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Cornea July 2020

Energy Shortage in Human and Mouse Models of SLC4A11 -Associated Corneal Endothelial Dystrophies

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Wenlin Zhang; Ricardo Frausto; Doug D. Chung; Christopher G. Griffis; Liyo Kao; Angela Chen; Rustam Azimov; Alapakkam P. Sampath; Ira Kurtz; Anthony J. Aldave
TAGS: cornea, endothelium, mice, corneal endothelium, rna, endothelial cells
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):39. https://doi.org/10.1167/iovs.61.8.39

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Genetic Analysis of a Rare Phenotype Characterized by Corneal Ectasia associated with Posterior Stromal Opacification

Angela Chen; Madeline Yung; Doug Chung; Alice Barrington; Junwei Zhang; Ricardo F Frausto; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2433.

ARVO Annual Meeting Abstract July 2019

Transcriptomic analysis of PPCD and the generation of a cell-based model of PPCD using CRISPR-Cas9 gene editing

Doug Chung; Ricardo F Frausto; Vinay Swamy; Liam Carrigan; Davey Wong; Marco Morselli; Matteo Pellegrini; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2161.

ARVO Annual Meeting Abstract July 2019

Metabolic Reprogramming in Human and Mouse Corneal Endothelial Cells with Reduced Expression of SLC4A11

Wenlin Zhang; Ricardo F Frausto; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3873.

ARVO Annual Meeting Abstract July 2019

Low mitogenic conditions maintain the corneal endothelial cell phenotype in vitro

Payton Boere; Jessica Wu; Ricardo F Frausto; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5413.

ARVO Annual Meeting Abstract July 2019

ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing

Anthony J Aldave; Ricardo F Frausto; Doug Chung; Vinay Swamy; Huong Duong; Wenlin Zhang; Payton Boere; Marina Zakharevich; Maryam Hanser; Ira Kurtz; Matteo Pellegrini

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5416.

ARVO Annual Meeting Abstract July 2018

Factors Affecting Primary Human Corneal Endothelial Cell Adhesion

Ricardo F Frausto; Vinay S Swamy; Doug D Chung; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1373.

ARVO Annual Meeting Abstract July 2018

Confirmation and Refinement of the Heterozygous Deletion of the Small Leucine-rich Proteoglycans Associated with Posterior Amorphous Corneal Dystrophy

Anthony Aldave; Aleck Cervantes; Katherine Gee; Martha Whiting; Ricardo F Frausto

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2924.

ARVO Annual Meeting Abstract July 2018

Transcriptomic Profiling of SLC4A11 Null Murine Corneal Endothelial Cells

Vinay Swamy; Wenlin Zhang; Ricardo F Frausto; Joseph A Bonanno; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4432.

Cornea June 2017

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

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Doug D. Chung; Ricardo F. Frausto; Benjamin R. Lin; Evelyn M. Hanser; Zack Cohen; Anthony J. Aldave
TAGS: cornea, genes, polymorphous corneal dystrophy, proteins, rna, zinc finger e-box-binding homeobox 1, endothelium
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3202-3214. https://doi.org/10.1167/iovs.17-21423

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Transcriptomic analysis of human corneal endothelial cells during in vitro expansion

Ricardo F Frausto; Gary S L Peh; Ben L George; Jodhbir Mehta; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3795.

ARVO Annual Meeting Abstract June 2017

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

Doug D Chung; Ricardo F Frausto; Benjamin Lin; E. Maryam Maryam Hanser; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5648.

ARVO Annual Meeting Abstract June 2017

The functional impact of CRISPR-Cas9-mediated ZEB1 deficiency in human corneal endothelial cells

Yue Li; Ricardo F Frausto; Doug D Chung; E. Maryam Maryam Hanser; Austin Kassels; Marina Zakharevich; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5652.

ARVO Annual Meeting Abstract June 2017

Generation of ZEB1-deficient human corneal endothelial cells using CRISPR-Cas9 as a model for posterior polymorphous corneal dystrophy 3

E. Maryam Maryam Hanser; Marina Zakharevich; Ricardo F Frausto; Austin Kassels; Yu Li; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5653.

ARVO Annual Meeting Abstract September 2016

Characterization of an Alternative ZEB1 Nuclear Localization Signal in Posterior Polymorphous Corneal Dystrophy 3

Lydia Ann; Ricardo F Frausto; Evelyn Hanser; Doug Chung; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4822.

ARVO Annual Meeting Abstract September 2016

Characterization of ZEB1-dependent Regulation of COL4A3 Expression

Doug Chung; Ricardo F Frausto; Stephan Chiu; Benjamin Lin; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4896.

ARVO Annual Meeting Abstract September 2016

Effects of increased ZEB1 expression on proliferation and apoptosis of corneal endothelial cells

Ricardo F Frausto; Jaffer Kattan; Judy Chen; Benjamin Lin; Doug Chung; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5301.

Cornea August 2016

Investigating the Molecular Basis of PPCD3: Characterization of ZEB1 Regulation of COL4A3 Expression

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Duk-Won D. Chung; Ricardo F. Frausto; Stephan Chiu; Benjamin R. Lin; Anthony J. Aldave
TAGS: binding (molecular function), collagen, e-cadherin, luciferases, promoter regions (genetics), protein overexpression, regulation, mutation, proteins, plasmids
Invest. Ophthalmol. Vis. Sci.. 2016; 57(10):4136-4143. https://doi.org/10.1167/iovs.16-19533

ARVO Annual Meeting Abstract June 2015

Elucidating the molecular basis of PPCD3: effect of reduced ZEB1 levels on corneal endothelial cell migration

Judy Lynn Chen; Benjamin Ray Lin; Ricardo F Frausto; Andres Codriansky; Doug Chung; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1182.

ARVO Annual Meeting Abstract June 2015

Elucidating the genetic basis of PPCD3: demonstration of ZEB1 binding to COL4A3 and COL4A4 E2 box domains

Doug Chung; Ricardo F Frausto; Anthony J Aldave

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3080.

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Energy Shortage in Human and Mouse Models of SLC4A11 -Associated Corneal Endothelial Dystrophies

Genetic Analysis of a Rare Phenotype Characterized by Corneal Ectasia associated with Posterior Stromal Opacification

Transcriptomic analysis of PPCD and the generation of a cell-based model of PPCD using CRISPR-Cas9 gene editing

Metabolic Reprogramming in Human and Mouse Corneal Endothelial Cells with Reduced Expression of SLC4A11

Low mitogenic conditions maintain the corneal endothelial cell phenotype in vitro

ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing

Factors Affecting Primary Human Corneal Endothelial Cell Adhesion

Confirmation and Refinement of the Heterozygous Deletion of the Small Leucine-rich Proteoglycans Associated with Posterior Amorphous Corneal Dystrophy

Transcriptomic Profiling of SLC4A11 Null Murine Corneal Endothelial Cells

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

Transcriptomic analysis of human corneal endothelial cells during in vitro expansion

Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy

The functional impact of CRISPR-Cas9-mediated ZEB1 deficiency in human corneal endothelial cells

Generation of ZEB1-deficient human corneal endothelial cells using CRISPR-Cas9 as a model for posterior polymorphous corneal dystrophy 3

Characterization of an Alternative ZEB1 Nuclear Localization Signal in Posterior Polymorphous Corneal Dystrophy 3

Characterization of ZEB1-dependent Regulation of COL4A3 Expression

Effects of increased ZEB1 expression on proliferation and apoptosis of corneal endothelial cells

Investigating the Molecular Basis of PPCD3: Characterization of ZEB1 Regulation of COL4A3 Expression

Elucidating the molecular basis of PPCD3: effect of reduced ZEB1 levels on corneal endothelial cell migration

Elucidating the genetic basis of PPCD3: demonstration of ZEB1 binding to COL4A3 and COL4A4 E2 box domains

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