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Anatomy and Pathology/Oncology December 2024

Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

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María Belen Cancela; Ursula Winter; Santiago Zugbi; Milagros Dinardi; Daniela Alves da Quinta; Rosario Aschero; Daiana Ganiewich; Claudia Sampor; Mariana Sgroi; Eduardo Lagomarsino; Adriana Fandiño; Andrea S. Llera; Guillermo Chantada; Angel M. Carcaboso; Paula Schaiquevich
TAGS: melphalan, retinoblastoma, topotecan, parent, membrane transport proteins, inhibitory concentration 50
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):14. https://doi.org/10.1167/iovs.65.14.14

Includes: Supplemental Content

Retina December 2023

Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments

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Santiago Zugbi; Rosario Aschero; Daiana Ganiewich; María B. Cancela; Ursula Winter; Daniela Ottaviani; Claudia Sampor; Milagros Dinardi; Ana V. Torbidoni; Marcela Mena; Leire Balaguer-Lluna; Gabriela Lamas; Mariana Sgroi; Eduardo Lagomarsino; Fabiana Lubieniecki; Adriana Fandiño; François Radvanyi; David H. Abramson; Osvaldo Podhajcer; Andrea S. Llera; Eduardo G. Cafferata; Guillermo Chantada; Angel M. Carcaboso; Paula Schaiquevich
TAGS: neoplasms, retinoblastoma, transplantation, heterologous, cell lines, genome, neoplasm metastasis, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2023; 64(15):27. https://doi.org/10.1167/iovs.64.15.27

Includes: Supplemental Content

Retina September 2023

Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model

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Flavio Requejo; Javier Opezzo; Alan Vater; Marcelo Asprea; Eduardo Lagomarsino; Claudia Sampor; Adriana Fandiño; Guillermo Chantada; Jasmine H. Francis; David H. Abramson; Paula Schaiquevich
TAGS: intravenous infusion procedures, ophthalmic artery, retinoblastoma, suidae, topotecan, pharmacokinetics, orbit
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):3. https://doi.org/10.1167/iovs.64.12.3

ARVO Annual Meeting Abstract June 2023

IN VITRO EVALUATION OF STRATEGIES TO OVERCOME PHARMACOLOGICAL RESISTANCE IN RETINOBLASTOMA

María Belén Cancela; Santiago Zugbi; Ursula winter; Claudia Sampor; Adriana Fandino; fabiana lubieniecki; Guillermo Chantada; Angel Montero Carcaboso; Paula Schaiquevich

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1260.

ARVO Annual Meeting Abstract June 2023

Orbital exposure of topotecan after ophthalmic artery chemosurgery in pigs: implications in disseminated retinoblastoma.

Paula Schaiquevich; Javier Opezzo; Flavio Requejo; Alan Vater; Marcelo Asprea; Claudia Sampor; Adriana Fandino; Jasmine Francis; David H Abramson; Guillermo Chantada

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1256.

ARVO Annual Meeting Abstract June 2020

Drug repurposing to circumvent pharmacological resistance in retinoblastoma

Paula Schaiquevich; Ursula Winter; Maria Belen Cancela; Santiago Zugbi; Guillem Pascual Pasto; Claudia Sampor; Mariana Sgroi; Adriana Fandiño; Guillermo Chantada; Angel Montero Carcaboso

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2818.

ARVO Annual Meeting Abstract June 2017

Development of a technique for assessment of retinoblastoma cell dissemination after intravitreal injection of chemotherapy

URSULA ANDREA WINTER; Michael Nicolas; Francis L Munier; Mariana Sgroi; Adriana Fandiño; Guillermo Chantada; Paula Schaiquevich

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3333.

ARVO Annual Meeting Abstract September 2016

Ophthalmic artery chemosurgery as a local route for optic nerve delivery of chemotherapy

Paula Schaiquevich; Paula Taich; Flavio Requejo; Marcelo Asprea; Mariana Sgroi; Pierre Gobin; David H Abramson; Guillermo Chantada

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3685.

Physiology and Pharmacology July 2015

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma

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Ursula Winter; Emiliano Buitrago; Hebe A. Mena; Maria José Del Sole; Viviana Laurent; Soledad Negrotto; Jasmine Francis; Eloisa Arana; Mariana Sgroi; Juan O. Croxatto; Hakim Djaballah; Guillermo L. Chantada; David Abramson; Paula Schaiquevich
TAGS: digoxin, retinoblastoma
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4382-4393. https://doi.org/10.1167/iovs.14-16239

ARVO Annual Meeting Abstract June 2015

Safety and efficacy of digoxin as a potential candidate agent for retinoblastoma treatment

URSULA ANDREA WINTER; Emiliano Buitrago; Hebe Mena; Soledad Negrotto; Maria Jose del Sole; Hakim Djaballah; Juan O Croxatto; Guillermo Luis Chantada; David H Abramson; Paula Schaiquevich

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):84.

ARVO Annual Meeting Abstract April 2014

Topotecan pharmacokinetics and safety after super-selective ophthalmic artery infusion concomitant to melphalan in children with retinoblastoma

Paula Juliana Taich; Alejandro Ceciliano; Emiliano Buitrago; Francisco Villasante; Claudia Sampor; Gabriel Mato; Guillermo Luis Chantada; Paula Schaiquevich

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3071.

ARVO Annual Meeting Abstract April 2014

Evaluation of retinal and systemic toxicity of intravitreal Melphalan in rabbits for potential treatment of retinoblastoma.

Emiliano Buitrago; Maria Jose Del Sole; Ursula Winter; Gustavo Zapata; Silvia Eandi; Alejandro Berra; Juan Croxatto; Guillermo Luis Chantada; Paula Schaiquevich; Retinoblastoma

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4893.

Retina June 2012

Pharmacokinetic Analysis of Melphalan after Superselective Ophthalmic Artery Infusion in Preclinical Models and Retinoblastoma Patients

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Paula Schaiquevich; Emiliano Buitrago; Paula Taich; Ana Torbidoni; Alejandro Ceciliano; Adriana Fandino; Marcelo Asprea; Flavio Requejo; David H. Abramson; Guillermo F. Bramuglia; Guillermo L. Chantada
TAGS: melphalan, retinoblastoma, infusion procedures, pharmacokinetics, ophthalmic artery
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):4205-4212. https://doi.org/10.1167/iovs.12-9501

ARVO Annual Meeting Abstract March 2012

Superselective Intra-arterial Chemotherapy For Retinoblastoma Treatment: Comparative Pharmacokinetics Of Topotecan And Melphalan In The Swine Model

Emiliano F. Buitrago; Ana Torbidoni; Adriana Fandino; Marcelo Asprea; Sergio Sierre; Flavio Requejo; David H. Abramson; Guillermo Bramuglia; Guillermo L. Chantada; Paula Schaiquevich

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1880.

ARVO Annual Meeting Abstract March 2012

Clinical Pharmacokinetics Of Melphalan After Super-Selective Ophthalmic Artery Infusion In Children With Retinoblastoma

Paula J. Taich; Emiliano Buitrago; Andres Porta; Alejandro Ceciliano; Adriana Fandiño; Claudia Sampor; Guillermo Chantada; Paula Schaiquevich

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1881.

ARVO Annual Meeting Abstract March 2012

Effect Of Melatonin On Prednisolone Eye Disposition In Cats

Maria J. Del Sole; Paula Schaiquevich; Marcelo A. Aba; Carlos E. Lanusse; Laura Moreno

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):462.

ARVO Annual Meeting Abstract April 2011

Topotecan Pharmacokinetics After Superselective Ophthalmic Artery Infusion And Periocular Administration In The Pig

Paula Schaiquevich; Emiliano Buitrago; Alejandro Ceciliano; Adriana Fandino; Marcelo Asprea; Sergio Sierre; David H. Abramson; Guillermo Bramuglia; Guillermo L. Chantada

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3260.

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Mimicking Retinoblastoma Treatment With Repeated Topotecan or Melphalan Develops Cross-Resistance to Classic Agents But Not to Repurposed Drugs

Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments

Pharmacokinetics of Orbital Topotecan After Ophthalmic Artery Chemosurgery and Intravenous Infusion in the Swine Model

IN VITRO EVALUATION OF STRATEGIES TO OVERCOME PHARMACOLOGICAL RESISTANCE IN RETINOBLASTOMA

Orbital exposure of topotecan after ophthalmic artery chemosurgery in pigs: implications in disseminated retinoblastoma.

Drug repurposing to circumvent pharmacological resistance in retinoblastoma

Development of a technique for assessment of retinoblastoma cell dissemination after intravitreal injection of chemotherapy

Ophthalmic artery chemosurgery as a local route for optic nerve delivery of chemotherapy

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma

Safety and efficacy of digoxin as a potential candidate agent for retinoblastoma treatment

Topotecan pharmacokinetics and safety after super-selective ophthalmic artery infusion concomitant to melphalan in children with retinoblastoma

Evaluation of retinal and systemic toxicity of intravitreal Melphalan in rabbits for potential treatment of retinoblastoma.

Pharmacokinetic Analysis of Melphalan after Superselective Ophthalmic Artery Infusion in Preclinical Models and Retinoblastoma Patients

Superselective Intra-arterial Chemotherapy For Retinoblastoma Treatment: Comparative Pharmacokinetics Of Topotecan And Melphalan In The Swine Model

Clinical Pharmacokinetics Of Melphalan After Super-Selective Ophthalmic Artery Infusion In Children With Retinoblastoma

Effect Of Melatonin On Prednisolone Eye Disposition In Cats

Topotecan Pharmacokinetics After Superselective Ophthalmic Artery Infusion And Periocular Administration In The Pig

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