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Biochemistry and Molecular Biology February 2019

DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

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Guangying Luo; Xia Jing; Shuai Yang; Dewei Peng; Jing Dong; Li Li; Peter S. Reinach; Dongsheng Yan
TAGS: epithelium, dna, dna methylation, wound healing, wounds and injuries, cornea, hypermethylation, dna (cytosine-5-)-methyltransferase 1, cdkn2b gene, rna, small interfering, methylation
Invest. Ophthalmol. Vis. Sci.. 2019; 60(2):650-660. doi: 10.1167/iovs.18-25443

Includes: Supplemental Content

Biochemistry and Molecular Biology December 2018

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

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Miaozhen Pan; Shiming Jiao; Peter S. Reinach; Jiaofeng Yan; Yanan Yang; Qihang Li; Nethrajeith Srinivasalu; Jia Qu; Xiangtian Zhou
TAGS: bezafibrate, caviidae, injections, myopia, apolipoprotein a-ii, eye, ppar alpha
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):5803-5815. doi: 10.1167/iovs.17-22297

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2018

SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14

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Yong Lin; Li Li; Junjie Liu; Xiaoting Zhao; Juxiu Ye; Peter S. Reinach; Jia Qu; Dongsheng Yan
TAGS: angiogenesis, vascular endothelial growth factor a, western blotting, endothelial cells, vascular endothelial growth factor receptor-2, down-regulation, mice, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5431-5440. doi: 10.1167/iovs.17-23558

Includes: Supplemental Content

Cornea November 2018

Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

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Liying Tang; Xue Wang; Jieli Wu; San Ming Li; Zhaoqiang Zhang; Sangang Wu; Ting Su; Zhirong Lin; Xueting Chen; Xulin Liao; Ting Bai; Yan Qiu; Peter Sol Reinach; Wei Li; Yongxiong Chen; Zuguo Liu
TAGS: dry eye syndromes, corneal epithelium, microvilli, sleep deprivation, cornea, lipids, mice, sleep, morphology, ppar alpha, language morphology
Invest. Ophthalmol. Vis. Sci.. 2018; 59(13):5494-5508. doi: 10.1167/iovs.18-24504

Biochemistry and Molecular Biology September 2018

Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs

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Sen Zhang; Jinglei Yang; Peter S. Reinach; Fengjiao Wang; Lishuai Zhang; Miaomiao Fan; Huangfang Ying; Miaozhen Pan; Jia Qu; Xiangtian Zhou
TAGS: 3,4-dihydroxyphenylacetic acid, caviidae, myopia, quinpirole, dopamine receptors, refractive errors, sk&f-38393, sulpiride, eye
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4441-4448. doi: 10.1167/iovs.17-21574

Includes: Supplemental Content

Biochemistry and Molecular Biology August 2018

Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis

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Nethrajeith Srinivasalu; Chanyi Lu; Miaozhen Pan; Peter Sol Reinach; Yingying Wen; Yang Hu; Jia Qu; Xiangtian Zhou
TAGS: gene expression, collagen, genes, caviidae, myopia, cyclic amp, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):4318-4325. doi: 10.1167/iovs.17-224685

Includes: Supplemental Content

Cornea July 2018

Corneal Collagen Cross-Linking With Riboflavin and UVA Regulates Hemangiogenesis and Lymphangiogenesis in Rats

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Yirui Zhu; Ling Li; Peter S. Reinach; Yun Li; Chaoxiang Ge; Jia Qu; Wei Chen
TAGS: cornea, rats, riboflavin, corneal collagen cross-linking, sutures, ultraviolet a radiation, lymphangiogenesis
Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3702-3712. doi: 10.1167/iovs.17-23036

ARVO Annual Meeting Abstract July 2018

Genome-wide Maps of Histone Modifications in the Human Retina

Weiwei Chen; Xiaoyan Chen; Shuai Yang; Peter S Reinach; Dongsheng Yan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5385. doi:

ARVO Annual Meeting Abstract July 2018

Fibroblast growth factor 2 (FGF-2) and epidermal growth factor (EGF) activate transient receptor potential vanilloid channel 1 (TRPV1) and 4 (TRPV4) in human corneal endothelial cells

Nina Ljubojevic; Margarita Pushina; Jana Loeffler; Christoforos Dimitropoulos; Christin Kupper; Peter Sol Reinach; Stefan Mergler; Monika Valtink

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1366. doi:

ARVO Annual Meeting Abstract July 2018

Sex influences TRPV1 driven lacrimal functional unit inflammation and corneal wound healing

Eduardo M Rocha; Lara Cristina Dias; Lilian Eslaine Silva; Ana Carolina Dias; Carolina Modulo; Adriana Andrade Murashima; Marina Zilio Fantucci; Cintia S De Paiva; Peter Sol Reinach

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4420. doi:

Cornea July 2018

Hyperosmotic Stress–Induced TRPM2 Channel Activation Stimulates NLRP3 Inflammasome Activity in Primary Human Corneal Epithelial Cells

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Qinxiang Zheng; Qiufan Tan; Yueping Ren; Peter S. Reinach; Ling Li; Chaoxiang Ge; Jia Qu; Wei Chen

Invest. Ophthalmol. Vis. Sci.. 2018; 59(8):3259-3268. doi: 10.1167/iovs.18-23965

Genetics December 2017

The Long Noncoding RNA Landscape of the Mouse Eye

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Weiwei Chen; Shuai Yang; Zhonglou Zhou; Xiaoting Zhao; Jiayun Zhong; Peter S. Reinach; Dongsheng Yan
TAGS: genes, rna, untranslated, body tissue, eye, mice, proteins
Invest. Ophthalmol. Vis. Sci.. 2017; 58(14):6308-6317. doi: 10.1167/iovs.17-22178

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Sleep Deprivation Compromises Lacrimal System and Homeostasis of the Ocular Surface

Wei Li; Sanming Li; Ke Ning; Jing Zhou; Yuli Guo; Houjian Zhang; Yu Zhu; Liying Zhang; Changkai Jia; Yongxiong Chen; Peter S Reinach; ZUGUO LIU

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):475. doi:

ARVO Annual Meeting Abstract June 2017

Endothelial-specific SIRT1 Deletion Inhibits Retinal Vascular Endothelial Cell Migration

Yong Lin; Junjie Liu; Li Li; JUxiu Ye; Peter S. Reinach; Jia Qu; Dongsheng Yan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3655. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology April 2017

Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina

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Si Chen; Zhina Zhi; Qingqing Ruan; Qingxia Liu; Fen Li; Fen Wan; Peter S. Reinach; Jiangfan Chen; Jia Qu; Xiangtian Zhou
TAGS: acute coronary syndromes, signal transduction, american cancer society, myopia, dopamine d1 receptor, retina, abdominal compartment syndrome, antagonists, biopharmaceutics classification system, american college of surgeons
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2306-2316. doi: 10.1167/iovs.16-20402

Immunology and Microbiology January 2017

Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing

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Haikun Zhang; Fuxin Zhao; Diane S. Hutchinson; Wenfeng Sun; Nadim J. Ajami; Shujuan Lai; Matthew C. Wong; Joseph F. Petrosino; Jianhuo Fang; Jun Jiang; Wei Chen; Peter S. Reinach; Jia Qu; Changqing Zeng; Dake Zhang; Xiangtian Zhou
TAGS: contact lenses, contact lenses, hydrophilic, genes, rna, ribosomal, 16s, conjunctiva, microbiome, orthokeratology contact lenses
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):128-136. doi: 10.1167/iovs.16-20231

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Effects of loss of TRPV4 function on corneal epithelial wound healing in mice.

Yuka Okada; Peter S Reinach; Masayasu Miyajima; Shizuya Saika

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1253. doi:

Anatomy and Pathology/Oncology May 2016

Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca 2+ Influx Dysfunction in Human Pterygial Cells

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Fabian Garreis; Antje Schröder; Peter S. Reinach; Stefanie Zoll; Noushafarin Khajavi; Priyavathi Dhandapani; Alexander Lucius; Uwe Pleyer; Friedrich Paulsen; Stefan Mergler
TAGS: vascular endothelial growth factor a, reverse transcriptase polymerase chain reaction, up-regulation (physiology), pterygium, pathophysiology, trpv1 receptor
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2564-2577. doi: 10.1167/iovs.16-19170

ARVO Annual Meeting Abstract June 2015

Bioinformatic Analyses of Signaling Pathway Networks and miRNA Expression Profile Changes Contributing to Corneal Epithelial Wound Healing

Dongsheng Yan; Xiaoyan Chen; Weiwei Chen; Peter S Reinach; Lili Tu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):701. doi:

ARVO Annual Meeting Abstract June 2015

Impairment of cornea epithelium wound healing in a TRPA1-deficient mouse

Yuka Okada; Kumi Shirai; Peter S Reinach; Masayasu Miyajima; Shizuya Saika

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):703. doi:

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DNA Methylation Regulates Corneal Epithelial Wound Healing by Targeting miR-200a and CDKN2B

Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs

SIRT1 Deletion Impairs Retinal Endothelial Cell Migration Through Downregulation of VEGF-A/VEGFR-2 and MMP14

Sleep Deprivation Induces Dry Eye Through Inhibition of PPARα Expression in Corneal Epithelium

Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs

Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis

Corneal Collagen Cross-Linking With Riboflavin and UVA Regulates Hemangiogenesis and Lymphangiogenesis in Rats

Genome-wide Maps of Histone Modifications in the Human Retina

Fibroblast growth factor 2 (FGF-2) and epidermal growth factor (EGF) activate transient receptor potential vanilloid channel 1 (TRPV1) and 4 (TRPV4) in human corneal endothelial cells

Sex influences TRPV1 driven lacrimal functional unit inflammation and corneal wound healing

Hyperosmotic Stress–Induced TRPM2 Channel Activation Stimulates NLRP3 Inflammasome Activity in Primary Human Corneal Epithelial Cells

The Long Noncoding RNA Landscape of the Mouse Eye

Sleep Deprivation Compromises Lacrimal System and Homeostasis of the Ocular Surface

Endothelial-specific SIRT1 Deletion Inhibits Retinal Vascular Endothelial Cell Migration

Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina

Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing

Effects of loss of TRPV4 function on corneal epithelial wound healing in mice.

Upregulation of Transient Receptor Potential Vanilloid Type-1 Channel Activity and Ca 2+ Influx Dysfunction in Human Pterygial Cells

Bioinformatic Analyses of Signaling Pathway Networks and miRNA Expression Profile Changes Contributing to Corneal Epithelial Wound Healing

Impairment of cornea epithelium wound healing in a TRPA1-deficient mouse

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