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ARVO Annual Meeting Abstract June 2022

Altered bile acids-gut microbiome axis in oxygen-induced retinopathy: potential implications for retinopathy of prematurity

Menaka Thounaojam; Allston Oxenrider; Tommy Bui; Ravirajsinh Jadeja; Pamela M Martin; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):803 – F0362. doi:

ARVO Annual Meeting Abstract June 2022

HBI-002 treatment improves retinal ischemia-reperfusion injury in mice

Ravirajsinh Jadeja; Edward Gomperts; Howard Levy; Leo Otterbein; Mark Young; Malita Jones; Menaka Thounaojam; Manuela Bartoli; Andrew Gomperts; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2983 – F0224. doi:

ARVO Annual Meeting Abstract June 2022

Inhibition of miR-21 prevents abnormal angiogenesis and subretinal fibrosis in an experimental model of choroidal neovascularization

Albert Xiong; Menaka Thounaojam; Qiuhua Yang; Ravirajsinh Jadeja; Pamela M Martin; Yuqing Huo; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3050 – F0421. doi:

ARVO Annual Meeting Abstract June 2022

Regulation of retinal endothelial cell barrier function by the hydroxycarboxylic acid receptor 2 (HCAR2)/GPR109A

Pamela M Martin; Ammar Abdelrahman; Folami Lamoke Powell; Menaka Thounaojam; Malita Jones; Manuela Bartoli; Ravirajsinh Jadeja

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3619 – A0074. doi:

ARVO Annual Meeting Abstract June 2022

Anti-senescence properties of the flavone Silymarin in the diabetic retina involve direct inhibition of the histone deacetylase 6 (HDAC6)

Manuela Bartoli; Hossameldin Abouhish; Ravirajsinh Jadeja; Pamela M Martin; Ahlam Elmasry; John Georrge; Ranjitsinh Devkar; Menaka Thounaojam

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4117 – F0354. doi:

ARVO Annual Meeting Abstract June 2021

Differential bile acids biosynthetic pathways in the developing retina and in the oxygen-induced model of retinopathy of prematurity

Menaka Thounaojam; Shubhra Rajpurohit; Hossameldin Abouhish; Juan Zou; Ravirajsinh Jadeja; Pamela M Martin; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3029. doi:

ARVO Annual Meeting Abstract June 2021

Diabetes-induced HDAC6-miR-34a pathway downregulates SIRT-1-miR-146a axis to promote stress-induced premature senescence and diabetic retinal microangiopathy

Manuela Bartoli; Ravirajsinh Jadeja; Hossameldin Abouhish; Shubhra Rajpurohit; Folami Lamoke Powell; Menaka Thounaojam; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):534. doi:

ARVO Annual Meeting Abstract June 2020

NMN supplementation prevents vascular senescence in experimental diabetic retinopathy

Manuela Bartoli; Menaka Thounaojam; Hossameldin Abouhish; Diana Gutsaeva; Folami Lamoke Powell; Ravirajsinh Jadeja; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1168. doi:

ARVO Annual Meeting Abstract June 2020

Altered balance of miR-144-3p and miR-124-5p regulates amyloid-beta autocrine production in retinal pigment epithelial cells

Shivani Kumaresan; Abdelsalam Sharkasi; Ravirajsinh Jadeja; Hossameldin Abouhish; Pamela M Martin; Manuela Bartoli; Menaka Thounaojam

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1536. doi:

ARVO Annual Meeting Abstract June 2020

Inactivation of Endothelial ADAM17 Reduces Retinal Ischemia-Reperfusion Induced Neurovascular Abnormalities

Diana Gutsaeva; Lamiaa Shalaby; Sara Wetzstein; Menaka Thounaojam; Ravirajsinh Jadeja; Folami Lamoke Powell; Pamela M Martin; Hang Fai Kwok; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1785. doi:

ARVO Annual Meeting Abstract June 2020

Oxidative stress-induced ADAM10 and BACE1 imbalance leads to amyloid beta (Abeta) production in retinal pigment epithelial cells (RPE)

ABDELSALAM SHARKASI; Shivani Kumaresan; Ravirajsinh Jadeja; Pamela M Martin; Menaka Thounaojam; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2259. doi:

ARVO Annual Meeting Abstract June 2020

Mechanisms of Mitochondrial Bioenergetic Crisis in Aging Retina

Ravirajsinh Jadeja; Bhaumik Pandya; Malita Jones; Folami Lamoke Powell; Menaka Thounaojam; Manuela Bartoli; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4146. doi:

ARVO Annual Meeting Abstract June 2020

All eyes on beta-hydroxybutyrate: the impact of local synthesis versus systemic provision on RPE health and function.

Pamela M Martin; Ravirajsinh Jadeja; Bhaumik Pandya; Malita Jones; Ammar Abdelrahman; Folami Lamoke Powell

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4454. doi:

ARVO Annual Meeting Abstract June 2020

Differential effects of bile acids on retinal barrier function in a mouse model of oxygen induced retinopathy

Menaka Thounaojam; Shubhra Rajpurohit; Ravirajsinh Jadeja; Diana Gutsaeva; Pamela M Martin; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5417. doi:

ARVO Annual Meeting Abstract July 2019

Recurrent hypoglycemia markedly decreases local insulin biosynthesis in the diabetic retina

Folami Lamoke Powell; Malita Jones; Ravirajsinh Jadeja; Orneika Flandrin; Ammar Abdelrahman; Menaka Thounaojam; Diana Gutsaeva; Manuela Bartoli; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2677. doi:

ARVO Annual Meeting Abstract July 2019

Loss of NAMPT and decreased NAD+ levels contributes to stress-associated premature senescence (SAPS) in the diabetic retinal microvasculature

Manuela Bartoli; Ravirajsinh Jadeja; Menaka Thounaojam; Diana Gutsaeva; Folami Lamoke Powell; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2695. doi:

ARVO Annual Meeting Abstract July 2019

Loss of endothelial TACE-ADAM17 reduces retinal vascular hyperpermeability and improves retinal morphology in diabetic mice

Diana Gutsaeva; Menaka Thounaojam; Amany M Tawfik; Ravirajsinh Jadeja; Pamela M Martin; Wan Jin Jahng; Manuela Bartoli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2733. doi:

ARVO Annual Meeting Abstract July 2018

Extracellular and intracellular miR-21 promotes oxidative stress and inflammation in the diabetic retinal microvasculature by activation of TLR-7

Manuela Bartoli; Menaka Thounaojam; Folami Lamoke Powell; Ravirajsinh Jadeja; Pamela M Martin; Diana Gutsaeva

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3003. doi:

ARVO Annual Meeting Abstract July 2018

Role of the hydroxycarboxylic acid receptor 2 in the interplay between intestinal microbiota and retinal immunity in diabetes

Folami Lamoke Powell; Malita A Jones; Ravirajsinh Jadeja; Menaka Thounaojam; Diana Gutsaeva; Manuela Bartoli; Nagendra Singh; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3005. doi:

ARVO Annual Meeting Abstract July 2018

MicroRNA 144 regulates Nrf2 and related antioxidant signaling in RPE

Ravirajsinh Jadeja; Folami Lamoke Powell; Menaka Thounaojam; Malita A Jones; Manuela Bartoli; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5381. doi:

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