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Retina May 2019

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

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Jakob Grauslund; Ulrik Frydkjaer-Olsen; Tunde Peto; Jimena Fernández-Carneado; Berta Ponsati; Cristina Hernández; José Cunha-Vaz; Rafael Simó; for the EUROCONDOR
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, dilatation, pathologic, somatostatin, brimonidine, retinal vascular caliber
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2257-2262. doi: 10.1167/iovs.18-26487

Articles May 2018

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes

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Yuanjun Zhao; Sarah R. Weber; Joshua Lease; Mariano Russo; Christopher A. Siedlecki; Li-Chong Xu; Han Chen; Weiwei Wang; Michael Ford; Rafael Simó; Jeffrey M. Sundstrom
TAGS: vitreous body, proteins, vesicle, exosomes, morphology, language morphology, liquid biopsy
Trans. Vis. Sci. Tech.. 2018; 7(3):6. doi: 10.1167/tvst.7.3.6

Includes: Multimedia, Supplemental Content

Retina May 2018

Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases

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Jeffrey M. Sundstrom; Cristina Hernández; Sarah R. Weber; Yuanjun Zhao; Mitchell Dunklebarger; Natalia Tiberti; Tatiana Laremore; Olga Simó-Servat; Marta Garcia-Ramirez; Alistair J. Barber; Thomas W. Gardner; Rafael Simó
TAGS: amyloid, diabetes mellitus, parkinson disease, alzheimer's disease, signal transduction, diabetic retinopathy, brain diseases, long-term potentiation, nerve degeneration, neuregulins, neurodegenerative disorders, brain, proteins, retina, proteomics, pathogenesis, unfolded protein response, donors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2264-2274. doi: 10.1167/iovs.17-23678

Includes: Supplemental Content

Special Issue August 2017

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration

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José Cunha-Vaz; Luísa Ribeiro; Miguel Costa; Rafael Simó
TAGS: phenotype, diabetic retinopathy, longitudinal studies, nonproliferative diabetic retinopathy, macular edema
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO206-BIO210. doi: 10.1167/iovs.17-21780

Retinal Cell Biology June 2017

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

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Ahmed M. Abu El-Asrar; Sofie Struyf; Ghulam Mohammad; Mieke Gouwy; Pieter Rytinx; Mohammad Mairaj Siddiquei; Cristina Hernández; Kaiser Alam; Ahmed Mousa; Gert De Hertogh; Ghislain Opdenakker; Rafael Simó
TAGS: angiogenesis, vascular endothelial growth factor a, diabetes mellitus, western blotting, enzyme-linked immunosorbent assay, immunohistochemistry, inflammation, endothelial cells, diabetes mellitus, type 2, epiretinal membrane, monocyte chemoattractant protein-1, vitreous body, proteins, retina, proliferative diabetic retinopathy, tumor necrosis factor receptor 11b
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3189-3201. doi: 10.1167/iovs.16-20993

ARVO Annual Meeting Abstract June 2017

Retinal Layer Location of Increased Retinal Thickness and Retinal Thinning on the cohort of the EUROCONDOR clinical trial

Miguel Ângelo Costa; Luísa Ribeiro; Jose Garcia-Arumi; Peter Scanlon; Jakob Grauslund; Francesco Bandello; Jonathan Gibson; Edoardo Midena; Gabriele Elisabeth Lang; Simon P Harding; Catherine A Egan; Pascale Massin; Torcato Santos; Berta Ponsati; Jose G Cunha-Vaz; Rafael Simó

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):62. doi:

ARVO Annual Meeting Abstract June 2017

Topical administration of dipeptidyl peptidase IV (DPP-IV) inhibitors prevents retinal neurodegeneration in experimental diabetes

Cristina Hernández; Patricia Bogdanov; Cristina Solà-Adell; Joel Sampedro; Marta Valeri; Olga Simó-Servat; Raul Herance; Rafael Simó

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5795. doi:

ARVO Annual Meeting Abstract June 2017

TOPICAL ADMINISTRATION OF SOMATOSTATIN AND BRIMONIDINE IN THE EARLY STAGES OF DIABETIC RETINOPATHY: RESULTS OF THE EUROCONDOR STUDY

Rafael Simó; Francesco Bandello; Catherine A Egan; Jose Garcia-Arumi; Jonathan Gibson; Jakob Grauslund; Simon P Harding; Gabriele Elisabeth Lang; Pascale Massin; Edoardo Midena; Peter Scanlon; Berta Ponsati; Massimo Porta; Luísa Ribeiro; Cristina Hernández; Jose G Cunha-Vaz

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5797. doi:

Special Issue May 2017

Local and Systemic Inflammatory Biomarkers of Diabetic Retinopathy: An Integrative Approach

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Stela Vujosevic; Rafael Simó
TAGS: cytokine, hypertension, diabetes mellitus, inflammatory markers, inflammation, biopsy, diabetic retinopathy, biological markers, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO68-BIO75. doi: 10.1167/iovs.17-21769

ARVO Annual Meeting Abstract June 2015

Retinal Vascular Fractals Correlate With Early Neurodegeneration in Patients With Type 2 Diabetes Mellitus

Ulrik Frydkjaer-Olsen; Rasmus Soegaard Hansen; Knud Pedersen; Jose G Cunha-Vaz; Rafael Simó; Tunde Peto; Jakob Grauslund

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1803. doi:

Retinal Cell Biology August 2011

Fenofibric Acid Reduces Fibronectin and Collagen Type IV Overexpression in Human Retinal Pigment Epithelial Cells Grown in Conditions Mimicking the Diabetic Milieu: Functional Implications in Retinal Permeability

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Kyle Trudeau; Sumon Roy; Wen Guo; Cristina Hernández; Marta Villarroel; Rafael Simó; Sayon Roy
TAGS: diabetes mellitus, fibronectins, glucose, collagen type iv, permeability, protein overexpression, fenofibric acid, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6348-6354. doi: 10.1167/iovs.11-7282

Biochemistry and Molecular Biology September 2010

Metabolic Fingerprints of Proliferative Diabetic Retinopathy: An 1 H-NMR–Based Metabonomic Approach Using Vitreous Humor

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Ignasi Barba; Marta Garcia-Ramírez; Cristina Hernández; María Angeles Alonso; Lluis Masmiquel; David García-Dorado; Rafael Simó
TAGS: glucose, galactitol, lactates, pattern recognition, vitreous body, ascorbic acid, proliferative diabetic retinopathy, metabolites, fingerprints
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4416-4421. doi: 10.1167/iovs.10-5348

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Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes

Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

Retinal Layer Location of Increased Retinal Thickness and Retinal Thinning on the cohort of the EUROCONDOR clinical trial

Topical administration of dipeptidyl peptidase IV (DPP-IV) inhibitors prevents retinal neurodegeneration in experimental diabetes

TOPICAL ADMINISTRATION OF SOMATOSTATIN AND BRIMONIDINE IN THE EARLY STAGES OF DIABETIC RETINOPATHY: RESULTS OF THE EUROCONDOR STUDY

Local and Systemic Inflammatory Biomarkers of Diabetic Retinopathy: An Integrative Approach

Retinal Vascular Fractals Correlate With Early Neurodegeneration in Patients With Type 2 Diabetes Mellitus

Fenofibric Acid Reduces Fibronectin and Collagen Type IV Overexpression in Human Retinal Pigment Epithelial Cells Grown in Conditions Mimicking the Diabetic Milieu: Functional Implications in Retinal Permeability

Metabolic Fingerprints of Proliferative Diabetic Retinopathy: An 1 H-NMR–Based Metabonomic Approach Using Vitreous Humor

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