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Articles August 2020

Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms

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Brooke M. Justis; Casey E. Coburn; Ethan M. Tyler; Ryan S. Showalter; Brianna J. Dissler; Melissa Li; Nancy A. McNamara; Gordon W. Laurie; Robert L. McKown
TAGS: antibodies, immunoassay, proteins, schirmer tear test procedure, protein measurement, total, western blotting, recovery of function, volume
Trans. Vis. Sci. Tech.. 2020; 9(9):13. https://doi.org/10.1167/tvst.9.9.13

ARVO Annual Meeting Abstract July 2018

Relative Deficiency of Active Lacritin, the Shed Form of Lacritin Co-Receptor Syndecan-1 and the Pro-Form of Syndecan-Activating Enzyme Heparanase in Dry Eye Tears, and Development of a Tear Interactome

Gordon W Laurie; Jeff Romano; Leran Mao; Karina Luiza Dias Teixeira; Robert L McKown; Denise Ryan; Bruce Rivers

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3828.

ARVO Annual Meeting Abstract July 2018

Development of a Quantitative Multiplex Western Blot Assay for Tear Lacritin Proteins

Robert L McKown; Brooke M Justis; Casey E Coburn; Ronald W Raab; Bruce Rivers; Rose K Sia; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4914.

ARVO Annual Meeting Abstract July 2018

Immunomodulatory Activity of Tear Protein Lacritin

Afsaneh Amouzegar; Sharad Mittal; Mingshun Li; Robert L McKown; Gordon W Laurie; Sunil Chauhan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3323.

ARVO Annual Meeting Abstract June 2017

Constitutive Release of Lacritin's Latent Bactericidal Activity Explored by MALDI-TOF Mass Spectrometry

Jeff Romano; Nick Sherman; Robert L McKown; Tadayuki Iwase; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2646.

ARVO Annual Meeting Abstract June 2017

Evaluation of conjunctival and lacrimal gland inflammation after corneal herpes simplex virus-1 infection

Pushpa Rao; Subhash Gaddipati; Bala Burugula; Andrew Jerome; Robert L McKown; Gordon W Laurie; Susmit Suvas

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3620.

Cornea October 2016

Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome

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Nancy A. McNamara; Shaokui Ge; Salena M. Lee; Alison M. Enghauser; Lindsey Kuehl; Feeling Y.-T. Chen; Marianne Gallup; Robert L. McKown
TAGS: cornea, dry eye syndromes, neurons, neuropathy, sjogren's syndrome, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5237-5243. https://doi.org/10.1167/iovs.16-19309

ARVO Annual Meeting Abstract September 2016

Lacritin acutely enhances corneal nerve sensitivity to ocular surface dryness as a key stimulus for basal tear production: Implications for dry eye disease.

Valentina Dallacasagrande; Harumitsu Hirata; Kamila K Mizerska; Toin H. van Kuppevelt; Robert L McKown; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):424.

ARVO Annual Meeting Abstract September 2016

Reduced Levels of Tear Lacritin are Associated with Corneal Neuropathy in Sjögren’s Syndrome-associated Dry Eye Disease

Robert L McKown; Alison M Enghauser; ShaoKui Ge; Salena Lee; Lindsey Kuehl; Yu Ting Feeling Chen; Marianne Gallup; Nancy A McNamara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5686.

ARVO Annual Meeting Abstract September 2016

Lacritin Enhances Cell Proliferation in Mouse Lacrimal Gland

Helen P Makarenkova; Daren Lui; Driss Zoukhri; Robert L McKown; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5709.

ARVO Annual Meeting Abstract September 2016

Release of Lacritin’s C-Terminal Bactericidal Domain by Esp, a Serine Protease Highly Expressed in Coagulase Negative Clinical Isolates from Bacterial Keratitis, but not from Endophthalmitis or Blepharitis

Jeff Romano; Robert L McKown; Regis P Kowalski; Tadayuki Iwase; Gordon W Laurie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6190.

ARVO Annual Meeting Abstract June 2015

Canine Tear Lacritin is Down Regulated in Clinical Dry Eye

Robert L McKown; Alan C. Tate; Alison M. Enghauser; Cara L. Soyars; Ronald W. Raab; Gordon W Laurie; Ian P. Herring

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):288.

ARVO Annual Meeting Abstract June 2015

Anti-Stress and Basal Tear Stimulatory Tear Factor ‘Lacritin’ Promotes Acetylation of ATG101-Associated Proteins but has No Apparent Effect on Transepithelial Resistance

Gordon W Laurie; Ningning Wang; Jeffrey Romano; Robert L McKown

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2490.

Cornea August 2014

Topical Administration of Lacritin Is a Novel Therapy for Aqueous-Deficient Dry Eye Disease

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Trinka Vijmasi; Feeling Y. T. Chen; Suganthalakshmi Balasubbu; Marianne Gallup; Robert L. McKown; Gordon W. Laurie; Nancy A. McNamara
TAGS: administration, topical, bodily secretions, dry eye syndromes, proteins, mice, eye, t-lymphocytes, personal integrity
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):5401-5409. https://doi.org/10.1167/iovs.14-13924

ARVO Annual Meeting Abstract April 2014

Differential Availability of Active Lacritin and Cell Targeting Machinery in Normal vs Aqueous Deficient Tears as Insight into Cause

Gordon Laurie; Ningning Wang; Robert L McKown; Denise S. Ryan; Rose Kristine Sia; Lamarr Peppers

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3680.

Cornea March 2013

Tissue Transglutaminase Is a Negative Regulator of Monomeric Lacritin Bioactivity

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Francisco Velez V; Jeffrey A. Romano; Robert L. McKown; Kari Green; Liwen Zhang; Ronald W. Raab; Denise S. Ryan; Cindy M. L. Hutnik; Henry F. Frierson, Jr; Gordon W. Laurie
TAGS: body tissue, cross-linking, polymerization, transglutaminases, antibodies, glutamine
Invest. Ophthalmol. Vis. Sci.. 2013; 54(3):2123-2132. https://doi.org/10.1167/iovs.12-11488

Cornea March 2013

Conserved Regional 3′ Grouping of Rare Codons in the Coding Sequence of Ocular Prosecretory Mitogen Lacritin

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Robert L. McKown; Ronald W. Raab; Patricia Kachelries; Sara Caldwell; Gordon W. Laurie
TAGS: codon nucleotides, growth factor, open reading frames, mitogens, proteins
Invest. Ophthalmol. Vis. Sci.. 2013; 54(3):1979-1987. https://doi.org/10.1167/iovs.12-10740

Includes: Supplemental Content

Cornea September 2012

Tear Lacritin Levels by Age, Sex, and Time of Day in Healthy Adults

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Kyle Seifert; Natasha C. Gandia; Jennifer K. Wilburn; Kraig S. Bower; Rose K. Sia; Denise S. Ryan; Michael L. Deaton; Katherine M. Still; Veronica C. Vassilev; Gordon W. Laurie; Robert L. McKown
TAGS: adult, enzyme-linked immunosorbent assay, proteins, western blotting, antibodies, dry eye syndromes, peptides
Invest. Ophthalmol. Vis. Sci.. 2012; 53(10):6610-6616. https://doi.org/10.1167/iovs.11-8729

Includes: Supplemental Content

Cornea September 2012

Detection of Prosecretory Mitogen Lacritin in Nonprimate Tears Primarily as a C-Terminal-Like Fragment

PDF

Diane E. Laurie; Rebecca K. Splan; Kari Green; Katherine M. Still; Robert L. McKown; Gordon W. Laurie
TAGS: equus caballus, growth factor, proteins, mitogens, equidae, genome
Invest. Ophthalmol. Vis. Sci.. 2012; 53(10):6130-6136. https://doi.org/10.1167/iovs.11-8567

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Lacritin Suppression of Inflammatory Stress Involves Rapid Changes in the Human Corneal Epithelial Cell Metabolome

Ningning Wang; Keith Zimmerman; Jae K. Lee; Robert L. McKown; Gordon W. Laurie

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4230.

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Development of a Quantitative Immunoassay for Tear Lacritin Proteoforms

Relative Deficiency of Active Lacritin, the Shed Form of Lacritin Co-Receptor Syndecan-1 and the Pro-Form of Syndecan-Activating Enzyme Heparanase in Dry Eye Tears, and Development of a Tear Interactome

Development of a Quantitative Multiplex Western Blot Assay for Tear Lacritin Proteins

Immunomodulatory Activity of Tear Protein Lacritin

Constitutive Release of Lacritin's Latent Bactericidal Activity Explored by MALDI-TOF Mass Spectrometry

Evaluation of conjunctival and lacrimal gland inflammation after corneal herpes simplex virus-1 infection

Reduced Levels of Tear Lacritin Are Associated With Corneal Neuropathy in Patients With the Ocular Component of Sjögren's Syndrome

Lacritin acutely enhances corneal nerve sensitivity to ocular surface dryness as a key stimulus for basal tear production: Implications for dry eye disease.

Reduced Levels of Tear Lacritin are Associated with Corneal Neuropathy in Sjögren’s Syndrome-associated Dry Eye Disease

Lacritin Enhances Cell Proliferation in Mouse Lacrimal Gland

Release of Lacritin’s C-Terminal Bactericidal Domain by Esp, a Serine Protease Highly Expressed in Coagulase Negative Clinical Isolates from Bacterial Keratitis, but not from Endophthalmitis or Blepharitis

Canine Tear Lacritin is Down Regulated in Clinical Dry Eye

Anti-Stress and Basal Tear Stimulatory Tear Factor ‘Lacritin’ Promotes Acetylation of ATG101-Associated Proteins but has No Apparent Effect on Transepithelial Resistance

Topical Administration of Lacritin Is a Novel Therapy for Aqueous-Deficient Dry Eye Disease

Differential Availability of Active Lacritin and Cell Targeting Machinery in Normal vs Aqueous Deficient Tears as Insight into Cause

Tissue Transglutaminase Is a Negative Regulator of Monomeric Lacritin Bioactivity

Conserved Regional 3′ Grouping of Rare Codons in the Coding Sequence of Ocular Prosecretory Mitogen Lacritin

Tear Lacritin Levels by Age, Sex, and Time of Day in Healthy Adults

Detection of Prosecretory Mitogen Lacritin in Nonprimate Tears Primarily as a C-Terminal-Like Fragment

Lacritin Suppression of Inflammatory Stress Involves Rapid Changes in the Human Corneal Epithelial Cell Metabolome

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