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ARVO Annual Meeting Abstract June 2024

A novel ELOVL4 variant, L168S, causes early childhood-onset retinal dysfunction and Spinocerebellar ataxia-34.

Martin-Paul Gameli Agbaga; Yeboah Kofi Gyening; Keren Boris; Mignot Cyril; Richard S Steve Brush; Marie-Cécile Nassogne

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4994.

ARVO Annual Meeting Abstract June 2022

Carbohydrate restriction preserves visual acuity and motor function in a mouse model of autoimmune demyelination

Scott Matthew Plafker; Katarzyna Zyla-Jackson; Dorothy Walton; Kendra Plafker; Susan Kovats; Richard Steve Brush; Martin-Paul Gameli Agbaga

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1096.

ARVO Annual Meeting Abstract June 2022

Deciphering ELOVL4 mutant activity in retinal degeneration

Yeboah Kofi Gyening; Neeraj Kumar Chauhan; Vicki Ea; Madison Tytanic; Richard Steve Brush; Robert E Anderson; Martin-Paul Gameli Agbaga

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3169 – F0443.

ARVO Annual Meeting Abstract June 2015

Depletion of Very Long Chain Polyunsaturated Fatty Acids Causes Functional and Ultrastructural Changes in Photoreceptors Independent of Mutant ELOVL4 Expression

Martin-Paul Gameli Agbaga; Jindong Ding; Blake Hopiavuori; Feng Li; Richard Steven Brush; Radha Ayyagari; Catherine Bowes Rickman; Robert E Anderson; Retinal Cell Biology

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):34.

ARVO Annual Meeting Abstract June 2015

Topically Administered PBN and Methyl-PBN inhibits the visual cycle and slows rhodopsin regeneration in mice and baboon eyes.

Megan Stiles; Nawajes A Mandal; Madeline Budda; Gary White; Roman Wolf; Richard Steven Brush; Robert Floyd; Robert E Anderson

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5411.

Visual Neuroscience July 2014

Examination of VLC-PUFA–Deficient Photoreceptor Terminals

PDF

Lea D. Bennett; Blake R. Hopiavuori; Richard S. Brush; Michael Chan; Matthew J. Van Hook; Wallace B. Thoreson; Robert E. Anderson
TAGS: mice, photoreceptors, polyunsaturated fatty acids, rod photoreceptors, retina, synapses
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4063-4072. https://doi.org/10.1167/iovs.14-13997

Retina May 2014

Effect of Reduced Retinal VLC-PUFA on Rod and Cone Photoreceptors

PDF

Lea D. Bennett; Richard S. Brush; Michael Chan; Todd A. Lydic; Kristen Reese; Gavin E. Reid; Julia V. Busik; Michael H. Elliott; Robert E. Anderson
TAGS: mice, polyunsaturated fatty acids, retinal cone, rod photoreceptors, photoreceptors, retina, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2014; 55(5):3150-3157. https://doi.org/10.1167/iovs.14-13995

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Differential Composition of Docosahexaenoic Acid and Very Long Chain Polyunsaturated Fatty Acids in Rod and Cone Photoreceptor Membranes

Martin-Paul Gameli Agbaga; Dana K Merriman; Richard Steven Brush; Todd Lydic; Shannon M Conley; Muna I Naash; Reid E Gavin; Julia V Busik; Robert E Anderson

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):370.

Biochemistry and Molecular Biology April 2014

In Vivo Effect of Mutant ELOVL4 on the Expression and Function of Wild-Type ELOVL4

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Nawajes A. Mandal; Julie-Thu A. Tran; Lixin Zheng; Joseph L. Wilkerson; Richard S. Brush; Joel McRae; Martin-Paul Agbaga; Kang Zhang; Konstantin Petrukhin; Radha Ayyagari; Robert E. Anderson
TAGS: fatty acids, mice, polyunsaturated fatty acids, proteins, retina, skin, mutant proteins
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2705-2713. https://doi.org/10.1167/iovs.13-13198

ARVO Annual Meeting Abstract March 2012

Sphingolipid Signaling in Mammalian Photoreceptor Cells

Md Nawajes A. Mandal; Nicole Prabhu; Carolina Abrahan; Nora Rotstein; Joel McRae; Annette Eckerd; Rishard S. Brush

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4293.

ARVO Annual Meeting Abstract March 2012

STGD3 Mutant Exerts A Dominant Negative Effect On Elovl4 Enzymatic Activity During VLC-PUFA Biosynthesis

Sreemathi Logan; Martin-Paul G. Agbaga; Michael D. Chan; Richard S. Brush; Robert E. Anderson

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6890.

ARVO Annual Meeting Abstract April 2011

Enzymatic Activity Of Elovl4 Is Dependent On HVYHH Motif In The Active Site

Sreemathi Logan; Martin-Paul Agbaga; Michael D. Chan; Richard S. Brush; Albert O. Edwards; Robert E. Anderson

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1770.

ARVO Annual Meeting Abstract April 2011

Determining The Role Of Ceramide And Sphingosine-1-phosphate In Light-induced Retinal Degeneration Of Albino Rats

Md Nawajes A. Mandal; Julie-Thu A. Tran; Richard S. Brush; Man Yu; Annie Y. Chan; Donald U. Stone; Hui Chen

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2566.

Biochemistry and Molecular Biology September 2010

Retinal Sphingolipids and Their Very-Long-Chain Fatty Acid–Containing Species

PDF

Richard S. Brush; Julie-Thu A. Tran; Kimberly R. Henry; Mark E. McClellan; Michael H. Elliott; Md Nawajes A. Mandal
TAGS: fatty acids, retina, sphingolipids, lipids, body tissue
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4422-4431. https://doi.org/10.1167/iovs.09-5134

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2010

Elongation of Very Long Chain Fatty Acids by Elovl4

S. Logan; M.-P. G. Agbaga; R. S. Brush; A. O. Edwards; R. E. Anderson

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):2495.

ARVO Annual Meeting Abstract April 2009

Sphingolipid Signaling in Retinal Cell Death

M. A. Mandal; J.-T. A. Tran; L. Zheng; R. S. Brush

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):5189.

ARVO Annual Meeting Abstract April 2009

Substrate Specificity of ELOVL4 in Very Long Chain Fatty Acid Biosynthesis

S. Logan; M.-P. Agbaga; R. S. Brush; K. R. Henry; J. Tran; R. E. Anderson

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):6004.

ARVO Annual Meeting Abstract April 2009

Quantitative Analysis of ELOVL4 Protein and Fatty Acid Products in Knock-out and Knock-in Mouse Tissues

M.-P. Agbaga; M. A. Mandal; R. S. Brush; L. Zheng; K. Henry; M. H. Elliott; V. Vasireddy; K. Petrukhin; R. Ayyagari; R. E. Anderson

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):6006.

ARVO Annual Meeting Abstract May 2008

ELOVL4 Protein and Biosynthesis of Very Long Chain Fatty Acids

M.-P. G. Agbaga; R. S. Brush; M. A. Mandal; K. Henry; M. H. Elliott; R. E. Anderson

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):765.

ARVO Annual Meeting Abstract May 2008

Comprehensive Evaluation of Sphingolipid Gene Expression in Normal and Light-Stressed Retina and Oxidant-Stressed 661W Cells

M. A. Mandal; M.-P. Agbaga; J.-T. Tran; K. Henry; L. Zheng; R. S. Brush

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):5173.

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A novel ELOVL4 variant, L168S, causes early childhood-onset retinal dysfunction and Spinocerebellar ataxia-34.

Carbohydrate restriction preserves visual acuity and motor function in a mouse model of autoimmune demyelination

Deciphering ELOVL4 mutant activity in retinal degeneration

Depletion of Very Long Chain Polyunsaturated Fatty Acids Causes Functional and Ultrastructural Changes in Photoreceptors Independent of Mutant ELOVL4 Expression

Topically Administered PBN and Methyl-PBN inhibits the visual cycle and slows rhodopsin regeneration in mice and baboon eyes.

Examination of VLC-PUFA–Deficient Photoreceptor Terminals

Effect of Reduced Retinal VLC-PUFA on Rod and Cone Photoreceptors

Differential Composition of Docosahexaenoic Acid and Very Long Chain Polyunsaturated Fatty Acids in Rod and Cone Photoreceptor Membranes

In Vivo Effect of Mutant ELOVL4 on the Expression and Function of Wild-Type ELOVL4

Sphingolipid Signaling in Mammalian Photoreceptor Cells

STGD3 Mutant Exerts A Dominant Negative Effect On Elovl4 Enzymatic Activity During VLC-PUFA Biosynthesis

Enzymatic Activity Of Elovl4 Is Dependent On HVYHH Motif In The Active Site

Determining The Role Of Ceramide And Sphingosine-1-phosphate In Light-induced Retinal Degeneration Of Albino Rats

Retinal Sphingolipids and Their Very-Long-Chain Fatty Acid–Containing Species

Elongation of Very Long Chain Fatty Acids by Elovl4

Sphingolipid Signaling in Retinal Cell Death

Substrate Specificity of ELOVL4 in Very Long Chain Fatty Acid Biosynthesis

Quantitative Analysis of ELOVL4 Protein and Fatty Acid Products in Knock-out and Knock-in Mouse Tissues

ELOVL4 Protein and Biosynthesis of Very Long Chain Fatty Acids

Comprehensive Evaluation of Sphingolipid Gene Expression in Normal and Light-Stressed Retina and Oxidant-Stressed 661W Cells

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