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ARVO Annual Meeting Abstract June 2020

Complement expression and immunolocalisation studies of the RPE/choroid complex provide evidence for Bruch’s membrane degradation in early AMD

Paul N Bishop; Selina McHarg; Fan He; Nadhim Bayatti; Richard Unwin; Anthony J Day; Simon J Clark

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3118. doi:

ARVO Annual Meeting Abstract June 2020

Proteomic analysis of vitreous humor samples obtained from donors with and without age-related macular degeneration (AMD) reveal an overactivation of complement protein expression.

Anna Buchberger; James Francis; Ashley Frazer-Abel; Selina McHarg; Paul N Bishop; Scott Ellis; Jane Hughes

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3650. doi:

ARVO Annual Meeting Abstract July 2019

Genetic risk of AMD at both the CFH and ARMS2/HTRA1 loci is associated with increased protease expression and activity in human Bruch’s membrane/inner choroid.

Paul N Bishop; Selina McHarg; Nadhim Bayatti; Rahat Perveen; Graeme Black; Anthony J Day; Andrew Dowsey; Simon J Clark; Richard J Unwin

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2814. doi:

ARVO Annual Meeting Abstract July 2019

Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in age-related macular degeneration

Valentina Cipriani; Laura Lorés de Motta; Fan He; Dina Fathalla; Selina McHarg; Nadhim Bayatti; Ilhan Erkin Acar; Carel C B Hoyng; Sascha Fauser; Anthony Moore; John RW Yates; Paul Morgan; Eiko de Jong; Anneke I Den Hollander; Paul N Bishop; Simon J Clark

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3870. doi:

ARVO Annual Meeting Abstract July 2019

Whole genome methylation profiling of retinal pigment epithelium reveals differential methylation and gene expression associated with AMD

Louise Frances Porter; Neil Saptarshi; Yongxiang Fang; Sonika Rathi; Anneke I Den Hollander; Eiko de Jong; Simon Clark; Paul N Bishop; Timothy W Olsen; Triantafillos Liloglu; Venkata Ramana Murthy Chavali; Luminita Paraoan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4247. doi:

ARVO Annual Meeting Abstract July 2019

Pharmacokinetics of the Anti-angiogenic Glycoprotein Opticin in Preclinical Studies

Eva Maria del Amo Páez; John R. Griffiths; Izabela P Klaska; Anne White; Leon Aarons; James WB Bainbridge; Richard J Unwin; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2716. doi:

ARVO Annual Meeting Abstract June 2017

Enhancing visual responses in retinal degeneration with human melanopsin

Jasmina Cehajic Kapetanovic; Annette E Allen; Nina Milosavljevic; Timothy M Brown; Paul N Bishop; Robert J Lucas

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1218. doi:

ARVO Annual Meeting Abstract June 2017

Expression of complement and other inflammatory pathway genes is co-ordinated in the human RPE cell transcriptome.

Paul N Bishop; Selina McHarg; Nicole Brace; Alexander W.W. Langford-Smith; Richard Unwin; Rahat Perveen; Graeme C. Black; Anthony Day; Simon John Clark

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3378. doi:

ARVO Annual Meeting Abstract June 2017

Human opticin reduces pathological preretinal neovascularization in the mouse model of oxygen-induced retinopathy.

Izabela Paulina Klaska; Catherine Orr; Anne White; Pilar Villacampa Alcubierre; Laura Abelleira Hervás; Justin Hoke; Catey V Bunce; Richard Unwin; Garth Cooper; Paul N Bishop; James W B Bainbridge

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4063. doi:

ARVO Annual Meeting Abstract September 2016

Efficacy and safety of glycosidic enzymes for improved gene delivery to the retina following intravitreal injection

Jasmina Cehajic Kapetanovic; Nina Milosavljevic; Robert Bedford; Robert J Lucas; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):777. doi:

ARVO Annual Meeting Abstract September 2016

The expression of complement genes by retinal pigment epithelial cells from donors with and without AMD

Selina McHarg; Nicole Brace; Rahat Perveen; Graeme C.M. Black; Richard Unwin; Gregory S Hageman; Anthony John Day; Simon John Clark; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2638. doi:

ARVO Annual Meeting Abstract September 2016

Permeability of Bruch’s membrane to complement proteins: Implications for translational medicine in AMD

Simon John Clark; Selina McHarg; Nicole Brace; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Extracellular matrix in retinal vascular development and pathological angiogenesis

Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Regulation of copper metabolism in the diabetic retina and effects of treatment with the Cu(II) chelator triethylenetetramine (TETA)

Sandra Callagy; Stephanie Church; Nicole Brace; Paul Begley; Natalie Gardiner; Garth Cooper; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5440. doi:

ARVO Annual Meeting Abstract September 2016

Age-related accumulation of metal ions in Bruch’s membrane: implications for AMD

Anthony John Day; Alex Langford-Smith; Viranga Tilakaratna; Larisa Logunova; Paul Lythgoe; Simon John Clark; Paul N Bishop

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6559. doi:

Anatomy and Pathology/Oncology July 2015

Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH -to- F13B

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Tiarnan D. L. Keenan; Marc Toso; Chris Pappas; Lisa Nichols; Paul N. Bishop; Gregory S. Hageman
TAGS: body tissue, chromosomes, human, pair 1, complement activation, homozygote, inflammation, macula densa, macula lutea, proteins, smoking, macule
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4870-4879. doi: https://doi.org/10.1167/iovs.15-17009

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Measuring visual acuity and assessing the efficacy of optogenetic therapy in mice using a voluntary behaviour paradigm

Abigail Pienaar; Jasmina Cehajic Kapetanovic; Katherine E Davis; Paul N Bishop; Robert J Lucas; Lucas Lab

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4252. doi:

ARVO Annual Meeting Abstract June 2015

Restoring vision with ectopic expression of human rod opsin

Jasmina Cehajic Kapetanovic; Annette E Allen; Katherine E Davis; Cyril Giles Eleftheriou; Nina Milosavljevic; Franck P Martial; Paul N Bishop; Robert J Lucas

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4832. doi:

ARVO Annual Meeting Abstract June 2015

Immunohistochemical Assessment of Proteins Associated with Complement Activation and Inflammation in Human Maculas with Homozygous Risk of AMD at Chromosome 1

Tiarnan D L Keenan; Marc Toso; Chris Pappas; Lisa Nichols; Paul N Bishop; Gregory S Hageman

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2351. doi:

Anatomy and Pathology/Oncology August 2014

Age-Dependent Changes in Heparan Sulfate in Human Bruch's Membrane: Implications for Age-Related Macular Degeneration

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Tiarnan D. L. Keenan; Claire E. Pickford; Rebecca J. Holley; Simon J. Clark; Wanchang Lin; Andrew W. Dowsey; Catherine L. Merry; Anthony J. Day; Paul N. Bishop
TAGS: age-related macular degeneration, biological response modifiers, heparitin sulfate, bruch's basal membrane, disaccharides, body tissue, donors
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5370-5379. doi: https://doi.org/10.1167/iovs.14-14126

Includes: Supplemental Content

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Complement expression and immunolocalisation studies of the RPE/choroid complex provide evidence for Bruch’s membrane degradation in early AMD

Proteomic analysis of vitreous humor samples obtained from donors with and without age-related macular degeneration (AMD) reveal an overactivation of complement protein expression.

Genetic risk of AMD at both the CFH and ARMS2/HTRA1 loci is associated with increased protease expression and activity in human Bruch’s membrane/inner choroid.

Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in age-related macular degeneration

Whole genome methylation profiling of retinal pigment epithelium reveals differential methylation and gene expression associated with AMD

Pharmacokinetics of the Anti-angiogenic Glycoprotein Opticin in Preclinical Studies

Enhancing visual responses in retinal degeneration with human melanopsin

Expression of complement and other inflammatory pathway genes is co-ordinated in the human RPE cell transcriptome.

Human opticin reduces pathological preretinal neovascularization in the mouse model of oxygen-induced retinopathy.

Efficacy and safety of glycosidic enzymes for improved gene delivery to the retina following intravitreal injection

The expression of complement genes by retinal pigment epithelial cells from donors with and without AMD

Permeability of Bruch’s membrane to complement proteins: Implications for translational medicine in AMD

Extracellular matrix in retinal vascular development and pathological angiogenesis

Regulation of copper metabolism in the diabetic retina and effects of treatment with the Cu(II) chelator triethylenetetramine (TETA)

Age-related accumulation of metal ions in Bruch’s membrane: implications for AMD

Assessment of Proteins Associated With Complement Activation and Inflammation in Maculae of Human Donors Homozygous Risk at Chromosome 1 CFH -to- F13B

Measuring visual acuity and assessing the efficacy of optogenetic therapy in mice using a voluntary behaviour paradigm

Restoring vision with ectopic expression of human rod opsin

Immunohistochemical Assessment of Proteins Associated with Complement Activation and Inflammation in Human Maculas with Homozygous Risk of AMD at Chromosome 1

Age-Dependent Changes in Heparan Sulfate in Human Bruch's Membrane: Implications for Age-Related Macular Degeneration

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