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ARVO Annual Meeting Abstract June 2022

Differential response of Muller cells to retinal injury in the fundus camera-delivered light induced retinal degeneration (FCD-LIRD) model

Bogale Aredo; Bo Chen; Yi Ding; Cynthia X. Zhao; Ashwani Kumar; Chao Xing; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1367 – F0298. doi:

ARVO Annual Meeting Abstract June 2022

Novel association to retinal homeostasis identified for a gene involved in ubiquitination and proteasomal degradation.

Yeshumenesh Zegeye; Bogale Aredo; Seher Yuksel; Cynthia X. Zhao; Sara Ludwig; Miao Tang; Xiaohong Li; Bruce A. Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1963 – F0381. doi:

ARVO Annual Meeting Abstract June 2022

Deletion of a cholesteryl ester hydrolase leads to a progressive retinal degeneration in mice

Seher Yuksel; Bogale Aredo; Yeshumenesh Zegeye; Cynthia X. Zhao; Miao Tang; Xiaohong Li; Laurent Gautron; Sara Ludwig; Igor A Butovich; Bruce A. Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1952 – F0370. doi:

ARVO Annual Meeting Abstract June 2021

Analysis of cell type-specific responses to retinal injury in the fundus camera delivered-light induced retinal degeneration (FCD-LIRD) model

Bogale Aredo; Bo Chen; Yi Ding; Cynthia Zhao; Ashwani Kumar; Chao Xing; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3120. doi:

ARVO Annual Meeting Abstract June 2020

Forward genetic analysis combined with OCT and fundus photography identifies mutations leading to progressive outer retinal degeneration in C57BL/6J mice

Bogale Aredo; Bo Chen; Yi Ding; Yuanfei Zhu; Cynthia Zhao; Ashwani Kumar; Chao Xing; Stephen Lyon; Jamie Russell; Xiaohong Li; Miao Tang; Priscilla Anderton; Sara Ludwig; Eva Marie Moresco; Bruce Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1896. doi:

Retinal Cell Biology September 2019

Mice With a Combined Deficiency of Superoxide Dismutase 1 ( Sod1 ), DJ-1 ( Park7 ), and Parkin ( Prkn ) Develop Spontaneous Retinal Degeneration With Aging

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Yuanfei Zhu; Bogale Aredo; Bo Chen; Cynthia X. Zhao; Yu-Guang He; Rafael L. Ufret-Vincenty
TAGS: aging, mice, parkinson disease 7, autosomal recessive early-onset, retinal degeneration, park2 gene, sod1 gene, retina, superoxide dismutase 1
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3740-3751. doi: https://doi.org/10.1167/iovs.19-27212

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Mice with a combined deficiency of SOD1, DJ-1 and Parkin develop spontaneous retinal degeneration with aging

Bogale Aredo; Bo Chen; Yuanfei Zhu; Cynthia X Zhao; Yu_Guang He; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4915. doi:

ARVO Annual Meeting Abstract July 2019

A destabilized domain-based approach to control protein abundance in aged mice and models of retinal degeneration

Shyamtanu Datta; Bo Chen; Marian Renwick; Hui Peng; Rafael Ufret-Vincenty; John Hulleman

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3392. doi:

ARVO Annual Meeting Abstract July 2019

Forward genetics: searching for novel genes essential to retinal development and homeostasis

Rafael Ufret-Vincenty; Bogale Aredo; Bo Chen; Yuanfei Zhu; Yi Ding; Cynthia X Zhao; Bruce Beutler

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6060. doi:

Retina March 2019

A Mouse Model of Retinal Recovery From Photo-Oxidative/Photo-Inflammatory Injury: Nrf2, SOD1, DJ-1, and Parkin Are Not Essential to Recovery

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Bo Chen; Bogale Aredo; Yuanfei Zhu; Yi Ding; Cynthia Xin-Zhao; Rafael L. Ufret-Vincenty
TAGS: mice, oxidative stress, park2 gene, recovery of function, sod1 gene, wounds and injuries, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(4):1165-1174. doi: https://doi.org/10.1167/iovs.18-25751

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Forward genetics: searching for novel genes essential to retinal development and function

Bogale Aredo; Yi Ding; Xin Zhong; Cynthia Xin-Zhao Wang; Bruce Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1841. doi:

ARVO Annual Meeting Abstract June 2017

The fundus camera delivered-light induced retinal degeneration model is mediated by oxidative stress

Cynthia Xin-Zhao Wang; Bogale Aredo; Yi Ding; Xin Zhong; Kaiyan Zhang; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5362. doi:

Retina October 2016

Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis

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Xin Zhong; Bogale Aredo; Yi Ding; Kaiyan Zhang; Cynthia X. Zhao; Rafael L. Ufret-Vincenty
TAGS: apoptosis, fluorescein, mice, oxidative stress, retinal degeneration, wounds and injuries, eye, retina
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5558-5567. doi: https://doi.org/10.1167/iovs.16-19965

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

A forward genetics approach to discovering novel genes essential to retinal development and function

Yi Ding; Xin Zhong; Bogale Aredo; Cynthia Xin-Zhao Wang; Bruce Beutler; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2636. doi:

ARVO Annual Meeting Abstract September 2016

Development of a new model of retinal light injury in pigmented mice

Bogale Aredo; Xin Zhong; Yi Ding; Kaiyan Zhang; Cynthia Xin-Zhao Wang; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5790. doi:

ARVO Annual Meeting Abstract September 2016

Towards an understanding of the molecular basis for subretinal macrophage/microglial infiltration

Cynthia Xin-Zhao Wang; Bogale Aredo; Xin Zhong; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6575. doi:

Retina November 2015

Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo

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Tao Li; Bogale Aredo; Kaiyan Zhang; Xin Zhong; Jose S. Pulido; Shusheng Wang; Yu-Guang He; Xianming Huang; Rolf A. Brekken; Rafael L. Ufret-Vincenty
TAGS: antibodies, choroidal neovascularization, phosphatidylserines, angiogenesis, lasers, endothelium
Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7137-7145. doi: https://doi.org/10.1167/iovs.15-17302

ARVO Annual Meeting Abstract June 2015

Differential gene expression in mouse eyes with high vs. low subretinal macrophage/microglial infiltration.

Cynthia Xin-Zhao Wang; Bogale Aredo; Tao Li; Rafael Ufret-Vincenty; Bogale Aredo, Tao Li, and Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):423. doi:

ARVO Annual Meeting Abstract June 2015

Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium, and PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo

Bogale Aredo; Tao Li; Kaiyan Zhang; Jose S Pulido; Shusheng Wang; Philip Thorpe; Rolf Brekken; Rafael Ufret-Vincenty

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2273. doi:

Retina June 2015

A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice

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Bogale Aredo; Tao Li; Xiao Chen; Kaiyan Zhang; Cynthia Xin-Zhao Wang; Darlene Gou; Biren Zhao; Yuguang He; Rafael L. Ufret-Vincenty
TAGS: mice, oxidative stress, inflammation, microglia, retina, chimera organism, transgenes
Invest. Ophthalmol. Vis. Sci.. 2015; 56(6):3427-3440. doi: https://doi.org/10.1167/iovs.14-16089

Includes: Supplemental Content

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Differential response of Muller cells to retinal injury in the fundus camera-delivered light induced retinal degeneration (FCD-LIRD) model

Novel association to retinal homeostasis identified for a gene involved in ubiquitination and proteasomal degradation.

Deletion of a cholesteryl ester hydrolase leads to a progressive retinal degeneration in mice

Analysis of cell type-specific responses to retinal injury in the fundus camera delivered-light induced retinal degeneration (FCD-LIRD) model

Forward genetic analysis combined with OCT and fundus photography identifies mutations leading to progressive outer retinal degeneration in C57BL/6J mice

Mice With a Combined Deficiency of Superoxide Dismutase 1 ( Sod1 ), DJ-1 ( Park7 ), and Parkin ( Prkn ) Develop Spontaneous Retinal Degeneration With Aging

Mice with a combined deficiency of SOD1, DJ-1 and Parkin develop spontaneous retinal degeneration with aging

A destabilized domain-based approach to control protein abundance in aged mice and models of retinal degeneration

Forward genetics: searching for novel genes essential to retinal development and homeostasis

A Mouse Model of Retinal Recovery From Photo-Oxidative/Photo-Inflammatory Injury: Nrf2, SOD1, DJ-1, and Parkin Are Not Essential to Recovery

Forward genetics: searching for novel genes essential to retinal development and function

The fundus camera delivered-light induced retinal degeneration model is mediated by oxidative stress

Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis

A forward genetics approach to discovering novel genes essential to retinal development and function

Development of a new model of retinal light injury in pigmented mice

Towards an understanding of the molecular basis for subretinal macrophage/microglial infiltration

Phosphatidylserine (PS) Is Exposed in Choroidal Neovascular Endothelium: PS-Targeting Antibodies Inhibit Choroidal Angiogenesis In Vivo and Ex Vivo

Differential gene expression in mouse eyes with high vs. low subretinal macrophage/microglial infiltration.

Phosphatidylserine (PS) is exposed in choroidal neovascular endothelium, and PS-targeting antibodies inhibit choroidal angiogenesis in vivo and ex vivo

A Chimeric Cfh Transgene Leads to Increased Retinal Oxidative Stress, Inflammation, and Accumulation of Activated Subretinal Microglia in Mice

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