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ARVO Annual Meeting Abstract June 2023

Structural and metabolic retinal markers of mild cognitive impairment in type 2 diabetes

Frederik Nørregaard Pedersen; Lonny Stokholm; Noemi Lois; Gabriel YANG; Carol Cheung; Geert Jan Biessels; Lieza Exalto; Rafael Simó; Tunde Peto; Jakob Grauslund

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4199.

ARVO Annual Meeting Abstract June 2022

Characterising retinal neurovascular dysfunction in a mouse model of Alzheimer’s disease combined with Type 2 diabetes

Karis Little; María Llorián-Salvador; Ángel del Marco; Monica Garcia-Alloza; Rafael Simó; Alan W Stitt

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):271 – F0316.

ARVO Annual Meeting Abstract June 2021

Diabetic retinopathy independently predicts five-year risk of Alzheimer’s disease

Frederik Pedersen; Lonny Stokholm; Frans Pouwer; Katrine Rubin; Tunde Peto; Ulrik Frydkjaer-Olsen; Anne Suhr Thykjær; Rafael Simó; Jakob Grauslund

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1071.

Retina September 2019

δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes

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Jacqueline M. Lopes de Faria; Diego A. Duarte; Rafael Simó; Marta García-Ramirez; Marcella N. Dátilo; Francieli C. Pasqualetto; José B. Lopes de Faria
TAGS: agonists, diabetes mellitus, diabetes mellitus, type 2, opioid receptor, retina, retinal diseases, tight junctions, mice, proteins, epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3842-3853. https://doi.org/10.1167/iovs.19-26761

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Usefulness of liquid biopsy of aqueous humor biomarkers in predicting anti-VEGF response in Diabetic Macular Edema. Results of a pilot study.

Patricia Udaondo; Marina Mesquida; Everson Nogoceke; Cristina Hernandez; Simo Rafael

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2628.

Retina May 2019

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

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Jakob Grauslund; Ulrik Frydkjaer-Olsen; Tunde Peto; Jimena Fernández-Carneado; Berta Ponsati; Cristina Hernández; José Cunha-Vaz; Rafael Simó; for the EUROCONDOR
TAGS: brimonidine, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, dilatation, pathologic, retinal vascular caliber, somatostatin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2257-2262. https://doi.org/10.1167/iovs.18-26487

Articles May 2018

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes

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Yuanjun Zhao; Sarah R. Weber; Joshua Lease; Mariano Russo; Christopher A. Siedlecki; Li-Chong Xu; Han Chen; Weiwei Wang; Michael Ford; Rafael Simó; Jeffrey M. Sundstrom
TAGS: exosomes, proteins, vesicle, vitreous body, language morphology, morphology, liquid biopsy
Trans. Vis. Sci. Tech.. 2018; 7(3):6. https://doi.org/10.1167/tvst.7.3.6

Includes: Multimedia, Supplemental Content

Retina May 2018

Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases

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Jeffrey M. Sundstrom; Cristina Hernández; Sarah R. Weber; Yuanjun Zhao; Mitchell Dunklebarger; Natalia Tiberti; Tatiana Laremore; Olga Simó-Servat; Marta Garcia-Ramirez; Alistair J. Barber; Thomas W. Gardner; Rafael Simó
TAGS: alzheimer's disease, brain diseases, diabetes mellitus, diabetic retinopathy, donors, proteins, proteomics, retina, signal transduction, amyloid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2264-2274. https://doi.org/10.1167/iovs.17-23678

Includes: Supplemental Content

Special Issue August 2017

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration

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José Cunha-Vaz; Luísa Ribeiro; Miguel Costa; Rafael Simó
TAGS: diabetic retinopathy, longitudinal studies, macular edema, phenotype, nonproliferative diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO206-BIO210. https://doi.org/10.1167/iovs.17-21780

Retinal Cell Biology June 2017

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

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Ahmed M. Abu El-Asrar; Sofie Struyf; Ghulam Mohammad; Mieke Gouwy; Pieter Rytinx; Mohammad Mairaj Siddiquei; Cristina Hernández; Kaiser Alam; Ahmed Mousa; Gert De Hertogh; Ghislain Opdenakker; Rafael Simó
TAGS: angiogenesis, diabetes mellitus, endothelial cells, epiretinal membrane, inflammation, proliferative diabetic retinopathy, proteins, retina, tumor necrosis factor receptor 11b, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3189-3201. https://doi.org/10.1167/iovs.16-20993

ARVO Annual Meeting Abstract June 2017

Topical administration of dipeptidyl peptidase IV (DPP-IV) inhibitors prevents retinal neurodegeneration in experimental diabetes

Cristina Hernández; Patricia Bogdanov; Cristina Solà-Adell; Joel Sampedro; Marta Valeri; Olga Simó-Servat; Raul Herance; Rafael Simó

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5795.

ARVO Annual Meeting Abstract June 2017

TOPICAL ADMINISTRATION OF SOMATOSTATIN AND BRIMONIDINE IN THE EARLY STAGES OF DIABETIC RETINOPATHY: RESULTS OF THE EUROCONDOR STUDY

Rafael Simó; Francesco Bandello; Catherine A Egan; Jose Garcia-Arumi; Jonathan Gibson; Jakob Grauslund; Simon P Harding; Gabriele Elisabeth Lang; Pascale Massin; Edoardo Midena; Peter Scanlon; Berta Ponsati; Massimo Porta; Luísa Ribeiro; Cristina Hernández; Jose G Cunha-Vaz

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5797.

ARVO Annual Meeting Abstract June 2017

Retinal Layer Location of Increased Retinal Thickness and Retinal Thinning on the cohort of the EUROCONDOR clinical trial

Miguel Ângelo Costa; Luísa Ribeiro; Jose Garcia-Arumi; Peter Scanlon; Jakob Grauslund; Francesco Bandello; Jonathan Gibson; Edoardo Midena; Gabriele Elisabeth Lang; Simon P Harding; Catherine A Egan; Pascale Massin; Torcato Santos; Berta Ponsati; Jose G Cunha-Vaz; Rafael Simó

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):62.

Special Issue May 2017

Local and Systemic Inflammatory Biomarkers of Diabetic Retinopathy: An Integrative Approach

PDF

Stela Vujosevic; Rafael Simó
TAGS: biological markers, cytokine, diabetic retinopathy, inflammation, inflammatory markers, hypertension, diabetes mellitus, diagnostic imaging, biopsy
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO68-BIO75. https://doi.org/10.1167/iovs.17-21769

ARVO Annual Meeting Abstract September 2016

Correlations between retinal vessel calibers and neurodegeneration in patients with no or mild diabetic retinopathy in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR).

Jakob Grauslund; Ulrik Frydkjaer-Olsen; Rasmus Soegaard Hansen; Rafael Simo; Jose G Cunha-Vaz; Tunde Peto

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1663.

ARVO Annual Meeting Abstract June 2015

Retinal Vascular Fractals Correlate With Early Neurodegeneration in Patients With Type 2 Diabetes Mellitus

Ulrik Frydkjaer-Olsen; Rasmus Soegaard Hansen; Knud Pedersen; Jose G Cunha-Vaz; Rafael Simó; Tunde Peto; Jakob Grauslund

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1803.

ARVO Annual Meeting Abstract March 2012

Effect of Fenofibrate on Overexpression of Extracellular Matrix Components, COX-2, and Barrier Permeability Associated with Diabetic Retinopathy

Casey Stottrup; Sumon Roy; Lucien Rizzo; Rafael Simo; Sayon Roy

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5415.

Retinal Cell Biology August 2011

Fenofibric Acid Reduces Fibronectin and Collagen Type IV Overexpression in Human Retinal Pigment Epithelial Cells Grown in Conditions Mimicking the Diabetic Milieu: Functional Implications in Retinal Permeability

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Kyle Trudeau; Sumon Roy; Wen Guo; Cristina Hernández; Marta Villarroel; Rafael Simó; Sayon Roy
TAGS: collagen type iv, diabetes mellitus, fenofibric acid, fibronectins, glucose, permeability, protein overexpression, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6348-6354. https://doi.org/10.1167/iovs.11-7282

ARVO Annual Meeting Abstract April 2011

Effect of Fenofibric Acid on Fibronectin Overexpression and Barrier Permeability Associated with Diabetic Retinopathy

Sumon Roy; Kyle Trudeau; Rafael Simo; Sayon Roy

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3577.

Biochemistry and Molecular Biology September 2010

Metabolic Fingerprints of Proliferative Diabetic Retinopathy: An 1 H-NMR–Based Metabonomic Approach Using Vitreous Humor

PDF

Ignasi Barba; Marta Garcia-Ramírez; Cristina Hernández; María Angeles Alonso; Lluis Masmiquel; David García-Dorado; Rafael Simó
TAGS: fingerprints, metabolites, proliferative diabetic retinopathy, vitreous body, ascorbic acid, glucose, lactates, galactitol, pattern recognition
Invest. Ophthalmol. Vis. Sci.. 2010; 51(9):4416-4421. https://doi.org/10.1167/iovs.10-5348

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Structural and metabolic retinal markers of mild cognitive impairment in type 2 diabetes

Characterising retinal neurovascular dysfunction in a mouse model of Alzheimer’s disease combined with Type 2 diabetes

Diabetic retinopathy independently predicts five-year risk of Alzheimer’s disease

δ Opioid Receptor Agonism Preserves the Retinal Pigmented Epithelial Cell Tight Junctions and Ameliorates the Retinopathy in Experimental Diabetes

Usefulness of liquid biopsy of aqueous humor biomarkers in predicting anti-VEGF response in Diabetic Macular Edema. Results of a pilot study.

Topical Treatment With Brimonidine and Somatostatin Causes Retinal Vascular Dilation in Patients With Early Diabetic Retinopathy From the EUROCONDOR

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes

Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases

Diabetic Retinopathy Phenotypes of Progression to Macular Edema: Pooled Analysis From Independent Longitudinal Studies of up to 2 Years' Duration

Osteoprotegerin Is a New Regulator of Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy

Topical administration of dipeptidyl peptidase IV (DPP-IV) inhibitors prevents retinal neurodegeneration in experimental diabetes

TOPICAL ADMINISTRATION OF SOMATOSTATIN AND BRIMONIDINE IN THE EARLY STAGES OF DIABETIC RETINOPATHY: RESULTS OF THE EUROCONDOR STUDY

Retinal Layer Location of Increased Retinal Thickness and Retinal Thinning on the cohort of the EUROCONDOR clinical trial

Local and Systemic Inflammatory Biomarkers of Diabetic Retinopathy: An Integrative Approach

Correlations between retinal vessel calibers and neurodegeneration in patients with no or mild diabetic retinopathy in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR).

Retinal Vascular Fractals Correlate With Early Neurodegeneration in Patients With Type 2 Diabetes Mellitus

Effect of Fenofibrate on Overexpression of Extracellular Matrix Components, COX-2, and Barrier Permeability Associated with Diabetic Retinopathy

Fenofibric Acid Reduces Fibronectin and Collagen Type IV Overexpression in Human Retinal Pigment Epithelial Cells Grown in Conditions Mimicking the Diabetic Milieu: Functional Implications in Retinal Permeability

Effect of Fenofibric Acid on Fibronectin Overexpression and Barrier Permeability Associated with Diabetic Retinopathy

Metabolic Fingerprints of Proliferative Diabetic Retinopathy: An 1 H-NMR–Based Metabonomic Approach Using Vitreous Humor

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