Pigmentosa: A Comprehensive Analysis of 258 Spanish Families

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Inmaculada Martin-Merida; Domingo Aguilera-Garcia; Patricia Fernandez-San Jose; Fiona Blanco-Kelly; Olga Zurita; Berta Almoguera; Blanca Garcia-Sandoval; Almudena Avila-Fernandez; Ana Arteche; Pablo Minguez; Miguel Carballo; Marta Corton; Carmen Ayuso
TAGS: mutation, choroidal neovascularization, cohort studies, family, genes, retinitis pigmentosa, genetic analysis, screening, massively-parallel genome sequencing, copy number polymorphism, spanish
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2345-2354. doi: 10.1167/iovs.18-23854

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Effect of Bevacizumab, Ranibizumab and Aflibercept on retinal pigment epithelium phagocytosis

Patricia Fernandez; Maria Hernandez; Sergio Recalde; Manuel Saenz de Viteri; Idoia Belza; Maite Moreno; Jaione Bezunartea; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1207. doi:

ARVO Annual Meeting Abstract June 2017

Rat Primary Cells transfected with PEDF using the Sleeping Beauty Transposon system are effective in reducing the proangiogenic status in choroidal neovascularization

Sergio Recalde; Maria Hernandez; Patricia Fernandez; Laura García-Garcia; Juan Roberto Rodriguez; Jaione Bezunartea; Maite Moreno; Idoia Belza; Corinne Marie; Daniel Scherman; Zsuzsanna Izsvák; Sandra Johnen; Gabriele Thumann; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1964. doi:

Genetics February 2017

Analysis of the PRPF31 Gene in Spanish Autosomal Dominant Retinitis Pigmentosa Patients: A Novel Genomic Rearrangement

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Inmaculada Martin-Merida; Rocio Sanchez-Alcudia; Patricia Fernandez-San Jose; Fiona Blanco-Kelly; Raquel Perez-Carro; Luciana Rodriguez-Jacy da Silva; Berta Almoguera; Blanca Garcia-Sandoval; Maria Isabel Lopez-Molina; Almudena Avila-Fernandez; Miguel Carballo; Marta Corton; Carmen Ayuso
TAGS: mutation, cohort studies, family, gene rearrangement, genes, retinitis pigmentosa, spanish
Invest. Ophthalmol. Vis. Sci.. 2017; 58(2):1045-1053. doi: 10.1167/iovs.16-20515

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Ranibizumab, Bevacizumab, and Aflibercept accumulation and their effect on cell migration and permeability on human ARPE-19 cells

Patricia Fernandez; Manuel Saenz de Viteri; Sergio Recalde; Maria Hernandez; Jaione Bezunartea-Bezunartea; Elena Alonso; Maite Moreno-Orduna; Natalia Aguado; Idoia Belza; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3363. doi:

ARVO Annual Meeting Abstract September 2016

Efficacy of Rat Primary Cells transfected with Pigment Epithelium-Derived Factor using the Sleeping Beauty Transposon system in choroidal neovascularization.

Maria Hernandez; Laura Garcia-Garcia; Sergio Recalde; Patricia Fernandez; Juan Roberto Rodriguez; Jaione Bezunartea-Bezunartea; Daniel Scherman; Sandra Johnen; Gabriele Thumann; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):271. doi:

ARVO Annual Meeting Abstract September 2016

RT-qPCR quantification of mRNAs specific of Pigment Epithelium-Derived Factor (PEDF) and Vascular Endothelial Growth Factor (VEGF) in Rat eyes injected in the subretinal space with Primary Cells transfected with hPEDF.

Sergio Recalde; Laurence Jeanson-LEH; Patricia Fernandez; Maria Hernandez; Laura Garcia-Garcia; Jaione Bezunartea-Bezunartea; Daniel Scherman; Séverine Pouillot; Gabriele Thumann; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):281. doi:

ARVO Annual Meeting Abstract June 2015

Different Association of ARMS2 , CFH , CFHR1-3, SERPINF1 , VEGFR1 and C5 Polymorphisms in response of Ranibizumab treatment in wet-AMD.

Alvaro Velazquez Villoria; Sergio Recalde; Patricia Fernandez-Robredo; Carla Barreales; Esefanía Cobos; Alicia Valverde; Marta Suarez-Figueroa; Fernando Cruz; Maximino Abraldes; Alfredo Garcia Layana

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3787. doi:

ARVO Annual Meeting Abstract June 2015

Improvement of hyper reflective dots visualization on OCT by gold nanoparticles

Patricia Fernandez-Robredo; Michael Powner; Senthil Selvam; Dawn A Sim; Pearse Andrew Keane; Marcus Fruttiger

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5925. doi:

ARVO Annual Meeting Abstract June 2015

Effect of EPA:DHA formulations on cell viability, proliferation and reactive oxygen species generation under inflamatory and oxidative stress conditions

Laura Garcia-Garcia; Sergio Recalde; Patricia Fernandez-Robredo; Maria Hernandez; Nahia Ispizua-Madariaga; Nicholas Reiter; Edurne Albiasu; Jaione Bezunartea; Elena Alonso; Alfredo Garcia Layana

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):16. doi:

ARVO Annual Meeting Abstract June 2015

Biodistribution of Rat Primary Cells transfected with SB100X transposon-mediated Pigment Epithelium-Derived Factor (PEDF) gene in Brown Norway rats after subretinal injection

Maria Hernandez; Laura Garcia-Garcia; Sergio Recalde; Patricia Fernandez-Robredo; Juan Roberto Rodriguez Madoz; Daniel Sherman; Zsuzsanna Izsvák; Sandra Johnen; Gabriele Thumann; Alfredo Garcia Layana

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1835. doi:

ARVO Annual Meeting Abstract June 2015

Toxicity Study of anti-VEGF drugs: Ranibizumab, Bevabizumab and Aflibercept on human ARPE19 cell line after single or repeated clinical doses.

Nicholas Reiter; Manuel Saenz de Viteri Vazquez; Sergio Recalde; Patricia Fernandez; Laura Garcia-Garcia; Jaione Bezunartea; Maria Hernandez; Elena Alonso; Maite Moreno; Alfredo Garcia Layana

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):216. doi:

Genetics April 2015

Targeted Next-Generation Sequencing Improves the Diagnosis of Autosomal Dominant Retinitis Pigmentosa in Spanish Patients

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Patricia Fernandez-San Jose; Marta Corton; Fiona Blanco-Kelly; Almudena Avila-Fernandez; Miguel Angel Lopez-Martinez; Iker Sanchez-Navarro; Rocio Sanchez-Alcudia; Raquel Perez-Carro; Olga Zurita; Noelia Sanchez-Bolivar; Maria Isabel Lopez-Molina; Blanca Garcia-Sandoval; Rosa Riveiro-Alvarez; Carmen Ayuso
TAGS: mutation, family, genes, retinitis pigmentosa, massively-parallel genome sequencing, spanish
Invest. Ophthalmol. Vis. Sci.. 2015; 56(4):2173-2182. doi: 10.1167/iovs.14-16178

Includes: Supplemental Content

Genetics November 2014

Contribution of Mutation Load to the Intrafamilial Genetic Heterogeneity in a Large Cohort of Spanish Retinal Dystrophies Families

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Rocío Sánchez-Alcudia; Marta Cortón; Almudena Ávila-Fernández; Olga Zurita; Sorina D. Tatu; Raquel Pérez-Carro; Patricia Fernandez-San Jose; Miguel Ángel Lopez-Martinez; Francisco J. del Castillo; Jose M. Millan; Fiona Blanco-Kelly; Blanca García-Sandoval; Maria Isabel Lopez-Molina; Rosa Riveiro-Alvarez; Carmen Ayuso
TAGS: phenotype, mutation, cohort studies, family, genes, genetic heterogeneity, spanish, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2014; 55(11):7562-7571. doi: 10.1167/iovs.14-14938

ARVO Annual Meeting Abstract April 2014

MOLECULAR AND FUNCTIONAL CHANGES IN THE RETINA OF MICE DEFICIENT IN COMPLEMENT FACTOR H AND APOLIPOPROTEIN E

Maria Hernandez; Laura Garcia-Garcia; Sergio Recalde; Patricia Fernandez; Maite Moreno-Orduña; Laura Fernandez Sanchez; Laura Ramirez; Pedro de la Villa; Nicolas Cuenca; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3462. doi:

ARVO Annual Meeting Abstract April 2014

Different Association of Timp3, LIPC, FRK/COL10A, CEPT and CFHR1-3 Polymorphisms in Spanish Patients with Early, Wet and Atrophic Age-Related Macular Degeneration.

Sergio Recalde; Patricia Fernandez; Ana I Hernandez-Caballero; Maite Moreno-Orduña; Jaione Bezunartea-Bezunartea; Laura Garcia-Garcia; Nicholas Reiter; Maria Hernandez; Alvaro Velazquez-Villoria; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2222. doi:

ARVO Annual Meeting Abstract April 2014

EFFECT OF THE ABSENCE OF BOTH, APOLIPOPROTEIN E AND COMPLEMENT FACTOR H, ON RETINAL GENE EXPRESSION, ENZYMATIC ACTIVITY AND LIPID PROFILE.

Laura Garcia-Garcia; Sergio Recalde; Patricia Fernandez; Maite Moreno-Orduña; Vanessa Fernandez-Garcia; Jaione Bezunartea-Bezunartea; Nicolas Cuenca; Pedro de la Villa; Alfredo Garcia-Layana

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1333. doi:

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Efficient choroidal neovascularization reduction by Sleeping Beauty Transposon-mediated PEDF gene delivery in rat iris and retinal pigment epithelial cells by using a clinical electroporator

Different gender risk distribution of CRP and A69S frequencies in wet-AMD Spanish patients

Recovering of inflammatory and oxidative stress damage in retinal epithelial and endothelial cells: synergistic action of anti-oxidant and vitamin D

Toward the Mutational Landscape of Autosomal Dominant Retinitis Pigmentosa: A Comprehensive Analysis of 258 Spanish Families

Effect of Bevacizumab, Ranibizumab and Aflibercept on retinal pigment epithelium phagocytosis

Rat Primary Cells transfected with PEDF using the Sleeping Beauty Transposon system are effective in reducing the proangiogenic status in choroidal neovascularization

Analysis of the PRPF31 Gene in Spanish Autosomal Dominant Retinitis Pigmentosa Patients: A Novel Genomic Rearrangement

Ranibizumab, Bevacizumab, and Aflibercept accumulation and their effect on cell migration and permeability on human ARPE-19 cells

Efficacy of Rat Primary Cells transfected with Pigment Epithelium-Derived Factor using the Sleeping Beauty Transposon system in choroidal neovascularization.

RT-qPCR quantification of mRNAs specific of Pigment Epithelium-Derived Factor (PEDF) and Vascular Endothelial Growth Factor (VEGF) in Rat eyes injected in the subretinal space with Primary Cells transfected with hPEDF.

Different Association of ARMS2 , CFH , CFHR1-3, SERPINF1 , VEGFR1 and C5 Polymorphisms in response of Ranibizumab treatment in wet-AMD.

Improvement of hyper reflective dots visualization on OCT by gold nanoparticles

Effect of EPA:DHA formulations on cell viability, proliferation and reactive oxygen species generation under inflamatory and oxidative stress conditions

Biodistribution of Rat Primary Cells transfected with SB100X transposon-mediated Pigment Epithelium-Derived Factor (PEDF) gene in Brown Norway rats after subretinal injection

Toxicity Study of anti-VEGF drugs: Ranibizumab, Bevabizumab and Aflibercept on human ARPE19 cell line after single or repeated clinical doses.

Targeted Next-Generation Sequencing Improves the Diagnosis of Autosomal Dominant Retinitis Pigmentosa in Spanish Patients

Contribution of Mutation Load to the Intrafamilial Genetic Heterogeneity in a Large Cohort of Spanish Retinal Dystrophies Families

MOLECULAR AND FUNCTIONAL CHANGES IN THE RETINA OF MICE DEFICIENT IN COMPLEMENT FACTOR H AND APOLIPOPROTEIN E

Different Association of Timp3, LIPC, FRK/COL10A, CEPT and CFHR1-3 Polymorphisms in Spanish Patients with Early, Wet and Atrophic Age-Related Macular Degeneration.

EFFECT OF THE ABSENCE OF BOTH, APOLIPOPROTEIN E AND COMPLEMENT FACTOR H, ON RETINAL GENE EXPRESSION, ENZYMATIC ACTIVITY AND LIPID PROFILE.

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