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Cornea February 2025

Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

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Ramaraj Kannan; Rohit Shetty; Trailokyanath Panigrahi; Siew Kwan Koh; Pooja Khamar; Vrushali Deshpande; Rudy M. M. A. Nuijts; Marlies Gijs; Krishnatej Nishtala; Lei Zhou; Arkasubhra Ghosh
TAGS: proteins, cohort studies, keratoconus, proteomics, signal transduction, metabolism
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):60. https://doi.org/10.1167/iovs.66.2.60

Includes: Supplemental Content

Cornea January 2025

Distinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation

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Nimisha Rajiv Kumar; Pooja Khamar; Ramaraj Kannan; Archana Padmanabhan; Rohit Shetty; Sharon D'Souza; Tanuja Vaidya; Swaminathan Sethu; Arkasubhra Ghosh
TAGS: immune dysregulation, keratoconus, microbiome, ocular surfaces
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):60. https://doi.org/10.1167/iovs.66.1.60

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Paraoxonase 2 (PON2) deficiency leads to RPE mitochondrial dysfunction and retinal degeneration.

Parameswaran G Sreekumar; Feng Su; Elise Hong; James T Handa; Deborah A Ferrington; Srinivasa T Reddy; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2557.

ARVO Annual Meeting Abstract June 2024

Proteomic analysis of urinary biomarkers in low and high-risk diabetic retinopathy patients

Dean P Hainsworth; Varsha Srinivasan; Abilash Gangula; Raghuraman Kannan; Anandhi Upendran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3217.

ARVO Annual Meeting Abstract June 2024

Mechanism of age-dependent senescence development in Tnfrsf10 knock out mice.

Iori Wada; Kenichiro Mori; Parameswaran G Sreekumar; Christine Spee; Elise Hong; Keijiro Ishikawa; Koh-Hei Sonoda; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6044.

ARVO Annual Meeting Abstract June 2024

Mechanism of αB-Crystallin Elastin-like Polypeptide conjugates protection against tunicamycin-induced ER stress in ARPE-19 cells

Sara Aly Attia; Parameswaran G Sreekumar; Ram Kannan; J. Andrew MacKay

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5098.

ARVO Annual Meeting Abstract June 2024

Ultralocal subretinal immunosuppressive nanoparticles to abrogate graft rejection in retinal cell therapy

Kang Li; Ying Liu; Wathsala Liyanage; Anjali Sharma; Bani Antonio-Aguirre; Yuchen Lu; Zhuolin Li; Krystal Yearis; Kenneth Jimenez; Boaz Goldberg; Sally Li; Annabelle Pan; Minda Mcnally; Kannan Rangaramanujam; Mandeep S Singh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):709.

ARVO Annual Meeting Abstract June 2024

Innovative in situ Formed HA-Dendrimer Cornea Substitute for Anterior Lamellar Keratoplasty

Samuel C Yiu; Minjie Chen; Anjali Sharma; Wathsala Liyanage; Xianni Simmons; Ryan Chow; Carson Yu; Siva Kambhampati; Kannan Rangaramanujam

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4470.

ARVO Annual Meeting Abstract June 2023

Characterization and contribution of RPE senescence to AMD in Tnfrsf10 knock out mice

Iori Wada; Kenichiro Mori; Parameswaran G Sreekumar; Christine Spee; Elise Hong; Keijiro Ishikawa; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5384.

ARVO Annual Meeting Abstract June 2023

ELP-fused mitochondrial peptide Humanin protects the retina and RPE from cigarette smoke-induced oxidative stress

Parameswaran G Sreekumar; Iori Wada; Christine Spee; Andrew J MacKay; Deborah A Ferrington; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2984.

ARVO Annual Meeting Abstract June 2023

Suppression of subretinal neovascularization in Vldlr knockout mice by systemic administration of a targeted VEGF-receptor inhibitor

Shirley Wu; Zhenhua Xu; Tony Wu; Lijuan Wu; Hongkwan Cho; Rangaramanujam Kannan; Elia J Duh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3900.

ARVO Annual Meeting Abstract June 2023

Untargeted metabolomics identifies Myristoleolyl Carnitine as a tear based detector for bacterial endophthalmitis

Vrushali Deshpande; Naren Shetty; Samayitree Das; Ramaraj Kannan; Priyanka Sathe; Padmamalini Mahendradas; ROHIT SHETTY; Arkasubhra Ghosh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4419.

ARVO Annual Meeting Abstract June 2022

Novel genes and variants associated with inflammation identified in Keratoconus families

Ramaraj Kannan; Rohit Shetty; Pooja Khamar; Arkasubhra Ghosh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):507 – A0084.

ARVO Annual Meeting Abstract June 2022

Regulation of LDLR in hRPE and loss of retinal function in Ldlr -/- mice exposed to NaIO3

Parameswaran Gangadharan Sreekumar; Feng Su; Christine Spee; Eduardo Araujo; Steven Nusinowitz; Srinivasa T Reddy; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1956 – F0374.

ARVO Annual Meeting Abstract June 2022

Identification and Validation of Biomarkers for Early Detection of Diabetic Retinopathy

Varsha Srinivasan; Abilash Gangula; Dean P Hainsworth; Raghuraman Kannan; Anandhi Upendran

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2191 – F0254.

ARVO Annual Meeting Abstract June 2022

Signal Mechanisms of EMT and role of αB Crystallin Chaperone Peptide in the prevention of experimental PVR

Iori Wada; Parameswaran Gangadharan Sreekumar; Christine Spee; Michael S Ip; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3455 – F0355.

ARVO Annual Meeting Abstract June 2021

Dendrimer-targeted immunosuppression of microglia reactivity super-accelerates photoreceptor regeneration kinetics in the zebrafish retina

Kevin Emmerich; David T White; Siva P Kambhampati; Grace Y Lee; Tian-Ming Fu; Arpan Sahoo; Meera T Saxena; Eric Betzig; Rangaramanujam M Kannan; Jeff S Mumm

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2243.

ARVO Annual Meeting Abstract June 2021

Dendrimer-based nanoparticles for early detection and therapeutic targeting of microglia in a rat glaucoma model

Ian F Pitha; Siva Kambhampati; anjali sharma; Rishi Sharma; Liam McCrea; Kannan Rangaramanujam

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2777.

ARVO Annual Meeting Abstract June 2021

A novel, easy-to-use hydrogel sealant (OcuPair TM ) for temporary corneal repair

Siva Pramodh Kambhampati; Hui Lin; Rishi Sharma; Santiago Appiani; Dan Saragnese; Samuel C Yiu; Jeffrey Cleland; Kannan Rangaramanujam

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):940.

ARVO Annual Meeting Abstract June 2020

Inhibition of mitochondrial GSH carrier proteins leading to mitochondrial dysfunction and restoration of function with αB crystallin peptide in human RPE cells

Parameswaran G Sreekumar; Mo Wang; Ram Kannan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3541.

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Untargeted Tear Proteomics in a Large South-Asian Cohort Reveals Inflammatory Signaling, ECM Remodeling, and Altered Metabolism in Keratoconus

Distinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation

Paraoxonase 2 (PON2) deficiency leads to RPE mitochondrial dysfunction and retinal degeneration.

Proteomic analysis of urinary biomarkers in low and high-risk diabetic retinopathy patients

Mechanism of age-dependent senescence development in Tnfrsf10 knock out mice.

Mechanism of αB-Crystallin Elastin-like Polypeptide conjugates protection against tunicamycin-induced ER stress in ARPE-19 cells

Ultralocal subretinal immunosuppressive nanoparticles to abrogate graft rejection in retinal cell therapy

Innovative in situ Formed HA-Dendrimer Cornea Substitute for Anterior Lamellar Keratoplasty

Characterization and contribution of RPE senescence to AMD in Tnfrsf10 knock out mice

ELP-fused mitochondrial peptide Humanin protects the retina and RPE from cigarette smoke-induced oxidative stress

Suppression of subretinal neovascularization in Vldlr knockout mice by systemic administration of a targeted VEGF-receptor inhibitor

Untargeted metabolomics identifies Myristoleolyl Carnitine as a tear based detector for bacterial endophthalmitis

Novel genes and variants associated with inflammation identified in Keratoconus families

Regulation of LDLR in hRPE and loss of retinal function in Ldlr -/- mice exposed to NaIO3

Identification and Validation of Biomarkers for Early Detection of Diabetic Retinopathy

Signal Mechanisms of EMT and role of αB Crystallin Chaperone Peptide in the prevention of experimental PVR

Dendrimer-targeted immunosuppression of microglia reactivity super-accelerates photoreceptor regeneration kinetics in the zebrafish retina

Dendrimer-based nanoparticles for early detection and therapeutic targeting of microglia in a rat glaucoma model

A novel, easy-to-use hydrogel sealant (OcuPair TM ) for temporary corneal repair

Inhibition of mitochondrial GSH carrier proteins leading to mitochondrial dysfunction and restoration of function with αB crystallin peptide in human RPE cells

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