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Clinical and Epidemiologic Research February 2021

Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort

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Karina Patasova; Anthony P. Khawaja; Bani Tamraz; Katie M. Williams; Omar A. Mahroo; Maxim Freidin; Ameenat L. Solebo; Jelle Vehof; Mario Falchi; Jugnoo S. Rahi; Chris J. Hammond; Pirro G. Hysi
TAGS: cohort studies, pharmaceutical preparations, refraction, refractive errors, drug usage, protein electrophoresis, serum
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):15. doi: https://doi.org/10.1167/iovs.62.2.15

Includes: Supplemental Content

Genetics September 2020

The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects

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Mark J. Simcoe; Anthony P. Khawaja; Omar A. Mahroo; Christopher J. Hammond; Pirro G. Hysi; for the UK Biobank Eye and Vision Consortium
TAGS: intraocular pressure, open-angle glaucoma, x chromosomes, single nucleotide polymorphism, biobanks, cohort studies
Invest. Ophthalmol. Vis. Sci.. 2020; 61(11):20. doi: https://doi.org/10.1167/iovs.61.11.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

A multiomics investigation of risk factors associated with intraocular pressure in the general population

Pirro G Hysi; Anthony P Khawaja; Christopher Hammond

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):979. doi:

ARVO Annual Meeting Abstract June 2020

Iris reflectance measurements in >1000 healthy adult twins: exploration of heritability and associations with eye color

Andrea Kimberly Uy; Xiaofan Jiang; Alex Tanner; Mark Simcoe; Diana Kozareva; Katie Williams; Pirro G Hysi; Christopher Hammond; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1866. doi:

ARVO Annual Meeting Abstract June 2020

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

Janey Wiggs; Puya Gharahkhani; Eric Jorgenson; Pirro G Hysi; Anthony Khawaja; Sarah Pendergrass; Xikun Han; David Mackey; Christopher Hammond; Michael A Hauser; Louis R Pasquale; Caroline Klaver; Michiaki Kubo; Tin Aung; Jamie E Craig; Stuart MacGregor

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1890. doi:

ARVO Annual Meeting Abstract June 2020

Evidence for a causal link between pseudoexfoliation syndrome and myocardial infarction using Mendelian randomization

Marianne T Kennedy Neary; Oliver J Kennedy; George Davey Smith; Pirro G Hysi; Louis R Pasquale; Janey Wiggs; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2738. doi:

ARVO Annual Meeting Abstract June 2020

Calcium Channel Blocker Use and Risk of Glaucoma in a Large United Kingdom Population

Alan Kastner; Giovanni Montesano; C Gustavo De Moraes; Jae H. Kang; Janey Wiggs; Louis Pasquale; Pirro G Hysi; Sharon Chua; Praveen J Patel; Paul J Foster; Sir Peng T. Khaw; Anthony Khawaja

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2739. doi:

ARVO Annual Meeting Abstract June 2020

Phenome-wide association analysis on risk variants for age-related macular degeneration reveals shared genetic influences with a wide range of disorders: the Million Veteran Program

Robert Igo; Tyler G Kinzy; Christopher W. Halladay; Dana C. Crawford; Paul B Greenberg; Jack M. Sullivan; Steven J. Fliesler; Wen-Chih Wu; Helene Choquet; Karina Patasova; Eric Jorgenson; Pirro G Hysi; Andrew J Lotery; Jessica Cooke Bailey; Neal S. Peachey; Sudha K Iyengar

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3518. doi:

ARVO Annual Meeting Abstract June 2020

Diminished light adaptation effect seen in cone-driven responses in GRK1 -associated Oguchi disease: evidence for possible rod input to cone adaptation pathways

ZIHE XU; Xiaofan Jiang; James Bellingham; Zakariya Jarrar; Christopher Hammond; Andrew R. Webster; Nigel Davies; Moin Mohamed; Gavin Arno; Pirro G Hysi; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5052. doi:

ARVO Annual Meeting Abstract July 2019

The relationship between refractive error, intraocular pressure, and glaucoma in the UK Biobank.

Robert Wojciechowski; Pirro G Hysi; Peizi Li

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5222. doi:

ARVO Annual Meeting Abstract July 2019

Gene-drug interactions alter response to prostaglandin analogue treatment of high intraocular pressure and glaucoma

Pirro G Hysi; Mark James Simcoe; Anthony P Khawaja; Christopher J Hammond

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5223. doi:

ARVO Annual Meeting Abstract July 2019

Effect of the age of myopia onset, environmental factors and genetic risk on myopia in the CREAM Consortium

Katie Williams; Pirro G Hysi; Sonoko Sensaki; Willem Tideman; Seyhan Yazar; juho wedenoja; Mingguang He; Olavi Parssinen; David A Mackey; Caroline C W Klaver; Christopher J Hammond; Seang-Mei Saw

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5226. doi:

ARVO Annual Meeting Abstract July 2019

GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology of ocular disease

Mark James Simcoe; Anthony P Khawaja; Christopher J Hammond; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5227. doi:

ARVO Annual Meeting Abstract July 2019

The use of analgesics associated with refractive error shift toward hypermetropia

Karina Patasova; Pirro G Hysi; Christopher J Hammond; Robert Wojciechowski

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5844. doi:

ARVO Annual Meeting Abstract July 2019

The incidence of negative electroretinograms in a healthy adult cohort

Talib Dar; Isabelle Chow; Xiaofan Jiang; Taha Bhatti; Ambreen Tariq; Katie Williams; Pirro G Hysi; Christopher J Hammond; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2497. doi:

ARVO Annual Meeting Abstract July 2019

Genome-wide association study of macular ganglion cell complex thickness in 41,504 participants of the UK Biobank study

Hannah Currant; Tomas Fitzgerald; Pirro G Hysi; Charles A Reisman; Qi Yang; Christopher J Hammond; Peng Tee Khaw; Paul J Foster; Praveen Patel; Ewan Birney; Anthony P Khawaja

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2830. doi:

ARVO Annual Meeting Abstract July 2019

Genome-wide association study on a large multi-ethnic sample identifies new genetic loci that predispose to keratoconus

Alison J Hardcastle; Pirro G Hysi; Karla Rojas-Lopez; Petra Liskova; Alice E Davidson; Manir Ali; Kathryn P Burdon; David O'Brart; Chris Inglehearn; Paul N Baird; Christopher J Hammond; Stephen J Tuft

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4249. doi:

ARVO Annual Meeting Abstract July 2019

Integrative analysis of GWAS and eQTLs proposes new genetic associations and causal genes for Primary Open Angle Glaucoma

Ayellet Segre; Andrew Hamel; John Rouhana; Anthony P Khawaja; Mark James Simcoe; Christopher J Hammond; Pirro G Hysi; GTEx consortium; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4252. doi:

ARVO Annual Meeting Abstract July 2018

A GWAS investigation of dry eye disease in two European populations

Jelle Vehof; Christopher J Hammond; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1962. doi:

ARVO Annual Meeting Abstract July 2018

RNA toxicity induced by TCF4 CTG expansions is ameliorated by antisense therapeutics in a patient-derived cell model of Fuchs corneal endothelial dystrophy (FECD).

Alice E Davidson; Christina Zarouchlioti; Beatriz Sanchez-Pintado; Nathaniel Hafford Tear; Pontus Klein; Petra Liskova; Kalyan Dulla; Kirithika Muthusamy; Lubica Dudakova; Pavlina Skalicka; Pirro G Hysi; Michael E. Cheetham; Stephen J. Tuft; Peter S Adamson; Alison J Hardcastle

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3022. doi:

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Association Between Medication-Taking and Refractive Error in a Large General Population-Based Cohort

The Role of Chromosome X in Intraocular Pressure Variation and Sex-Specific Effects

A multiomics investigation of risk factors associated with intraocular pressure in the general population

Iris reflectance measurements in >1000 healthy adult twins: exploration of heritability and associations with eye color

A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma, and shows a genetic link to Alzheimer’s disease.

Evidence for a causal link between pseudoexfoliation syndrome and myocardial infarction using Mendelian randomization

Calcium Channel Blocker Use and Risk of Glaucoma in a Large United Kingdom Population

Phenome-wide association analysis on risk variants for age-related macular degeneration reveals shared genetic influences with a wide range of disorders: the Million Veteran Program

Diminished light adaptation effect seen in cone-driven responses in GRK1 -associated Oguchi disease: evidence for possible rod input to cone adaptation pathways

The relationship between refractive error, intraocular pressure, and glaucoma in the UK Biobank.

Gene-drug interactions alter response to prostaglandin analogue treatment of high intraocular pressure and glaucoma

Effect of the age of myopia onset, environmental factors and genetic risk on myopia in the CREAM Consortium

GWAS of corneal biomechanics identifies over 200 novel associated loci providing additional insight into the genetic aetiology of ocular disease

The use of analgesics associated with refractive error shift toward hypermetropia

The incidence of negative electroretinograms in a healthy adult cohort

Genome-wide association study of macular ganglion cell complex thickness in 41,504 participants of the UK Biobank study

Genome-wide association study on a large multi-ethnic sample identifies new genetic loci that predispose to keratoconus

Integrative analysis of GWAS and eQTLs proposes new genetic associations and causal genes for Primary Open Angle Glaucoma

A GWAS investigation of dry eye disease in two European populations

RNA toxicity induced by TCF4 CTG expansions is ameliorated by antisense therapeutics in a patient-derived cell model of Fuchs corneal endothelial dystrophy (FECD).

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