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ARVO Annual Meeting Abstract July 2019

Target 5000: Target Capture Genotyping of Retinal Degenerations in Ireland

Adrian Dockery; Niamh C Wynne; Kirk Stephenson; Laura Whelan; Peter Humphries; Giuliana Silvestri; Matthew Carrigan; David J Keegan; Paul F Kenna; G. Jane Farrar

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2812. doi:

ARVO Annual Meeting Abstract July 2018

Variability in therapeutic outcome due to age of P23H rhodopsin mice at time of dosing can be reduced by enhanced retinal drug delivery.

Anna-Sophia Kiang; Paul Kenna; Marian M Humphries; Anh Nguyen; James Keaney; Jane G Farrar; Matthew Campbell; Peter Humphries

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1013. doi:

ARVO Annual Meeting Abstract July 2018

Exploration of Mitochondrially Targeted Gene Therapies

Daniel Manraj Maloney; Matthew Carrigan; Naomi Chadderton; Sophia Millington-Ward; Arpad Palfi; Peter Humphries; Jane G Farrar

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4539. doi:

ARVO Annual Meeting Abstract July 2018

INDUCIBLE MMP-3 EXPRESSION IN A STEROID-INDUCED MURINE MODEL OF GLAUCOMA

Jeffrey O'Callaghan; Paul S. Cassidy; Ester Reina-Torres; Joseph Sherwood; Marian M Humphries; Matthew Campbell; Colm J O'Brien; Elke Lütjen-Drecoll; W Daniel Stamer; Darryl R Overby; Peter Humphries

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3505. doi:

ARVO Annual Meeting Abstract June 2017

Target 5000: Genetic characterisation of a cohort of inherited retinal degeneration (IRD) patients

Adrian Dockery; Matthew Carrigan; Conor Patrick Malone; Emma Duignan; David J Keegan; Kirk Stephenson; Giuliana Silvestri; Andrew Green; John McCourt; Peter Humphries; Paul F Kenna; Jane G Farrar

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2752. doi:

ARVO Annual Meeting Abstract September 2016

AAV-mediated MMP3 expression from corneal endothelium as a targeted gene therapy approach for glaucoma

Jeffrey O'Callaghan; Darragh Crosbie; Paul Cassidy; Marian M Humphries; Anna-Sophia Kiang; Joseph M. Sherwood; Darryl R. Overby; W Daniel Stamer; Lawrence Tam; Peter Humphries

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):793. doi:

ARVO Annual Meeting Abstract September 2016

Target 5000: Next-Generation Sequencing of the Irish Inherited Retinal Degeneration Population

Matthew Carrigan; Emma Duignan; Conor Patrick Malone; Kirk Stephenson; David J Keegan; Peter Humphries; Paul Kenna; G Jane Farrar

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Slowing and prevention of vision loss in Retinitis Pigmentosa of the 'Protein Logistics Disease' type

Mathias W Seeliger; Susanne C Beck; Marina Garcia Garrido; Vithiyanjali Sothilingam; Regine Muehlfriedel; Marijana Samardzija; Christian Grimm; Peter Humphries; G Jane Farrar; Peter Carmeliet; Naoyuki Tanimoto

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2735. doi:

ARVO Annual Meeting Abstract September 2016

Assessment of age-related eye morphology and aqueous humor flow dynamics in the DBA/2J mouse model of pigmentary glaucoma using ocular MRI and anterior chamber iPerfusion systems.

Darragh Crosbie; James Keaney; Joseph M. Sherwood; Darryl R. Overby; W Daniel Stamer; Lawrence Tam; Peter Humphries

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5145. doi:

Letters to the Editor December 2015

Author Response: The Role of IL-18 in the Treatment of AMD

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Sarah L. Doyle; Francisco J. López; Peter Humphries; Peter Adamson; Matthew Campbell
TAGS: interleukin-18
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8237-8238. doi: 10.1167/iovs.15-18714

Biochemistry and Molecular Biology August 2015

IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates

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Sarah L. Doyle; Francisco J. López; Lucia Celkova; Kiva Brennan; Kelly Mulfaul; Ema Ozaki; Paul F. Kenna; Edit Kurali; Natalie Hudson; Teresa Doggett; Thomas A. Ferguson; Peter Humphries; Peter Adamson; Matthew Campbell
TAGS: immunotherapy, interleukin-18, primates, exudative age-related macular degeneration
Invest. Ophthalmol. Vis. Sci.. 2015; 56(9):5424-5430. doi: 10.1167/iovs.15-17264

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

IL-18 immunotherapy for neovascular AMD; Tolerability and efficacy in non-human primates

Matthew Campbell; Peter S Adamson; Francisco J Lopez; Edit Kurali; Peter Humphries; Sarah Doyle

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4803. doi:

ARVO Annual Meeting Abstract June 2015

IL-18 promotes wound healing and has anti-angiogenic properties in the eye

Sarah Doyle; Peter S Adamson; Francisco J Lopez; Peter Humphries; Matthew Campbell

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2462. doi:

Letters to the Editor December 2014

Interleukin-18 Bioactivity and Dose: Data Interpretation at a Crossroads

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Sarah L. Doyle; Peter Adamson; Francisco J. López; Peter Humphries; Matthew Campbell
TAGS: interleukin-18, interpretation of findings
Invest. Ophthalmol. Vis. Sci.. 2014; 55(12):8349-8350. doi: 10.1167/iovs.14-15786

ARVO Annual Meeting Abstract April 2014

NLRP3 independent mechanisms of RPE cell death

Matthew Campbell; Ema Ozaki; Marian M Humphries; Peter S Adamson; Peter Humphries; Sarah L Doyle

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1318. doi:

ARVO Annual Meeting Abstract June 2013

Contributions of Non-Visual Sensory Signals to the Murine Flash ERG

Naoyuki Tanimoto; Vithiyanjali Sothilingam; Gabriele Gloeckner; Elizabeth Bryda; Peter Humphries; Martin Biel; Mathias Seeliger

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):6126. doi:

ARVO Annual Meeting Abstract March 2012

Flicker ERG Frequency Series at the ISCEV Standard Flash Intensity in Mice

Naoyuki Tanimoto; Vithiyanjali Sothilingam; Peter Humphries; Shigetada Nakanishi; Martin Biel; Mathias W. Seeliger

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2463. doi:

ARVO Annual Meeting Abstract March 2012

AAV Mediated Systemic Low Molecular Weight Drug Delivery To The Retina

Matthew Campbell; Marian M. Humphries; Anna-Sophia Kiang; Anh T. Nguyen; Paul F. Kenna; Peter Humphries

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4162. doi:

ARVO Annual Meeting Abstract April 2011

Detection Of A Dominant-acting Mutation In RPE65 Using Whole-genome Linkage Mapping And Whole-exome Sequencing

Lori S. Sullivan; Sara J. Bowne; Marian M. Humphries; Paul F. Kenna; George M. Weinstock; Daniel C. Koboldt; Susan H. Blanton; Peter Humphries; Stephen P. Daiger

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5403. doi:

ARVO Annual Meeting Abstract April 2011

ADRP With Choroidal Involvement Associated With Asp477gly Mutation Within The Rpe65 Gene

Peter Humphries; Paul F. Kenna; Lawrence C. Tam; Sara J. Bowne; Lori S. Sullivan; George Weinstock; Susan H. Blanton; Jane G. Farrar; Stephen P. Daiger; Marian M. Humphries

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5408. doi:

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Target 5000: Target Capture Genotyping of Retinal Degenerations in Ireland

Variability in therapeutic outcome due to age of P23H rhodopsin mice at time of dosing can be reduced by enhanced retinal drug delivery.

Exploration of Mitochondrially Targeted Gene Therapies

INDUCIBLE MMP-3 EXPRESSION IN A STEROID-INDUCED MURINE MODEL OF GLAUCOMA

Target 5000: Genetic characterisation of a cohort of inherited retinal degeneration (IRD) patients

AAV-mediated MMP3 expression from corneal endothelium as a targeted gene therapy approach for glaucoma

Target 5000: Next-Generation Sequencing of the Irish Inherited Retinal Degeneration Population

Slowing and prevention of vision loss in Retinitis Pigmentosa of the 'Protein Logistics Disease' type

Assessment of age-related eye morphology and aqueous humor flow dynamics in the DBA/2J mouse model of pigmentary glaucoma using ocular MRI and anterior chamber iPerfusion systems.

Author Response: The Role of IL-18 in the Treatment of AMD

IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates

IL-18 immunotherapy for neovascular AMD; Tolerability and efficacy in non-human primates

IL-18 promotes wound healing and has anti-angiogenic properties in the eye

Interleukin-18 Bioactivity and Dose: Data Interpretation at a Crossroads

NLRP3 independent mechanisms of RPE cell death

Contributions of Non-Visual Sensory Signals to the Murine Flash ERG

Flicker ERG Frequency Series at the ISCEV Standard Flash Intensity in Mice

AAV Mediated Systemic Low Molecular Weight Drug Delivery To The Retina

Detection Of A Dominant-acting Mutation In RPE65 Using Whole-genome Linkage Mapping And Whole-exome Sequencing

ADRP With Choroidal Involvement Associated With Asp477gly Mutation Within The Rpe65 Gene

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