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Cornea May 2025

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

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Runze Zhang; Lihong Liang; Kai Liao; Hao Zeng; Xue Yang; Xiaoran Wang; Bowen Wang; Jin Yuan
TAGS: corneal epithelial cells, dry eye syndromes, ferroptosis, stress, autophagy, western blotting, impairment
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):23. https://doi.org/10.1167/iovs.66.5.23

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Immunology and Microbiology April 2025

Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren’s Syndrome Related Dry Eye

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Bowen Wang; Lihong Liang; Hao Zeng; Xue Yang; Runze Zhang; Wenrui Deng; Xiaoran Wang; Jin Yuan
TAGS: conjunctiva, dry eye syndromes, keratinocytes, sequence analysis, rna, signal transduction, sjogren's syndrome, rna, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):43. https://doi.org/10.1167/iovs.66.4.43

Includes: Supplemental Content

Lens April 2025

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

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Le Chang; Fen Song; Shijia Qu; Huazheng Cao; Yanan Wu; Lulu Xu; Jing Wang; Ruirui Zhang; Chao Xue; Yan Wang
TAGS: cell nucleus, eye, lens (device), lens, crystalline, myopia, visual accommodation, adult, regression analysis
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):6. https://doi.org/10.1167/iovs.66.4.6

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Physiology and Pharmacology November 2024

Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia

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Miao Zhang; Ruixue Zhang; Jiawen Hao; Xiaoyue Zhao; Zhongyu Ma; Yuan Peng; Bo Bao; Jizhao Xin; Xuewei Yin; Hongsheng Bi; Dadong Guo
TAGS: myopia, quercetin, sclera, caviidae, proteins, body tissue
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):11. https://doi.org/10.1167/iovs.65.13.11

Glaucoma November 2024

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

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Xuejin Zhang; Ting Li; Rong Zhang; Junfeng Li; Kaidi Wang; Jihong Wu
TAGS: axon, down-regulation, glaucoma, ocular hypertension, optic nerve, retina, retinal ganglion cells, tissue degeneration, wounds and injuries, injections
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):7. https://doi.org/10.1167/iovs.65.13.7

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Tessellated fundus occurs earlier than myopia in children aged 3-6 years.

Xuejing Mi; Yuxin Fang; Jianing Pu; Wei Chen; Zhen Zhou; Mengmeng Qin; Ranran Zhang; Dan Wang; Yanyan Yang; Chuzhi Peng; Shimeng Bian; Huaying Xu; Yonghong Jiao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):OD15.

ARVO Annual Meeting Abstract June 2024

Trends in the Prevalence of Retinal and Optic Nerve Diseases in China: An Artificial Intelligence Based National Screening

Li Dong; Ruiheng Zhang; Wen-bin Wei

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):579.

ARVO Annual Meeting Abstract June 2024

KIF21A -F355S in motor domain affects development of ocular motor nerves and microtubule-stimulated ATPase activity

Ranran Zhang; Weiye Song; Hongyan Jia; Shuyan Yang; Chuzhi Peng; Jinqi Ren; Wei Feng; Yonghong Jiao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4659.

ARVO Annual Meeting Abstract June 2024

Elevated Thrombospondin-1 in Keratoconus Patient Tears

Prasida Unni; Stuti Phalahari; Rachel Zhang; Eugene Hsu; Sreevardhan Alluri; Hyunjoo J Lee

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3863.

ARVO Annual Meeting Abstract June 2024

Mechanosensitive Channel Distribution in Crushed (Control) and Axon Regenerating Optic Nerves

Jessica Lee; Runze Zhang; Kevin Park; Laura Bianchi; Sanjoy K Bhattacharya

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3539.

ARVO Annual Meeting Abstract June 2024

Shared RPE transcriptomic changes in response to two oxidants implicated in AMD pathogenesis: cigarette smoke and iron

Rohini M Nair; Elie Mer; Kevin R Zhang; John W Tobias; Venkata R M Chavali; Joshua L Dunaief

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):741.

Artificial Intelligence April 2024

Trends in the Prevalence of Common Retinal and Optic Nerve Diseases in China: An Artificial Intelligence Based National Screening

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Ruiheng Zhang; Li Dong; Xuefei Fu; Lin Hua; Wenda Zhou; Heyan Li; Haotian Wu; Chuyao Yu; Yitong Li; Xuhan Shi; Yangjie Ou; Bing Zhang; Bin Wang; Zhiqiang Ma; Yuan Luo; Meng Yang; Xiangang Chang; Zhaohui Wang; Wenbin Wei
TAGS: artificial intelligence, china, optic nerve disorders, prevalence, screening, trend
Trans. Vis. Sci. Tech.. 2024; 13(4):28. https://doi.org/10.1167/tvst.13.4.28

Includes: Supplemental Content

Genetics February 2024

m 6 A-Mediated Upregulation of Imprinted in Prader–Willi Syndrome Induces Aberrant Apical–Basal Polarization and Oxidative Damage in RPE Cells

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Ying Wang; Ye-Ran Zhang; Zi-Qin Ding; Yi-Chen Zhang; Ru-Xu Sun; Hong-Jing Zhu; Jia-Nan Wang; Bei Xu; Ping Zhang; Jiang-Dong Ji; Qing-Huai Liu; Xue Chen
TAGS: mtor serine-threonine kinases, prader-willi syndrome, proto-oncogene proteins c-akt, retinal pigment cell, rna, up-regulation (physiology), proteins, protein overexpression, rapamycin, immunoblotting
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):10. https://doi.org/10.1167/iovs.65.2.10

Includes: Supplemental Content

Optica Fall Vision Meeting Abstract September 2023

Poster Session: Investigating temporal evolutions of perceptual choice within biological and artificial neural networks

Yunlong Xu; Oh-Sang Kwon; Ruyuan Zhang; Duje Tadin
TAGS: evolution, posters
Journal of Vision. 2023; 23(11):77. https://doi.org/10.1167/jov.23.11.77

Vision Sciences Society Annual Meeting Abstract August 2023

Noise reduction as a unified mechanism of perceptual learning in both artificial and biological visual systems

Yu-Ang Cheng; Ke Jia; Takeo Watanabe; Sheng Li; Ru-Yuan Zhang

Journal of Vision. 2023; 23(9):4719. https://doi.org/10.1167/jov.23.9.4719

Visual Neuroscience July 2023

mTORC1 Signaling and Negative Lens-Induced Axial Elongation

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Ruiheng Zhang; Li Dong; Haotian Wu; Xuhan Shi; Wenda Zhou; Heyan Li; Yitong Li; Chuyao Yu; Yifan Li; Yao Nie; Lei Shao; Chuan Zhang; Yueming Liu; Jost B. Jonas; Wenbin Wei; Qiong Yang
TAGS: lens (device), lens, crystalline, mechanistic target of rapamycin complex 1, signal transduction, caviidae, everolimus
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):24. https://doi.org/10.1167/iovs.64.10.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Association of human antigen class I and class II genes with Stevens-Johnson syndrome/toxic epidermal necrolysis in a United States population

Abdelrahman M. Elhusseiny; James Kwan; Rebecca Zhang; Mayumi Ueta; Derek Metclafe; Ramy Rashad; Swapna Shanbagh; Janey L Wiggs; James Chodosh; Hajirah Saeed

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5398.

ARVO Annual Meeting Abstract June 2023

A cornea-derived scaffold for regenerating corneal epithelia in limbal stem cell deficiency

Nick Di Girolamo; Mijeong Park; Naomi Delic; Alexander Richardson; Kim Nguyen; Richard Zhang; Lina Sprogyte; Lamia Nureen; Justin Lees; Gila Moalem-Taylor; Joanna Richmond; Angelica Fajardo; Ursula Kunicki; John Males

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1881.

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Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren’s Syndrome Related Dry Eye

In Vivo Brillouin Analysis of Lens Nucleus and Cortex in Adult Myopic Eyes and Their Correlation With Accommodation

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia

Downregulation of SARM1 Protects Retinal Ganglion Cell Axonal and Somal Degeneration Via JNK Activation in a Glaucomatous Model of Ocular Hypertension

Tessellated fundus occurs earlier than myopia in children aged 3-6 years.

Trends in the Prevalence of Retinal and Optic Nerve Diseases in China: An Artificial Intelligence Based National Screening

KIF21A -F355S in motor domain affects development of ocular motor nerves and microtubule-stimulated ATPase activity

Elevated Thrombospondin-1 in Keratoconus Patient Tears

Mechanosensitive Channel Distribution in Crushed (Control) and Axon Regenerating Optic Nerves

Shared RPE transcriptomic changes in response to two oxidants implicated in AMD pathogenesis: cigarette smoke and iron

Trends in the Prevalence of Common Retinal and Optic Nerve Diseases in China: An Artificial Intelligence Based National Screening

m 6 A-Mediated Upregulation of Imprinted in Prader–Willi Syndrome Induces Aberrant Apical–Basal Polarization and Oxidative Damage in RPE Cells

Poster Session: Investigating temporal evolutions of perceptual choice within biological and artificial neural networks

Noise reduction as a unified mechanism of perceptual learning in both artificial and biological visual systems

mTORC1 Signaling and Negative Lens-Induced Axial Elongation

Association of human antigen class I and class II genes with Stevens-Johnson syndrome/toxic epidermal necrolysis in a United States population

A cornea-derived scaffold for regenerating corneal epithelia in limbal stem cell deficiency

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