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ARVO Annual Meeting Abstract June 2022

Autoregulatory dynamics of the PERG in mice with induced and rescued mitochondrial dysfunction

Tsung-Han Chou; Hong Yu; Rajeshwari D. Koilkonda; Angelina Lazo; Vittorio Porciatti

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):762 – F0414. doi:

ARVO Annual Meeting Abstract June 2021

Potency study of high-titer AAV2 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in a preclinical mouse model.

Tsung-Han Chou; Rajeshwari D Koilkonda; William J Feuer; Hong Yu; Vittorio Porciatti

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1187. doi:

ARVO Annual Meeting Abstract July 2019

Kruppel-like factor (KLF4) knockout in retinal ganglion cells improves visual function in Experimental Autoimmune Encephalomyelitis (EAE) mice model of optic neuritis

Venu Talla; Rajeshwari D Koilkonda; John Guy

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1394. doi:

ARVO Annual Meeting Abstract July 2019

Gene Therapy for Leber Hereditary Optic NeuropathY An update of Where We Stand (Clinicaltrials.gov number: NCT02161380)

John Guy; William Feuer; Janet L Davis; Vittorio Porciatti; Philip Gonzalez; Rajeshwari D Koilkonda; Huijun Yuan; Byron L Lam

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3602. doi:

ARVO Annual Meeting Abstract July 2018

Comparision of Allotopic and Mito targeted ND4 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in mice

Rajeshwari D Koilkonda; Hong Yu; Venu Talla; John Guy

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3964. doi:

ARVO Annual Meeting Abstract June 2017

Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in LHON Gene Therapy Clinical Trial Patients: An Update

Rajeshwari D Koilkonda; William J Feuer; Joyce Schiffman; Janet L Davis; Vittorio Porciatti; Phillip Gonzalez; Byron L Lam; John Guy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3861. doi:

ARVO Annual Meeting Abstract June 2017

Gene Therapy for LHON Suppresses Neurodegeneration

John Guy; Rajeshwari D Koilkonda; William J Feuer; Janet L Davis; Vittorio Porciatti; Phillip Gonzalez; Huijan Yuan; Byron L Lam

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4492. doi:

ARVO Annual Meeting Abstract September 2016

Assessment of Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in Serum and Ocular Fluid Samples of Leber’ Hereditary Optic Neuropathy (LHON) Gene Therapy Clinical Trial Patients

Rajeshwari D Koilkonda; William J Feuer; Joyce C Schiffman; Janet L Davis; Vittorio Porciatti; Phillip Gonzalez; Byron L Lam; John Guy

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5083. doi:

ARVO Annual Meeting Abstract September 2016

LHON Gene Therapy Clinical Trial: Year 2 Results

John Guy; William J Feuer; Janet L Davis; Vittorio Porciatti; Rajeshwari D Koilkonda; Huijun Yuan; Byron L Lam; William Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5086. doi:

ARVO Annual Meeting Abstract June 2015

Evaluation of Pre-existing Neutralizing Antibodies Against Tyrosine-Mutant AAV2 in Leber Hereditary Optic Neuropathy (LHON) Patients

Rajeshwari D Koilkonda; William W Hauswirth; Vince Chiodo; Sanford L Boye; Phillip Gonzalez; John Guy

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):693. doi:

ARVO Annual Meeting Abstract June 2015

Leber Hereditary Optic Neuropathy Gene Therapy (LHON) Clinical Trial: Initial Results

John Guy; William J Feuer; Vittorio Porciatti; William W Hauswirth; Janet L Davis; Byron L Lam; Rajeshwari D Koilkonda; Huijun Yuan; Phillip Gonzalez; Anil Lalwani

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2608. doi:

ARVO Annual Meeting Abstract April 2014

Gene Therapy For Mitochondrial Disease: Are We Ready?

Rajeshwari D Koilkonda; Hong Yu; Huijun Yuan; Vittorio Porciatti; William W Hauswirth; Thomas J Conlon; Lauren Renner; Martha Neuringer; Carol Detrisac; John Guy

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):836. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2013

Noninvasive Assessments of Optic Nerve Neurodegeneration in Transgenic Mice With Isolated Optic Neuritis

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Venu Talla; Cui Yang; Gerry Shaw; Vittorio Porciatti; Rajeshwari D. Koilkonda; John Guy
TAGS: animals, transgenic, mice, mice, transgenic, nerve degeneration, optic nerve, optic neuritis, proprioceptive neuromuscular facilitation, magnetic resonance imaging, axon
Invest. Ophthalmol. Vis. Sci.. 2013; 54(7):4440-4450. doi: https://doi.org/10.1167/iovs.13-11899

ARVO Annual Meeting Abstract March 2012

Efficient Transduction of Tyrosine-to-Phenylalanine Mutated AAV2 vectors carrying Human ND4 gene and Biodistribution following Intravitreal Delivery in a Rodent Model- a Gene Therapy for Leber Hereditary Optic Neuropathy

Rajeshwari D. Koilkonda; William W. Hauswirth; Vince Chiodo; Sanford L. Boye; John Guy

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1885. doi:

ARVO Annual Meeting Abstract April 2011

LHON Gene Therapy Clinical Trial: Serial Pretreatment Evaluations and ND4 Expression in the Human Eye

John Guy; Rajeshwari D. Koilkonda; Byron L. Lam; William J. Feuer; Vittorio Porciatti; David T. Tse; Fawzi Abukhalil; Sanford Boye; Vince Chiodo; William W. Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3893. doi:

ARVO Annual Meeting Abstract April 2011

Early Functional and Long-term Rescue of the LHON Mouse With Wild-type Human ND4 Gene Delivery

Rajeshwari D. Koilkonda; Tsung-Han Chou; Marco Ruggeri; Vittorio Porciatti; William W. Hauswirth; Vince Chiodo; Sanford L. Boye; John Guy

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1416. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology September 2009

Efficiency and Safety of AAV-Mediated Gene Delivery of the Human ND4 Complex I Subunit in the Mouse Visual System

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John Guy; Xiaoping Qi; Rajeshwari D. Koilkonda; Tania Arguello; Tsung-Han Chou; Marco Ruggeri; Vittorio Porciatti; Alfred S. Lewin; William W. Hauswirth
TAGS: eye, genes, mice, safety, visual system, retina, mitochondria, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2009; 50(9):4205-4214. doi: https://doi.org/10.1167/iovs.08-3214

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Autoregulatory dynamics of the PERG in mice with induced and rescued mitochondrial dysfunction

Potency study of high-titer AAV2 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in a preclinical mouse model.

Kruppel-like factor (KLF4) knockout in retinal ganglion cells improves visual function in Experimental Autoimmune Encephalomyelitis (EAE) mice model of optic neuritis

Gene Therapy for Leber Hereditary Optic NeuropathY An update of Where We Stand (Clinicaltrials.gov number: NCT02161380)

Comparision of Allotopic and Mito targeted ND4 gene therapy for treating Leber Hereditary Optic Neuropathy (LHON) in mice

Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in LHON Gene Therapy Clinical Trial Patients: An Update

Gene Therapy for LHON Suppresses Neurodegeneration

Assessment of Neutralizing Antibodies Against Adeno-associated virus (AAV)2 Capsids in Serum and Ocular Fluid Samples of Leber’ Hereditary Optic Neuropathy (LHON) Gene Therapy Clinical Trial Patients

LHON Gene Therapy Clinical Trial: Year 2 Results

Evaluation of Pre-existing Neutralizing Antibodies Against Tyrosine-Mutant AAV2 in Leber Hereditary Optic Neuropathy (LHON) Patients

Leber Hereditary Optic Neuropathy Gene Therapy (LHON) Clinical Trial: Initial Results

Gene Therapy For Mitochondrial Disease: Are We Ready?

Noninvasive Assessments of Optic Nerve Neurodegeneration in Transgenic Mice With Isolated Optic Neuritis

Efficient Transduction of Tyrosine-to-Phenylalanine Mutated AAV2 vectors carrying Human ND4 gene and Biodistribution following Intravitreal Delivery in a Rodent Model- a Gene Therapy for Leber Hereditary Optic Neuropathy

LHON Gene Therapy Clinical Trial: Serial Pretreatment Evaluations and ND4 Expression in the Human Eye

Early Functional and Long-term Rescue of the LHON Mouse With Wild-type Human ND4 Gene Delivery

Efficiency and Safety of AAV-Mediated Gene Delivery of the Human ND4 Complex I Subunit in the Mouse Visual System

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